TFDP3

Functionⁱ

Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G₁ to S phase.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	121	Critical for repression of E2F activity	1
Siteⁱ	130	Critical for repression of E2F activity	1
Siteⁱ	131	Critical for repression of E2F activity	1
Siteⁱ	140	Critical for repression of E2F activity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	108 – 190	Sequence analysisAdd BLAST		83

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17062573

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 20559320
G1/S transition of mitotic cell cycle
Source: UniProtKB
Inferred from direct assayⁱ
- 17062573
regulation of cell cycle Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor Dp family member 3 Alternative name(s): Cancer/testis antigen 30 Short name: CT30 Hepatocellular carcinoma-associated antigen 661
Gene namesⁱ	Name:TFDP3 Synonyms:DP4, HCA661
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183434.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24603 TFDP3
MIMⁱ	300772 gene
neXtProtⁱ	NX_Q5H9I0

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	112	C → R: No effect on down-regulation of E2F transcriptional activity; when associated with or without R-161 or with V-164.	1
Mutagenesisⁱ	121	T → K: Restores enhanced E2F-mediated transcriptional activity; when associated with Y-130; N-131 and E-145. 1 Publication	1
Mutagenesisⁱ	130	C → Y: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; N-131 and E-145. 1 Publication	1
Mutagenesisⁱ	131	Q → N: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; Y-130 and E-145. 1 Publication	1
Mutagenesisⁱ	140	K → E: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; Y-130 and N-131. 1 Publication	1
Mutagenesisⁱ	161	K → R: No effect on down-regulation of E2F transcriptional activity; when associated with or without R-112.	1
Mutagenesisⁱ	164	T → V: No effect on down-regulation of E2F transcriptional activity; when associated R-112.	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51270
Open Targets More...OpenTargetsⁱ	ENSG00000183434
PharmGKBⁱ	PA134898258

Polymorphism and mutation databases

BioMutaⁱ	TFDP3
DMDMⁱ	74762180

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305940	1 – 405	Transcription factor Dp family member 3Add BLAST		405

Proteomic databases

PaxDbⁱ	Q5H9I0
PeptideAtlas More...PeptideAtlasⁱ	Q5H9I0
PRIDEⁱ	Q5H9I0
ProteomicsDBⁱ	62889

PTM databases

iPTMnetⁱ	Q5H9I0
PhosphoSitePlusⁱ	Q5H9I0

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.2 Publications

Inductionⁱ

In response to DNA damage.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000183434 Expressed in 11 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_TFDP3
Genevisibleⁱ	Q5H9I0 HS

Interactionⁱ

Subunit structureⁱ

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17062573

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119423, 29 interactors
IntActⁱ	Q5H9I0, 11 interactors
STRINGⁱ	9606.ENSP00000385461

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5H9I0
SMRⁱ	Q5H9I0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	175 – 306	Involved in negatively regulating E2F activityAdd BLAST	132
Regionⁱ	209 – 241	DCB1By similarityAdd BLAST	33
Regionⁱ	254 – 310	DCB2By similarityAdd BLAST	57

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	156 – 190	DEF boxBy similarityAdd BLAST		35

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	386 – 402	Asp/Glu-rich (acidic; NCB domain)Add BLAST		17

Domainⁱ

The potential DNA-binding domain differs in sequence from that of other DP family members and cannot bind DNA.

Sequence similaritiesⁱ

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2829 Eukaryota ENOG410Y9QP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018222
HOGENOMⁱ	HOG000030696
HOVERGENⁱ	HBG009894
InParanoidⁱ	Q5H9I0
KEGG Orthology (KO) More...KOⁱ	K09393
OMAⁱ	NIKRRTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AVY
PhylomeDBⁱ	Q5H9I0
TreeFamⁱ	TF314396

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14458 DP_DD, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 1.20.140.80, 1 hit
InterProⁱ	View protein in InterPro IPR037241 E2F-DP_heterodim IPR003316 E2F_WHTH_DNA-bd_dom IPR038168 TF_DP_C_sf IPR028315 TFDP3 IPR014889 Transc_factor_DP_C IPR015648 Transcrpt_fac_DP IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR12548 PTHR12548, 1 hit PTHR12548:SF13 PTHR12548:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08781 DP, 1 hit PF02319 E2F_TDP, 1 hit
PIRSFⁱ	PIRSF009404 Transcription_factor_DP, 1 hit
SMARTⁱ	View protein in SMART SM01138 DP, 1 hit SM01372 E2F_TDP, 1 hit
SUPFAMⁱ	SSF144074 SSF144074, 1 hit SSF46785 SSF46785, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5H9I0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKYVSLTEA NEELKVLMDE NQTSRPVAVH TSTVNPLGKQ LLPKTFGQSS 
        60         70         80         90        100
VNIDQQVVIG MPQRPAASNI PVVGSPNPPS THFASQNQHS YSSPPWAGQH 
       110        120        130        140        150
NRKGEKNGMG LCRLSMKVWE TVQRKGTTSC QEVVGELVAK FRAASNHASP 
       160        170        180        190        200
NESAYDVKNI KRRTYDALNV LMAMNIISRE KKKIKWIGLT TNSAQNCQNL 
       210        220        230        240        250
RVERQKRLER IKQKQSELQQ LILQQIAFKN LVLRNQYVEE QVSQRPLPNS 
       260        270        280        290        300
VIHVPFIIIS SSKKTVINCS ISDDKSEYLF KFNSSFEIHD DTEVLMWMGM 
       310        320        330        340        350
TFGLESGSCS AEDLKMARNL VPKALEPYVT EMAQGTFGGV FTTAGSRSNG 
       360        370        380        390        400
TWLSASDLTN IAIGMLATSS GGSQYSGSRV ETPAVEEEEE EDNNDDDLSE 

