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Protein

Dystrophin

Gene

DMD

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3296 – 3343ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • dystroglycan binding Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dystrophin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002275221 – 3674DystrophinCuratedAdd BLAST3674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3472PhosphoserineBy similarity1
Modified residuei3479PhosphoserineBy similarity1
Modified residuei3489PhosphoserineBy similarity1
Modified residuei3601PhosphoserineBy similarity1
Modified residuei3602PhosphoserineBy similarity1
Modified residuei3606PhosphoserineBy similarity1
Modified residuei3612PhosphoserineBy similarity1
Modified residuei3613PhosphoserineBy similarity1
Modified residuei3655PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5GN48

PeptideAtlas

More...
PeptideAtlasi
Q5GN48

PRoteomics IDEntifications database

More...
PRIDEi
Q5GN48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the retina, expressed in the outer plexiform layer (OPL) and around the blood vessels. Also observed at the vitreal border of the retina corresponding to the inner limiting membrane (ILM). Presynaptically localized in cone pedicles and postsynaptically in bipolar cells (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYNM (By similarity). Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity). Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells. Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000030238

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5GN48

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5GN48

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 115Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini130 – 236Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST107
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati335 – 443Spectrin 1Sequence analysisAdd BLAST109
Repeati444 – 552Spectrin 2Sequence analysisAdd BLAST109
Repeati555 – 663Spectrin 3Sequence analysisAdd BLAST109
Repeati715 – 824Spectrin 4Sequence analysisAdd BLAST110
Repeati826 – 930Spectrin 5Sequence analysisAdd BLAST105
Repeati939 – 1041Spectrin 6Sequence analysisAdd BLAST103
Repeati1044 – 1150Spectrin 7Sequence analysisAdd BLAST107
Repeati1153 – 1259Spectrin 8Sequence analysisAdd BLAST107
Repeati1262 – 1363Spectrin 9Sequence analysisAdd BLAST102
Repeati1364 – 1459Spectrin 10Add BLAST96
Repeati1464 – 1564Spectrin 11Add BLAST101
Repeati1567 – 1672Spectrin 12Add BLAST106
Repeati1675 – 1774Spectrin 13Add BLAST100
Repeati1775 – 1870Spectrin 14Add BLAST96
Repeati1873 – 1975Spectrin 15Add BLAST103
Repeati1988 – 2097Spectrin 16Add BLAST110
Repeati2100 – 2204Spectrin 17Add BLAST105
Repeati2207 – 2314Spectrin 18Add BLAST108
Repeati2315 – 2412Spectrin 19Add BLAST98
Repeati2464 – 2566Spectrin 20Add BLAST103
Repeati2569 – 2675Spectrin 21Add BLAST107
Repeati2678 – 2791Spectrin 22Add BLAST114
Repeati2797 – 2919Spectrin 23Add BLAST123
Repeati2924 – 3029Spectrin 24Add BLAST106
Domaini3044 – 3077WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 236Actin-bindingAdd BLAST236
Regioni59 – 68ANK2- and ANK-3 bindingBy similarity10
Regioni1411 – 1909Interaction with SYNMBy similarityAdd BLAST499
Regioni3047 – 3397Interaction with SYNMBy similarityAdd BLAST351
Regioni3455 – 3507Binds to SNTB1By similarityAdd BLAST53

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3296 – 3343ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4286 Eukaryota
COG5069 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231175

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005495

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5GN48

KEGG Orthology (KO)

More...
KOi
K10366

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR016344 Dystrophin
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ

The PANTHER Classification System

More...
PANTHERi
PTHR44318:SF1 PTHR44318:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 17 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002341 Dystrophin/utrophin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 22 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q5GN48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEVSSDERE DVQKKTFTKW INAQFSKFGK QHIENLFNDL QDGRRLLDLL
60 70 80 90 100
EGLTGQKLPK EKGSTRVHAL NNVNKALQVL QKNNVDLVNI GSTDIVDGNH
110 120 130 140 150
KLTLGLIWNI ILHWQVKNVM KNIMAGLQQT NSEKILLSWV RQSTRNYPQV
160 170 180 190 200
NVINFTTSWS DGLALNALIH SHRPDLFDWN SVVCQQSATQ RLEHAFNIAK
210 220 230 240 250
YQLGIEKLLD PEDVATTYPD KKSILMYVTS LFQVLPQQVS IEAIQEVEML
260 270 280 290 300
PRPSKVTREE HFQLHHQMHY SQQITVCLAQ GYERTPSPKP RFKSYAYTQA
310 320 330 340 350
AYVTTSDPTR SPFPSQRLES PEDKSFGSSL LETEVNLDSY QTALEEVLSW
360 370 380 390 400
LLSAEDTLQA QGEISNDVEE VKEQFHTHEG YMMDLTSHQG RIGSVLQLGS
410 420 430 440 450
QLIGKGKLSE DEETEVQEQM NLLNSRWECL RVASVEKQSN LHKVLMDLQN
460 470 480 490 500
QQLKELNDWL TKTEEKTRKM EKEPLGPDLE DLKHQIQQHK VLQEDLEQEQ
510 520 530 540 550
VRVNSLTHMV VVVDESSGDH ATAALEEQLK VLGDRWANIC RWTEDRWVLL
560 570 580 590 600
QDILLKWQRF TEEQCLFSTW LSEKEDALNK IHTTGFKDQG EMLSSLQKLA
610 620 630 640 650
VLKTDLEKKK QTMDKLSSLN QDLLSTLKNT LVAQKMEAWL DNFAQRWDNL
660 670 680 690 700
VQKLEKSSTQ ISQAVTTTQP SLTQTTVMET VTMVTTREQI LVKHAQEELP
710 720 730 740 750
PPPPQKKRQI IVDSEIRKRL DVDITELHSW ITRSEAVLQS PEFAIYRKEG
760 770 780 790 800
NFSDLKEKVN AIEREKAEKF RKLQDASRSA QALVEQMVNE GVNADSIKQA
810 820 830 840 850
AEQLNSRWIE FCQLLSERLN WLEYQNRIIT FYNQLQQLEQ ITTAAENWLK
860 870 880 890 900
TQPITTSEPT AVKSQLKICK DEVNRLSALQ PQIERLKIES IALKEKGQGP
910 920 930 940 950
MFLDADSVAF TNHFNQVFAD MQAKEKELQI IFDTLPPMRY QETMSTILTW
960 970 980 990 1000
IQHSEAKLSI PQATVTEYEI MEQRLGELQA LQSSLQEQQN GLNYLSTTVK
1010 1020 1030 1040 1050
EMSKKAPSNI SRKYQSEFEE IEGRWKKLSA QLMEHCQKLE EQIAKLRKLQ
1060 1070 1080 1090 1100
NHIKTLKNWM AEVDIFLKEE WPALGDSEIL RKQLKQCRLL VSDIQTIQPS
1110 1120 1130 1140 1150
LNSVNEGGQK IKKEAEPEFA SRLETELREL NTQWDYICRQ VYARKEALKG
1160 1170 1180 1190 1200
GLDKTISLQK DLSEMHEWMT QAEEEYLERD FEYKTPDELQ TAVEEMKRAK
1210 1220 1230 1240 1250
EEAQQKEAKV KLLTESVNSV IAQAPPAAQE ALKKELDTLT TNYQWLCTRL
1260 1270 1280 1290 1300
NGKCKTLEEV WACWHELLSY LEKANKWLSE VEFKLKTTEN IPGGAEEISE
1310 1320 1330 1340 1350
VLESLENLMQ HSEDNPNQIR ILAQTLTDGG VMDELINEEL ETFNSRWREL
1360 1370 1380 1390 1400
HEEAVRRQKL LEQSIQSAQE IEKSLHLIQD SLSSIDHQLA VYIADKVDAA
1410 1420 1430 1440 1450
QMPQEAQKIQ SDLTSHEISL EEMKKHYQGK EAAPRVLSQI ELAQKKLQDV
1460 1470 1480 1490 1500
SMKFRLFQKP ANFEQRLQES KMILDEVKMH LPALEIKSVE QEVVQSQLNH
1510 1520 1530 1540 1550
CVNLYKSLSE VKSEVEMVIK TGRQIVQKKQ TENPKELDER VTALKLHYNE
1560 1570 1580 1590 1600
LGAKVTERKQ QLEKCLKLSR KMRKEMNVLT EWLAATDTEL TKRSAVEGMP
1610 1620 1630 1640 1650
SNLDSEVVWG KATQKEIEKQ KFHLKSISEI GEALKMVLGK KETLVEDKLS
1660 1670 1680 1690 1700
LLNSNWIAVT SRAEEWLNLL LEYQKHMENF DQNVDHITKW IIQADTLLDE
1710 1720 1730 1740 1750
SEKKKPQQKE DVLKRLKAEM NDMRPKVDST RDQAANLMAN RGDHCRKVIE
1760 1770 1780 1790 1800
PKISELNHRF AAISHRIKTG KASIPLKELE QFNSDIQKLL EPLEAEIQQG
1810 1820 1830 1840 1850
VNLKEEDFNK DMSEDNEGTV KELLQRGDNL QQRITDERKR EEIKIKQQLL
1860 1870 1880 1890 1900
