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Protein

Vacuolar protein sorting-associated protein 13A

Gene

Vps13a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • autophagy Source: MGI
  • locomotory behavior Source: MGI
  • nervous system development Source: MGI
  • protein retention in Golgi apparatus Source: GO_Central
  • protein targeting to vacuole Source: GO_Central
  • social behavior Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 13A
Alternative name(s):
Chorea-acanthocytosis protein homolog
Chorein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vps13aImported
Synonyms:ChacImported, Kiaa0986Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444304 Vps13a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show defects in motor coordination, social investigation, erythrocyte morphology as well as size and morphology of the striatum. Provides a mouse model for chorea-acanthocytosis (CHAC) with a mild phenotype and late adult onset.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002629481 – 3166Vacuolar protein sorting-associated protein 13AAdd BLAST3166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei831PhosphothreonineCombined sources1
Modified residuei835PhosphoserineCombined sources1
Modified residuei1410PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5H8C4

PeptideAtlas

More...
PeptideAtlasi
Q5H8C4

PRoteomics IDEntifications database

More...
PRIDEi
Q5H8C4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5H8C4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5H8C4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046230 Expressed in 138 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
MM_VPS13A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5H8C4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5H8C4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068716

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5H8C4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5H8C4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati212 – 245TPR 1Sequence analysisAdd BLAST34
Repeati373 – 406TPR 2Sequence analysisAdd BLAST34
Repeati1806 – 1840TPR 3Sequence analysisAdd BLAST35
Repeati1999 – 2034TPR 4Sequence analysisAdd BLAST36
Repeati2716 – 2750TPR 5Sequence analysisAdd BLAST35
Repeati2852 – 2890TPR 6Sequence analysisAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS13 family.Sequence analysis

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1809 Eukaryota
COG5043 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156158

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218634

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079736

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5H8C4

KEGG Orthology (KO)

More...
KOi
K19525

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQRCIIE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G001Z

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5H8C4

TreeFam database of animal gene trees

More...
TreeFami
TF300316

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015412 Autophagy-rel_C
IPR009543 SHR-BD
IPR026847 VPS13
IPR031645 VPS13_C
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2

The PANTHER Classification System

More...
PANTHERi
PTHR16166 PTHR16166, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q5H8C4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVFESVVVEV LNRFLGDYVV NLDESQLSLG IWKGAVALKN LVIKENALHE
60 70 80 90 100
LDVPFKVKVG HIGSLKLKIP WKNLYTQPVE AVLEEIFLLI VPSSRIQYDP
110 120 130 140 150
IKEEKQLMET KQQELKRIEK AKQKVFDKEK PREEKQDTFT EKLVTQIIQN
160 170 180 190 200
LQVQISSIHI RYEDDITNGD KPLSFGISLQ NISLQTTDQY WIPCLHDNTE
210 220 230 240 250
KLVRKLIRLD NLFAYWNVNS EMFYLNDYDE SLKALKNGIV NENIVPEGYD
260 270 280 290 300
FVFRPISASA KLQMNRRSDF DFSDPKINLA VDLHTIAIEF NKPQYFSLME
310 320 330 340 350
LLESIDMMTQ NQPYRKFKPS VPLHLHAKEW WAYAIHSILE VNVCPSLRMW
360 370 380 390 400
SWEHIRNHRY KMKRYREFYK KKLTSKKPSP EILMSLEELE KTLDVFNITI
410 420 430 440 450
ARQQAEVEAK KAGYKIYKEG VKDPEDNAGW FGWLWTWSES NANQQQDVKP
460 470 480 490 500
GILEEMLTPE EKSLLYEAIG YSETAVDPTL PKTFEALKFF VHLKSMSIVL
510 520 530 540 550
RENHQKPELL NVVVEGLSTS VVQRPGAQAI KFETKIDSFH ITGLPDDFKK
560 570 580 590 600
PHLLSSLDDT SLLQITFEIN PLNETVAQRC TIEAEPLEII YDARTVNSIV
610 620 630 640 650
EFFRPPKDVH LAQLTSVTLT KLEEFRAKTA TGLLYVIETQ KVLDLRINVK
660 670 680 690 700
ASYVIVPQYG NFSPTSNLLL LDLGHLKVSS KRRSLLPDVR PSEASLEDIM
710 720 730 740 750
HRAYDSFDIQ LTSIQLLYSR VGDNWKEARK LNVSTQHILI PMHVNVELSK
760 770 780 790 800
AMVFMDIKMP KFKISGKLPL VSLRISDKKL QGIMELLGSI PKPEPVTDVS
810 820 830 840 850
APARSFQIQA SALPVSHISQ KLIPLLEQPV TEDDSEEEFF DAPCSPLEEC
860 870 880 890 900
PQVSCRDKCT RQKKLQKKDC VMNLIQLRMR FEVAEVSIQF YHLVGDCELP
910 920 930 940 950
VLEMGALGLG TEAEFRTFDL KGSAFLKELW LKCPEYLDEN KKPVYLITTL
960 970 980 990 1000
DNTMEDLLTL EFMKVEKNAP NLNSTYNNVL QLIKVNFSSL DIHLHTEALL
1010 1020 1030 1040 1050
NTMNYLNNIL PELREKSASV SAAEPEDKGD IIKKLALKLP TNEDIITLQL
1060 1070 1080 1090 1100
LAELSCLQIF IQDQKQNISE IKIEGLDSEM IMKPLVTEIN AKLRNIIVLD
1110 1120 1130 1140 1150
SDKMAIYKKA LYITGKEVFS FKMISYMDAT AGYAYTDMSV VDIRVHLTVG
1160 1170 1180 1190 1200
CIEVVFITKF LYSILAFIDN FQAVKDALAE ATVQAAEMAA DGVKELARKS
1210 1220 1230 1240 1250
SRFALDVNIK APVVLIPQSP VSQNVFVADF GLITMKNIFV TVTETQSNIP
1260 1270 1280 1290 1300
PVIDLITIKL SKMRLYRSQF RNDTYQEVLD LLLPLNLEVI VERNLSWEWY
1310 1320 1330 1340 1350
KEVPCFNIKA QLKPMEFILS QEDLTTVFQT LHGNIWYGQD LSAPSSANKD
1360 1370 1380 1390 1400
PETMTSGVTS PPDHSPATVV TAAVVEVHPQ ASQAHTMLNV SFQTDYLTMA
1410 1420 1430 1440 1450
LYSPGPDEAS FTDVRDPSLE LAEFKLENII SSLKIYTDDS TVFSFSVKNC
1460 1470 1480 1490 1500
ILDDKRSHVM KATPRMIGLT VGFDKKDMVD IKYRKIKTFV VTDAVVQEMY
1510 1520 1530 1540 1550
VCASVEFLMT VAHIFFDAYM TSTALETSVQ TRTTREAPAQ ELGKWEMNIL
1560 1570 1580 1590 1600
IKNPEIVFVA DMTRNDAPAL VITTQCEICC KGEPTSNTVT AAIKDLQVRA
1610 1620 1630 1640 1650
CPFLPVKRKG KVTTVLQPCD LFYQATQLGR DPQMIDISVK SLTLKVSPVI
1660 1670 1680 1690 1700
INTIITITSA LYTTKETVPE ENTSNIAHLW DKKDTKNLKM WFLEESNESE
1710 1720 1730 1740 1750
KVVPTNEVMP GGETLNLRID SIFIVLEAGI GHRTVPMLLA KACFSGESKN
1760 1770 1780 1790 1800
WLSLINLHCH LELEVHYYNE MFGVWEPLLE PLEIDQTDDF RPWNLGIKMK
1810 1820 1830 1840 1850
KKAKEAIVES DSEAENYKVP EYKTAISFYS RDQLNITLSK CGLVMLNNLV
1860 1870 1880 1890 1900
EAFTEAATGS SSVFLRDLAP FMIFNSLGLT VSVSPSDSFS VLNVPLAKSY
1910 1920 1930 1940 1950
ELKNDESLSM DYVRTKDNDH FNAMTSLSSK LFFILLTPAN HSVADKIPLT
1960 1970 1980 1990 2000
KVGRRLYTVR HRESGVERSI ICQIDTVEGS KKVTIRSPVQ IKNHFSIPIS
2010 2020 2030 2040 2050
VFEGDTLLGI ASPENEFNIP LASYRSSLSL VPEDQDYQLC EGIDFEEIIK
2060 2070 2080 2090 2100
YDGQLLKKKC RSTNPSKKSF VINIVPEKDN LASLSVYSED GWDLPYVLHL
2110 2120 2130 2140 2150
WPPILIRNLL PYKVAYYIEG IENTVVTLSE GHSSQIYNVE MDQAKLHLKL
2160 2170 2180 2190 2200
LDYLNHDWKS EFYIRSSQQD INFINFTCLT EMEKSDLDIA IHMTYNTGQT
2210 2220 2230 2240 2250
VVAFHSPYWM VNKTNRMLQY KADGIHRKHP PNYTKPVLFS FQPNHFFNNN
2260 2270 2280 2290 2300
KVQLMVTDSE LSDQFSIDTV GSHGAIRCKG LKMEYQVGVT INLSSFNITR
2310 2320 2330 2340 2350
IVTFIPFYMI KNKSKYHISV AEEGSDKWLS LDLEQSIPFW PENASNILLI
2360 2370 2380 2390 2400
QVERSEDPPK RIYFNKQDNC ILLRLNNELG GIIAEVNLAE HSTVITFSDY
2410 2420 2430 2440 2450
HDGAATFLLI NHTKSDPVQY NQSSLGEIED SLPPGKAVYY TWADPVGSRK
2460 2470 2480 2490 2500
LKWSCGQSYG EVTHKDDMMT PISVGKKTIY LVSFFEGLQR IILFTEDPRV
2510 2520 2530 2540 2550
FKVTYESEKA ELAELEVVLA LQDVGISLVN NYTKQEVAYI GITSSDVVWE
2560 2570 2580 2590 2600
AKPKKKARWK PMSVKHTEKL EKEFREYTEA SPLEDKVVEL DNIPVRLTPS
2610 2620 2630 2640 2650
GNDMKILQPH VIPVRRNYLP ALKVEYNTSA HQSSFRIQIY RIQIQNQIHG
2660 2670 2680 2690 2700
AIFPFVFYPI KPPRSVTMDS APKPFTDVSI VMRSAGHSQI SRIKYFKVLI
2710 2720 2730 2740 2750
QEMDLSLDLG FVYALADLVT KAEVTEKTEV EHFHKDVEAF EQEYEVVSSV
2760 2770 2780 2790 2800
DQSQVNLFEY FHISPIKLHL SVSLSSGRDE AKDSEQHGGL IPVHSLNLLL
2810 2820 2830 2840 2850
KSIGATLTDV QDVVFKLAFF ELNYQFHTTS ELQSEVIRHY SKQAIKQMYV
2860 2870 2880 2890 2900
LILGLDVLGN PFGLIREFSE GVEAFFYEPY QGAIQGPEEF VEGMALGLKA
2910 2920 2930 2940 2950
LVGGAVGGLA GAASKITSAM AKGVAAMTMD EDYQQKRREA MNKQPAGLRE
2960 2970 2980 2990 3000
GITRGGKGLV SGFVSGITGI VTKPIKGAQK EGAAGFFKGV GKGLVGAVTR
3010 3020 3030 3040 3050
PTGGIIDMAS STFQGIKRAT ETSEVESLRP PRFFNEDGVI RPYRLRDGSG
3060 3070 3080 3090 3100
NQMLQVMENG RFAKYKYFTH VMINKTDMFM ITRRGVLFVT KGTFGQLTCE
3110 3120 3130 3140 3150
WQYTFDEFTK EPFIVHGRRL RIEAKERVKS VFHAKEFGKI VNFKTPEDAR
3160
WILTKLEEAR EPSPRL
Length:3,166
Mass (Da):359,401
Last modified:March 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68EFBB87EF7833B0
GO
Isoform 21 Publication (identifier: Q5H8C4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3056-3061: VMENGR → ASKSLI
     3062-3166: Missing.

