UniProtKB - Q5H9K5 (ZMAT1_HUMAN)
Protein
Zinc finger matrin-type protein 1
Gene
ZMAT1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 56 – 86 | Matrin-type 1Add BLAST | 31 | |
Zinc fingeri | 121 – 151 | Matrin-type 2Add BLAST | 31 | |
Zinc fingeri | 172 – 206 | Matrin-type 3Add BLAST | 35 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q5H9K5 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger matrin-type protein 1 |
Gene namesi | Name:ZMAT1 Synonyms:KIAA1789 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166432.14 |
HGNCi | HGNC:29377, ZMAT1 |
MIMi | 301007, gene |
neXtProti | NX_Q5H9K5 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84460 |
PharmGKBi | PA134880461 |
Miscellaneous databases
Pharosi | Q5H9K5, Tdark |
Polymorphism and mutation databases
BioMutai | ZMAT1 |
DMDMi | 74762181 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311348 | 1 – 638 | Zinc finger matrin-type protein 1Add BLAST | 638 |
Proteomic databases
MassIVEi | Q5H9K5 |
MaxQBi | Q5H9K5 |
PaxDbi | Q5H9K5 |
PeptideAtlasi | Q5H9K5 |
PRIDEi | Q5H9K5 |
ProteomicsDBi | 62892 [Q5H9K5-1] 62893 [Q5H9K5-2] |
PTM databases
iPTMneti | Q5H9K5 |
PhosphoSitePlusi | Q5H9K5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166432, Expressed in right lobe of thyroid gland and 193 other tissues |
ExpressionAtlasi | Q5H9K5, baseline and differential |
Genevisiblei | Q5H9K5, HS |
Organism-specific databases
HPAi | ENSG00000166432, Tissue enhanced (epididymis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124094, 25 interactors |
IntActi | Q5H9K5, 7 interactors |
MINTi | Q5H9K5 |
STRINGi | 9606.ENSP00000361868 |
Miscellaneous databases
RNActi | Q5H9K5, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 56 – 86 | Matrin-type 1Add BLAST | 31 | |
Zinc fingeri | 121 – 151 | Matrin-type 2Add BLAST | 31 | |
Zinc fingeri | 172 – 206 | Matrin-type 3Add BLAST | 35 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502S5D7, Eukaryota |
HOGENOMi | CLU_032533_1_0_1 |
InParanoidi | Q5H9K5 |
OrthoDBi | 1565630at2759 |
PhylomeDBi | Q5H9K5 |
TreeFami | TF337202 |
Family and domain databases
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits SM00451, ZnF_U1, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5H9K5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESCSVTRLE CSGAISAHCS LHLPGSSDSP ASASQIAGTT DAIWNEQEKA
60 70 80 90 100
ELFTDKFCQV CGVMLQFESQ RISHYEGEKH AQNVSFYFQM HGEQNEVPGK
110 120 130 140 150
KMKMHVENFQ VHRYEGVDKN KFCDLCNMMF SSPLIAQSHY VGKVHAKKLK
160 170 180 190 200
QLMEEHDQAS PSGFQPEMAF SMRTYVCHIC SIAFTSLDMF RSHMQGSEHQ
210 220 230 240 250
IKESIVINLV KNSRKTQDSY QNECADYINV QKARGLEAKT CFRKMEESSL
260 270 280 290 300
ETRRYREVVD SRPRHRMFEQ RLPFETFRTY AAPYNISQAM EKQLPHSKKT
310 320 330 340 350
YDSFQDELED YIKVQKARGL DPKTCFRKMR ENSVDTHGYR EMVDSGPRSR
360 370 380 390 400
MCEQRFSHEA SQTYQRPYHI SPVESQLPQW LPTHSKRTYD SFQDELEDYI
410 420 430 440 450
KVQKARGLEP KTCFRKIGDS SVETHRNREM VDVRPRHRML EQKLPCETFQ
460 470 480 490 500
TYSGPYSISQ VVENQLPHCL PAHDSKQRLD SISYCQLTRD CFPEKPVPLS
510 520 530 540 550
LNQQENNSGS YSVESEVYKH LSSENNTADH QAGHKQKHQK RKRHLEEGKE
560 570 580 590 600
RPEKEQSKHK RKKSYEDTDL DKDKSIRQRK REEDRVKVSS GKLKHRKKKK
610 620 630
SHDVPSEKEE RKHRKEKKKS VEERTEEEML WDESILGF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494C0A7 | A0A494C0A7_HUMAN | Zinc finger matrin-type protein 1 | ZMAT1 | 695 | Annotation score: |
Sequence cautioni
