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Protein

Zinc transporter ZIP12

Gene

Slc39a12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a zinc-influx transporter.Curated

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular zinc ion homeostasis Source: GO_Central
  • regulation of microtubule polymerization Source: MGI
  • regulation of neuron projection development Source: MGI
  • signal transduction Source: MGI
  • zinc ion import across plasma membrane Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP12
Alternative name(s):
Solute carrier family 39 member 12
Zrt- and Irt-like protein 12
Short name:
ZIP-12
Gene namesi
Name:Slc39a12
Synonyms:Zip12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139274 Slc39a12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 201ExtracellularSequence analysisAdd BLAST201
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 369CytoplasmicSequence analysisAdd BLAST147
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 397ExtracellularSequence analysis7
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 447CytoplasmicSequence analysisAdd BLAST29
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 536ExtracellularSequence analysisAdd BLAST68
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 600CytoplasmicSequence analysisAdd BLAST43
Transmembranei601 – 621HelicalSequence analysisAdd BLAST21
Topological domaini622 – 629ExtracellularSequence analysis8
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Topological domaini651 – 662CytoplasmicSequence analysisAdd BLAST12
Transmembranei663 – 683HelicalSequence analysisAdd BLAST21
Topological domaini684 – 689ExtracellularSequence analysis6

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003124991 – 689Zinc transporter ZIP12Add BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FWH7
PeptideAtlasiQ5FWH7
PRIDEiQ5FWH7

PTM databases

iPTMnetiQ5FWH7
PhosphoSitePlusiQ5FWH7

Expressioni

Gene expression databases

BgeeiENSMUSG00000036949 Expressed in 116 organ(s), highest expression level in choroid plexus epithelium
ExpressionAtlasiQ5FWH7 baseline and differential
GenevisibleiQ5FWH7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080911

Structurei

3D structure databases

SMRiQ5FWH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi578 – 583XEXPHE-motifBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi115 – 118Poly-Leu4
Compositional biasi677 – 680Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000293181
HOVERGENiHBG108449
InParanoidiQ5FWH7
KOiK14718
OMAiRRPWLMF
OrthoDBiEOG091G035V
PhylomeDBiQ5FWH7
TreeFamiTF318470

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5FWH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCFWTNLSVW MILLSHSLSL VSSTETGKTL TQNNSRAGSQ GLLEVLRVLS
60 70 80 90 100
AGDHWSLNHP QSLIKILLER TGCPQRTDWT QGDCKLCLEA DALLLTAGGN
110 120 130 140 150
LEDELREEVV QRVSLLLLYY IIHQEEICSS KLNMSNREYE FYLHSLLGLR
160 170 180 190 200
QDEDSYFLSE KETDDILAFT RKYFGTSSSQ CMETKILQRE SGIQGSNGAD
210 220 230 240 250
EKTLPQLAAT IIALSLQGVC LGRKALPSPD DFTEYIFSFL NSTNTLHLSE
260 270 280 290 300
IEQLLNMLTT RRTCAKEDKY LHQYQRKQNT EEHSLRDPKT STAMDKESDD
310 320 330 340 350
HSPSWDQACF SARQLVEIFL QNHSSLSISK EDFKQLSPGI IQQLLSCSCQ
360 370 380 390 400
MPKDQQAKPP PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYSLI
410 420 430 440 450
LQLFVGLAVG TLSGDALLHL IPQVLGLHKQ EAEFGHFHES QSPIWKLLGL
460 470 480 490 500
LGGIHGFFLI EKCFILLVSP NTKGLPLVNE HVGHTHHLGL NPELNDQSSG
510 520 530 540 550
GKSISTIQLK GPEDSQTTVL PIGNVPASNR NGKTISLLAI MILVGDSLHN
560 570 580 590 600
FADGLVIGTA FSSSLESGVT TTIAILCHEI PHEMGDFAVL LSSGLSVRTA
610 620 630 640 650
ILMNFLSALT AFAGLYIGLS VSADPRVQDW ILTVTAGMFL YLSLVGMLPE
660 670 680
MTHVQTQRPW MTFLLQNVGL VLGWFSLLLL AVYEQNIKI
Length:689
Mass (Da):76,215
Last modified:March 1, 2005 - v1
Checksum:i9DA3FB51682147C2
GO
Isoform 2 (identifier: Q5FWH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-509: Missing.

Note: No experimental confirmation available.
Show »
Length:653
Mass (Da):72,433
Checksum:i658D45ABC28FB415
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AQ77A2AQ77_MOUSE
Zinc transporter ZIP12
Slc39a12
73Annotation score:

Sequence cautioni

The sequence CAM22554 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029851474 – 509Missing in isoform 2. CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844558 Genomic DNA Translation: CAM22554.1 Different initiation.
BC089362 mRNA Translation: AAH89362.1
BC113764 mRNA Translation: AAI13765.1
BC113765 mRNA Translation: AAI13766.1
CCDSiCCDS15701.1 [Q5FWH7-1]
RefSeqiNP_001012305.1, NM_001012305.2 [Q5FWH7-1]
UniGeneiMm.44662

Genome annotation databases

EnsembliENSMUST00000082290; ENSMUSP00000080911; ENSMUSG00000036949 [Q5FWH7-1]
ENSMUST00000114731; ENSMUSP00000110379; ENSMUSG00000036949 [Q5FWH7-2]
GeneIDi277468
KEGGimmu:277468
UCSCiuc008ikl.2 mouse [Q5FWH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844558 Genomic DNA Translation: CAM22554.1 Different initiation.
BC089362 mRNA Translation: AAH89362.1
BC113764 mRNA Translation: AAI13765.1
BC113765 mRNA Translation: AAI13766.1
CCDSiCCDS15701.1 [Q5FWH7-1]
RefSeqiNP_001012305.1, NM_001012305.2 [Q5FWH7-1]
UniGeneiMm.44662

3D structure databases

SMRiQ5FWH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080911

PTM databases

iPTMnetiQ5FWH7
PhosphoSitePlusiQ5FWH7

Proteomic databases

PaxDbiQ5FWH7
PeptideAtlasiQ5FWH7
PRIDEiQ5FWH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082290; ENSMUSP00000080911; ENSMUSG00000036949 [Q5FWH7-1]
ENSMUST00000114731; ENSMUSP00000110379; ENSMUSG00000036949 [Q5FWH7-2]
GeneIDi277468
KEGGimmu:277468
UCSCiuc008ikl.2 mouse [Q5FWH7-1]

Organism-specific databases

CTDi221074
MGIiMGI:2139274 Slc39a12

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000293181
HOVERGENiHBG108449
InParanoidiQ5FWH7
KOiK14718
OMAiRRPWLMF
OrthoDBiEOG091G035V
PhylomeDBiQ5FWH7
TreeFamiTF318470

Miscellaneous databases

PROiPR:Q5FWH7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036949 Expressed in 116 organ(s), highest expression level in choroid plexus epithelium
ExpressionAtlasiQ5FWH7 baseline and differential
GenevisibleiQ5FWH7 MM

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS39AC_MOUSE
AccessioniPrimary (citable) accession number: Q5FWH7
Secondary accession number(s): A2AQ76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2005
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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