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UniProtKB - Q5FWH2 (UNKL_MOUSE)

Entry version 121 (02 Dec 2020)
Sequence version 2 (13 Jul 2010)
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Protein

Putative E3 ubiquitin-protein ligase UNKL

Gene

Unkl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri75 – 104C3H1-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri115 – 145C3H1-type 2PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri243 – 277C3H1-type 3PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri285 – 313C3H1-type 4PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri686 – 721RING-typePROSITE-ProRule annotationAdd BLAST36

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative E3 ubiquitin-protein ligase UNKL (EC:2.3.2.-)
Alternative name(s):
RING finger protein unkempt-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Unkl
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921404, Unkl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002786681 – 727Putative E3 ubiquitin-protein ligase UNKLAdd BLAST727

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitination is enhanced by activated Rac1. The presence of the RING finger domain is not essential for ubiquitination to occur (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5FWH2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5FWH2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5FWH2

PRoteomics IDEntifications database

More...PRIDEi		Q5FWH2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5FWH2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5FWH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000015127, Expressed in blastocyst and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5FWH2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5FWH2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GTP-bound form of Rac1.

Interacts with Baf60b/Smarcd2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		216531, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q5FWH2, 1 interactor

Molecular INTeraction database

More...MINTi		Q5FWH2

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000015271

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5FWH2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5FWH2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 11Poly-Ala5
Compositional biasi61 – 64Poly-Arg4
Compositional biasi327 – 562Ser-richAdd BLAST236

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unkempt family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri75 – 104C3H1-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri115 – 145C3H1-type 2PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri243 – 277C3H1-type 3PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri285 – 313C3H1-type 4PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri686 – 721RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1100, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014526_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5FWH2

Identification of Orthologs from Complete Genome Data

More...OMAi		ANEWSSN

Database of Orthologous Groups

More...OrthoDBi		720138at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5FWH2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040594, Unkempt_Znf
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00642, zf-CCCH, 1 hit
PF18384, zf_CCCH_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00356, ZnF_C3H1, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90229, SSF90229, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50103, ZF_C3H1, 4 hits
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q5FWH2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSVSKAAAA ALSGSPPQTE KPTHYRYLKE FRTEQCSLFL QHKCSQHRPF 
        60         70         80         90        100
TCFHWHFLNQ RRRRPLRRRD GTFNYSPDIY CSKYDEATGL CPDGDECPYL 
       110        120        130        140        150
HRTTGDTERK YHLRYYKTGT CIHETDARGH CVKNGLHCAF AHGPLDLRPP 
       160        170        180        190        200
VCDIRELQAQ EALQNGQLSG GDGVPDLQPG VLASQAMIEK ILGEDPRWQD 
       210        220        230        240        250
SNFVLGSYKT EQCPKPPRLC RQGYACPHYH NSRDRRRNPR RFQYRSTPCP 
       260        270        280        290        300
SVKHGDEWGE PSRCDGGDSC QYCHSRTEQQ FHPEIYKSTK CNDMRQTGYC 
       310        320        330        340        350
PRGPFCAFAH TEKSLAMVNE WSCRDLSSNS TSAYSSQPGS AKRKDSPSEG 
       360        370        380        390        400
SQKATEDSKQ NHLAVFSVAH PLAHSISSSV ASSLASSTGS GSSSPTTLPT 
       410        420        430        440        450
LPARALPLDP AGNTVGAVIG SALDLRLSDI NIASLDKDLE EQDLGLTGPR 
       460        470        480        490        500
SLAGSAPVTI PGSLPRSPSL HSSSSLSTSP LSSLSQSLSG PLVSSAMTPP 
       510        520        530        540        550
QQPPPLRSEP ATLGSAASSY SSLGLNGVPG SIWDFVSGSF SPSPSPILNS 
       560        570        580        590        600
GPSASSSASP NSAELARVRR QLDEAKRKIR QWEESWQQVK QACDAWQREA 
       610        620        630        640        650
QEAKERARVA DSDRQLALQR KEEVEAKVKQ LQEELEGLGL SSLPGLQSLG 
       660        670        680        690        700
DISDIPLPKL HSLQSKLRLD LEAVDGVIFQ LRAKQCVACQ ERAHGTVLRP 
       710        720 
CQHRVLCEPC AASTPECPYC KGQPLPW
Length:727
Mass (Da):79,636
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A5A50A449BE9C8E
GO
Isoform 1 (identifier: Q5FWH2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-496: Missing.

