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UniProtKB - Q5FWI9 (Q5FWI9_MOUSE)

Entry version 142 (02 Jun 2021)
Sequence version 1 (10 May 2005)
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Protein

AP-2 complex subunit mu

Gene

Ap2m1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei341Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei343Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei345Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei354Phosphatidylinositol lipid headgroupUniRule annotation1
Binding sitei356Phosphatidylinositol lipid headgroupUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosisARBA annotation, Protein transportUniRule annotationARBA annotation, Transport
LigandLipid-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-2 complex subunit muARBA annotation
Alternative name(s):
AP-2 mu chainARBA annotation
Clathrin assembly protein complex 2 mu medium chainARBA annotation
Clathrin coat assembly protein AP50ARBA annotation
Clathrin coat-associated protein AP50ARBA annotation
Plasma membrane adaptor AP-2 50 kDa proteinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ap2m1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1298405, Ap2m1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membraneARBA annotation, Coated pitARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5FWI9

PRoteomics IDEntifications database

More...PRIDEi		Q5FWI9

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q5FWI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022841, Expressed in brain and 127 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5FWI9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5FWI9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini170 – 434MHDInterPro annotationAdd BLAST265

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.UniRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		ALVFEFC

Database of Orthologous Groups

More...OrthoDBi		725236at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd09251, AP-2_Mu2_Cterm, 1 hit
cd14836, AP2_Mu_N, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR043532, AP2_Mu_N
IPR022775, AP_mu_sigma_su
IPR001392, Clathrin_mu
IPR018240, Clathrin_mu_CS
IPR011012, Longin-like_dom_sf
IPR028565, MHD
IPR043512, Mu2_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PF01217, Clat_adaptor_s, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005992, Clathrin_mu, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00314, CLATHRINADPT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49447, SSF49447, 1 hit
SSF64356, SSF64356, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00990, CLAT_ADAPTOR_M_1, 1 hit
PS00991, CLAT_ADAPTOR_M_2, 1 hit
PS51072, MHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5FWI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI 
        60         70         80         90        100
ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMA AYFGKISEEN 
       110        120        130        140        150
IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QHQTKEEQSQ 
       160        170        180        190        200
ITSQVTGQIG WRREGIKYRR NELFLDVLES VNLLMSPQGQ VLSAHVSGRV 
       210        220        230        240        250
VMKSYLSGMP ECKFGMNDKI VIEKQGKGTA DETSKSGKQS IAIDDCTFHQ 
       260        270        280        290        300
CVRLSKFDSE RSISFIPPDG EFELMRYRTT KDIILPFRVI PLVREVGRTK 
       310        320        330        340        350
LEVKVVIKSN FKPSLLAQKI EVRIPTPLNT SGVQVICMKG KAKYKASENA 
       360        370        380        390        400
IVWKIKRMAG MKESQISAEI ELLPTNDKKK WARPPISMNF EVPFAPSGLK 
       410        420        430 
VRYLKVFEPK LNYSDHDVIK WVRYIGRSGI YETRC
Length:435
Mass (Da):49,655
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82803219BA279954
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC089342 mRNA Translation: AAH89342.1
BC094510 mRNA Translation: AAH94510.1
AK141862 mRNA Translation: BAE24863.1
AK146517 mRNA Translation: BAE27229.1

NCBI Reference Sequences

More...RefSeqi		NP_001289899.1, NM_001302970.1
NP_033809.1, NM_009679.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11773

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11773

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089342 mRNA Translation: AAH89342.1
BC094510 mRNA Translation: AAH94510.1
AK141862 mRNA Translation: BAE24863.1
AK146517 mRNA Translation: BAE27229.1
RefSeqiNP_001289899.1, NM_001302970.1
NP_033809.1, NM_009679.3

3D structure databases

SMRiQ5FWI9
ModBaseiSearch...

PTM databases

SwissPalmiQ5FWI9

Proteomic databases

MaxQBiQ5FWI9
PRIDEiQ5FWI9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33793, 539 antibodies

The DNASU plasmid repository

More...DNASUi		11773

Genome annotation databases

GeneIDi11773
KEGGimmu:11773

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1173
MGIiMGI:1298405, Ap2m1

Phylogenomic databases

OMAiALVFEFC
OrthoDBi725236at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11773, 20 hits in 56 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ap2m1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022841, Expressed in brain and 127 other tissues
ExpressionAtlasiQ5FWI9, baseline and differential

Family and domain databases

CDDicd09251, AP-2_Mu2_Cterm, 1 hit
cd14836, AP2_Mu_N, 1 hit
InterProiView protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR043532, AP2_Mu_N
IPR022775, AP_mu_sigma_su
IPR001392, Clathrin_mu
IPR018240, Clathrin_mu_CS
IPR011012, Longin-like_dom_sf
IPR028565, MHD
IPR043512, Mu2_C
PfamiView protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PF01217, Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992, Clathrin_mu, 1 hit
PRINTSiPR00314, CLATHRINADPT
SUPFAMiSSF49447, SSF49447, 1 hit
SSF64356, SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990, CLAT_ADAPTOR_M_1, 1 hit
PS00991, CLAT_ADAPTOR_M_2, 1 hit
PS51072, MHD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5FWI9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5FWI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 2, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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