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Entry version 121 (16 Oct 2019)
Sequence version 2 (14 Oct 2008)
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Protein

Vascular endothelial growth factor receptor 2

Gene

kdr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis.2 Publications

Caution

This entry should not be confused with kdrl (AC Q8AXB3), which used to be called kdr.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei877ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1039Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi849 – 857ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processAngiogenesis, Differentiation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-194306 Neurophilin interactions with VEGF and VEGFR
R-DRE-195399 VEGF binds to VEGFR leading to receptor dimerization
R-DRE-4420097 VEGFA-VEGFR2 Pathway
R-DRE-5218921 VEGFR2 mediated cell proliferation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vascular endothelial growth factor receptor 2 (EC:2.7.10.1)
Short name:
VEGFR-2
Alternative name(s):
Fetal liver kinase 1b
Short name:
FLK-1b
Kinase insert domain receptor
Kinase insert domain receptor-B
Protein-tyrosine kinase receptor flk-1b
Vascular endothelial growth factor receptor 2 homolog B
Short name:
VEGFR-2 homolog B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kdr
Synonyms:flk1b, kdrb
ORF Names:si:busm1-205d10.1, si:ch211-254j6.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041001-112 kdr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 774ExtracellularSequence analysisAdd BLAST752
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei775 – 795HelicalSequence analysisAdd BLAST21
Topological domaini796 – 1357CytoplasmicSequence analysisAdd BLAST562

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2331049

DrugCentral

More...
DrugCentrali
Q5GIT4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024946523 – 1357Vascular endothelial growth factor receptor 2Add BLAST1335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 104PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 203PROSITE-ProRule annotation
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi248 ↔ 314PROSITE-ProRule annotation
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi457 ↔ 538PROSITE-ProRule annotation
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi579 ↔ 651PROSITE-ProRule annotation
Glycosylationi621N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi697 ↔ 746PROSITE-ProRule annotation
Glycosylationi713N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1065Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1070Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1186Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1222Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5GIT4

PRoteomics IDEntifications database

More...
PRIDEi
Q5GIT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

First expressed in embryos between 5- and 7-somites in the bilateral stripes that contain the developing angioblasts, and then localized to the intermediate cell mass (ICM) and the developing vasculature. By 30 hpf, expressed in the major trunk, head and intersomitic vessels, persisting through 4 dpf when expression is seen in developing subintestinal veins and in the remaining vasculature.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

The first vegfr expressed during development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000017321 Expressed in 31 organ(s), highest expression level in heart

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform VEGF165 of vegfaa and, to a lesser extent, with isoform VEGF171 of vegfab (PubMed:17698971).

Interacts (via juxtamembrane region) with chaperone pdcl3 (via thioredoxin fold region); the interaction leads to increased vegfr2 abundance through inhibition of its ubiquitination and degradation (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000049203

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q5GIT4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5GIT4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 120Ig-like C2-type 1Add BLAST89
Domaini120 – 222Ig-like C2-type 2Add BLAST103
Domaini216 – 330Ig-like C2-type 3Add BLAST115
Domaini335 – 426Ig-like C2-type 4Add BLAST92
Domaini433 – 553Ig-like C2-type 5Add BLAST121
Domaini556 – 667Ig-like C2-type 6Add BLAST112
Domaini676 – 762Ig-like C2-type 7Add BLAST87
Domaini843 – 1173Protein kinasePROSITE-ProRule annotationAdd BLAST331

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0200 Eukaryota
COG0515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156710

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037949

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5GIT4

KEGG Orthology (KO)

More...
KOi
K05098

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSHMVSL

Database of Orthologous Groups

More...
OrthoDBi
236292at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5GIT4

TreeFam database of animal gene trees

More...
TreeFami
TF325768

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR041348 VEGFR-2_TMD
IPR009136 VEGFR2_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24416:SF45 PTHR24416:SF45, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF17988 VEGFR-2_TMD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 5 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5GIT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKTSYALLL LDILLTFNVA KAIELRFVPD PPTLNITEKT IKINASDTLQ
60 70 80 90 100
ITCRGRQILE WSTPHNRTSS ETRLTISDCS GDGLFCSTLT LSKAVANETG
110 120 130 140 150
EYRCFYKSLP KEDGKTSVAV YVFIQDYRTP FVRIAQDYDV VFIREGEQVV
160 170 180 190 200
IPCLVSVEDL NVTLYTKYPV KELSTDGKEV IWDSRRGFIL PSRVVSYAGV
210 220 230 240 250
VYCQTTIRNE TFQSSPYIVA VVGYKIYDLT LSPQHERLTV GERLILNCTA
260 270 280 290 300
HTELNVGIDF QWTFPHEKRS VNGSMSTSRY KTSSNKKKLW NSLELSNTLT
310 320 330 340 350
VENVTLNDTG EYICTASSGQ MQKIAQASLI VYEKPFIALS DQLWQTVEAK
360 370 380 390 400
AGDAEAKILV KYYAYPEPAV RWYKNDQLIV LRDEYRMKFY RGVHLTIYGV
410 420 430 440 450
TEKDAGNYTV VMTNKITKEE QRRTFQLVVN DLPRIFEKDV SLDRDVHMYG
460 470 480 490 500
SSPTLTCTAS GGSSPVTIKW QWMPREDCPV RFLPKSDTRM AKCDKWREMS
510 520 530 540 550
NNTGKNPLIS QTSVDERTLK TISTLKIQKA VDHALYRCIA TNKMGQDQRV
560 570 580 590 600
IVFQVTRFLN LSVLPSSSPI EGQDVIMRCV ADRLLYYNLR WYRVANVANH
610 620 630 640 650
DPPPAAVPCD TLTLSHLHQP NVTVSGLQGT NVTLDMPIPN ATMMDQGLYA
660 670 680 690 700
CQVEIVGTNE KTCLLHNLRL RALEMSRIVT NLTDQRVNVS DSTTLVCEVS
710 720 730 740 750
GTPTPTIVWT KDNQTVMEGS GVILKRSNRV LTIQRVKKED SGLYICTACN
760 770 780 790 800
QQGCESSEAR ISVDGAEEKM NVELIMPIGA VVIAMFLWLL IVFVIRNRKR
810 820 830 840 850
PNDGDLKTGY LSIILDSDDM PMDEHCERLT YDASKWEFPR DRLKLGEPLG
860 870 880 890 900
RGAFGQVVEA TAYGIEKATT CTTVAVKMLK EGATSSEYRA LMSELKILIH
910 920 930 940 950
IGHHLNVVNL LGACTKQGGP LMVIVEYCKH GNLSSYLKSK RGEYSPYKKR
960 970 980 990 1000
TPRMPNRREV QQDEDPREGD LGLGTSTRLD ICTGTAVCTR TGEQTYKTLQ
1010 1020 1030 1040 1050
DEQESSDWDH LTMEDLISYS FQVAKGMEFL ASRKCIHRDL AARNILLSEN
1060 1070 1080 1090 1100
SVVKICDFGL ARDVYKDPDY VRKGDARLPL KWMAPETIFD RVYTTQSDVW
1110 1120 1130 1140 1150
SFGVLLWEIF SLGASPYPGV CIDESFCRRL KEGTRMRAPD YATPEIYQTM
1160 1170 1180 1190 1200
LDCWLDRPLD RPTFTQLVEH LGNLLQASAQ QDGKDYIPLT NGEMEEELVA
1210 1220 1230 1240 1250
PHLNVTSKRS FYAGNTEAQL HYDNAPPLGF PQQMNSSGVP VNMTGFVDIP
1260 1270 1280 1290 1300
LEHTTVMDGH VDCGVGLSRE QMKALDRQAQ RPLNFSPLLR CKSKESLASE
1310 1320 1330 1340 1350
SSNQTSGYQS GYHSDDAEAP IYANEEMILK RDIRKKPPLP KRNDKFSAEV

