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UniProtKB - Q5H9L2 (TCAL5_HUMAN)
Protein
Transcription elongation factor A protein-like 5
Gene
TCEAL5
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
GO - Molecular functioni
- WW domain binding Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q5H9L2 |
SignaLinki | Q5H9L2 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription elongation factor A protein-like 5Short name: TCEA-like protein 5 Alternative name(s): Transcription elongation factor S-II protein-like 5 |
Gene namesi | Name:TCEAL5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22282, TCEAL5 |
neXtProti | NX_Q5H9L2 |
VEuPathDBi | HostDB:ENSG00000204065 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000204065 |
PharmGKBi | PA134950668 |
Miscellaneous databases
Pharosi | Q5H9L2, Tdark |
Genetic variation databases
BioMutai | TCEAL5 |
DMDMi | 74762182 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239211 | 1 – 206 | Transcription elongation factor A protein-like 5Add BLAST | 206 |
Proteomic databases
EPDi | Q5H9L2 |
jPOSTi | Q5H9L2 |
MassIVEi | Q5H9L2 |
MaxQBi | Q5H9L2 |
PaxDbi | Q5H9L2 |
PeptideAtlasi | Q5H9L2 |
PRIDEi | Q5H9L2 |
ProteomicsDBi | 62895 |
PTM databases
iPTMneti | Q5H9L2 |
PhosphoSitePlusi | Q5H9L2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204065, Expressed in dorsolateral prefrontal cortex and 105 other tissues |
Organism-specific databases
HPAi | ENSG00000204065, Group enriched (brain, choroid plexus, pituitary gland, retina, testis) |
Interactioni
Binary interactionsi
Q5H9L2
With | #Exp. | IntAct |
---|---|---|
NR4A2 [P43354] | 2 | EBI-2681773,EBI-2681738 |
GO - Molecular functioni
- WW domain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 131070, 6 interactors |
IntActi | Q5H9L2, 4 interactors |
STRINGi | 9606.ENSP00000361765 |
Miscellaneous databases
RNActi | Q5H9L2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 206 | DisorderedSequence analysisAdd BLAST | 206 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 30 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 40 – 60 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 67 – 88 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 99 – 168 | Basic and acidic residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 192 – 206 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502RKY0, Eukaryota |
GeneTreei | ENSGT00950000183164 |
HOGENOMi | CLU_078412_1_0_1 |
InParanoidi | Q5H9L2 |
OMAi | PKDEKRP |
OrthoDBi | 1432394at2759 |
PhylomeDBi | Q5H9L2 |
TreeFami | TF336871 |
Family and domain databases
InterProi | View protein in InterPro IPR021156, TF_A-like/BEX |
Pfami | View protein in Pfam PF04538, BEX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5H9L2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKLYKENEG KPENERNLES EGKPEDEGST EDEGKSDEEE KPDMEGKTEC
60 70 80 90 100
EGKREDEGEP GDEGQLEDEG NQEKQGKSEG EDKPQSEGKP ASQAKPESQP
110 120 130 140 150
RAAEKRPAED YVPRKAKRKT DRGTDDSPKD SQEDLQERHL SSEEMMRECG
160 170 180 190 200
DVSRAQEELR KKQKMGGFHW MQRDVQDPFA PRGQRGVRGV RGGGRGQKDL
EDVPYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z68694 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54717.1 BC132922 mRNA Translation: AAI32923.1 BC132924 mRNA Translation: AAI32925.1 |
CCDSi | CCDS35356.1 |
RefSeqi | NP_001012997.1, NM_001012979.2 |
Genome annotation databases
Ensembli | ENST00000372680; ENSP00000361765; ENSG00000204065 |
GeneIDi | 340543 |
KEGGi | hsa:340543 |
MANE-Selecti | ENST00000372680.2; ENSP00000361765.1; NM_001012979.3; NP_001012997.1 |
UCSCi | uc004ejz.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z68694 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54717.1 BC132922 mRNA Translation: AAI32923.1 BC132924 mRNA Translation: AAI32925.1 |
CCDSi | CCDS35356.1 |
RefSeqi | NP_001012997.1, NM_001012979.2 |
3D structure databases
SMRi | Q5H9L2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131070, 6 interactors |
IntActi | Q5H9L2, 4 interactors |
STRINGi | 9606.ENSP00000361765 |
PTM databases
iPTMneti | Q5H9L2 |
PhosphoSitePlusi | Q5H9L2 |
Genetic variation databases
BioMutai | TCEAL5 |
DMDMi | 74762182 |
Proteomic databases
EPDi | Q5H9L2 |
jPOSTi | Q5H9L2 |
MassIVEi | Q5H9L2 |
MaxQBi | Q5H9L2 |
PaxDbi | Q5H9L2 |
PeptideAtlasi | Q5H9L2 |
PRIDEi | Q5H9L2 |
ProteomicsDBi | 62895 |
Protocols and materials databases
Antibodypediai | 71662, 27 antibodies from 14 providers |
DNASUi | 340543 |
Genome annotation databases
Ensembli | ENST00000372680; ENSP00000361765; ENSG00000204065 |
GeneIDi | 340543 |
KEGGi | hsa:340543 |
MANE-Selecti | ENST00000372680.2; ENSP00000361765.1; NM_001012979.3; NP_001012997.1 |
UCSCi | uc004ejz.3, human |
Organism-specific databases
CTDi | 340543 |
GeneCardsi | TCEAL5 |
HGNCi | HGNC:22282, TCEAL5 |
HPAi | ENSG00000204065, Group enriched (brain, choroid plexus, pituitary gland, retina, testis) |
neXtProti | NX_Q5H9L2 |
OpenTargetsi | ENSG00000204065 |
PharmGKBi | PA134950668 |
VEuPathDBi | HostDB:ENSG00000204065 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RKY0, Eukaryota |
GeneTreei | ENSGT00950000183164 |
HOGENOMi | CLU_078412_1_0_1 |
InParanoidi | Q5H9L2 |
OMAi | PKDEKRP |
OrthoDBi | 1432394at2759 |
PhylomeDBi | Q5H9L2 |
TreeFami | TF336871 |
Enzyme and pathway databases
PathwayCommonsi | Q5H9L2 |
SignaLinki | Q5H9L2 |
Miscellaneous databases
BioGRID-ORCSi | 340543, 1 hit in 601 CRISPR screens |
GenomeRNAii | 340543 |
Pharosi | Q5H9L2, Tdark |
PROi | PR:Q5H9L2 |
RNActi | Q5H9L2, protein |
Gene expression databases
Bgeei | ENSG00000204065, Expressed in dorsolateral prefrontal cortex and 105 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR021156, TF_A-like/BEX |
Pfami | View protein in Pfam PF04538, BEX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCAL5_HUMAN | |
Accessioni | Q5H9L2Primary (citable) accession number: Q5H9L2 Secondary accession number(s): A2RUJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families