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Protein

XK-related protein 3

Gene

XKR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi2.A.112.1.7 the kx blood-group antigen (kxa) family

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 3
Alternative name(s):
X Kell blood group-related 3
XTES
Gene namesi
Name:XKR3
Synonyms:XRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000172967.7
HGNCiHGNC:28778 XKR3
MIMi611674 gene
neXtProtiNX_Q5GH77

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi150165
OpenTargetsiENSG00000172967
PharmGKBiPA142670562

Polymorphism and mutation databases

BioMutaiXKR3
DMDMi74707819

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907761 – 459XK-related protein 3Add BLAST459

Proteomic databases

PaxDbiQ5GH77
PeptideAtlasiQ5GH77
PRIDEiQ5GH77
ProteomicsDBi62835

PTM databases

iPTMnetiQ5GH77
PhosphoSitePlusiQ5GH77

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively, in testis.1 Publication

Gene expression databases

BgeeiENSG00000172967 Expressed in 14 organ(s), highest expression level in testis
CleanExiHS_XKR3

Organism-specific databases

HPAiHPA003379
HPA035081

Interactioni

Protein-protein interaction databases

BioGridi127266, 1 interactor
STRINGi9606.ENSP00000331704

Structurei

3D structure databases

ProteinModelPortaliQ5GH77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCAN Eukaryota
ENOG4110P5T LUCA
GeneTreeiENSGT00390000003231
HOGENOMiHOG000118070
HOVERGENiHBG055838
InParanoidiQ5GH77
OMAiWRFLEVI
OrthoDBiEOG091G07Y7
PhylomeDBiQ5GH77
TreeFamiTF331465

Family and domain databases

InterProiView protein in InterPro
IPR018629 XK-rel
PfamiView protein in Pfam
PF09815 XK-related, 1 hit

Sequencei

Sequence statusi: Complete.

Q5GH77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METVFEEMDE ESTGGVSSSK EEIVLGQRLH LSFPFSIIFS TVLYCGEVAF
60 70 80 90 100
GLYMFEIYRK ANDTFWMSFT ISFIIVGAIL DQIILMFFNK DLRRNKAALL
110 120 130 140 150
FWHILLLGPI VRCLHTIRNY HKWLKNLKQE KEETQVSITK RNTMLEREIA
160 170 180 190 200
FSIRDNFMQQ KAFKYMSVIQ AFLGSVPQLI LQMYISLTIR EWPLNRALLM
210 220 230 240 250
TFSLLSVTYG AIRCNILAIQ ISNDDTTIKL PPIEFFCVVM WRFLEVISRV
260 270 280 290 300
VTLAFFIASL KLKSLPVLLI IYFVSLLAPW LEFWKSGAHL PGNKENNSNM
310 320 330 340 350
VGTVLMLFLI TLLYAAINFS CWSAVKLQLS DDKIIDGRQR WGHRILHYSF
360 370 380 390 400
QFLENVIMIL VFRFFGGKTL LNCCDSLIAV QLIISYLLAT GFMLLFYQYL
410 420 430 440 450
YPWQSGKVLP GRTENQPEAP YYYVNIEKTE KNKNKQLRNY CHSCNRVGYF

SIRKSMTCS
Length:459
Mass (Da):53,448
Last modified:March 1, 2005 - v1
Checksum:i291FDD2A952F6BD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053740143T → M. Corresponds to variant dbSNP:rs5748648Ensembl.1
Natural variantiVAR_053741232P → L1 PublicationCorresponds to variant dbSNP:rs9605146Ensembl.1
Natural variantiVAR_053742255F → L2 PublicationsCorresponds to variant dbSNP:rs5748623Ensembl.1
Natural variantiVAR_053743442H → N2 PublicationsCorresponds to variant dbSNP:rs5748622Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534240 mRNA Translation: AAT07089.1
AY989815 mRNA Translation: AAX86010.1
AK098608 mRNA Translation: BAC05352.1
BC137521 mRNA Translation: AAI37522.1
BC137522 mRNA Translation: AAI37523.1
CCDSiCCDS42975.1
RefSeqiNP_001305180.1, NM_001318251.1
NP_787074.2, NM_175878.4
XP_016884089.1, XM_017028600.1
UniGeneiHs.356069

Genome annotation databases

EnsembliENST00000331428; ENSP00000331704; ENSG00000172967
GeneIDi150165
KEGGihsa:150165
UCSCiuc002zlv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534240 mRNA Translation: AAT07089.1
AY989815 mRNA Translation: AAX86010.1
AK098608 mRNA Translation: BAC05352.1
BC137521 mRNA Translation: AAI37522.1
BC137522 mRNA Translation: AAI37523.1
CCDSiCCDS42975.1
RefSeqiNP_001305180.1, NM_001318251.1
NP_787074.2, NM_175878.4
XP_016884089.1, XM_017028600.1
UniGeneiHs.356069

3D structure databases

ProteinModelPortaliQ5GH77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127266, 1 interactor
STRINGi9606.ENSP00000331704

Protein family/group databases

TCDBi2.A.112.1.7 the kx blood-group antigen (kxa) family

PTM databases

iPTMnetiQ5GH77
PhosphoSitePlusiQ5GH77

Polymorphism and mutation databases

BioMutaiXKR3
DMDMi74707819

Proteomic databases

PaxDbiQ5GH77
PeptideAtlasiQ5GH77
PRIDEiQ5GH77
ProteomicsDBi62835

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331428; ENSP00000331704; ENSG00000172967
GeneIDi150165
KEGGihsa:150165
UCSCiuc002zlv.4 human

Organism-specific databases

CTDi150165
DisGeNETi150165
EuPathDBiHostDB:ENSG00000172967.7
GeneCardsiXKR3
HGNCiHGNC:28778 XKR3
HPAiHPA003379
HPA035081
MIMi611674 gene
neXtProtiNX_Q5GH77
OpenTargetsiENSG00000172967
PharmGKBiPA142670562
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCAN Eukaryota
ENOG4110P5T LUCA
GeneTreeiENSGT00390000003231
HOGENOMiHOG000118070
HOVERGENiHBG055838
InParanoidiQ5GH77
OMAiWRFLEVI
OrthoDBiEOG091G07Y7
PhylomeDBiQ5GH77
TreeFamiTF331465

Miscellaneous databases

ChiTaRSiXKR3 human
GenomeRNAii150165
PROiPR:Q5GH77
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172967 Expressed in 14 organ(s), highest expression level in testis
CleanExiHS_XKR3

Family and domain databases

InterProiView protein in InterPro
IPR018629 XK-rel
PfamiView protein in Pfam
PF09815 XK-related, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXKR3_HUMAN
AccessioniPrimary (citable) accession number: Q5GH77
Secondary accession number(s): B2RPN1, Q52PG8, Q8N7E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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