The sequence BAB47418 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053766 | 214 | R → K. Corresponds to variant dbSNP:rs17282855Ensembl. | 1 | |
Natural variantiVAR_062159 | 536 | Q → R2 PublicationsCorresponds to variant dbSNP:rs5944882Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029533 | 1 – 171 | Missing in isoform 2. 1 PublicationAdd BLAST | 171 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB058692 mRNA Translation: BAB47418.1 Different initiation. Z68868 Genomic DNA No translation available. Z69304 Genomic DNA No translation available. AL831883 mRNA Translation: CAD38564.1 |
CCDSi | CCDS35348.1 [Q5H9K5-1] |
RefSeqi | NP_001269329.1, NM_001282400.1 NP_001269330.1, NM_001282401.1 XP_006724774.1, XM_006724711.3 XP_016885393.1, XM_017029904.1 |
Genome annotation databases
Ensembli | ENST00000372782; ENSP00000361868; ENSG00000166432 ENST00000540921; ENSP00000437529; ENSG00000166432 |
GeneIDi | 84460 |
KEGGi | hsa:84460 |
UCSCi | uc011mrl.3, human [Q5H9K5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB058692 mRNA Translation: BAB47418.1 Different initiation. Z68868 Genomic DNA No translation available. Z69304 Genomic DNA No translation available. AL831883 mRNA Translation: CAD38564.1 |
CCDSi | CCDS35348.1 [Q5H9K5-1] |
RefSeqi | NP_001269329.1, NM_001282400.1 NP_001269330.1, NM_001282401.1 XP_006724774.1, XM_006724711.3 XP_016885393.1, XM_017029904.1 |
3D structure databases
SMRi | Q5H9K5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124094, 25 interactors |
IntActi | Q5H9K5, 7 interactors |
MINTi | Q5H9K5 |
STRINGi | 9606.ENSP00000361868 |
PTM databases
iPTMneti | Q5H9K5 |
PhosphoSitePlusi | Q5H9K5 |
Polymorphism and mutation databases
BioMutai | ZMAT1 |
DMDMi | 74762181 |
Proteomic databases
MassIVEi | Q5H9K5 |
MaxQBi | Q5H9K5 |
PaxDbi | Q5H9K5 |
PeptideAtlasi | Q5H9K5 |
PRIDEi | Q5H9K5 |
ProteomicsDBi | 62892 [Q5H9K5-1] 62893 [Q5H9K5-2] |
Protocols and materials databases
Antibodypediai | 539, 56 antibodies |
Genome annotation databases
Ensembli | ENST00000372782; ENSP00000361868; ENSG00000166432 ENST00000540921; ENSP00000437529; ENSG00000166432 |
GeneIDi | 84460 |
KEGGi | hsa:84460 |
UCSCi | uc011mrl.3, human [Q5H9K5-1] |
Organism-specific databases
CTDi | 84460 |
DisGeNETi | 84460 |
EuPathDBi | HostDB:ENSG00000166432.14 |
GeneCardsi | ZMAT1 |
HGNCi | HGNC:29377, ZMAT1 |
HPAi | ENSG00000166432, Tissue enhanced (epididymis) |
MIMi | 301007, gene |
neXtProti | NX_Q5H9K5 |
PharmGKBi | PA134880461 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5D7, Eukaryota |
HOGENOMi | CLU_032533_1_0_1 |
InParanoidi | Q5H9K5 |
OrthoDBi | 1565630at2759 |
PhylomeDBi | Q5H9K5 |
TreeFami | TF337202 |
Enzyme and pathway databases
PathwayCommonsi | Q5H9K5 |
Miscellaneous databases
BioGRID-ORCSi | 84460, 3 hits in 478 CRISPR screens |
ChiTaRSi | ZMAT1, human |
GenomeRNAii | 84460 |
Pharosi | Q5H9K5, Tdark |
PROi | PR:Q5H9K5 |
RNActi | Q5H9K5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166432, Expressed in right lobe of thyroid gland and 193 other tissues |
ExpressionAtlasi | Q5H9K5, baseline and differential |
Genevisiblei | Q5H9K5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits SM00451, ZnF_U1, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZMAT1_HUMAN | |
Accessioni | Q5H9K5Primary (citable) accession number: Q5H9K5 Secondary accession number(s): Q8NDS3, Q96JN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations