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Protein

Alpha-defensin 23

Gene

Defa23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May have microbicidal activities.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-defensin 23
Alternative name(s):
Defensin-related cryptdin-23
Gene namesi
Name:Defa23
Synonyms:Defcr23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3630381 Defa23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000030007220 – 58By similarityAdd BLAST39
PeptideiPRO_000030007359 – 92Alpha-defensin 23Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 92By similarity
Disulfide bondi66 ↔ 81By similarity
Disulfide bondi71 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5G866
PeptideAtlasiQ5G866
PRIDEiQ5G866

PTM databases

iPTMnetiQ5G866
PhosphoSitePlusiQ5G866

Expressioni

Gene expression databases

BgeeiENSMUSG00000074442 Expressed in 6 organ(s), highest expression level in colon

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096498

Structurei

3D structure databases

ProteinModelPortaliQ5G866
SMRiQ5G866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00900000141423
HOVERGENiHBG011703
InParanoidiQ5G866
KOiK05230
OMAiCQRTELR
OrthoDBiEOG091G12GE
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5G866-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLVLLSAL ILLAFQVQAD PIQNTDEETK TEEQPGKEDQ AVSVSFGDPE
60 70 80 90
GSSLQEESLR DLVCYCRTRG CKRRERMNGT CRKGHLIYTL CCR
Length:93
Mass (Da):10,510
Last modified:March 1, 2005 - v1
Checksum:i3B3D87557D869A49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11I → V in AAI25551 (PubMed:15489334).Curated1
Sequence conflicti11I → V in AAI25549 (PubMed:15489334).Curated1
Sequence conflicti37K → E in AAI25551 (PubMed:15489334).Curated1
Sequence conflicti37K → E in AAI25549 (PubMed:15489334).Curated1
Sequence conflicti87I → M in AAI25551 (PubMed:15489334).Curated1
Sequence conflicti87I → M in AAI25549 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY746428 mRNA Translation: AAW78337.1
BC125548 mRNA Translation: AAI25549.1
BC125550 mRNA Translation: AAI25551.1
CCDSiCCDS40265.1
RefSeqiNP_001012307.1, NM_001012307.2
NP_031874.2, NM_007848.2
UniGeneiMm.425522
Mm.442051

Genome annotation databases

EnsembliENSMUST00000098896; ENSMUSP00000096495; ENSMUSG00000074442
ENSMUST00000098899; ENSMUSP00000096498; ENSMUSG00000074446
GeneIDi13226
497114
KEGGimmu:13226
mmu:497114
UCSCiuc009lbk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY746428 mRNA Translation: AAW78337.1
BC125548 mRNA Translation: AAI25549.1
BC125550 mRNA Translation: AAI25551.1
CCDSiCCDS40265.1
RefSeqiNP_001012307.1, NM_001012307.2
NP_031874.2, NM_007848.2
UniGeneiMm.425522
Mm.442051

3D structure databases

ProteinModelPortaliQ5G866
SMRiQ5G866
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096498

PTM databases

iPTMnetiQ5G866
PhosphoSitePlusiQ5G866

Proteomic databases

PaxDbiQ5G866
PeptideAtlasiQ5G866
PRIDEiQ5G866

Protocols and materials databases

DNASUi13226
497114
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098896; ENSMUSP00000096495; ENSMUSG00000074442
ENSMUST00000098899; ENSMUSP00000096498; ENSMUSG00000074446
GeneIDi13226
497114
KEGGimmu:13226
mmu:497114
UCSCiuc009lbk.2 mouse

Organism-specific databases

CTDi13226
497114
MGIiMGI:3630381 Defa23

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00900000141423
HOVERGENiHBG011703
InParanoidiQ5G866
KOiK05230
OMAiCQRTELR
OrthoDBiEOG091G12GE
TreeFamiTF338414

Miscellaneous databases

PROiPR:Q5G866
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074442 Expressed in 6 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDFA23_MOUSE
AccessioniPrimary (citable) accession number: Q5G866
Secondary accession number(s): Q059S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2005
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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