RYSAPPV
Length:1,357
Mass (Da):153,042
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43B97B484DBEA38F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17F → V in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti72T → S in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti109L → P in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti254L → R in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti262W → C in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti287K → R in AAS92270 (Ref. 1) Curated1
Sequence conflicti384E → G in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti459A → G in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti488 – 489TR → PS in AAY89336 (PubMed:17698971).Curated2
Sequence conflicti488 – 489TR → PS in AAI63563 (PubMed:23594743).Curated2
Sequence conflicti553F → S in AAS92270 (Ref. 1) Curated1
Sequence conflicti958R → K in AAS92270 (Ref. 1) Curated1
Sequence conflicti996Y → S in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti996Y → S in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti996Y → S in AAV93319 (PubMed:16617120).Curated1
Sequence conflicti997K → T in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti997K → T in AAI63563 (PubMed:23594743).Curated1
Sequence conflicti1100W → R in AAS92270 (Ref. 1) Curated1
Sequence conflicti1223D → G in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti1234M → I in AAY89336 (PubMed:17698971).Curated1
Sequence conflicti1234M → I in AAI63563 (PubMed:23594743).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY523999 mRNA Translation: AAS92270.1
DQ026829 mRNA Translation: AAY89336.1
BX088688, BX511058 Genomic DNA Translation: CAM14201.1
BX248242 Genomic DNA Translation: CAI11526.1
BX511058, BX088688 Genomic DNA Translation: CAH68950.2
BC163563 mRNA Translation: AAI63563.1
AY833405 mRNA Translation: AAV93319.1

NCBI Reference Sequences

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RefSeqi
NP_001019824.2, NM_001024653.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSDART00000049204; ENSDARP00000049203; ENSDARG00000017321

Database of genes from NCBI RefSeq genomes

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GeneIDi
554230

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dre:554230

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY523999 mRNA Translation: AAS92270.1
DQ026829 mRNA Translation: AAY89336.1
BX088688, BX511058 Genomic DNA Translation: CAM14201.1
BX248242 Genomic DNA Translation: CAI11526.1
BX511058, BX088688 Genomic DNA Translation: CAH68950.2
BC163563 mRNA Translation: AAI63563.1
AY833405 mRNA Translation: AAV93319.1
RefSeqiNP_001019824.2, NM_001024653.2

3D structure databases

SMRiQ5GIT4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000049203

Chemistry databases

BindingDBiQ5GIT4
ChEMBLiCHEMBL2331049
DrugCentraliQ5GIT4

Proteomic databases

PaxDbiQ5GIT4
PRIDEiQ5GIT4

Genome annotation databases

EnsembliENSDART00000049204; ENSDARP00000049203; ENSDARG00000017321
GeneIDi554230
KEGGidre:554230

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3791
ZFINiZDB-GENE-041001-112 kdr

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000156710
HOGENOMiHOG000037949
InParanoidiQ5GIT4
KOiK05098
OMAiQSHMVSL
OrthoDBi236292at2759
PhylomeDBiQ5GIT4
TreeFamiTF325768

Enzyme and pathway databases

ReactomeiR-DRE-194306 Neurophilin interactions with VEGF and VEGFR
R-DRE-195399 VEGF binds to VEGFR leading to receptor dimerization
R-DRE-4420097 VEGFA-VEGFR2 Pathway
R-DRE-5218921 VEGFR2 mediated cell proliferation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q5GIT4

Gene expression databases

BgeeiENSDARG00000017321 Expressed in 31 organ(s), highest expression level in heart

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR041348 VEGFR-2_TMD
IPR009136 VEGFR2_rcpt
PANTHERiPTHR24416:SF45 PTHR24416:SF45, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF17988 VEGFR-2_TMD, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 7 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVGFR2_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5GIT4
Secondary accession number(s): B3DJQ0
, Q1ANK7, Q5MD88, Q5RIP2, Q5TZ34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 14, 2008
Last modified: October 16, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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