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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 3

Gene

PPP6R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein phosphatase binding Source: MGI

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • regulation of phosphoprotein phosphatase activity Source: MGI

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Alternative name(s):
SAPS domain family member 3
Sporulation-induced transcript 4-associated protein SAPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP6R3
Synonyms:C11orf23, KIAA1558, PP6R3, SAPL, SAPS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110075.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1173 PPP6R3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610879 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5H9R7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55291

Open Targets

More...
OpenTargetsi
ENSG00000110075

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25487

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP6R3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
88941982

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000461001 – 873Serine/threonine-protein phosphatase 6 regulatory subunit 3Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei315PhosphoserineBy similarity1
Modified residuei579PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei631PhosphothreonineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei722PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5H9R7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5H9R7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5H9R7

PeptideAtlas

More...
PeptideAtlasi
Q5H9R7

PRoteomics IDEntifications database

More...
PRIDEi
Q5H9R7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62903
62904 [Q5H9R7-2]
62905 [Q5H9R7-3]
62906 [Q5H9R7-4]
62907 [Q5H9R7-5]
62908 [Q5H9R7-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5H9R7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5H9R7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110075 Expressed in 224 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5H9R7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5H9R7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017183
HPA038467
HPA038468

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and ANKRD28.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120579, 75 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5H9R7

Protein interaction database and analysis system

More...
IntActi
Q5H9R7, 34 interactors

Molecular INTeraction database

More...
MINTi
Q5H9R7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377390

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5H9R7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2073 Eukaryota
ENOG410XRM1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009899

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG069733

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5H9R7

KEGG Orthology (KO)

More...
KOi
K15501

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDAWEMN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0893

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5H9R7

TreeFam database of animal gene trees

More...
TreeFami
TF313227

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS

The PANTHER Classification System

More...
PANTHERi
PTHR12634 PTHR12634, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04499 SAPS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5H9R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK
60 70 80 90 100
AECLEDLVSF IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE
110 120 130 140 150
SLLMKLYSFL LNDSPLNPLL ASFFSKVLSI LISRKPEQIV DFLKKKHDFV
160 170 180 190 200
DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ DVLNWLNEEK IIQRLVEIVH
210 220 230 240 250
PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA TLEKQEIIEQ
260 270 280 290 300
LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS
310 320 330 340 350
VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL
360 370 380 390 400
ISSLLQTNTS SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL
410 420 430 440 450
ASPFENTENA TITDQDSTGD NLLLKHLFQK CQLIERILEA WEMNEKKQAE
460 470 480 490 500
GGRRHGYMGH LTRIANCIVH STDKGPNSAL VQQLIKDLPD EVRERWETFC
510 520 530 540 550
TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS SLQQAFSDYQ
560 570 580 590 600
MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL
610 620 630 640 650
FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD
660 670 680 690 700
SEEEDGAKQD LFEPSSANTE DKMEVDLSEP PNWSANFDVP METTHGAPLD
710 720 730 740 750
SVGSDVWSTE EPMPTKETGW ASFSEFTSSL STKDSLRSNS PVEMETSTEP
760 770 780 790 800
MDPLTPSAAA LAVQPEAAGS VAMEASSDGE EDAESTDKVT ETVMNGGMKE
810 820 830 840 850
TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA EAKCAAPRPP
860 870
SSSPEQRTGQ PSAPGDTSVN GPV
Length:873
Mass (Da):97,669
Last modified:February 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B4C69991E7DE16F
GO
Isoform 2 (identifier: Q5H9R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-549: Missing.

Show »
Length:867
Mass (Da):96,957
Checksum:i9E76BCA0E23EE3DE
GO
Isoform 3 (identifier: Q5H9R7-3) [UniParc]FASTAAdd to basket
Also known as: B, C11orf23b, SAPLb

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.
     857-873: RTGQPSAPGDTSVNGPV → SGVEIPALPGQWSQQ

Show »
Length:791
Mass (Da):88,909
Checksum:i1C936F03A484D53D
GO
Isoform 4 (identifier: Q5H9R7-4) [UniParc]FASTAAdd to basket
Also known as: A, C11orf23a, SAPLa

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.

Show »
Length:793
Mass (Da):88,952
Checksum:iAC5BEE22285932F4
GO
Isoform 5 (identifier: Q5H9R7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-817: S → RVLKSYR

Show »
Length:879
Mass (Da):98,485
Checksum:iE0AE6571756853C1
GO
Isoform 6 (identifier: Q5H9R7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-544: Missing.

Show »
Length:844
Mass (Da):94,445
Checksum:iADB89AA9C567C580
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXH2H7BXH2_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
827Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKF6E9PKF6_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
838Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQP7E9PQP7_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
641Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEN2H0YEN2_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
580Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMU2A0A1D5RMU2_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK08E9PK08_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNN8E9PNN8_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDW1H0YDW1_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJD8E9PJD8_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKG4E9PKG4_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAZ99639 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91978 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13384 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292P → S in CAH18675 (PubMed:17974005).Curated1
Sequence conflicti443M → V in BAB71396 (PubMed:14702039).Curated1
Sequence conflicti477N → S in CAI45957 (PubMed:17974005).Curated1
Sequence conflicti677L → P in CAI45957 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057720842A → V. Corresponds to variant dbSNP:rs34009811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017140326 – 376Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_017141516 – 544Missing in isoform 3, isoform 4 and isoform 6. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_017142544 – 549Missing in isoform 2. 1 Publication6
Alternative sequenceiVSP_017143817S → RVLKSYR in isoform 5. 1 Publication1
Alternative sequenceiVSP_017144857 – 873RTGQP…VNGPV → SGVEIPALPGQWSQQ in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF264779 mRNA Translation: AAG36934.1
AF264780 mRNA Translation: AAG36935.1
DQ111954 mRNA Translation: AAZ99639.2 Different initiation.
AB046778 mRNA Translation: BAB13384.2 Different initiation.
AL834471 mRNA Translation: CAD39130.1
CR749815 mRNA Translation: CAH18675.1
CR933658 mRNA Translation: CAI45957.1
BC007738 mRNA Translation: AAH07738.2
BC105933 mRNA Translation: AAI05934.1
BC105934 mRNA Translation: AAI05935.1
BC107599 mRNA Translation: AAI07600.1
AK001920 mRNA Translation: BAA91978.1 Different initiation.
AK057250 mRNA Translation: BAB71396.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53671.1 [Q5H9R7-5]
CCDS53672.1 [Q5H9R7-1]
CCDS53673.1 [Q5H9R7-2]
CCDS53674.1 [Q5H9R7-6]
CCDS53675.1 [Q5H9R7-3]
CCDS8182.1 [Q5H9R7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001157632.1, NM_001164160.1 [Q5H9R7-5]
NP_001157633.1, NM_001164161.1 [Q5H9R7-1]
NP_001157634.1, NM_001164162.1 [Q5H9R7-2]
NP_001157635.1, NM_001164163.1 [Q5H9R7-6]
NP_001157636.1, NM_001164164.1 [Q5H9R7-3]
NP_060782.2, NM_018312.4 [Q5H9R7-4]
XP_006718676.1, XM_006718613.2
XP_006718677.1, XM_006718614.2 [Q5H9R7-2]
XP_006718681.1, XM_006718618.3
XP_006718687.1, XM_006718624.2 [Q5H9R7-4]
XP_011543442.1, XM_011545140.2
XP_016873451.1, XM_017017962.1
XP_016873452.1, XM_017017963.1
XP_016873455.1, XM_017017966.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.503022

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265636; ENSP00000265636; ENSG00000110075 [Q5H9R7-4]
ENST00000393800; ENSP00000377389; ENSG00000110075 [Q5H9R7-1]
ENST00000393801; ENSP00000377390; ENSG00000110075 [Q5H9R7-5]
ENST00000524845; ENSP00000431415; ENSG00000110075 [Q5H9R7-6]
ENST00000524904; ENSP00000433058; ENSG00000110075 [Q5H9R7-2]
ENST00000529710; ENSP00000437329; ENSG00000110075 [Q5H9R7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55291

