Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase receptor

Gene

ROS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:ROS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000047936.10
HGNCiHGNC:10261 ROS1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1856 – 1877HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047936

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PeptideAtlasiQ5H8Y1
PRIDEiQ5H8Y1

Expressioni

Gene expression databases

BgeeiENSG00000047936
ExpressionAtlasiQ5H8Y1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5H8Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 205Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini206 – 294Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini566 – 666Fibronectin type-IIIInterPro annotationAdd BLAST101
Domaini942 – 1037Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1038 – 1145Fibronectin type-IIIInterPro annotationAdd BLAST108
Domaini1444 – 1550Fibronectin type-IIIInterPro annotationAdd BLAST107
Domaini1551 – 1650Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1652 – 1745Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1746 – 1848Fibronectin type-IIIInterPro annotationAdd BLAST103
Domaini1939 – 2216Protein kinaseInterPro annotationAdd BLAST278

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IQAA Eukaryota
ENOG410XSTC LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000137937
HOVERGENiHBG058631

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.120.10.30, 3 hits
2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q5H8Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNIYCLIPK LVNFATLGCL WISVVQCTVL NSCLKSCVTN LGQQLDLGTP
60 70 80 90 100
HNLSEPCIQG CHFWNSVDQK NCALKCNDTY ATVCERESCE VGCSSAEGAY
110 120 130 140 150
EEEVLENADL PTAPFASSIG SHNMTLRWKS ANFSGVKYII QWKYAQLLGS
160 170 180 190 200
WTYTKTVSRP SYVVKPLHPF TEYIFRVVWI FTAQLQLYSP PSPSYRTHPH
210 220 230 240 250
GVPETAPLIR NIESSSPDTV EVSWDPPQFP GGPILGYNLR LISKNQKLDA
260 270 280 290 300
GTQRTSFQFY STLPNTIYRF SIAAVNEVGE GPEAESSITT SSSAVQQEEQ
310 320 330 340 350
WLFLSRKTSL RKRSLKHLVD EAHCLRLDAI YHNITGISVD VHQQIVYFSE
360 370 380 390 400
GTLIWAKKAA NMSDVSDLRI FYRGSGLISS ISIDWLYQRM YFIMDELVCV
410 420 430 440 450
CDLENCSNIE EITPPSISAP QKIVADSYNG YVFYLLRDGI YRADLPVPSG
460 470 480 490 500
RCAEAVRIVE SCTLKDFAIK PQAKRIIYFN DTAQVFMSTF LDGSASHLIL
510 520 530 540 550
PRIPFADVKS FACENNDFLV TDGKVIFQQD ALSFNEFIVG CDLSHIEEFG
560 570 580 590 600
FGNLVIFGSS SQLHPLPGRP QELSVLFGSH QALVQWKPPA LAIGASPSAW
610 620 630 640 650
QNWTYEVKVS TQDPPEVTHI FLNISGTMLN VPELQSAMKY KVSVRASSPK
660 670 680 690 700
RPGPWSEPSV GTTLVPASEP PFIMAVKEDG LWSKPLNSFG PGEFLSSDIG
710 720 730 740 750
NVSDMDWYNN SLYYSDTKGD VFVWLLNGTD ISENYHLPSI AGAGALAFEW
760 770 780 790 800
LGHFLYWAGK TYVIQRQSVL TGHTDIVTHV KLLVNDMVVD SVGGYLYWTT
810 820 830 840 850
LYSVESTRLN GESSLVLQTQ PWFSGKKVIA LTLDLSDGLL YWLVQDSQCI
860 870 880 890 900