NDEDD

Length:405

Mass (Da):44,967

Last modified:February 15, 2005 - v1

Checksum:ⁱAE6F5709FE7E4C03

GO

Sequence cautionⁱ

The sequence AAF37562 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF219119 mRNA Translation: AAF37562.2 Different initiation. Z77249 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11773.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14636.2
NCBI Reference Sequences More...RefSeqⁱ	NP_057605.3, NM_016521.2
UniGeneⁱ	Hs.142908

Genome annotation databases

Ensemblⁱ	ENST00000310125; ENSP00000385461; ENSG00000183434
GeneIDⁱ	51270
KEGGⁱ	hsa:51270
UCSC genome browser More...UCSCⁱ	uc004exb.1 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5H9I0	Transcription factor		PANTR		405	UniRef90_Q5H9I0
Transcription factor		PONAB		405
Transcription factor		GORGO		405
UPI0002744617		PANPA		405

Protein	Similar proteins		Species	Score	Length	Source
Q5H9I0	Isoform 2 of Transcription factor Dp-1		HUMAN		311	UniRef50_Q14186-2
Transcription factor		PONAB		383
Transcription factor		LEPWE		311
Transcription factor		RHIBE		408
Transcription factor		MACMU		406
+100

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF219119 mRNA Translation: AAF37562.2 Different initiation. Z77249 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11773.1
CCDSⁱ	CCDS14636.2
RefSeqⁱ	NP_057605.3, NM_016521.2
UniGeneⁱ	Hs.142908

3D structure databases

ProteinModelPortalⁱ	Q5H9I0
SMRⁱ	Q5H9I0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119423, 29 interactors
IntActⁱ	Q5H9I0, 11 interactors
STRINGⁱ	9606.ENSP00000385461

PTM databases

iPTMnetⁱ	Q5H9I0
PhosphoSitePlusⁱ	Q5H9I0

Polymorphism and mutation databases

BioMutaⁱ	TFDP3
DMDMⁱ	74762180

Proteomic databases

PaxDbⁱ	Q5H9I0
PeptideAtlasⁱ	Q5H9I0
PRIDEⁱ	Q5H9I0
ProteomicsDBⁱ	62889

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51270
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310125; ENSP00000385461; ENSG00000183434
GeneIDⁱ	51270
KEGGⁱ	hsa:51270
UCSCⁱ	uc004exb.1 human

Organism-specific databases

CTDⁱ	51270
DisGeNETⁱ	51270
EuPathDBⁱ	HostDB:ENSG00000183434.9
GeneCardsⁱ	TFDP3
HGNCⁱ	HGNC:24603 TFDP3
MIMⁱ	300772 gene
neXtProtⁱ	NX_Q5H9I0
OpenTargetsⁱ	ENSG00000183434
PharmGKBⁱ	PA134898258
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2829 Eukaryota ENOG410Y9QP LUCA
GeneTreeⁱ	ENSGT00390000018222
HOGENOMⁱ	HOG000030696
HOVERGENⁱ	HBG009894
InParanoidⁱ	Q5H9I0
KOⁱ	K09393
OMAⁱ	NIKRRTY
OrthoDBⁱ	EOG091G0AVY
PhylomeDBⁱ	Q5H9I0
TreeFamⁱ	TF314396

Miscellaneous databases

GenomeRNAiⁱ	51270
Protein Ontology More...PROⁱ	PR:Q5H9I0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183434 Expressed in 11 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_TFDP3
Genevisibleⁱ	Q5H9I0 HS

Family and domain databases

CDDⁱ	cd14458 DP_DD, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 1.20.140.80, 1 hit
InterProⁱ	View protein in InterPro IPR037241 E2F-DP_heterodim IPR003316 E2F_WHTH_DNA-bd_dom IPR038168 TF_DP_C_sf IPR028315 TFDP3 IPR014889 Transc_factor_DP_C IPR015648 Transcrpt_fac_DP IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR12548 PTHR12548, 1 hit PTHR12548:SF13 PTHR12548:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF08781 DP, 1 hit PF02319 E2F_TDP, 1 hit
PIRSFⁱ	PIRSF009404 Transcription_factor_DP, 1 hit
SMARTⁱ	View protein in SMART SM01138 DP, 1 hit SM01372 E2F_TDP, 1 hit
SUPFAMⁱ	SSF144074 SSF144074, 1 hit SSF46785 SSF46785, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFDP3_HUMAN
Accessionⁱ	Q5H9I0Primary (citable) accession number: Q5H9I0 Secondary accession number(s): Q6DK49, Q9NZ54
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	February 15, 2005
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5H9I0 (TFDP3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription factor Dp family member 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