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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 3

Gene

PPP6R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.2 Publications

GO - Molecular functioni

  • protein phosphatase binding Source: MGI

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • regulation of phosphoprotein phosphatase activity Source: MGI

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Alternative name(s):
SAPS domain family member 3
Sporulation-induced transcript 4-associated protein SAPL
Gene namesi
Name:PPP6R3
Synonyms:C11orf23, KIAA1558, PP6R3, SAPL, SAPS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110075.14
HGNCiHGNC:1173 PPP6R3
MIMi610879 gene
neXtProtiNX_Q5H9R7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55291
OpenTargetsiENSG00000110075
PharmGKBiPA25487

Polymorphism and mutation databases

BioMutaiPPP6R3
DMDMi88941982

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461001 – 873Serine/threonine-protein phosphatase 6 regulatory subunit 3Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei315PhosphoserineBy similarity1
Modified residuei579PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei631PhosphothreonineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei722PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5H9R7
MaxQBiQ5H9R7
PaxDbiQ5H9R7
PeptideAtlasiQ5H9R7
PRIDEiQ5H9R7
ProteomicsDBi62903
62904 [Q5H9R7-2]
62905 [Q5H9R7-3]
62906 [Q5H9R7-4]
62907 [Q5H9R7-5]
62908 [Q5H9R7-6]

PTM databases

iPTMnetiQ5H9R7
PhosphoSitePlusiQ5H9R7

Expressioni

Tissue specificityi

Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000110075 Expressed in 224 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5H9R7 baseline and differential
GenevisibleiQ5H9R7 HS

Organism-specific databases

HPAiCAB017183
HPA038467
HPA038468

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and ANKRD28.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120579, 73 interactors
CORUMiQ5H9R7
IntActiQ5H9R7, 34 interactors
MINTiQ5H9R7
STRINGi9606.ENSP00000377390

Structurei

3D structure databases

ProteinModelPortaliQ5H9R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiQ5H9R7
KOiK15501
OMAiLDAWEMN
OrthoDBiEOG091G0893
PhylomeDBiQ5H9R7
TreeFamiTF313227

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5H9R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK
60 70 80 90 100
AECLEDLVSF IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE
110 120 130 140 150
SLLMKLYSFL LNDSPLNPLL ASFFSKVLSI LISRKPEQIV DFLKKKHDFV
160 170 180 190 200
DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ DVLNWLNEEK IIQRLVEIVH
210 220 230 240 250
PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA TLEKQEIIEQ
260 270 280 290 300
LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS
310 320 330 340 350
VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL
360 370 380 390 400
ISSLLQTNTS SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL
410 420 430 440 450
ASPFENTENA TITDQDSTGD NLLLKHLFQK CQLIERILEA WEMNEKKQAE
460 470 480 490 500
GGRRHGYMGH LTRIANCIVH STDKGPNSAL VQQLIKDLPD EVRERWETFC
510 520 530 540 550
TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS SLQQAFSDYQ
560 570 580 590 600
MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL
610 620 630 640 650
FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD
660 670 680 690 700
SEEEDGAKQD LFEPSSANTE DKMEVDLSEP PNWSANFDVP METTHGAPLD
710 720 730 740 750
SVGSDVWSTE EPMPTKETGW ASFSEFTSSL STKDSLRSNS PVEMETSTEP
760 770 780 790 800
MDPLTPSAAA LAVQPEAAGS VAMEASSDGE EDAESTDKVT ETVMNGGMKE
810 820 830 840 850
TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA EAKCAAPRPP
860 870
SSSPEQRTGQ PSAPGDTSVN GPV
Length:873
Mass (Da):97,669
Last modified:February 7, 2006 - v2
Checksum:i5B4C69991E7DE16F
GO
Isoform 2 (identifier: Q5H9R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-549: Missing.

Show »
Length:867
Mass (Da):96,957
Checksum:i9E76BCA0E23EE3DE
GO
Isoform 3 (identifier: Q5H9R7-3) [UniParc]FASTAAdd to basket
Also known as: B, C11orf23b, SAPLb

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.
     857-873: RTGQPSAPGDTSVNGPV → SGVEIPALPGQWSQQ

Show »
Length:791
Mass (Da):88,909
Checksum:i1C936F03A484D53D
GO
Isoform 4 (identifier: Q5H9R7-4) [UniParc]FASTAAdd to basket
Also known as: A, C11orf23a, SAPLa

The sequence of this isoform differs from the canonical sequence as follows:
     326-376: Missing.
     516-544: Missing.

