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Entry version 145 (12 Aug 2020)
Sequence version 1 (15 Feb 2005)
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Protein

BCL-6 corepressor-like protein 1

Gene

BCORL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5H9F3

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5H9F3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BCL-6 corepressor-like protein 1
Short name:
BCoR-L1
Short name:
BCoR-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCORL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000085185.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25657, BCORL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300688, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5H9F3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Shukla-Vernon syndrome (SHUVER)2 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn X-linked neurodevelopmental disorder manifesting in affected males with intellectual and learning disability, motor and language delay, autism spectrum disorder, attention deficit and hyperactivity disorder, and dysmorphic features. Some patients may have seizures and/or cerebellar atrophy on brain imaging. Carrier females may have mild disease manifestations.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08228832P → L in SHUVER; unknown pathological significance. 1 Publication1
Natural variantiVAR_082289496S → F in SHUVER; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057521638EnsemblClinVar.1
Natural variantiVAR_082290782V → E in SHUVER; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1488781894Ensembl.1
Natural variantiVAR_070559820N → S in SHUVER; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398123004EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi623 – 624DL → AS: Strongly reduced repressor activity. Interferes with CTBP1 binding. 1 Publication2
Mutagenesisi1665L → D or R: Slightly inhibits interaction with PCGF1. 1 Publication1

Keywords - Diseasei

Autism spectrum disorder, Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
63035

MalaCards human disease database

More...
MalaCardsi
BCORL1
MIMi301029, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
528084, Non-specific syndromic intellectual disability

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5H9F3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCORL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762178

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122681 – 1711BCL-6 corepressor-like protein 1Add BLAST1711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei496PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki747Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Cross-linki1092Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1162PhosphoserineCombined sources1
Isoform 3 (identifier: Q5H9F3-3)
Modified residuei1476PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5H9F3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5H9F3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5H9F3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5H9F3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5H9F3

PeptideAtlas

More...
PeptideAtlasi
Q5H9F3

PRoteomics IDEntifications database

More...
PRIDEi
Q5H9F3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62886 [Q5H9F3-1]
62887 [Q5H9F3-2]
62888 [Q5H9F3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5H9F3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5H9F3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085185, Expressed in cerebellum and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5H9F3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5H9F3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000085185, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCGF1, forming heterodimers (PubMed:23523425, PubMed:27568929). The PCGF1-BCORL1 heterodimeric complex interacts with the KDM2B-SKP1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929).

Interacts with CTBP1, HDAC4, HDAC5 and HDAC7 (PubMed:17379597).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121961, 28 interactors

Database of interacting proteins

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DIPi
DIP-60148N

Protein interaction database and analysis system

More...
IntActi
Q5H9F3, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000437775

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5H9F3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5H9F3

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1455 – 1484ANK 1Add BLAST30
Repeati1488 – 1517ANK 2Add BLAST30
Repeati1521 – 1549ANK 3Add BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1594 – 1711PCGF Ub-like fold domain (PUFD); required for the interaction with the KDM2B-SKP1 heterodimeric complex1 PublicationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1328 – 1336Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 649Pro-richAdd BLAST452

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCOR family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QSMY, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5H9F3

Database of Orthologous Groups

More...
OrthoDBi
85469at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5H9F3

TreeFam database of animal gene trees

More...
TreeFami
TF333317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.10.260.40, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00623

