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UniProtKB - Q5H9L2 (TCAL5_HUMAN)

Entry version 122 (23 Feb 2022)
Sequence version 1 (15 Feb 2005)
Previous versions | rss
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Protein

Transcription elongation factor A protein-like 5

Gene

TCEAL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • WW domain binding Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5H9L2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5H9L2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor A protein-like 5
Short name:
TCEA-like protein 5
Alternative name(s):
Transcription elongation factor S-II protein-like 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCEAL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:22282, TCEAL5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5H9L2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204065

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000204065

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134950668

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5H9L2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TCEAL5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762182

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002392111 – 206Transcription elongation factor A protein-like 5Add BLAST206

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5H9L2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5H9L2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5H9L2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5H9L2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5H9L2

PeptideAtlas

More...PeptideAtlasi		Q5H9L2

PRoteomics IDEntifications database

More...PRIDEi		Q5H9L2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62895

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5H9L2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5H9L2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204065, Expressed in dorsolateral prefrontal cortex and 105 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204065, Group enriched (brain, choroid plexus, pituitary gland, retina, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131070, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q5H9L2, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361765

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5H9L2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5H9L2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 206DisorderedSequence analysisAdd BLAST206

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 30Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi40 – 60Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi67 – 88Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi99 – 168Basic and acidic residuesSequence analysisAdd BLAST70
Compositional biasi192 – 206Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RKY0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183164

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_078412_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5H9L2

Identification of Orthologs from Complete Genome Data

More...OMAi		PKDEKRP

Database of Orthologous Groups

More...OrthoDBi		1432394at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5H9L2

TreeFam database of animal gene trees

More...TreeFami		TF336871

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021156, TF_A-like/BEX

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04538, BEX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5H9L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLYKENEG KPENERNLES EGKPEDEGST EDEGKSDEEE KPDMEGKTEC 
        60         70         80         90        100
EGKREDEGEP GDEGQLEDEG NQEKQGKSEG EDKPQSEGKP ASQAKPESQP 
       110        120        130        140        150
RAAEKRPAED YVPRKAKRKT DRGTDDSPKD SQEDLQERHL SSEEMMRECG 
       160        170        180        190        200
DVSRAQEELR KKQKMGGFHW MQRDVQDPFA PRGQRGVRGV RGGGRGQKDL 

EDVPYV
Length:206
Mass (Da):23,307
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCDB6A1ACCCE3BAD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z68694 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54717.1
BC132922 mRNA Translation: AAI32923.1
BC132924 mRNA Translation: AAI32925.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35356.1

NCBI Reference Sequences

More...RefSeqi		NP_001012997.1, NM_001012979.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372680; ENSP00000361765; ENSG00000204065

Database of genes from NCBI RefSeq genomes

More...GeneIDi		340543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:340543

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000372680.2; ENSP00000361765.1; NM_001012979.3; NP_001012997.1

UCSC genome browser

More...UCSCi		uc004ejz.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68694 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54717.1
BC132922 mRNA Translation: AAI32923.1
BC132924 mRNA Translation: AAI32925.1
CCDSiCCDS35356.1
RefSeqiNP_001012997.1, NM_001012979.2

3D structure databases

SMRiQ5H9L2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131070, 6 interactors
IntActiQ5H9L2, 4 interactors
STRINGi9606.ENSP00000361765

PTM databases

iPTMnetiQ5H9L2
PhosphoSitePlusiQ5H9L2

Genetic variation databases

BioMutaiTCEAL5
DMDMi74762182

Proteomic databases

EPDiQ5H9L2
jPOSTiQ5H9L2
MassIVEiQ5H9L2
MaxQBiQ5H9L2
PaxDbiQ5H9L2
PeptideAtlasiQ5H9L2
PRIDEiQ5H9L2
ProteomicsDBi62895

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		71662, 27 antibodies from 14 providers

The DNASU plasmid repository

More...DNASUi		340543

Genome annotation databases

EnsembliENST00000372680; ENSP00000361765; ENSG00000204065
GeneIDi340543
KEGGihsa:340543
MANE-SelectiENST00000372680.2; ENSP00000361765.1; NM_001012979.3; NP_001012997.1
UCSCiuc004ejz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		340543

GeneCards: human genes, protein and diseases

More...GeneCardsi		TCEAL5
HGNCiHGNC:22282, TCEAL5
HPAiENSG00000204065, Group enriched (brain, choroid plexus, pituitary gland, retina, testis)
neXtProtiNX_Q5H9L2
OpenTargetsiENSG00000204065
PharmGKBiPA134950668
VEuPathDBiHostDB:ENSG00000204065

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RKY0, Eukaryota
GeneTreeiENSGT00950000183164
HOGENOMiCLU_078412_1_0_1
InParanoidiQ5H9L2
OMAiPKDEKRP
OrthoDBi1432394at2759
PhylomeDBiQ5H9L2
TreeFamiTF336871

Enzyme and pathway databases

PathwayCommonsiQ5H9L2
SignaLinkiQ5H9L2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		340543, 1 hit in 601 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		340543
PharosiQ5H9L2, Tdark

Protein Ontology

More...PROi		PR:Q5H9L2
RNActiQ5H9L2, protein

Gene expression databases

BgeeiENSG00000204065, Expressed in dorsolateral prefrontal cortex and 105 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR021156, TF_A-like/BEX
PfamiView protein in Pfam
PF04538, BEX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCAL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5H9L2
Secondary accession number(s): A2RUJ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 15, 2005
Last modified: February 23, 2022
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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