Show »
Length:793
Mass (Da):88,952
Checksum:iAC5BEE22285932F4
GO
Isoform 5 (identifier: Q5H9R7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-817: S → RVLKSYR

Show »
Length:879
Mass (Da):98,485
Checksum:iE0AE6571756853C1
GO
Isoform 6 (identifier: Q5H9R7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-544: Missing.

Show »
Length:844
Mass (Da):94,445
Checksum:iADB89AA9C567C580
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXH2H7BXH2_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
827Annotation score:
E9PQP7E9PQP7_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
641Annotation score:
E9PKF6E9PKF6_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
838Annotation score:
H0YEN2H0YEN2_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
580Annotation score:
A0A1D5RMU2A0A1D5RMU2_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
8Annotation score:
E9PNN8E9PNN8_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
186Annotation score:
E9PK08E9PK08_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
140Annotation score:
H0YDW1H0YDW1_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
112Annotation score:
E9PJD8E9PJD8_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
39Annotation score:
E9PKG4E9PKG4_HUMAN
Serine/threonine-protein phosphatas...
PPP6R3
75Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAZ99639 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91978 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13384 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292P → S in CAH18675 (PubMed:17974005).Curated1
Sequence conflicti443M → V in BAB71396 (PubMed:14702039).Curated1
Sequence conflicti477N → S in CAI45957 (PubMed:17974005).Curated1
Sequence conflicti677L → P in CAI45957 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057720842A → V. Corresponds to variant dbSNP:rs34009811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017140326 – 376Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_017141516 – 544Missing in isoform 3, isoform 4 and isoform 6. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_017142544 – 549Missing in isoform 2. 1 Publication6
Alternative sequenceiVSP_017143817S → RVLKSYR in isoform 5. 1 Publication1
Alternative sequenceiVSP_017144857 – 873RTGQP…VNGPV → SGVEIPALPGQWSQQ in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264779 mRNA Translation: AAG36934.1
AF264780 mRNA Translation: AAG36935.1
DQ111954 mRNA Translation: AAZ99639.2 Different initiation.
AB046778 mRNA Translation: BAB13384.2 Different initiation.
AL834471 mRNA Translation: CAD39130.1
CR749815 mRNA Translation: CAH18675.1
CR933658 mRNA Translation: CAI45957.1
BC007738 mRNA Translation: AAH07738.2
BC105933 mRNA Translation: AAI05934.1
BC105934 mRNA Translation: AAI05935.1
BC107599 mRNA Translation: AAI07600.1
AK001920 mRNA Translation: BAA91978.1 Different initiation.
AK057250 mRNA Translation: BAB71396.1 Different initiation.
CCDSiCCDS53671.1 [Q5H9R7-5]
CCDS53672.1 [Q5H9R7-1]
CCDS53673.1 [Q5H9R7-2]
CCDS53674.1 [Q5H9R7-6]
CCDS53675.1 [Q5H9R7-3]
CCDS8182.1 [Q5H9R7-4]
RefSeqiNP_001157632.1, NM_001164160.1 [Q5H9R7-5]
NP_001157633.1, NM_001164161.1 [Q5H9R7-1]
NP_001157634.1, NM_001164162.1 [Q5H9R7-2]
NP_001157635.1, NM_001164163.1 [Q5H9R7-6]
NP_001157636.1, NM_001164164.1 [Q5H9R7-3]
NP_060782.2, NM_018312.4 [Q5H9R7-4]
XP_006718676.1, XM_006718613.2
XP_006718677.1, XM_006718614.2 [Q5H9R7-2]
XP_006718681.1, XM_006718618.3
XP_006718687.1, XM_006718624.2 [Q5H9R7-4]
XP_011543442.1, XM_011545140.2
XP_016873451.1, XM_017017962.1
XP_016873452.1, XM_017017963.1
XP_016873455.1, XM_017017966.1
UniGeneiHs.503022

Genome annotation databases

EnsembliENST00000265636; ENSP00000265636; ENSG00000110075 [Q5H9R7-4]
ENST00000393800; ENSP00000377389; ENSG00000110075 [Q5H9R7-1]
ENST00000393801; ENSP00000377390; ENSG00000110075 [Q5H9R7-5]
ENST00000524845; ENSP00000431415; ENSG00000110075 [Q5H9R7-6]
ENST00000524904; ENSP00000433058; ENSG00000110075 [Q5H9R7-2]
ENST00000529710; ENSP00000437329; ENSG00000110075 [Q5H9R7-3]
GeneIDi55291
KEGGihsa:55291
UCSCiuc001onu.4 human [Q5H9R7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264779 mRNA Translation: AAG36934.1
AF264780 mRNA Translation: AAG36935.1
DQ111954 mRNA Translation: AAZ99639.2 Different initiation.
AB046778 mRNA Translation: BAB13384.2 Different initiation.
AL834471 mRNA Translation: CAD39130.1
CR749815 mRNA Translation: CAH18675.1
CR933658 mRNA Translation: CAI45957.1
BC007738 mRNA Translation: AAH07738.2
BC105933 mRNA Translation: AAI05934.1
BC105934 mRNA Translation: AAI05935.1
BC107599 mRNA Translation: AAI07600.1
AK001920 mRNA Translation: BAA91978.1 Different initiation.
AK057250 mRNA Translation: BAB71396.1 Different initiation.
CCDSiCCDS53671.1 [Q5H9R7-5]
CCDS53672.1 [Q5H9R7-1]
CCDS53673.1 [Q5H9R7-2]
CCDS53674.1 [Q5H9R7-6]
CCDS53675.1 [Q5H9R7-3]
CCDS8182.1 [Q5H9R7-4]
RefSeqiNP_001157632.1, NM_001164160.1 [Q5H9R7-5]
NP_001157633.1, NM_001164161.1 [Q5H9R7-1]
NP_001157634.1, NM_001164162.1 [Q5H9R7-2]
NP_001157635.1, NM_001164163.1 [Q5H9R7-6]
NP_001157636.1, NM_001164164.1 [Q5H9R7-3]
NP_060782.2, NM_018312.4 [Q5H9R7-4]
XP_006718676.1, XM_006718613.2
XP_006718677.1, XM_006718614.2 [Q5H9R7-2]
XP_006718681.1, XM_006718618.3
XP_006718687.1, XM_006718624.2 [Q5H9R7-4]
XP_011543442.1, XM_011545140.2
XP_016873451.1, XM_017017962.1
XP_016873452.1, XM_017017963.1
XP_016873455.1, XM_017017966.1
UniGeneiHs.503022

3D structure databases

ProteinModelPortaliQ5H9R7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120579, 73 interactors
CORUMiQ5H9R7
IntActiQ5H9R7, 34 interactors
MINTiQ5H9R7
STRINGi9606.ENSP00000377390

PTM databases

iPTMnetiQ5H9R7
PhosphoSitePlusiQ5H9R7

Polymorphism and mutation databases

BioMutaiPPP6R3
DMDMi88941982

Proteomic databases

EPDiQ5H9R7
MaxQBiQ5H9R7
PaxDbiQ5H9R7
PeptideAtlasiQ5H9R7
PRIDEiQ5H9R7
ProteomicsDBi62903
62904 [Q5H9R7-2]
62905 [Q5H9R7-3]
62906 [Q5H9R7-4]
62907 [Q5H9R7-5]
62908 [Q5H9R7-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265636; ENSP00000265636; ENSG00000110075 [Q5H9R7-4]
ENST00000393800; ENSP00000377389; ENSG00000110075 [Q5H9R7-1]
ENST00000393801; ENSP00000377390; ENSG00000110075 [Q5H9R7-5]
ENST00000524845; ENSP00000431415; ENSG00000110075 [Q5H9R7-6]
ENST00000524904; ENSP00000433058; ENSG00000110075 [Q5H9R7-2]
ENST00000529710; ENSP00000437329; ENSG00000110075 [Q5H9R7-3]
GeneIDi55291
KEGGihsa:55291
UCSCiuc001onu.4 human [Q5H9R7-1]

Organism-specific databases

CTDi55291
DisGeNETi55291
EuPathDBiHostDB:ENSG00000110075.14
GeneCardsiPPP6R3
HGNCiHGNC:1173 PPP6R3
HPAiCAB017183
HPA038467
HPA038468
MIMi610879 gene
neXtProtiNX_Q5H9R7
OpenTargetsiENSG00000110075
PharmGKBiPA25487
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiQ5H9R7
KOiK15501
OMAiLDAWEMN
OrthoDBiEOG091G0893
PhylomeDBiQ5H9R7
TreeFamiTF313227

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRSiPPP6R3 human
GenomeRNAii55291
PROiPR:Q5H9R7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110075 Expressed in 224 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5H9R7 baseline and differential
GenevisibleiQ5H9R7 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPP6R3_HUMAN
AccessioniPrimary (citable) accession number: Q5H9R7
Secondary accession number(s): Q3B7I1
, Q3I4Y0, Q3KR35, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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