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031628, BCOR
IPR032365, PUFD
IPR038227, PUFD_som_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF15808, BCOR, 1 hit
PF16553, PUFD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5H9F3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE
60 70 80 90 100
FCVSSSFSKV ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD
110 120 130 140 150
YAGNVAEAEG FLVPLSSPGD GLKLPASDSA EASNSRADCS WTPLNTQMSK
160 170 180 190 200
QVDCSPAGVK ALDSRQGVGE KNTFILATLG TGVPVEGTLP LVTTNFSPLP
210 220 230 240 250
APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ VATSVPAPSP
260 270 280 290 300
PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP
310 320 330 340 350
APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP
360 370 380 390 400
APPSVPMPTP TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA
410 420 430 440 450
TPAAIPTSAP IPASFSLSRV CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV
460 470 480 490 500
YIPPPSCGQP LSVATLPTTL GVSSTLTLPV LPSYLQDRCL PGVLASPELR
510 520 530 540 550
SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA PDGVPGPLAD
560 570 580 590 600
TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP
610 620 630 640 650
LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV
660 670 680 690 700
HTSSKALLST VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS
710 720 730 740 750
TWVKNSTALI STIPGTYVGV ANPVPASLLL NKDPNLGLNR DPRHLPKQEP
760 770 780 790 800
ISIIDQGEPK GTGATCGKKG SQAGAEGQPS TVKRYTPARI APGLPGCQTK
810 820 830 840 850
ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS LLSIGISSAG
860 870 880 890 900
QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD
910 920 930 940 950
PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP
960 970 980 990 1000
EESESHLCSD STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP
1010 1020 1030 1040 1050
QNLPKMPELP LLPHDSHPKE LILDVVPSSR RGSSTERPQL GSQVDLGRVK
1060 1070 1080 1090 1100
MEKVDGDVVF NLATCFRADG LPVAPQRGQA EVRAKAGQAR VKQESVGVFA
1110 1120 1130 1140 1150
CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV RSSHRPKCRK
1160 1170 1180 1190 1200
LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH
1210 1220 1230 1240 1250
EEGSLEKKAK SSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF
1260 1270 1280 1290 1300
PTEEEEEVTP TPAKRRKVRK TQRDTQYRSH HAQDKSLLSQ GRRHLWRARE
1310 1320 1330 1340 1350
MPWRTEAARQ MWDTNEEEEE EEEEGLLKRK KRRRQKSRKY QTGEYLTEQE
1360 1370 1380 1390 1400
DEQRRKGRAD LKARKQKTSS SQSLEHRLRN RNLLLPNKVQ GISDSPNGFL
1410 1420 1430 1440 1450
PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKDVVLY CLQKDSEDVN
1460 1470 1480 1490 1500
HRDNAGYTAL HEACSRGWTD ILNILLEHGA NVNCSAQDGT RPVHDAVVND
1510 1520 1530 1540 1550
NLETIWLLLS YGADPTLATY SGQTAMKLAS SDTMKRFLSD HLSDLQGRAE
1560 1570 1580 1590 1600
GDPGVSWDFY SSSVLEEKDG FACDLLHNPP GSSDQEGDDP MEEDDFMFEL
1610 1620 1630 1640 1650
SDKPLLPCYN LQVSVSRGPC NWFLFSDVLK RLKLSSRIFQ ARFPHFEITT
1660 1670 1680 1690 1700
MPKAEFYRQV ASSQLLTPAE RPGGLDDRSP PGSSETVELV RYEPDLLRLL
1710
GSEVEFQSCN S
Length:1,711
Mass (Da):182,526
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD78A00598703C53
GO
Isoform 2 (identifier: Q5H9F3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1230-1359: Missing.

Show »
Length:1,581
Mass (Da):166,958
Checksum:i08F656081607E8C7
GO
Isoform 3 (identifier: Q5H9F3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1434: A → AKGKGRWSQQ...LLQRAARLGY

Show »
Length:1,785
Mass (Da):190,595
Checksum:i28D139925EE1E2CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6Q3A0A075B6Q3_HUMAN
BCL-6 corepressor-like protein 1
BCORL1
1,385Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4B2H7C4B2_HUMAN
BCL-6 corepressor-like protein 1
BCORL1
741Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1F0A0A087X1F0_HUMAN
BCL-6 corepressor-like protein 1
BCORL1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYD4V9GYD4_HUMAN
BCL-6 corepressor-like protein 1
BCORL1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC85922 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1564V → A in BAC85922 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08228832P → L in SHUVER; unknown pathological significance. 1 Publication1
Natural variantiVAR_061020111F → L1 PublicationCorresponds to variant dbSNP:rs4830173Ensembl.1
Natural variantiVAR_037467209G → S. Corresponds to variant dbSNP:rs5932715Ensembl.1
Natural variantiVAR_080909327T → I Found in a patient with Uruguay faciocardiomusculoskeletal syndrome; unknown pathological significance. 1 Publication1
Natural variantiVAR_082289496S → F in SHUVER; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057521638EnsemblClinVar.1
Natural variantiVAR_082290782V → E in SHUVER; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1488781894Ensembl.1
Natural variantiVAR_070559820N → S in SHUVER; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398123004EnsemblClinVar.1
Natural variantiVAR_037468832G → D in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0297781230 – 1359Missing in isoform 2. 2 PublicationsAdd BLAST130
Alternative sequenceiVSP_0297791434A → AKGKGRWSQQKTRSPKSPTP VKPTEPCTPSKSRSASSEEA SESPTARQIPPEARRLIVNK NAGETLLQRAARLGY in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL034405 Genomic DNA No translation available.
AL136450 Genomic DNA No translation available.
Z82208 Genomic DNA No translation available.
AK074089 mRNA Translation: BAB84915.1
AL096777 mRNA Translation: CAB46626.1
AK124676 mRNA Translation: BAC85922.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS14616.1 [Q5H9F3-1]

NCBI Reference Sequences

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RefSeqi
NP_068765.3, NM_021946.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000218147; ENSP00000218147; ENSG00000085185
ENST00000540052; ENSP00000437775; ENSG00000085185

Database of genes from NCBI RefSeq genomes

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GeneIDi
63035

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63035

UCSC genome browser

More...
UCSCi
uc022cdu.1, human [Q5H9F3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034405 Genomic DNA No translation available.
AL136450 Genomic DNA No translation available.
Z82208 Genomic DNA No translation available.
AK074089 mRNA Translation: BAB84915.1
AL096777 mRNA Translation: CAB46626.1
AK124676 mRNA Translation: BAC85922.1 Different initiation.
CCDSiCCDS14616.1 [Q5H9F3-1]
RefSeqiNP_068765.3, NM_021946.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HPMX-ray1.85A/C1594-1711[»]
5JH5X-ray2.55D1594-1711[»]
SMRiQ5H9F3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121961, 28 interactors
DIPiDIP-60148N
IntActiQ5H9F3, 17 interactors
STRINGi9606.ENSP00000437775

PTM databases

iPTMnetiQ5H9F3
PhosphoSitePlusiQ5H9F3

Polymorphism and mutation databases

BioMutaiBCORL1
DMDMi74762178

Proteomic databases

EPDiQ5H9F3
jPOSTiQ5H9F3
MassIVEiQ5H9F3
MaxQBiQ5H9F3
PaxDbiQ5H9F3
PeptideAtlasiQ5H9F3
PRIDEiQ5H9F3
ProteomicsDBi62886 [Q5H9F3-1]
62887 [Q5H9F3-2]
62888 [Q5H9F3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30129, 76 antibodies

The DNASU plasmid repository

More...
DNASUi
63035

Genome annotation databases

EnsembliENST00000218147; ENSP00000218147; ENSG00000085185
ENST00000540052; ENSP00000437775; ENSG00000085185
GeneIDi63035
KEGGihsa:63035
UCSCiuc022cdu.1, human [Q5H9F3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63035
DisGeNETi63035
EuPathDBiHostDB:ENSG00000085185.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCORL1
HGNCiHGNC:25657, BCORL1
HPAiENSG00000085185, Low tissue specificity
MalaCardsiBCORL1
MIMi300688, gene
301029, phenotype
neXtProtiNX_Q5H9F3
Orphaneti528084, Non-specific syndromic intellectual disability

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSMY, Eukaryota
InParanoidiQ5H9F3
OrthoDBi85469at2759
PhylomeDBiQ5H9F3
TreeFamiTF333317

Enzyme and pathway databases

PathwayCommonsiQ5H9F3
SIGNORiQ5H9F3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
63035, 9 hits in 504 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BCORL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63035
PharosiQ5H9F3, Tbio

Protein Ontology

More...
PROi
PR:Q5H9F3
RNActiQ5H9F3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000085185, Expressed in cerebellum and 227 other tissues
ExpressionAtlasiQ5H9F3, baseline and differential
GenevisibleiQ5H9F3, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.10.260.40, 1 hit
IDEALiIID00623
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031628, BCOR
IPR032365, PUFD
IPR038227, PUFD_som_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF15808, BCOR, 1 hit
PF16553, PUFD, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCORL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5H9F3
Secondary accession number(s): B5MDQ8
, Q5H9F2, Q5H9F4, Q6ZVE0, Q8TEN3, Q9Y528
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 15, 2005
Last modified: August 12, 2020
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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