We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q5G291 (PA2A5_NAJSG)
Protein
Acidic phospholipase A2 5
Gene
N/A
Organism
Naja sagittifera (Andaman cobra)
Status
Functioni
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
By similarityCaution
Contains two extra cysteines at two highly conserved sites. Cys-37 and Cys-54 replaces the conventional calcium-binding Gly-32 and Asp-49 respectively.Curated
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+PROSITE-ProRule annotationEC:3.1.1.4PROSITE-ProRule annotation
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 28 | Carbohydrate; N-acetylglucosamine; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 30 | Zinc 1; shared with dimeric partnerCombined sources1 Publication | 1 | |
Metal bindingi | 34 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 36 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 53 | By similarity | 1 | |
Binding sitei | 53 | Carbohydrate; N-acetylglucosamineCombined sources1 Publication | 1 | |
Binding sitei | 69 | Carbohydrate; N-acetylglucosamineCombined sources1 Publication | 1 | |
Metal bindingi | 76 | Zinc 2Combined sources1 Publication | 1 | |
Active sitei | 99 | By similarity | 1 | |
Metal bindingi | 117 | Zinc 1; shared with dimeric partner | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Acidic phospholipase A2 5 (EC:3.1.1.4)Short name: svPLA2 Alternative name(s): Phosphatidylcholine 2-acylhydrolase |
Organismi | Naja sagittifera (Andaman cobra) |
Taxonomic identifieri | 195058 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Elapinae › Naja |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | ‹1 | Sequence analysis | ›1 | |
PropeptideiPRO_0000346752 | 2 – 7 | By similarity | 6 | |
ChainiPRO_5000094846 | 8 – 125 | Acidic phospholipase A2 5Add BLAST | 118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 18 ↔ 77 | Combined sources1 Publication | ||
Disulfide bondi | 33 ↔ 124 | Combined sources1 Publication | ||
Disulfide bondi | 35 ↔ 50 | Combined sources1 Publication | ||
Disulfide bondi | 37 ↔ 54 | Combined sources1 Publication | ||
Disulfide bondi | 49 ↔ 105 | Combined sources1 Publication | ||
Disulfide bondi | 56 ↔ 98 | Combined sources1 Publication | ||
Disulfide bondi | 66 ↔ 91 | Combined sources1 Publication | ||
Disulfide bondi | 84 ↔ 96 | Combined sources1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Heterodimer formed between isoform 5 and isoform 6 in presence of zinc ion and monomer in absence of zinc ion.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q5G291 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5G291 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5G291-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SNRPMPLNTY QFRNMIQCTV PSRSWWDFAD YGCYCGCGSG TPVDDLDRCC
60 70 80 90 100
QVHCNCYRQA GEISGCRPKF KTYTYECSGG TLTCKGDNNA CAASSCDCDR
110 120
LAAICFAGAP YNDNNYNIDL KARCN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Mass spectrometryi
Molecular mass is 13282.8 Da. Determined by MALDI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY862399 mRNA Translation: AAW65725.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY862399 mRNA Translation: AAW65725.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Y75 | X-ray | 2.30 | A | 8-125 | [»] | |
SMRi | Q5G291 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5G291 |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2A5_NAJSG | |
Accessioni | Q5G291Primary (citable) accession number: Q5G291 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | March 1, 2005 | |
Last modified: | February 23, 2022 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families