Show »
Length:3,061
Mass (Da):346,722
Checksum:i4377D51797F753ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCT3A0A286YCT3_MOUSE
Vacuolar protein sorting-associated...
Vps13a
2,339Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCC3A0A286YCC3_MOUSE
Vacuolar protein sorting-associated...
Vps13a
857Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE22761 differs from that shown. Intron retention.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0522413056 – 3061VMENGR → ASKSLI in isoform 2. 1 Publication6
Alternative sequenceiVSP_0522423062 – 3166Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB115421 mRNA Translation: BAD89296.1
AK052697 mRNA Translation: BAC35101.1
AK135983 mRNA Translation: BAE22761.1 Sequence problems.
AK142462 mRNA Translation: BAE25075.1
AK220362 mRNA Translation: BAD90423.1
BC050055 mRNA Translation: AAH50055.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37929.1 [Q5H8C4-1]

NCBI Reference Sequences

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RefSeqi
NP_766616.2, NM_173028.4 [Q5H8C4-1]
XP_006527189.1, XM_006527126.3 [Q5H8C4-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.211963

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000068156; ENSMUSP00000068716; ENSMUSG00000046230 [Q5H8C4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
271564

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:271564

UCSC genome browser

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UCSCi
uc008gwv.2 mouse [Q5H8C4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB115421 mRNA Translation: BAD89296.1
AK052697 mRNA Translation: BAC35101.1
AK135983 mRNA Translation: BAE22761.1 Sequence problems.
AK142462 mRNA Translation: BAE25075.1
AK220362 mRNA Translation: BAD90423.1
BC050055 mRNA Translation: AAH50055.1
CCDSiCCDS37929.1 [Q5H8C4-1]
RefSeqiNP_766616.2, NM_173028.4 [Q5H8C4-1]
XP_006527189.1, XM_006527126.3 [Q5H8C4-2]
UniGeneiMm.211963

3D structure databases

ProteinModelPortaliQ5H8C4
SMRiQ5H8C4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068716

PTM databases

iPTMnetiQ5H8C4
PhosphoSitePlusiQ5H8C4

Proteomic databases

PaxDbiQ5H8C4
PeptideAtlasiQ5H8C4
PRIDEiQ5H8C4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068156; ENSMUSP00000068716; ENSMUSG00000046230 [Q5H8C4-1]
GeneIDi271564
KEGGimmu:271564
UCSCiuc008gwv.2 mouse [Q5H8C4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23230
MGIiMGI:2444304 Vps13a

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1809 Eukaryota
COG5043 LUCA
GeneTreeiENSGT00940000156158
HOGENOMiHOG000218634
HOVERGENiHBG079736
InParanoidiQ5H8C4
KOiK19525
OMAiAQRCIIE
OrthoDBiEOG091G001Z
PhylomeDBiQ5H8C4
TreeFamiTF300316

Miscellaneous databases

Protein Ontology

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PROi
PR:Q5H8C4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046230 Expressed in 138 organ(s), highest expression level in secondary oocyte
CleanExiMM_VPS13A
ExpressionAtlasiQ5H8C4 baseline and differential
GenevisibleiQ5H8C4 MM

Family and domain databases

InterProiView protein in InterPro
IPR015412 Autophagy-rel_C
IPR009543 SHR-BD
IPR026847 VPS13
IPR031645 VPS13_C
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2
PANTHERiPTHR16166 PTHR16166, 1 hit
PfamiView protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP13A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5H8C4
Secondary accession number(s): Q3UQG7
, Q3UX03, Q5DU08, Q80YV7, Q8C722
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: December 5, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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