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Protein

Arylsulfatase J

Gene

ARSJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84CalciumBy similarity1
Metal bindingi85CalciumBy similarity1
Active sitei122NucleophileBy similarity1
Metal bindingi122Calcium; via 3-oxoalanineBy similarity1
Binding sitei176SubstrateBy similarity1
Active sitei178By similarity1
Binding sitei269SubstrateBy similarity1
Metal bindingi327CalciumBy similarity1
Metal bindingi328CalciumBy similarity1
Binding sitei345SubstrateBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase J (EC:3.1.6.-)
Short name:
ASJ
Gene namesi
Name:ARSJ
ORF Names:UNQ372/PRO708
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000180801.12
HGNCiHGNC:26286 ARSJ
MIMi610010 gene
neXtProtiNX_Q5FYB0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79642
OpenTargetsiENSG00000180801
PharmGKBiPA143485310

Polymorphism and mutation databases

BioMutaiARSJ
DMDMi74722580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 49Sequence analysisAdd BLAST49
ChainiPRO_000004221750 – 599Arylsulfatase JAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1223-oxoalanine (Cys)By similarity1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi527N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FYB0
PeptideAtlasiQ5FYB0
PRIDEiQ5FYB0
ProteomicsDBi62820

PTM databases

iPTMnetiQ5FYB0
PhosphoSitePlusiQ5FYB0

Expressioni

Gene expression databases

BgeeiENSG00000180801 Expressed in 124 organ(s), highest expression level in cartilage tissue
CleanExiHS_ARSJ
ExpressionAtlasiQ5FYB0 baseline and differential
GenevisibleiQ5FYB0 HS

Organism-specific databases

HPAiHPA036481
HPA036482

Interactioni

Protein-protein interaction databases

BioGridi122770, 4 interactors
IntActiQ5FYB0, 1 interactor
MINTiQ5FYB0
STRINGi9606.ENSP00000320219

Structurei

3D structure databases

ProteinModelPortaliQ5FYB0
SMRiQ5FYB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOGENOMiHOG000135354
HOVERGENiHBG004282
InParanoidiQ5FYB0
KOiK12375
OMAiAIRVQHW
OrthoDBiEOG091G06C3
PhylomeDBiQ5FYB0
TreeFamiTF314186

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q5FYB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRGCAGHP PPPSPQACVC PGKMLAMGAL AGFWILCLLT YGYLSWGQAL
60 70 80 90 100
EEEEEGALLA QAGEKLEPST TSTSQPHLIF ILADDQGFRD VGYHGSEIKT
110 120 130 140 150
PTLDKLAAEG VKLENYYVQP ICTPSRSQFI TGKYQIHTGL QHSIIRPTQP
160 170 180 190 200
NCLPLDNATL PQKLKEVGYS THMVGKWHLG FYRKECMPTR RGFDTFFGSL
210 220 230 240 250
LGSGDYYTHY KCDSPGMCGY DLYENDNAAW DYDNGIYSTQ MYTQRVQQIL
260 270 280 290 300
ASHNPTKPIF LYIAYQAVHS PLQAPGRYFE HYRSIININR RRYAAMLSCL
310 320 330 340 350
DEAINNVTLA LKTYGFYNNS IIIYSSDNGG QPTAGGSNWP LRGSKGTYWE
360 370 380 390 400
GGIRAVGFVH SPLLKNKGTV CKELVHITDW YPTLISLAEG QIDEDIQLDG
410 420 430 440 450
YDIWETISEG LRSPRVDILH NIDPIYTKAK NGSWAAGYGI WNTAIQSAIR
460 470 480 490 500
VQHWKLLTGN PGYSDWVPPQ SFSNLGPNRW HNERITLSTG KSVWLFNITA
510 520 530 540 550
DPYERVDLSN RYPGIVKKLL RRLSQFNKTA VPVRYPPKDP RSNPRLNGGV
560 570 580 590
WGPWYKEETK KKKPSKNQAE KKQKKSKKKK KKQQKAVSGS TCHSGVTCG
Length:599
Mass (Da):67,235
Last modified:March 1, 2005 - v1
Checksum:i1548898E95C43A7A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGC1D6RGC1_HUMAN
Arylsulfatase J
ARSJ
133Annotation score:

Sequence cautioni

The sequence AAQ89010 differs from that shown. Reason: Frameshift at position 425.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182Y → N in AAQ89010 (PubMed:12975309).Curated1
Sequence conflicti263I → T in AAQ89010 (PubMed:12975309).Curated1
Sequence conflicti495L → P in AAH89445 (PubMed:15489334).Curated1
Sequence conflicti576S → K in AAH89445 (PubMed:15489334).Curated1
Sequence conflicti590 – 599STCHSGVTCG → KPANLAR in CAJ18095 (PubMed:16500042).Curated10
Sequence conflicti590 – 599STCHSGVTCG → KPANLAR in AAQ89010 (PubMed:12975309).Curated10

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052515565S → R. Corresponds to variant dbSNP:rs17046588Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875938 mRNA Translation: AAW66666.1
AM049401 mRNA Translation: CAJ18095.1
AY358647 mRNA Translation: AAQ89010.1 Frameshift.
AC104779 Genomic DNA No translation available.
BC089445 mRNA Translation: AAH89445.1
BC132879 mRNA Translation: AAI32880.1
BC132881 mRNA Translation: AAI32882.1
BC144265 mRNA Translation: AAI44266.1
CCDSiCCDS43264.1
RefSeqiNP_078866.3, NM_024590.3
XP_005263269.1, XM_005263212.4
XP_016864081.1, XM_017008592.1
UniGeneiHs.22895
Hs.700496
Hs.712042

Genome annotation databases

EnsembliENST00000315366; ENSP00000320219; ENSG00000180801
GeneIDi79642
KEGGihsa:79642
UCSCiuc003ibq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARSJ_HUMAN
AccessioniPrimary (citable) accession number: Q5FYB0
Secondary accession number(s): A2RUG0
, B7ZM45, Q1HA39, Q5FWE4, Q6UWT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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