UniProtKB - Q5H8A3 (NMS_HUMAN)
Protein
Neuromedin-S
Gene
NMS
Organism
Homo sapiens (Human)
Status
Functioni
Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity
GO - Molecular functioni
- G protein-coupled receptor binding Source: Ensembl
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- locomotor rhythm Source: Ensembl
- neuropeptide signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Neuropeptide |
Enzyme and pathway databases
PathwayCommonsi | Q5H8A3 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q5H8A3 |
Names & Taxonomyi
Protein namesi | Recommended name: Neuromedin-S |
Gene namesi | Name:NMS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204640.1 |
HGNCi | HGNC:32203, NMS |
neXtProti | NX_Q5H8A3 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 129521 |
OpenTargetsi | ENSG00000204640 |
PharmGKBi | PA142671260 |
Miscellaneous databases
Pharosi | Q5H8A3, Tbio |
Polymorphism and mutation databases
BioMutai | NMS |
DMDMi | 74722605 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
PropeptideiPRO_0000262480 | 27 – 69 | Add BLAST | 43 | |
PropeptideiPRO_0000262481 | 70 – 105 | Add BLAST | 36 | |
PropeptideiPRO_0000262482 | 106 – 108 | 3 | ||
PeptideiPRO_0000262483 | 109 – 141 | Neuromedin-SAdd BLAST | 33 | |
PropeptideiPRO_0000262484 | 144 – 153 | 10 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 141 | Asparagine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesProteomic databases
PaxDbi | Q5H8A3 |
PRIDEi | Q5H8A3 |
ProteomicsDBi | 62843 |
TopDownProteomicsi | Q5H8A3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204640, Expressed in hypothalamus and 25 other tissues |
ExpressionAtlasi | Q5H8A3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000204640, Group enriched (brain, testis) |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9606.ENSP00000366061 |
Miscellaneous databases
RNActi | Q5H8A3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NmU family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SB16, Eukaryota |
GeneTreei | ENSGT00510000049213 |
HOGENOMi | CLU_090356_1_0_1 |
InParanoidi | Q5H8A3 |
OMAi | CMLPIPS |
OrthoDBi | 1542759at2759 |
PhylomeDBi | Q5H8A3 |
TreeFami | TF338319 |
Family and domain databases
InterProi | View protein in InterPro IPR018070, Neuromedin-U_amidation-site IPR043253, NmS |
PANTHERi | PTHR32414, PTHR32414, 1 hit |
PROSITEi | View protein in PROSITE PS00967, NMU, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5H8A3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL
60 70 80 90 100
SQWAPLSRQP KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK
110 120 130 140 150
LANRRMKRIL QRGSGTAAVD FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ
IQW
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029495 | 6 | P → S. Corresponds to variant dbSNP:rs13411940Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB164464 mRNA Translation: BAD89024.1 |
CCDSi | CCDS33259.1 |
RefSeqi | NP_001011717.1, NM_001011717.1 |
Genome annotation databases
Ensembli | ENST00000376865; ENSP00000366061; ENSG00000204640 |
GeneIDi | 129521 |
KEGGi | hsa:129521 |
UCSCi | uc002tan.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB164464 mRNA Translation: BAD89024.1 |
CCDSi | CCDS33259.1 |
RefSeqi | NP_001011717.1, NM_001011717.1 |
3D structure databases
SMRi | Q5H8A3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000366061 |
Polymorphism and mutation databases
BioMutai | NMS |
DMDMi | 74722605 |
Proteomic databases
PaxDbi | Q5H8A3 |
PRIDEi | Q5H8A3 |
ProteomicsDBi | 62843 |
TopDownProteomicsi | Q5H8A3 |
Protocols and materials databases
Antibodypediai | 48800, 110 antibodies |
DNASUi | 129521 |
Genome annotation databases
Ensembli | ENST00000376865; ENSP00000366061; ENSG00000204640 |
GeneIDi | 129521 |
KEGGi | hsa:129521 |
UCSCi | uc002tan.1, human |
Organism-specific databases
CTDi | 129521 |
DisGeNETi | 129521 |
EuPathDBi | HostDB:ENSG00000204640.1 |
GeneCardsi | NMS |
HGNCi | HGNC:32203, NMS |
HPAi | ENSG00000204640, Group enriched (brain, testis) |
neXtProti | NX_Q5H8A3 |
OpenTargetsi | ENSG00000204640 |
PharmGKBi | PA142671260 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SB16, Eukaryota |
GeneTreei | ENSGT00510000049213 |
HOGENOMi | CLU_090356_1_0_1 |
InParanoidi | Q5H8A3 |
OMAi | CMLPIPS |
OrthoDBi | 1542759at2759 |
PhylomeDBi | Q5H8A3 |
TreeFami | TF338319 |
Enzyme and pathway databases
PathwayCommonsi | Q5H8A3 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q5H8A3 |
Miscellaneous databases
BioGRID-ORCSi | 129521, 6 hits in 835 CRISPR screens |
GenomeRNAii | 129521 |
Pharosi | Q5H8A3, Tbio |
PROi | PR:Q5H8A3 |
RNActi | Q5H8A3, protein |
Gene expression databases
Bgeei | ENSG00000204640, Expressed in hypothalamus and 25 other tissues |
ExpressionAtlasi | Q5H8A3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR018070, Neuromedin-U_amidation-site IPR043253, NmS |
PANTHERi | PTHR32414, PTHR32414, 1 hit |
PROSITEi | View protein in PROSITE PS00967, NMU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NMS_HUMAN | |
Accessioni | Q5H8A3Primary (citable) accession number: Q5H8A3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | March 1, 2005 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations