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Entry version 100 (17 Jun 2020)
Sequence version 3 (18 Sep 2019)
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Protein

Armadillo repeat-containing X-linked protein 4

Gene

ARMCX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARMCX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196440.11

Human Gene Nomenclature Database

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HGNCi
HGNC:28615 ARMCX4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5H9R4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 24HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196440

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5H9R4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARMCX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
84027758

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913701 – 2290Armadillo repeat-containing X-linked protein 4Add BLAST2290

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5H9R4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5H9R4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5H9R4

PeptideAtlas

More...
PeptideAtlasi
Q5H9R4

PRoteomics IDEntifications database

More...
PRIDEi
Q5H9R4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30227
62901 [Q5H9R4-1]
62902 [Q5H9R4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5H9R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5H9R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196440 Expressed in muscle layer of sigmoid colon and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5H9R4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5H9R4 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q5H9R4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000404304

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5H9R4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2031 – 2071ARM 1Sequence analysisAdd BLAST41
Repeati2073 – 2112ARM 2Sequence analysisAdd BLAST40
Repeati2153 – 2192ARM 3Sequence analysisAdd BLAST40
Repeati2194 – 2234ARM 4Sequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JB0F Eukaryota
ENOG4111A6X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162587

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_065826_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5H9R4

Identification of Orthologs from Complete Genome Data

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OMAi
VYAKPEA

Database of Orthologous Groups

More...
OrthoDBi
860703at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5H9R4

