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UniProtKB - Q5FWI9 (Q5FWI9_MOUSE)
Protein
AP-2 complex subunit mu
Gene
Ap2m1
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 341 | Phosphatidylinositol lipid headgroupUniRule annotation | 1 | |
Binding sitei | 343 | Phosphatidylinositol lipid headgroupUniRule annotation | 1 | |
Binding sitei | 345 | Phosphatidylinositol lipid headgroupUniRule annotation | 1 | |
Binding sitei | 354 | Phosphatidylinositol lipid headgroupUniRule annotation | 1 | |
Binding sitei | 356 | Phosphatidylinositol lipid headgroupUniRule annotation | 1 |
GO - Molecular functioni
- lipid binding Source: UniProtKB-KW
- low-density lipoprotein particle receptor binding Source: Ensembl
- signal sequence binding Source: Ensembl
- transmembrane transporter binding Source: Ensembl
GO - Biological processi
- clathrin-dependent endocytosis Source: Ensembl
- intracellular protein transport Source: UniProtKB-UniRule
- negative regulation of protein localization to plasma membrane Source: Ensembl
- positive regulation of receptor internalization Source: Ensembl
- positive regulation of synaptic vesicle endocytosis Source: Ensembl
- postsynaptic neurotransmitter receptor internalization Source: Ensembl
- protein-containing complex assembly Source: Ensembl
- regulation of vesicle size Source: Ensembl
- synaptic vesicle endocytosis Source: Ensembl
- vesicle budding from membrane Source: Ensembl
Keywordsi
Biological process | EndocytosisARBA annotation, Protein transportUniRule annotationARBA annotation, Transport |
Ligand | Lipid-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: AP-2 complex subunit muARBA annotationAlternative name(s): AP-2 mu chainARBA annotation Clathrin assembly protein complex 2 mu medium chainARBA annotation Clathrin coat assembly protein AP50ARBA annotation Clathrin coat-associated protein AP50ARBA annotation Plasma membrane adaptor AP-2 50 kDa proteinARBA annotation |
Gene namesi | Name:Ap2m1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1298405, Ap2m1 |
VEuPathDBi | HostDB:ENSMUSG00000022841 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation
Other locations
- coated pit ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Plasma Membrane
- AP-2 adaptor complex Source: Ensembl
Other locations
- glutamatergic synapse Source: Ensembl
- postsynapse Source: GOC
- presynapse Source: GOC
Keywords - Cellular componenti
Cell membraneARBA annotation, Coated pitARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000022841, Expressed in brain and 127 other tissues |
Interactioni
GO - Molecular functioni
- low-density lipoprotein particle receptor binding Source: Ensembl
- transmembrane transporter binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 170 – 434 | MHDInterPro annotationAdd BLAST | 265 |
Sequence similaritiesi
Phylogenomic databases
OMAi | VWKIPRI |
OrthoDBi | 725236at2759 |
Family and domain databases
CDDi | cd09251, AP-2_Mu2_Cterm, 1 hit cd14836, AP2_Mu_N, 1 hit |
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR043532, AP2_Mu_N IPR022775, AP_mu_sigma_su IPR001392, Clathrin_mu IPR018240, Clathrin_mu_CS IPR011012, Longin-like_dom_sf IPR028565, MHD IPR043512, Mu2_C |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit PF01217, Clat_adaptor_s, 1 hit |
PIRSFi | PIRSF005992, Clathrin_mu, 1 hit |
PRINTSi | PR00314, CLATHRINADPT |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00990, CLAT_ADAPTOR_M_1, 1 hit PS00991, CLAT_ADAPTOR_M_2, 1 hit PS51072, MHD, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5FWI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI
60 70 80 90 100
ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMA AYFGKISEEN
110 120 130 140 150
IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QHQTKEEQSQ
160 170 180 190 200
ITSQVTGQIG WRREGIKYRR NELFLDVLES VNLLMSPQGQ VLSAHVSGRV
210 220 230 240 250
VMKSYLSGMP ECKFGMNDKI VIEKQGKGTA DETSKSGKQS IAIDDCTFHQ
260 270 280 290 300
CVRLSKFDSE RSISFIPPDG EFELMRYRTT KDIILPFRVI PLVREVGRTK
310 320 330 340 350
LEVKVVIKSN FKPSLLAQKI EVRIPTPLNT SGVQVICMKG KAKYKASENA
360 370 380 390 400
IVWKIKRMAG MKESQISAEI ELLPTNDKKK WARPPISMNF EVPFAPSGLK
410 420 430
VRYLKVFEPK LNYSDHDVIK WVRYIGRSGI YETRC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC089342 mRNA Translation: AAH89342.1 BC094510 mRNA Translation: AAH94510.1 AK141862 mRNA Translation: BAE24863.1 AK146517 mRNA Translation: BAE27229.1 |
RefSeqi | NP_001289899.1, NM_001302970.1 NP_033809.1, NM_009679.3 |
Genome annotation databases
GeneIDi | 11773 |
KEGGi | mmu:11773 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC089342 mRNA Translation: AAH89342.1 BC094510 mRNA Translation: AAH94510.1 AK141862 mRNA Translation: BAE24863.1 AK146517 mRNA Translation: BAE27229.1 |
RefSeqi | NP_001289899.1, NM_001302970.1 NP_033809.1, NM_009679.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 33793, 551 antibodies from 35 providers |
DNASUi | 11773 |
Genome annotation databases
GeneIDi | 11773 |
KEGGi | mmu:11773 |
Organism-specific databases
CTDi | 1173 |
MGIi | MGI:1298405, Ap2m1 |
VEuPathDBi | HostDB:ENSMUSG00000022841 |
Phylogenomic databases
OMAi | VWKIPRI |
OrthoDBi | 725236at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11773, 23 hits in 78 CRISPR screens |
ChiTaRSi | Ap2m1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022841, Expressed in brain and 127 other tissues |
Family and domain databases
CDDi | cd09251, AP-2_Mu2_Cterm, 1 hit cd14836, AP2_Mu_N, 1 hit |
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR043532, AP2_Mu_N IPR022775, AP_mu_sigma_su IPR001392, Clathrin_mu IPR018240, Clathrin_mu_CS IPR011012, Longin-like_dom_sf IPR028565, MHD IPR043512, Mu2_C |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit PF01217, Clat_adaptor_s, 1 hit |
PIRSFi | PIRSF005992, Clathrin_mu, 1 hit |
PRINTSi | PR00314, CLATHRINADPT |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00990, CLAT_ADAPTOR_M_1, 1 hit PS00991, CLAT_ADAPTOR_M_2, 1 hit PS51072, MHD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5FWI9_MOUSE | |
Accessioni | Q5FWI9Primary (citable) accession number: Q5FWI9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |