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Protein

Kita-kyushu lung cancer antigen 1

Gene

CT83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kita-kyushu lung cancer antigen 1
Short name:
KK-LC-1
Alternative name(s):
Cancer/testis antigen 83
Gene namesi
Name:CT83
Synonyms:CXorf61, KKLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000204019.4
HGNCiHGNC:33494 CT83
MIMi300625 gene
neXtProtiNX_Q5H943

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 21Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini22 – 113ExtracellularSequence analysisAdd BLAST92

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi203413
OpenTargetsiENSG00000204019
PharmGKBiPA162383081

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002937361 – 113Kita-kyushu lung cancer antigen 1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5H943
MaxQBiQ5H943
PaxDbiQ5H943
PeptideAtlasiQ5H943
PRIDEiQ5H943
ProteomicsDBi62868

PTM databases

iPTMnetiQ5H943
PhosphoSitePlusiQ5H943

Expressioni

Tissue specificityi

Specifically expressed in testis. Expressed by cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000204019 Expressed in 39 organ(s), highest expression level in sperm
CleanExiHS_CXorf61
GenevisibleiQ5H943 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360961

Structurei

3D structure databases

ProteinModelPortaliQ5H943
SMRiQ5H943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1QT Eukaryota
ENOG4111405 LUCA
GeneTreeiENSGT00390000018873
HOGENOMiHOG000113230
HOVERGENiHBG095532
InParanoidiQ5H943
OMAiPRSIAMQ
OrthoDBiEOG091G1AHH
PhylomeDBiQ5H943

Family and domain databases

InterProiView protein in InterPro
IPR027940 KKLCAg1
PANTHERiPTHR38650 PTHR38650, 1 hit
PfamiView protein in Pfam
PF15204 KKLCAg1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5H943-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFYLLLASS ILCALIVFWK YRRFQRNTGE MSSNSTALAL VRPSSSGLIN
60 70 80 90 100
SNTDNNLAVY DLSRDILNNF PHSIARQKRI LVNLSMVENK LVELEHTLLS
110
KGFRGASPHR KST
Length:113
Mass (Da):12,784
Last modified:February 15, 2005 - v1
Checksum:i7BC40E0AFFAC587A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z96810 Genomic DNA Translation: CAI42798.1
BC062223 mRNA Translation: AAH62223.1
CCDSiCCDS35372.1
RefSeqiNP_001017978.1, NM_001017978.3
UniGeneiHs.97892

Genome annotation databases

EnsembliENST00000371894; ENSP00000360961; ENSG00000204019
GeneIDi203413
KEGGihsa:203413
UCSCiuc004eqj.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z96810 Genomic DNA Translation: CAI42798.1
BC062223 mRNA Translation: AAH62223.1
CCDSiCCDS35372.1
RefSeqiNP_001017978.1, NM_001017978.3
UniGeneiHs.97892

3D structure databases

ProteinModelPortaliQ5H943
SMRiQ5H943
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360961

PTM databases

iPTMnetiQ5H943
PhosphoSitePlusiQ5H943

Proteomic databases

EPDiQ5H943
MaxQBiQ5H943
PaxDbiQ5H943
PeptideAtlasiQ5H943
PRIDEiQ5H943
ProteomicsDBi62868

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371894; ENSP00000360961; ENSG00000204019
GeneIDi203413
KEGGihsa:203413
UCSCiuc004eqj.3 human

Organism-specific databases

CTDi203413
DisGeNETi203413
EuPathDBiHostDB:ENSG00000204019.4
GeneCardsiCT83
H-InvDBiHIX0017004
HGNCiHGNC:33494 CT83
MIMi300625 gene
neXtProtiNX_Q5H943
OpenTargetsiENSG00000204019
PharmGKBiPA162383081
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1QT Eukaryota
ENOG4111405 LUCA
GeneTreeiENSGT00390000018873
HOGENOMiHOG000113230
HOVERGENiHBG095532
InParanoidiQ5H943
OMAiPRSIAMQ
OrthoDBiEOG091G1AHH
PhylomeDBiQ5H943

Miscellaneous databases

GenomeRNAii203413
PROiPR:Q5H943
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204019 Expressed in 39 organ(s), highest expression level in sperm
CleanExiHS_CXorf61
GenevisibleiQ5H943 HS

Family and domain databases

InterProiView protein in InterPro
IPR027940 KKLCAg1
PANTHERiPTHR38650 PTHR38650, 1 hit
PfamiView protein in Pfam
PF15204 KKLCAg1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKKLC1_HUMAN
AccessioniPrimary (citable) accession number: Q5H943
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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