Show »
Length:231
Mass (Da):25,257
Checksum:i5B36255553CD1861
GO
Isoform 2 (identifier: Q5FWH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-412: Missing.
     413-419: NTVGAVI → MRPPTLP
     449-524: Missing.

Show »
Length:239
Mass (Da):26,294
Checksum:i3224FFA4309E3F99
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYD7E0CYD7_MOUSE
Putative E3 ubiquitin-protein ligas...
Unkl
541Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TWQ1F6TWQ1_MOUSE
Putative E3 ubiquitin-protein ligas...
Unkl
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CY27E0CY27_MOUSE
Putative E3 ubiquitin-protein ligas...
Unkl
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti629K → T in AAS21649 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0394441 – 496Missing in isoform 1. 1 PublicationAdd BLAST496
Alternative sequenceiVSP_0394451 – 412Missing in isoform 2. 1 PublicationAdd BLAST412
Alternative sequenceiVSP_039446413 – 419NTVGAVI → MRPPTLP in isoform 2. 1 Publication7
Alternative sequenceiVSP_039447449 – 524Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK004898 mRNA Translation: BAB23653.1
AY491413 Genomic DNA Translation: AAS21649.1
BC089378 mRNA Translation: AAH89378.1
BC059910 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28510.1 [Q5FWH2-2]
CCDS57058.1 [Q5FWH2-3]

NCBI Reference Sequences

More...RefSeqi		NP_001183953.1, NM_001197024.1 [Q5FWH2-3]
NP_083065.1, NM_028789.3 [Q5FWH2-2]
XP_017173186.1, XM_017317697.1 [Q5FWH2-1]
XP_017173187.1, XM_017317698.1 [Q5FWH2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000015271; ENSMUSP00000015271; ENSMUSG00000015127 [Q5FWH2-2]
ENSMUST00000039734; ENSMUSP00000039670; ENSMUSG00000015127 [Q5FWH2-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		74154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:74154

UCSC genome browser

More...UCSCi		uc008baa.2, mouse [Q5FWH2-2]
uc012ana.2, mouse [Q5FWH2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004898 mRNA Translation: BAB23653.1
AY491413 Genomic DNA Translation: AAS21649.1
BC089378 mRNA Translation: AAH89378.1
BC059910 mRNA No translation available.
CCDSiCCDS28510.1 [Q5FWH2-2]
CCDS57058.1 [Q5FWH2-3]
RefSeqiNP_001183953.1, NM_001197024.1 [Q5FWH2-3]
NP_083065.1, NM_028789.3 [Q5FWH2-2]
XP_017173186.1, XM_017317697.1 [Q5FWH2-1]
XP_017173187.1, XM_017317698.1 [Q5FWH2-1]

3D structure databases

SMRiQ5FWH2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi216531, 1 interactor
IntActiQ5FWH2, 1 interactor
MINTiQ5FWH2
STRINGi10090.ENSMUSP00000015271

PTM databases

iPTMnetiQ5FWH2
PhosphoSitePlusiQ5FWH2

Proteomic databases

EPDiQ5FWH2
MaxQBiQ5FWH2
PaxDbiQ5FWH2
PRIDEiQ5FWH2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34818, 107 antibodies

Genome annotation databases

EnsembliENSMUST00000015271; ENSMUSP00000015271; ENSMUSG00000015127 [Q5FWH2-2]
ENSMUST00000039734; ENSMUSP00000039670; ENSMUSG00000015127 [Q5FWH2-3]
GeneIDi74154
KEGGimmu:74154
UCSCiuc008baa.2, mouse [Q5FWH2-2]
uc012ana.2, mouse [Q5FWH2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64718
MGIiMGI:1921404, Unkl

Phylogenomic databases

eggNOGiKOG1100, Eukaryota
GeneTreeiENSGT00940000158822
HOGENOMiCLU_014526_1_0_1
InParanoidiQ5FWH2
OMAiANEWSSN
OrthoDBi720138at2759
PhylomeDBiQ5FWH2

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		74154, 2 hits in 16 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Unkl, mouse

Protein Ontology

More...PROi		PR:Q5FWH2
RNActiQ5FWH2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000015127, Expressed in blastocyst and 242 other tissues
ExpressionAtlasiQ5FWH2, baseline and differential
GenevisibleiQ5FWH2, MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR040594, Unkempt_Znf
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00642, zf-CCCH, 1 hit
PF18384, zf_CCCH_5, 1 hit
SMARTiView protein in SMART
SM00356, ZnF_C3H1, 4 hits
SUPFAMiSSF90229, SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 4 hits
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNKL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5FWH2
Secondary accession number(s): Q6RUT6, Q9DBK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 13, 2010
Last modified: December 2, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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