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Protein

Secretin receptor

Gene

Sctr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:Sctr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2441720 Sctr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 142ExtracellularSequence analysisAdd BLAST114
Transmembranei143 – 166Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini167 – 173CytoplasmicSequence analysis7
Transmembranei174 – 193Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini194 – 215ExtracellularSequence analysisAdd BLAST22
Transmembranei216 – 239Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini240 – 253CytoplasmicSequence analysisAdd BLAST14
Transmembranei254 – 275Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini276 – 293ExtracellularSequence analysisAdd BLAST18
Transmembranei294 – 316Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini317 – 342CytoplasmicSequence analysisAdd BLAST26
Transmembranei343 – 361Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini362 – 368ExtracellularSequence analysis7
Transmembranei369 – 391Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini392 – 447CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000004322229 – 447Secretin receptorAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FWI2
PRIDEiQ5FWI2

Expressioni

Gene expression databases

BgeeiENSMUSG00000026387 Expressed in 41 organ(s), highest expression level in brown adipose tissue
CleanExiMM_SCTR
ExpressionAtlasiQ5FWI2 baseline and differential
GenevisibleiQ5FWI2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072660

Structurei

3D structure databases

ProteinModelPortaliQ5FWI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiQ5FWI2
KOiK04588
PhylomeDBiQ5FWI2

Family and domain databases

CDDicd15275 7tmB1_secretin, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR002144 GPCR_2_secretin_rcpt
PANTHERiPTHR12011:SF29 PTHR12011:SF29, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00490 SECRETINR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q5FWI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSTMSPRLS LLLLWLLLLI NAAHPVGALP RLCDVRRVLL EERAECLREL
60 70 80 90 100
SEEKKALGPK TASGCERFWD NMSCWPSSAL AQTVEVPCPK FLRMFSGRNG
110 120 130 140 150
SLFRNCTKDG WSETFPRPDL ACGVNMNGSF NERRHAYLLK LKVMYTVGYS
160 170 180 190 200
SSLAMLLVAL SILCSFRRLH CTRNYIHMHL FVSFILRALS NFIKDAVLFP
210 220 230 240 250
ADDVTYCDAH RAGCKLVMIF FQYCIMANYA WLLVEGLYLH TLLAISFFSE
260 270 280 290 300
RKCLQAFVLF GWGSPAIFVA LWAVTRHFLE DFGCWDINSN ASIWWVIRGP
310 320 330 340 350
VILSIVINFI FFINILRILM RKLRTQETRG NETHHYKRLA KSTLLLIPLF
360 370 380 390 400
GIHYIVFAFS PEGAMEVQLF FELALGSFQG LVVAVLYCFL NGELEVQKKW
410 420 430 440
RQWHLQEFPL RPVALSNSFS NATNGPTHST KAGTSEQSRS IPGANVI
Length:447
Mass (Da):50,932
Last modified:March 1, 2005 - v1
Checksum:iDD937AFC33D41115
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BX37H7BX37_MOUSE
Secretin receptor
Sctr
464Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089355 mRNA Translation: AAH89355.1
AY255623 mRNA Translation: AAO85135.1
CCDSiCCDS78668.1
RefSeqiNP_001012322.2, NM_001012322.2
NP_001298006.1, NM_001311077.1
UniGeneiMm.189223

Genome annotation databases

EnsembliENSMUST00000189037; ENSMUSP00000139932; ENSMUSG00000026387
GeneIDi319229
KEGGimmu:319229
UCSCiuc007cjc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSCTR_MOUSE
AccessioniPrimary (citable) accession number: Q5FWI2
Secondary accession number(s): Q80T66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2005
Last modified: September 12, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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