QTKHNALKDL RSQRRKKALE ISHQWYQYKR QADDLLKCLD DIEKKLASLP
1910 1920 1930 1940 1950
EPQDEKKIKE IDRELQKKKE ELDAVRRQAE GLSEDGAAMA VEPTQIQLSK
1960 1970 1980 1990 2000
RWREIESKFA HFRRLNFAQI HTVHEESVMV MTEDMPLEIS YVPSAYLTEI
2010 2020 2030 2040 2050
THVSQALSEV EQLLNAPDLC AKDFEDLFKQ EESLKNIKDS LQQISGRVDI
2060 2070 2080 2090 2100
IHNKKTAGLQ SATPVERTRL QEALSQLDFQ WERVNKMYKD RQGKFDRSVE
2110 2120 2130 2140 2150
KWRRFHYDMK IFNQWLTEAE HFLKKTQIPE NWEHAKYKWY LKELQDGIGQ
2160 2170 2180 2190 2200
RQTIVRVLNA TGEEVIQQSS KTDASILQEK LGSLNLRWQE VCKQLAERKK
2210 2220 2230 2240 2250
RLEEQKNILS EFQRDLNEFV LWLEEADNIT SVALEPGNEQ QLKEKLEEIK
2260 2270 2280 2290 2300
LLAEELPLRQ GTLKQLNETG GTVLVSAPIS PEEQDKIENK LKQTNLQWIK
2310 2320 2330 2340 2350
VSRILPEKQG EIEAHIKDLG QFEEQLNHLL VWLSPIKNQL EIYNQPNQTG
2360 2370 2380 2390 2400
PFDIKETEVA VQAKQLDVEG ILSKGQHLYK EKPATQPVKR KLEDLSSEWK
2410 2420 2430 2440 2450
AVTHLLQELR AKWPGPTPGL TTIEAPTSQT VTLVTQPTVT KETAISKPEM
2460 2470 2480 2490 2500
PSSLLLEVPA LADFNRAWTE LTDWLSLLDR VIKSQRVMVG DLEDINEMII
2510 2520 2530 2540 2550
KQKATLQDLE QRRPQLEELI TAAQNLKNKT SNQEARTIIT DRIERIQSQW
2560 2570 2580 2590 2600
DEVQEHLQNR RQQLNEMLKD STQWLEAKEE AEQVLGQARA KLESWKEGPY
2610 2620 2630 2640 2650
TMDAIQRKIT ETKQLAKDLR QWQINVDVAN DLALKLLRDY SADDTRKVHM
2660 2670 2680 2690 2700
ITENINASWA NIHKRLSERE TVLEETHRLL QQFPLDLEKF LAWLTEAETT
2710 2720 2730 2740 2750
ANVLQDATHK ERLLEDSKGV RELMKQWQDL QGEIEAHTDI YHNLDENGQK
2760 2770 2780 2790 2800
ILRSLEGSDD AILLQRRLDN MNFKWSELRK KSLNIRSHLE ASSDQWKRLH
2810 2820 2830 2840 2850
LSLQELLVWL QLKDDELSRQ APIGGDCPAV QKQNDVHRAF KRELKTKEPV
2860 2870 2880 2890 2900
IMSTLETVRI FLTEQPLEGL EKLYQEPREL PPEERAQNVT RLLRKQAEEV
2910 2920 2930 2940 2950
NTEWEKLNLH SADWQRKIDE ALERLQELQE ATDELDLKLR QAEVIKGSWQ
2960 2970 2980 2990 3000
PVGDLLIDSL QDHLEKVKAL RGEKAPLKEN VSHVNDLARQ LTTLGIQLSP
3010 3020 3030 3040 3050
YNLSTLEDLN TRWKLLQVAV EDRIRQLHEA HRDFGPASQH FLSTSVQGPW
3060 3070 3080 3090 3100
ERAISPNKVP YYINHETQTT CWDHPKMTEL YQSLADLNNV RFSAYRTAMK
3110 3120 3130 3140 3150
LRRLQKALCL DLLSLSAACD ALDQHNLKQN DQPMDILQII NCLTTVYDRL
3160 3170 3180 3190 3200
EQEHNNLVNV PLCVDMCLNW LLNVYDTGRT GRIRVLSFKT GIVSLCKAHL
3210 3220 3230 3240 3250
EDKYRYLFKQ VASSTGFCDQ RRLGLLLHDS IQIPRQLGEV ASFGGSNIEP
3260 3270 3280 3290 3300
SVRSCFQFAN NKPEIEAALF LDWMRLEPQS MVWLPVLHRV AAAETAKHQA
3310 3320 3330 3340 3350
KCNICKECPI IGFRYRSLKH FNYDICQSCF FSGRVAKGHK MHYPMVEYCT
3360 3370 3380 3390 3400
PTTSGEDVRD FAKVLKNKFR TKRYFAKHPR MGYLPVQTVL EGDNMETPVT
3410 3420 3430 3440 3450
LINFWPVDSA PASSPQLSHD DTHSRIEHYA SRLAEMENSN GSYLNDSISP
3460 3470 3480 3490 3500
NESIDDEHLL IQHYCQSLNQ DSPLSQPRSP AQILISLESE ERGELERILA
3510 3520 3530 3540 3550
DLEEENRNLQ AEYDRLKQQH EHKGLSPLPS PPEMMPTSPQ SPRDAELIAE
3560 3570 3580 3590 3600
AKLLRQHKGR LEARMQTLED HNKQLESQLH RLRQLLEQPQ AEAKVNGTTV
3610 3620 3630 3640 3650
SSPSTSLQRS DSSQPMLLRV VGSQTSESMG EEDLLSPPQD TSTGLEEVME
3660 3670
QLNNSFPSSR GRNTPGKPVR EDTM
Length:3,674
Mass (Da):424,858
Last modified:March 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03C22FB8D805632C
GO
Isoform 31 Publication (identifier: Q5GN48-3) [UniParc]FASTAAdd to basket
Also known as: Dp711 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MREQLKG
     2-3064: Missing.
     3397-3410: Missing.

