UniProtKB - Q5H7C2 (Q5H7C2_DANRE)
Protein
Submitted name:
Forkhead box L1
Gene
foxl1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 52 – 146 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: ZFIN
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- blood vessel development Source: InterPro
- brain development Source: ZFIN
- camera-type eye development Source: ZFIN
- cartilage development Source: ZFIN
- cell differentiation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: ZFIN
- pectoral fin morphogenesis Source: ZFIN
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box L1ImportedSubmitted name: Forkhead transcription factorImported |
Gene namesi | Name:foxl1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-1181, foxl1 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000008133, Expressed in swim bladder and 31 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 146 | Fork-headInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 210 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 227 – 283 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 148 – 162 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 168 – 182 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 184 – 199 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 227 – 258 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 263 – 283 | PolyampholyteSequence analysisAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162251 |
HOGENOMi | CLU_052451_0_0_1 |
OMAi | MGFPLCS |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR033067, FoxS1 IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11829:SF68, PTHR11829:SF68, 1 hit |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5H7C2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLYHSPVPQ SGVAASALGL SGSSLIYVYG GEVGGIIPAL GFASGRQEPP
60 70 80 90 100
QKPPYSYIAL IAMAIKNAPD KRATLSGIYQ FIMDRFPYYH DNKQGWQNSI
110 120 130 140 150
RHNLSLNDCF IKVPREKGRP GKGSYWTLDT KCLDMFENGN YRRRKRKCRT
160 170 180 190 200
QDTGDTKVGH KRTRVTSFKL HQGAQSEKVS PLKQNPGRDI KEKSNDTQPQ
210 220 230 240 250
NEEENVASES AKDWCLASST TIVSLPRCTT PERSSTVAVN THTPLSSASE
260 270 280 290 300
TRVPVKSDTG RAQSGDAKSK ESNPRKTTDK AKEFSIDSIL SKKENQFQRR
310 320 330 340 350
CAAAGGASVD SRGYALASSL IAHAHPQLYP RGFPLCSYLS LTCPDKILSL
360
TEKTDEKLFF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX908765 Genomic DNA No translation available. AB191484 mRNA Translation: BAD89148.1 |
Genome annotation databases
Ensembli | ENSDART00000018764; ENSDARP00000027106; ENSDARG00000008133 ENSDART00000181521; ENSDARP00000152646; ENSDARG00000111418 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX908765 Genomic DNA No translation available. AB191484 mRNA Translation: BAD89148.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000027106 |
Genome annotation databases
Ensembli | ENSDART00000018764; ENSDARP00000027106; ENSDARG00000008133 ENSDART00000181521; ENSDARP00000152646; ENSDARG00000111418 |
Organism-specific databases
ZFINi | ZDB-GENE-040426-1181, foxl1 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162251 |
HOGENOMi | CLU_052451_0_0_1 |
OMAi | MGFPLCS |
TreeFami | TF316127 |
Gene expression databases
Bgeei | ENSDARG00000008133, Expressed in swim bladder and 31 other tissues |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR033067, FoxS1 IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11829:SF68, PTHR11829:SF68, 1 hit |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5H7C2_DANRE | |
Accessioni | Q5H7C2Primary (citable) accession number: Q5H7C2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2005 |
Last sequence update: | March 1, 2005 | |
Last modified: | October 7, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |