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Entry version 112 (16 Oct 2019)
Sequence version 1 (01 Mar 2005)
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Protein

Cell surface hyaluronidase

Gene

Cemip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.By similarity EC:3.2.1.35

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Glycosidase, Hydrolase
Biological processAngiogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell surface hyaluronidase1 Publication (EC:3.2.1.35By similarity)
Alternative name(s):
Cell migration-inducing hyaluronidase 2By similarity
Transmembrane protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cemip2Imported
Synonyms:Kiaa14121 Publication, Tmem21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890373 Cemip2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 82CytoplasmicCuratedAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini104 – 1383ExtracellularCuratedAdd BLAST1280

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002899731 – 1383Cell surface hyaluronidaseAdd BLAST1383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineBy similarity1
Modified residuei53PhosphoserineCombined sources1
Modified residuei63PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi292N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi914N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1234N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5FWI3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5FWI3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5FWI3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5FWI3

PeptideAtlas

More...
PeptideAtlasi
Q5FWI3

PRoteomics IDEntifications database

More...
PRIDEi
Q5FWI3

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2793

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5FWI3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5FWI3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5FWI3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

expressed ubiquitously at early stages of development. Expressed in the endocardial cells lining the ventricles and atria at 9.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024754 Expressed in 289 organ(s), highest expression level in rostral migratory stream

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5FWI3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5FWI3, 1 interactor

Molecular INTeraction database

More...
MINTi
Q5FWI3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093908

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5FWI3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini121 – 245G8PROSITE-ProRule annotationAdd BLAST125
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati669 – 691PbH1 1Add BLAST23
Repeati711 – 733PbH1 2Add BLAST23
Repeati791 – 812PbH1 3Add BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEMIP family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFCM Eukaryota
ENOG410XQ01 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153636

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5FWI3

KEGG Orthology (KO)

More...
KOi
K22144

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHGAWVR

Database of Orthologous Groups

More...
OrthoDBi
294134at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5FWI3

TreeFam database of animal gene trees

More...
TreeFami
TF316575

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13938 PANDER_like_TMEM2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019316 G8_domain
IPR039477 ILEI/PANDER_dom
IPR011050 Pectin_lyase_fold/virulence
IPR039473 TMEM2_PANDER-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10162 G8, 1 hit
PF15711 ILEI, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01225 G8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126 SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51484 G8, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5FWI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYAAGSRGHS PAFLQPQNGN GHRSPGYVPG KVVPLRPAPP PKNHASAKLT
60 70 80 90 100
SRSQDAPATF AFSPEEQRTP SESRKRKRHK NTFICFAITS FSFFVALAVI
110 120 130 140 150
LGISSKYAPD ENCPDQNPRL RNWDPGQDSA KHIVIKEGDL FRLTSDATVD
160 170 180 190 200
SIVIQDGGLL VFGDDKDGSK NITLRTRYIL IQDGGALHIG AEKCRYRSKA
210 220 230 240 250
TITLYGKSDE RESMPIFGKK FIGVEAGGTL ELHGAQRTSW TMLARTLHSS
260 270 280 290 300
GLPFGSYAFE KDFSRGLNVR VIDQDTARVL ENEKFDTHEY HNESRRLQEF
310 320 330 340 350
LRAQEPGRIV AIAVGDSAVK SLLQGTIQMI QDRLGSKLIQ GLGYRQAWAL
360 370 380 390 400
VGVIDGGSSS CNESVRNYEN HSTGGKALAQ GEFYTLDGQK FSVTAYSEWS
410 420 430 440 450
QGISLSGFRV DIADGVKLHL LDDVSTWEAG DRIVVASTDY SMYQAEELTL
460 470 480 490 500
LRCPECSRSQ VKVKEIPQYL HVGEIIDGID MRAEVGLLTR NIVIQGEMED
510 520 530 540 550
SCYAENHCQF FDYDTFGGHV MIEKNFTSVH LSYVELKHMG QQHMGRYPVH
560 570 580 590 600
FHLCGDVDSK GGYSQPASVD GLSVHHSFSR CITVHGTSGL LIKDTIGFDT
610 620 630 640 650
LGHCFFLEDG VEQRNILYHN LGLLTKPGTL LPTDRNSSMC TVMRDGVFGN
660 670 680 690 700
YVPVPTTDCM AVSTFWIAHP NNHLINNAAA GSQDAGIWYL FHKEPTGESS
710 720 730 740 750
GLQLLEKPEL TPLGIFYNNR VHSNFKAGLF VDKGVKTTNA SASDPREYLC
760 770 780 790 800
LDNSARFRPH QDADPEKPRV AAIIDRLIAF KNNDNGAWVR GGDIIVQNSA
810 820 830 840 850
FADNGKGLTF ASDGSFPSDE GSSQEVTESL FVGESRNYGF QGGQNKYMGT
860 870 880 890 900
GGIDQKPRTL PRNRTFPIRG FQIYDGPIHL TKSTFKKYVP TPDRYSSAIG
910 920 930 940 950
FLMKNSWQTT PRNNVSLVKF GPQVSLNVFF GKPGPWFEDC ELDGDKNSIF
960 970 980 990 1000
HDIDGSVTGY KDTYVGRMDN YLIRHPNCVN VTKWNAVICS GTYAQVYVQT
1010 1020 1030 1040 1050
WNTPNLSMII TRDEYPSHPM VLRGINQRAI SPQYQPVVML EKGYTIHWNG
1060 1070 1080 1090 1100
PAPRTTFLYL VNFNKDDWIR VGLCYPANTS FQVTVGFLQR QNGSLSRIED
1110 1120 1130 1140 1150
YEPARSMEEL QKKPSERKFY FDSGTGLLFL YLRAHSHRDG HSYCSSQGCE
1160 1170 1180 1190 1200
RVKIQAATDS KDISNCMAKA YPQYYKKPSA VKRMPAMLTG LCQGCGTHQM
1210 1220 1230 1240 1250
VFTSDPHKSY LPVRFQSPGK AEIQRGDPSI ISVNGTDFTF RSAGALLLIV
1260 1270 1280 1290 1300
DACSVPFRVK EKRMFLSADV SHMEEYFKAS IPPRSIVLLS TRGEIKQLNI
1310 1320 1330 1340 1350
SDSLAVLGLA KPAHLYSKGS VVFLGFSGNF APSWTKLFTS PDEQGLGVLE
1360 1370 1380
QFLPLQMEEY GCSRTGSVHR RDLDLLQQAL KVL
Length:1,383
Mass (Da):153,801
Last modified:March 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AB8F747A8FC659C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BB04A0A494BB04_MOUSE
Cell surface hyaluronidase
Cemip2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19745 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti165D → G in BAE29013 (PubMed:16141072).Curated1
Sequence conflicti1134A → S in AAF21349 (PubMed:10767548).Curated1
Sequence conflicti1161K → R in AAF21349 (PubMed:10767548).Curated1
Sequence conflicti1180A → G in AAF21349 (PubMed:10767548).Curated1
Sequence conflicti1245A → V in AAH19745 (PubMed:15489334).Curated1
Sequence conflicti1249I → V in AAH19745 (PubMed:15489334).Curated1
Sequence conflicti1306V → L in AAH19745 (PubMed:15489334).Curated1
Sequence conflicti1342D → N in AAH19745 (PubMed:15489334).Curated1
Sequence conflicti1382V → L in AAH76570 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC019745 mRNA Translation: AAH19745.1 Different initiation.
BC076570 mRNA Translation: AAH76570.1
BC089353 mRNA Translation: AAH89353.1
AK149667 mRNA Translation: BAE29013.1
AK149803 mRNA Translation: BAE29096.1
AK129352 mRNA Translation: BAC98162.1
AF137031 mRNA Translation: AAF21349.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37934.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028931.1, NM_001033759.2
NP_114386.3, NM_031997.4
XP_006527549.1, XM_006527486.3
XP_006527550.1, XM_006527487.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025663; ENSMUSP00000025663; ENSMUSG00000024754
ENSMUST00000096194; ENSMUSP00000093908; ENSMUSG00000024754

Database of genes from NCBI RefSeq genomes

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GeneIDi
83921

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:83921

UCSC genome browser

More...
UCSCi
uc008gzg.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019745 mRNA Translation: AAH19745.1 Different initiation.
BC076570 mRNA Translation: AAH76570.1
BC089353 mRNA Translation: AAH89353.1
AK149667 mRNA Translation: BAE29013.1
AK149803 mRNA Translation: BAE29096.1
AK129352 mRNA Translation: BAC98162.1
AF137031 mRNA Translation: AAF21349.1
CCDSiCCDS37934.1
RefSeqiNP_001028931.1, NM_001033759.2
NP_114386.3, NM_031997.4
XP_006527549.1, XM_006527486.3
XP_006527550.1, XM_006527487.3

3D structure databases

SMRiQ5FWI3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ5FWI3, 1 interactor
MINTiQ5FWI3
STRINGi10090.ENSMUSP00000093908

PTM databases

GlyConnecti2793
iPTMnetiQ5FWI3
PhosphoSitePlusiQ5FWI3
SwissPalmiQ5FWI3

Proteomic databases

EPDiQ5FWI3
jPOSTiQ5FWI3
MaxQBiQ5FWI3
PaxDbiQ5FWI3
PeptideAtlasiQ5FWI3
PRIDEiQ5FWI3

Genome annotation databases

EnsembliENSMUST00000025663; ENSMUSP00000025663; ENSMUSG00000024754
ENSMUST00000096194; ENSMUSP00000093908; ENSMUSG00000024754
GeneIDi83921
KEGGimmu:83921
UCSCiuc008gzg.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23670
MGIiMGI:1890373 Cemip2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410IFCM Eukaryota
ENOG410XQ01 LUCA
GeneTreeiENSGT00940000153636
InParanoidiQ5FWI3
KOiK22144
OMAiDHGAWVR
OrthoDBi294134at2759
PhylomeDBiQ5FWI3
TreeFamiTF316575

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tmem2 mouse

Protein Ontology

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PROi
PR:Q5FWI3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024754 Expressed in 289 organ(s), highest expression level in rostral migratory stream
GenevisibleiQ5FWI3 MM

Family and domain databases

CDDicd13938 PANDER_like_TMEM2, 1 hit
InterProiView protein in InterPro
IPR019316 G8_domain
IPR039477 ILEI/PANDER_dom
IPR011050 Pectin_lyase_fold/virulence
IPR039473 TMEM2_PANDER-like
PfamiView protein in Pfam
PF10162 G8, 1 hit
PF15711 ILEI, 2 hits
SMARTiView protein in SMART
SM01225 G8, 1 hit
SUPFAMiSSF51126 SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51484 G8, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEIP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5FWI3
Secondary accession number(s): Q3UE15
, Q3UE98, Q6DFZ0, Q6ZPR7, Q8VE53, Q9QY22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 1, 2005
Last modified: October 16, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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