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55291

UCSC genome browser

More...
UCSCi
uc001onu.4 human [Q5H9R7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264779 mRNA Translation: AAG36934.1
AF264780 mRNA Translation: AAG36935.1
DQ111954 mRNA Translation: AAZ99639.2 Different initiation.
AB046778 mRNA Translation: BAB13384.2 Different initiation.
AL834471 mRNA Translation: CAD39130.1
CR749815 mRNA Translation: CAH18675.1
CR933658 mRNA Translation: CAI45957.1
BC007738 mRNA Translation: AAH07738.2
BC105933 mRNA Translation: AAI05934.1
BC105934 mRNA Translation: AAI05935.1
BC107599 mRNA Translation: AAI07600.1
AK001920 mRNA Translation: BAA91978.1 Different initiation.
AK057250 mRNA Translation: BAB71396.1 Different initiation.
CCDSiCCDS53671.1 [Q5H9R7-5]
CCDS53672.1 [Q5H9R7-1]
CCDS53673.1 [Q5H9R7-2]
CCDS53674.1 [Q5H9R7-6]
CCDS53675.1 [Q5H9R7-3]
CCDS8182.1 [Q5H9R7-4]
RefSeqiNP_001157632.1, NM_001164160.1 [Q5H9R7-5]
NP_001157633.1, NM_001164161.1 [Q5H9R7-1]
NP_001157634.1, NM_001164162.1 [Q5H9R7-2]
NP_001157635.1, NM_001164163.1 [Q5H9R7-6]
NP_001157636.1, NM_001164164.1 [Q5H9R7-3]
NP_060782.2, NM_018312.4 [Q5H9R7-4]
XP_006718676.1, XM_006718613.2
XP_006718677.1, XM_006718614.2 [Q5H9R7-2]
XP_006718681.1, XM_006718618.3
XP_006718687.1, XM_006718624.2 [Q5H9R7-4]
XP_011543442.1, XM_011545140.2
XP_016873451.1, XM_017017962.1
XP_016873452.1, XM_017017963.1
XP_016873455.1, XM_017017966.1
UniGeneiHs.503022

3D structure databases

ProteinModelPortaliQ5H9R7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120579, 75 interactors
CORUMiQ5H9R7
IntActiQ5H9R7, 34 interactors
MINTiQ5H9R7
STRINGi9606.ENSP00000377390

PTM databases

iPTMnetiQ5H9R7
PhosphoSitePlusiQ5H9R7

Polymorphism and mutation databases

BioMutaiPPP6R3
DMDMi88941982

Proteomic databases

EPDiQ5H9R7
MaxQBiQ5H9R7
PaxDbiQ5H9R7
PeptideAtlasiQ5H9R7
PRIDEiQ5H9R7
ProteomicsDBi62903
62904 [Q5H9R7-2]
62905 [Q5H9R7-3]
62906 [Q5H9R7-4]
62907 [Q5H9R7-5]
62908 [Q5H9R7-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265636; ENSP00000265636; ENSG00000110075 [Q5H9R7-4]
ENST00000393800; ENSP00000377389; ENSG00000110075 [Q5H9R7-1]
ENST00000393801; ENSP00000377390; ENSG00000110075 [Q5H9R7-5]
ENST00000524845; ENSP00000431415; ENSG00000110075 [Q5H9R7-6]
ENST00000524904; ENSP00000433058; ENSG00000110075 [Q5H9R7-2]
ENST00000529710; ENSP00000437329; ENSG00000110075 [Q5H9R7-3]
GeneIDi55291
KEGGihsa:55291
UCSCiuc001onu.4 human [Q5H9R7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55291
DisGeNETi55291
EuPathDBiHostDB:ENSG00000110075.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP6R3
HGNCiHGNC:1173 PPP6R3
HPAiCAB017183
HPA038467
HPA038468
MIMi610879 gene
neXtProtiNX_Q5H9R7
OpenTargetsiENSG00000110075
PharmGKBiPA25487

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiQ5H9R7
KOiK15501
OMAiLDAWEMN
OrthoDBiEOG091G0893
PhylomeDBiQ5H9R7
TreeFamiTF313227

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP6R3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55291

Protein Ontology

More...
PROi
PR:Q5H9R7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110075 Expressed in 224 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5H9R7 baseline and differential
GenevisibleiQ5H9R7 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP6R3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5H9R7
Secondary accession number(s): Q3B7I1
, Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: December 5, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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