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Entry version 96 (08 May 2019)
Sequence version 1 (05 Feb 2008)
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Protein

Tyrosine-protein kinase receptor

Gene

ROS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10261 ROS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1856 – 1877HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000047936

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q5H8Y1

PRoteomics IDEntifications database

More...
PRIDEi
Q5H8Y1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000047936 Expressed in 49 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5H8Y1 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 205Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini206 – 294Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini566 – 666Fibronectin type-IIIInterPro annotationAdd BLAST101
Domaini942 – 1037Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1038 – 1145Fibronectin type-IIIInterPro annotationAdd BLAST108
Domaini1444 – 1550Fibronectin type-IIIInterPro annotationAdd BLAST107
Domaini1551 – 1650Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1652 – 1745Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1746 – 1848Fibronectin type-IIIInterPro annotationAdd BLAST103
Domaini1939 – 2216Protein kinaseInterPro annotationAdd BLAST278

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQAA Eukaryota
ENOG410XSTC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000137937

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 3 hits
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5H8Y1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNIYCLIPK LVNFATLGCL WISVVQCTVL NSCLKSCVTN LGQQLDLGTP
60 70 80 90 100
HNLSEPCIQG CHFWNSVDQK NCALKCNDTY ATVCERESCE VGCSSAEGAY
110 120 130 140 150
EEEVLENADL PTAPFASSIG SHNMTLRWKS ANFSGVKYII QWKYAQLLGS
160 170 180 190 200
WTYTKTVSRP SYVVKPLHPF TEYIFRVVWI FTAQLQLYSP PSPSYRTHPH
210 220 230 240 250
GVPETAPLIR NIESSSPDTV EVSWDPPQFP GGPILGYNLR LISKNQKLDA
260 270 280 290 300
GTQRTSFQFY STLPNTIYRF SIAAVNEVGE GPEAESSITT SSSAVQQEEQ
310 320 330 340 350
WLFLSRKTSL RKRSLKHLVD EAHCLRLDAI YHNITGISVD VHQQIVYFSE
360 370 380 390 400
GTLIWAKKAA NMSDVSDLRI FYRGSGLISS ISIDWLYQRM YFIMDELVCV
410 420 430 440 450
CDLENCSNIE EITPPSISAP QKIVADSYNG YVFYLLRDGI YRADLPVPSG
460 470 480 490 500
RCAEAVRIVE SCTLKDFAIK PQAKRIIYFN DTAQVFMSTF LDGSASHLIL
510 520 530 540 550
PRIPFADVKS FACENNDFLV TDGKVIFQQD ALSFNEFIVG CDLSHIEEFG
560 570 580 590 600
FGNLVIFGSS SQLHPLPGRP QELSVLFGSH QALVQWKPPA LAIGASPSAW
610 620 630 640 650
QNWTYEVKVS TQDPPEVTHI FLNISGTMLN VPELQSAMKY KVSVRASSPK
660 670 680 690 700
RPGPWSEPSV GTTLVPASEP PFIMAVKEDG LWSKPLNSFG PGEFLSSDIG
710 720 730 740 750
NVSDMDWYNN SLYYSDTKGD VFVWLLNGTD ISENYHLPSI AGAGALAFEW
760 770 780 790 800
LGHFLYWAGK TYVIQRQSVL TGHTDIVTHV KLLVNDMVVD SVGGYLYWTT
810 820 830 840 850
LYSVESTRLN GESSLVLQTQ PWFSGKKVIA LTLDLSDGLL YWLVQDSQCI
860 870 880 890 900
HLYTAVLRGQ STGDTTITEF AAWSTSEISQ NALMYYSGRL FWINGFRIIT
910 920 930 940 950
TQEIGQKTSV SVLEPARFNQ FTIIQTSLKP LPGNFSFTPK VIPDSVQESS
960 970 980 990 1000
FRIEGNASSF QILWNGPPAV DWGVVFYSVE FSAHSKFLAS EQHSLPVFTV
1010 1020 1030 1040 1050
EGLEPYALFN LSVTPYTYWG KGPKTSLSLR APETVPSAPE NPRIFILPSG
1060 1070 1080 1090 1100
KCCNKNEVVV EFRWNKPKHE NGVLTKFEIF YNISNQSITN KTCEDWIAVN
1110 1120 1130 1140 1150
VTPSVMSFQL EGMSPRCFIA FQVRAFTSKG PGPYADVVKS TTSEINPFPH
1160 1170 1180 1190 1200
LITLLGNKIV FLDMDQNQVV WTFSAERVIS AVCYTADNEM GYYAEGDSLF
1210 1220 1230 1240 1250
