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Entry version 107 (13 Feb 2019)
Sequence version 1 (15 Feb 2005)
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Protein

Transcription elongation factor A protein-like 5

Gene

TCEAL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • WW domain binding Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor A protein-like 5
Short name:
TCEA-like protein 5
Alternative name(s):
Transcription elongation factor S-II protein-like 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCEAL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204065.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22282 TCEAL5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5H9L2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204065

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134950668

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TCEAL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762182

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002392111 – 206Transcription elongation factor A protein-like 5Add BLAST206

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5H9L2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5H9L2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5H9L2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5H9L2

PeptideAtlas

More...
PeptideAtlasi
Q5H9L2

PRoteomics IDEntifications database

More...
PRIDEi
Q5H9L2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62895

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5H9L2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5H9L2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204065 Expressed in 83 organ(s), highest expression level in dorsolateral prefrontal cortex

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045564
HPA058982
HPA072199

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A2P433542EBI-2681773,EBI-2681738

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131070, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q5H9L2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361765

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5H9L2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 81Glu-richAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JBBY Eukaryota
ENOG41113V2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153204

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231342

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055896

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5H9L2

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRENDGK

Database of Orthologous Groups

More...
OrthoDBi
1432394at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5H9L2

TreeFam database of animal gene trees

More...
TreeFami
TF336871

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021156 TF_A-like/BEX

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04538 BEX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5H9L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLYKENEG KPENERNLES EGKPEDEGST EDEGKSDEEE KPDMEGKTEC
60 70 80 90 100
EGKREDEGEP GDEGQLEDEG NQEKQGKSEG EDKPQSEGKP ASQAKPESQP
110 120 130 140 150
RAAEKRPAED YVPRKAKRKT DRGTDDSPKD SQEDLQERHL SSEEMMRECG
160 170 180 190 200
DVSRAQEELR KKQKMGGFHW MQRDVQDPFA PRGQRGVRGV RGGGRGQKDL

EDVPYV
Length:206
Mass (Da):23,307
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCDB6A1ACCCE3BAD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z68694 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54717.1
BC132922 mRNA Translation: AAI32923.1
BC132924 mRNA Translation: AAI32925.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35356.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012997.1, NM_001012979.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.403462

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372680; ENSP00000361765; ENSG00000204065

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340543

UCSC genome browser

More...
UCSCi
uc004ejz.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68694 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54717.1
BC132922 mRNA Translation: AAI32923.1
BC132924 mRNA Translation: AAI32925.1
CCDSiCCDS35356.1
RefSeqiNP_001012997.1, NM_001012979.2
UniGeneiHs.403462

3D structure databases

ProteinModelPortaliQ5H9L2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131070, 6 interactors
IntActiQ5H9L2, 4 interactors
STRINGi9606.ENSP00000361765

PTM databases

iPTMnetiQ5H9L2
PhosphoSitePlusiQ5H9L2

Polymorphism and mutation databases

BioMutaiTCEAL5
DMDMi74762182

Proteomic databases

EPDiQ5H9L2
jPOSTiQ5H9L2
MaxQBiQ5H9L2
PaxDbiQ5H9L2
PeptideAtlasiQ5H9L2
PRIDEiQ5H9L2
ProteomicsDBi62895

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372680; ENSP00000361765; ENSG00000204065
GeneIDi340543
KEGGihsa:340543
UCSCiuc004ejz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340543
EuPathDBiHostDB:ENSG00000204065.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TCEAL5
HGNCiHGNC:22282 TCEAL5
HPAiHPA045564
HPA058982
HPA072199
neXtProtiNX_Q5H9L2
OpenTargetsiENSG00000204065
PharmGKBiPA134950668

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JBBY Eukaryota
ENOG41113V2 LUCA
GeneTreeiENSGT00940000153204
HOGENOMiHOG000231342
HOVERGENiHBG055896
InParanoidiQ5H9L2
OMAiCRENDGK
OrthoDBi1432394at2759
PhylomeDBiQ5H9L2
TreeFamiTF336871

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340543

Protein Ontology

More...
PROi
PR:Q5H9L2

Gene expression databases

BgeeiENSG00000204065 Expressed in 83 organ(s), highest expression level in dorsolateral prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCAL5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5H9L2
Secondary accession number(s): A2RUJ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 15, 2005
Last modified: February 13, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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