HLYTAVLRGQ STGDTTITEF AAWSTSEISQ NALMYYSGRL FWINGFRIIT
910 920 930 940 950
TQEIGQKTSV SVLEPARFNQ FTIIQTSLKP LPGNFSFTPK VIPDSVQESS
960 970 980 990 1000
FRIEGNASSF QILWNGPPAV DWGVVFYSVE FSAHSKFLAS EQHSLPVFTV
1010 1020 1030 1040 1050
EGLEPYALFN LSVTPYTYWG KGPKTSLSLR APETVPSAPE NPRIFILPSG
1060 1070 1080 1090 1100
KCCNKNEVVV EFRWNKPKHE NGVLTKFEIF YNISNQSITN KTCEDWIAVN
1110 1120 1130 1140 1150
VTPSVMSFQL EGMSPRCFIA FQVRAFTSKG PGPYADVVKS TTSEINPFPH
1160 1170 1180 1190 1200
LITLLGNKIV FLDMDQNQVV WTFSAERVIS AVCYTADNEM GYYAEGDSLF
1210 1220 1230 1240 1250
LLHLHNRSSS ELFQDSLVFD ITVITIDWIS RHLYFALKES QNGMQVFDVD
1260 1270 1280 1290 1300
LEHKVKYPRE VKIHNRNSTI ISFSVYPLLS RLYWTEVSNF GYQMFYYSII
1310 1320 1330 1340 1350
SHTLHRILQP TATNQQNKRN QCSCNVTEFE LSGAMAIDTS NLEKPLIYFA
1360 1370 1380 1390 1400
KAQEIWAMDL EGCQCWRVIT VPAMLGKTLV SLTVDGDLIY WIITAKDSTQ
1410 1420 1430 1440 1450
IYQAKKGNGA IVSQVKALRS RHILAYSSVM QPFPDKAFLS LASDTVEPTI
1460 1470 1480 1490 1500
LNATNTSLTI RLPLAKTNLT WYGITSPTPT YLVYYAEVND RKNSSDLKYR
1510 1520 1530 1540 1550
ILEFQDSIAL IEDLQPFSTY MIQIAVKNYY SDPLEHLPPG KEIWGKTKNG
1560 1570 1580 1590 1600
VPEAVQLINT TVRSDTSLII SWRESHKPNG PKESVRYQLA ISHLALIPET
1610 1620 1630 1640 1650
PLRQSEFPNG RLTLLVTRLS GGNIYVLKVL ACHSEEMWCT ESHPVTVEMF
1660 1670 1680 1690 1700
NTPEKPYSLV PENTSLQFNW KAPLNVNLIR FWVELQKWKY NEFYHVKTSC
1710 1720 1730 1740 1750
SQGPAYVCNI TNLQPYTSYN VRVVVVYKTG ENSTSLPESF KTKAGVPNKP
1760 1770 1780 1790 1800
GIPKLLEGSK NSIQWEKAED NGCRITYYIL EIRKSTSNNL QNQNLRWKMT
1810 1820 1830 1840 1850
FNGSCSSVCT WKSKNLKGIF QFRVVAANNL GFGEYSGISE NIILVGDDFW
1860 1870 1880 1890 1900
IPETSFILTI IVGIFLVVTI PLTFVWHRRL KNQKSAKEGV TVLINEDKEL
1910 1920 1930 1940 1950
AELRGLAAGV GLANACYAIH TLPTQEEIEN LPAFPREKLT LRLLLGSGAF
1960 1970 1980 1990 2000
GEVYEGTAVD ILGVGSGEIK VAVKTLKKGS TDQEKIEFLK EAHLMSKFNH
2010 2020 2030 2040 2050
PNILKQLGVC LLNEPQYIIL ELMEGGDLLT YLRKARMATF YGPLLTLVDL
2060 2070 2080 2090 2100
VDLCVDISKG CVYLERMHFI HRDLAARNCL VSVKDYTSPR IVKIGDFGLA
2110 2120 2130 2140 2150
RDIYKNDYYR KRGEGLLPVR WMAPESLMDG IFTTQSDVWS FGILIWEILT
2160 2170 2180 2190 2200
LGHQPYPAHS NLDVLNYVQT GGRLEPPRNC PDDLWNLMTQ CWAQEPDQRP
2210 2220 2230 2240 2250
TFHRIQDQLQ LFRNFFLNSI YKSRDEANNS GVINESFEGE DGDVICLNSD
2260 2270 2280 2290 2300
DIMPVALMET KNREGLNYMV LATECGQGEE KSEGPLGSQE SESCGLRKEE
2310 2320 2330 2340
KEPHADKDFC QEKQVAYCPS GKPEGLNYAC LTHSGYGDGS D
Length:2,341
Mass (Da):263,258
Last modified:February 5, 2008 - v1
Checksum:i448C5946E96CAE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132671 Genomic DNA No translation available.
KF458262 Genomic DNA No translation available.
Z98880 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000368507; ENSP00000357493; ENSG00000047936
UCSCiuc063qym.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5H8Y1_HUMAN
AccessioniPrimary (citable) accession number: Q5H8Y1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health