Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuromedin-S

Gene

NMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ5H8A3

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-S
Gene namesi
Name:NMS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000204640.1
HGNCiHGNC:32203 NMS
neXtProtiNX_Q5H8A3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi129521
OpenTargetsiENSG00000204640
PharmGKBiPA142671260

Polymorphism and mutation databases

BioMutaiNMS
DMDMi74722605

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000026248027 – 69Add BLAST43
PropeptideiPRO_000026248170 – 105Add BLAST36
PropeptideiPRO_0000262482106 – 1083
PeptideiPRO_0000262483109 – 141Neuromedin-SAdd BLAST33
PropeptideiPRO_0000262484144 – 15310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ5H8A3
PRIDEiQ5H8A3
ProteomicsDBi62843
TopDownProteomicsiQ5H8A3

Expressioni

Gene expression databases

BgeeiENSG00000204640
CleanExiHS_NMS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366061

Structurei

3D structure databases

ProteinModelPortaliQ5H8A3
SMRiQ5H8A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX42 Eukaryota
ENOG4111CPK LUCA
GeneTreeiENSGT00510000049213
HOGENOMiHOG000060184
HOVERGENiHBG082033
InParanoidiQ5H8A3
OMAiNRRMKRF
OrthoDBiEOG091G0YD0
PhylomeDBiQ5H8A3
TreeFamiTF338319

Family and domain databases

InterProiView protein in InterPro
IPR018070 Neuromedin-U_amidation-site
PROSITEiView protein in PROSITE
PS00967 NMU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5H8A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLRPQFPL ILAIYCFCML QIPSSGFPQP LADPSDGLDI VQLEQLAYCL
60 70 80 90 100
SQWAPLSRQP KDNQDIYKRF LFHYSRTQEA THPVKTGFPP VHPLMHLAAK
110 120 130 140 150
LANRRMKRIL QRGSGTAAVD FTKKDHTATW GRPFFLFRPR NGRNIEDEAQ

IQW
Length:153
Mass (Da):17,731
Last modified:March 1, 2005 - v1
Checksum:i93B65FB17876C600
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0294956P → S. Corresponds to variant dbSNP:rs13411940Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164464 mRNA Translation: BAD89024.1
CCDSiCCDS33259.1
RefSeqiNP_001011717.1, NM_001011717.1
UniGeneiHs.567676

Genome annotation databases

EnsembliENST00000376865; ENSP00000366061; ENSG00000204640
GeneIDi129521
KEGGihsa:129521
UCSCiuc002tan.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNMS_HUMAN
AccessioniPrimary (citable) accession number: Q5H8A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2005
Last modified: June 20, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health