TreeFam database of animal gene trees

More...
TreeFami
TF335652

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
IPR000225 Armadillo

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04826 Arm_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5H9R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRIQEVGWV TAGLVIWAGT CYYIYKFTKG RAQSVRTLAR NGSTVKMETV
60 70 80 90 100
VGVQSQTLAI NEAEIKTKPQ VEIGAETGAR SGPRAEVETK ATAIAIHRAN
110 120 130 140 150
SQAKAMVGAE PETQSESKVV AGTLVMTEAV TLTEVKAKAR EVAMKEAVTQ
160 170 180 190 200
TDAEAGKIVK KEAVTQTKAK AWALVAKTEA KREAMTQTKA ETHILAEKET
210 220 230 240 250
EINRVMVTQS ETLAVPREVA KMGATNKTGI VDETKTRALE ETVSVAKTQS
260 270 280 290 300
EARPGATVDA RGNPNGMSRE VAGVDMKSCA QSQAVTKIQG DDMPGTGVED
310 320 330 340 350
MGNCKTMSRA ESGADTRASA QPQIFAKTQT EAIPGAKIDA GGNTNAMCKV
360 370 380 390 400
GAGADVRACI QPQTVAKKQA EVTSGARVDG RGNTNVISKA ITGADMRAAA
410 420 430 440 450
QPQAVASTHA EAMSDAKVKN RGNPNAMTKA GAKANLRANS QVEALPDARD
460 470 480 490 500
KSRGNPNVMA KVGDGTDMLS CTQPQLVASV QADTLSDGKI KVRGNVNTMP
510 520 530 540 550
KEGAGVDMKA QGMAQSQGEA LPNTRGKARG KAKAKCKTGP GMDMKTCTQP
560 570 580 590 600
QAGVKTPAEA LLDSRVDGRG NPNATSKAGT KADQRVCGQP LVVANPQGEA
610 620 630 640 650
LPGAKNKVKG NPHTVLKVGA GEGTTDSAQP EAVVSFQGEA LLGTKNKVKG
660 670 680 690 700
NPNVVLKAEV GEGAMGTAQL QIMASSKGEA LLDSKNKVKG NSNAVSKAGA
710 720 730 740 750
GTDTTGSVQP QIVANSQGEV LPGAKNKIRG NPTTVPNSGV GPYTTDSARL
760 770 780 790 800
QAVANSQGEV LPGAKNKVKA NLNAVSKAEA GMGATGSVQP QAVANSHCET
810 820 830 840 850
LPGAKNKVRG NWNAVSKAGA GMDTRGSAQP QAVANSQGEV LPGAKNKVKG
860 870 880 890 900
NPNVVSKAGA REDTVGSTQP QVLASSQRET LPGARNKVKG NSNVVSKAGA
910 920 930 940 950
REDTMGSAQP QVVANSQRET LPGARNKVKG NSNAISKAEA GAGIMGSVQV
960 970 980 990 1000
QVVASFQGEV LPGAKNKVRG NSNAVPKAEA GADTVGSAQP QAVANSQSET
1010 1020 1030 1040 1050
LLGARNKVKG NTIAVPKAGT GAGTRHSAQP QIVAGSQGET LPGARDKSMS
1060 1070 1080 1090 1100
TSEAEATAED EAYAKPEAEA MPTSESEGGS GTQACRKTQP NIHDYYWNGI
1110 1120 1130 1140 1150
GVEDWIAAER WIKFRFQTMD GDWENSVSWA DDENEASIGS WSGASDKAGI
1160 1170 1180 1190 1200
IRSWAVACDE TSVKSWAGAR AENVVGIGTW ARAGEQASGG LWAGGQTSEG
1210 1220 1230 1240 1250
TWAGDKASGG AWTGAENQAS GGSWALAGNQ AIGELWAAGQ ASDGSWPGGQ
1260 1270 1280 1290 1300
ASGVSWVGEE AIGGSWTGAE NQASEGSWAG AGAGNMSSVS YWAGVVDQAG
1310 1320 1330 1340 1350
GGSWAGTSDQ SGGGSKPRFE DQASGEGSWA GAGGQASGGS MLGPEDQSSG
1360 1370 1380 1390 1400
RSWADTADQA SGGSRLGHVD QSSGGAWAGT LDQSGGGSKP RFENQTTEEG
1410 1420 1430 1440 1450
SWAGAGGQAG GGSKVGPEDQ SSGRSWANSG DQISGGFLVG IVDQANGGSW
1460 1470 1480 1490 1500
TGAGHPASVG PKPIFEDQVS GRGSWADARE QVVGDSRLGL RDQSSGDSWA
1510 1520 1530 1540 1550
GTGDQASGWF CVCPGSQTNG GSWGGASGQD VGGSRPGPTN QSSAGSWDSP
1560 1570 1580 1590 1600
GSQVSGSCWT GAGAVDQAGG CSKPGFEDQA IGGGFWPGAG DQTGGGSRPG
1610 1620 1630 1640 1650
SEDQSSGIGS WGVAGGQVLG GARPGPADQS SGGSWAGTGN QSSGRSWIGP
1660 1670 1680 1690 1700
GDQAVDCSKP EFEDQACGGG SWAGAGSQAS GESWAGSRPG NEAIGGSRMG
1710 1720 1730 1740 1750
SEDQATGGSW ARSEDQASGR FQVSFEVEAN EGFWFGPGAE AVIGSWCWTE
1760 1770 1780 1790 1800
EKADIVSRPD DKDEATTASR SGAGEEAMIC SRIEAENKAS SGSWIRSEEV
1810 1820 1830 1840 1850
AYMGSCVGAE AGAGAEAGAG AEAGAGAGAE AGAEAGAGAG AGPGTESGAG
1860 1870 1880 1890 1900
IWSWDGDATT VESRLGAGEE AGVESWTLAR NVGEDELSRE SSPDIEEISL
1910 1920 1930 1940 1950
RSLFWAESEN SNTFRSKSGK DASFESGAGD NTSIKDKFEA AGGVDIGSWF
1960 1970 1980 1990 2000
CAGNENTSED KSAPKAKAKK SSESRGIYPY MVPGAGMGSW DGAMIWSETK
2010 2020 2030 2040 2050
FAHQSEASFP VEDESRKQTR TGEKTRPWSC RCKHEANMDP RDLEKLICMI
2060 2070 2080 2090 2100
EMTEDPSVHE IANNALYNSA DYSYSHEVVR NVGGISVIES LLNNPYPSVR
2110 2120 2130 2140 2150
QKALNALNNI SVAAENHRKV KTYLNQVCED TVTYPLNSNV QLAGLRLIRH
2160 2170 2180 2190 2200
LTITSEYQHM VTNYISEFLR LLTVGSGETK DHVLGMLLNF SKNPSMTKDL
2210 2220 2230 2240 2250
LIANAPTSLI NIFSKKETKE NILNALSLFE NINYHFKRRA KAFTQDKFSK
2260 2270 2280 2290
NSLYFLFQRP KACAKKLRAL AAECNDPEVK ERVELLISKL
Length:2,290
Mass (Da):235,964
Last modified:September 18, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23A640FF02ABBF31
GO
Isoform 2 (identifier: Q5H9R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSAAGLKITG...VRAFSRGDYM
     244-256: SVAKTQSEARPGA → LIPRAFPSKNASC
     257-2290: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:348
Mass (Da):37,893
Checksum:iB1F7B37580575021
GO
Isoform 3 (identifier: Q5H9R4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSAAGLKITG...VRAFSRGDYM
     244-256: SVAKTQSEARPGA → LIPRAFPSKNASC
     257-2290: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:360
Mass (Da):39,406
Checksum:iAFD1BF07D758CC06
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBS8D6RBS8_HUMAN
Armadillo repeat-containing X-linke...
ARMCX4
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q5H9R4-3)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82P → R in CAI45960 (PubMed:17974005).Curated1
Sequence conflicti84S → C in CAI45960 (PubMed:17974005).Curated1
Isoform 2 (identifier: Q5H9R4-2)
Sequence conflicti345N → D in BAC04910 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02476184R → G2 PublicationsCorresponds to variant dbSNP:rs5951332Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0602481M → MSAAGLKITGSKETKRRLLL ISIDWVYCQEKQEERRELPR IITGPPPEAAVVAFEWLKTS TLTGLHPQLPLSLPQPECAL PYLVRAFSRGDYM in isoform 2. 1
Alternative sequenceiVSP_0602491M → MSAAGLKITGSKETKRRLLL ISIDWSRDLMNLCIYFRVYC QEKQEERRELPRIITGPPPE AAVVAFEWLKTSTLTGLHPQ LPLSLPQPECALPYLVRAFS RGDYM in isoform 3. 1
Alternative sequenceiVSP_060250244 – 256SVAKT…ARPGA → LIPRAFPSKNASC in isoform 2 and isoform 3. Add BLAST13
Alternative sequenceiVSP_060251257 – 2290Missing in isoform 2 and isoform 3. Add BLAST2034