Show »
Length:603
Mass (Da):68,775
Checksum:i47D2A48AA6DAB02F
GO
Isoform 41 Publication (identifier: Q5GN48-4) [UniParc]FASTAAdd to basket
Also known as: Dp741 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MREQLKG
     2-3064: Missing.
     3454-3507: IDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR → M

Show »
Length:564
Mass (Da):64,194
Checksum:i16C18C3BD424AEFD
GO
Isoform 51 Publication (identifier: Q5GN48-5) [UniParc]FASTAAdd to basket
Also known as: Dp71-741 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MREQLKG
     2-3064: Missing.
     3398-3507: Missing.

Show »
Length:507
Mass (Da):57,895
Checksum:iFDAE7EB1BA70ECEC
GO
Isoform 21 Publication (identifier: Q5GN48-2)
Also known as: Dp2601 Publication
Sequence is not available
Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0519671M → MREQLKG in isoform 3, isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0519682 – 3064Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST3063
Alternative sequenceiVSP_0519693397 – 3410Missing in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0519703398 – 3507Missing in isoform 5. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_0519713454 – 3507IDDEH…EEENR → M in isoform 4. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ865385 mRNA Translation: CAI26302.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012408.1, NM_001012408.1 [Q5GN48-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Ssc.42754
Ssc.93582

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
497636

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:497636

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ865385 mRNA Translation: CAI26302.1
RefSeqiNP_001012408.1, NM_001012408.1 [Q5GN48-1]
UniGeneiSsc.42754
Ssc.93582

3D structure databases

ProteinModelPortaliQ5GN48
SMRiQ5GN48
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000030238

Proteomic databases

PaxDbiQ5GN48
PeptideAtlasiQ5GN48
PRIDEiQ5GN48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi497636
KEGGissc:497636

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1756

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
HOGENOMiHOG000231175
HOVERGENiHBG005495
InParanoidiQ5GN48
KOiK10366

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR016344 Dystrophin
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PANTHERiPTHR44318:SF1 PTHR44318:SF1, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 17 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 22 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMD_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5GN48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2005
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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