LLHLHNRSSS ELFQDSLVFD ITVITIDWIS RHLYFALKES QNGMQVFDVD
1260 1270 1280 1290 1300
LEHKVKYPRE VKIHNRNSTI ISFSVYPLLS RLYWTEVSNF GYQMFYYSII
1310 1320 1330 1340 1350
SHTLHRILQP TATNQQNKRN QCSCNVTEFE LSGAMAIDTS NLEKPLIYFA
1360 1370 1380 1390 1400
KAQEIWAMDL EGCQCWRVIT VPAMLGKTLV SLTVDGDLIY WIITAKDSTQ
1410 1420 1430 1440 1450
IYQAKKGNGA IVSQVKALRS RHILAYSSVM QPFPDKAFLS LASDTVEPTI
1460 1470 1480 1490 1500
LNATNTSLTI RLPLAKTNLT WYGITSPTPT YLVYYAEVND RKNSSDLKYR
1510 1520 1530 1540 1550
ILEFQDSIAL IEDLQPFSTY MIQIAVKNYY SDPLEHLPPG KEIWGKTKNG
1560 1570 1580 1590 1600
VPEAVQLINT TVRSDTSLII SWRESHKPNG PKESVRYQLA ISHLALIPET
1610 1620 1630 1640 1650
PLRQSEFPNG RLTLLVTRLS GGNIYVLKVL ACHSEEMWCT ESHPVTVEMF
1660 1670 1680 1690 1700
NTPEKPYSLV PENTSLQFNW KAPLNVNLIR FWVELQKWKY NEFYHVKTSC
1710 1720 1730 1740 1750
SQGPAYVCNI TNLQPYTSYN VRVVVVYKTG ENSTSLPESF KTKAGVPNKP
1760 1770 1780 1790 1800
GIPKLLEGSK NSIQWEKAED NGCRITYYIL EIRKSTSNNL QNQNLRWKMT
1810 1820 1830 1840 1850
FNGSCSSVCT WKSKNLKGIF QFRVVAANNL GFGEYSGISE NIILVGDDFW
1860 1870 1880 1890 1900
IPETSFILTI IVGIFLVVTI PLTFVWHRRL KNQKSAKEGV TVLINEDKEL
1910 1920 1930 1940 1950
AELRGLAAGV GLANACYAIH TLPTQEEIEN LPAFPREKLT LRLLLGSGAF
1960 1970 1980 1990 2000
GEVYEGTAVD ILGVGSGEIK VAVKTLKKGS TDQEKIEFLK EAHLMSKFNH
2010 2020 2030 2040 2050
PNILKQLGVC LLNEPQYIIL ELMEGGDLLT YLRKARMATF YGPLLTLVDL
2060 2070 2080 2090 2100
VDLCVDISKG CVYLERMHFI HRDLAARNCL VSVKDYTSPR IVKIGDFGLA
2110 2120 2130 2140 2150
RDIYKNDYYR KRGEGLLPVR WMAPESLMDG IFTTQSDVWS FGILIWEILT
2160 2170 2180 2190 2200
LGHQPYPAHS NLDVLNYVQT GGRLEPPRNC PDDLWNLMTQ CWAQEPDQRP
2210 2220 2230 2240 2250
TFHRIQDQLQ LFRNFFLNSI YKSRDEANNS GVINESFEGE DGDVICLNSD
2260 2270 2280 2290 2300
DIMPVALMET KNREGLNYMV LATECGQGEE KSEGPLGSQE SESCGLRKEE
2310 2320 2330 2340
KEPHADKDFC QEKQVAYCPS GKPEGLNYAC LTHSGYGDGS D
Length:2,341
Mass (Da):263,258
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i448C5946E96CAE2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P08922ROS1_HUMAN
Proto-oncogene tyrosine-protein kin...
ROS1 MCF3, ROS
2,347Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3T9H0Y3T9_HUMAN
Proto-oncogene tyrosine-protein kin...
ROS1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL132671 Genomic DNA No translation available.
KF458262 Genomic DNA No translation available.
Z98880 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368507; ENSP00000357493; ENSG00000047936

UCSC genome browser

More...
UCSCi
uc063qym.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132671 Genomic DNA No translation available.
KF458262 Genomic DNA No translation available.
Z98880 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ5H8Y1
PRIDEiQ5H8Y1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368507; ENSP00000357493; ENSG00000047936
UCSCiuc063qym.1 human

Organism-specific databases

HGNCiHGNC:10261 ROS1
OpenTargetsiENSG00000047936

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQAA Eukaryota
ENOG410XSTC LUCA
GeneTreeiENSGT00940000160831
HOGENOMiHOG000137937

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ROS1 human

Gene expression databases

BgeeiENSG00000047936 Expressed in 49 organ(s), highest expression level in lung
ExpressionAtlasiQ5H8Y1 baseline and differential

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.120.10.30, 3 hits
2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5H8Y1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5H8Y1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 8, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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