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096955 mRNA Translation: BAC04910.1
AK126987 mRNA Translation: BAG54416.1
AK292543 mRNA Translation: BAF85232.1
CR933662 mRNA Translation: CAI45960.1
AL035422 Genomic DNA No translation available.
KF459251 Genomic DNA No translation available.
KF459256 Genomic DNA No translation available.
KF459252 Genomic DNA No translation available.
KF510605 Genomic DNA No translation available.
Z68873 Genomic DNA No translation available.
Z69838 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02869.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59170.1 [Q5H9R4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001243084.2, NM_001256155.2 [Q5H9R4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354842; ENSP00000423927; ENSG00000196440 [Q5H9R4-2]
ENST00000423738; ENSP00000404304; ENSG00000196440 [Q5H9R4-1]
ENST00000433011; ENSP00000424452; ENSG00000196440 [Q5H9R4-3]
ENST00000452188; ENSP00000425302; ENSG00000196440 [Q5H9R4-3]
ENST00000455331; ENSP00000423440; ENSG00000196440 [Q5H9R4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100131755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100131755

UCSC genome browser

More...
UCSCi
uc065ahn.1 human [Q5H9R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096955 mRNA Translation: BAC04910.1
AK126987 mRNA Translation: BAG54416.1
AK292543 mRNA Translation: BAF85232.1
CR933662 mRNA Translation: CAI45960.1
AL035422 Genomic DNA No translation available.
KF459251 Genomic DNA No translation available.
KF459256 Genomic DNA No translation available.
KF459252 Genomic DNA No translation available.
KF510605 Genomic DNA No translation available.
Z68873 Genomic DNA No translation available.
Z69838 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02869.1
CCDSiCCDS59170.1 [Q5H9R4-1]
RefSeqiNP_001243084.2, NM_001256155.2 [Q5H9R4-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ5H9R4, 1 interactor
STRINGi9606.ENSP00000404304

PTM databases

iPTMnetiQ5H9R4
PhosphoSitePlusiQ5H9R4

Polymorphism and mutation databases

BioMutaiARMCX4
DMDMi84027758

Proteomic databases

jPOSTiQ5H9R4
MassIVEiQ5H9R4
PaxDbiQ5H9R4
PeptideAtlasiQ5H9R4
PRIDEiQ5H9R4
ProteomicsDBi30227
62901 [Q5H9R4-1]
62902 [Q5H9R4-2]

Genome annotation databases

EnsembliENST00000354842; ENSP00000423927; ENSG00000196440 [Q5H9R4-2]
ENST00000423738; ENSP00000404304; ENSG00000196440 [Q5H9R4-1]
ENST00000433011; ENSP00000424452; ENSG00000196440 [Q5H9R4-3]
ENST00000452188; ENSP00000425302; ENSG00000196440 [Q5H9R4-3]
ENST00000455331; ENSP00000423440; ENSG00000196440 [Q5H9R4-2]
GeneIDi100131755
KEGGihsa:100131755
UCSCiuc065ahn.1 human [Q5H9R4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
100131755
EuPathDBiHostDB:ENSG00000196440.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ARMCX4
HGNCiHGNC:28615 ARMCX4
neXtProtiNX_Q5H9R4
OpenTargetsiENSG00000196440

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410JB0F Eukaryota
ENOG4111A6X LUCA
GeneTreeiENSGT00940000162587
HOGENOMiCLU_065826_0_0_1
InParanoidiQ5H9R4
OMAiVYAKPEA
OrthoDBi860703at2759
PhylomeDBiQ5H9R4
TreeFamiTF335652

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
100131755 2 hits in 406 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARMCX4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
100131755
PharosiQ5H9R4 Tdark

Protein Ontology

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PROi
PR:Q5H9R4
RNActiQ5H9R4 protein

Gene expression databases

BgeeiENSG00000196440 Expressed in muscle layer of sigmoid colon and 178 other tissues
ExpressionAtlasiQ5H9R4 baseline and differential
GenevisibleiQ5H9R4 HS

Family and domain databases

InterProiView protein in InterPro
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF04826 Arm_2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARMX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5H9R4
Secondary accession number(s): A8K928
, B3KXA4, F8W8Y7, Q5H9K8, Q8N8D6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: September 18, 2019
Last modified: June 17, 2020
This is version 100 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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