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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalUniRule annotationAdd BLAST22
Transmembranei510 – 533HelicalUniRule annotationAdd BLAST24
Transmembranei676 – 703HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5G5U9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 140GP120InterPro annotationAdd BLAST108
Domaini146 – 509GP120InterPro annotationAdd BLAST364
Domaini528 – 716GP41InterPro annotationAdd BLAST189

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909 HIV-1-like_HR1-HR2, 1 hit
Gene3Di2.170.40.20, 2 hits
HAMAPiMF_04083 HIV_ENV, 1 hit
InterProiView protein in InterPro
IPR036377 Gp120_core_sf
IPR037527 Gp160
IPR000328 GP41-like
IPR000777 HIV1_Gp120
PfamiView protein in Pfam
PF00516 GP120, 2 hits
PF00517 GP41, 1 hit
SUPFAMiSSF56502 SSF56502, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5G5U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMGIRKNY QHLWKWGTML LWLLMICSAA DQLWVTVYYG VPVWKEANTT
60 70 80 90 100
LFCASDAKAY DTEAHNVWAT HACVPTDPNP QEVVLENVTE NFNMWKNHMV
110 120 130 140 150
EQMHEDIISL WDQSLKPCVK LTPLCVTLNC TDLVNSNITR VDNTTEKEMK
160 170 180 190 200
NCSFNVTSGI RDKVQKEYAL LYKLDIVQID NDNTSHRDNT SYRLISCNTS
210 220 230 240 250
VITQACPKIS FEPIPIHFCA PAGFAILKCN DKKFNGTGPC TNVSTVQCTH
260 270 280 290 300
GIRPVVSTQL LLNGSLAEEE VVIRSENFTN NVKNIIVQLN ESVQINCTRH
310 320 330 340 350
NNNTRKSINI GPGRAFYATG KIIGDIRQAH CNISREKWQN TLKQIVKKLR
360 370 380 390 400
EQFKNKTIAF APSSGGDPEI VMHSFNCNGE FFYCNTTKLF TSTWNSTWNS
410 420 430 440 450
TWNNTEGSNS TVITLPCRIR QIINMWQEVG KAMYAPPIQG QIKCSSNITG
460 470 480 490 500
LLLTRDGGVD TTKETFRPGG GNMKDNWRSE LYKYKVVRIE PLGVAPTKAK
510 520 530 540 550
RRVVQREKRA VGIGAMFLGF LGAAGSTMGA ASITLTVQAR LLLSGIVQQQ
560 570 580 590 600
SNLLRAIEAQ QHLLQLTVWG IKQLQARVLA VERYLKDQQL LGIWGCSGKL
610 620 630 640 650
ICTTAVPWNA SWSNKSQDTI WGNMTWMQWE REIDNYTDLI YNLLEESQNQ
660 670 680 690 700
QEKNEQELLA LDKWASLWSW FSITHWLWYI KMFIMIVGGL VGLRIVFAVL
710 720 730 740 750
SIVNRVRQGY SPLSFQTRFP APRGPDRPEG IEEEGGERDR DRSGRSADGF
760 770 780 790 800
LVLVWVDLRN LCLFSYHRLR DLLLIVTRTV ELLGRRGWEA LKYWWNLLQY
810 820 830 840 850
WSQELKKSAV SLLDAIAIAV AEGTDRIIEL LQRIFRAFLH IPTRIRQGLE

RALQ
Length:854
Mass (Da):97,360
Last modified:March 1, 2005 - v1
Checksum:iF441D947ED3DD3E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY835447 Genomic RNA Translation: AAW64262.1

Similar proteinsi

Entry informationi

Entry nameiQ5G5U9_9HIV1
AccessioniPrimary (citable) accession number: Q5G5U9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: July 18, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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