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Entry version 145 (29 Sep 2021)
Sequence version 3 (17 Oct 2006)
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Protein

N-acetyltransferase ESCO1

Gene

ESCO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053).

Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053).

6 Publications

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=77 µM for acetyl-CoA1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri617 – 641CCHH-type1 PublicationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCell cycle
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5FWF5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2468052, Establishment of Sister Chromatid Cohesion

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5FWF5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-acetyltransferase ESCO1 (EC:2.3.1.-3 Publications)
Alternative name(s):
CTF7 homolog 1
Establishment factor-like protein 11 Publication
Short name:
EFO11 Publication
Short name:
EFO1p1 Publication
Short name:
hEFO1
Establishment of cohesion 1 homolog 1
Short name:
ECO1 homolog 1
Short name:
ESO1 homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESCO1
Synonyms:EFO1, KIAA1911
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24645, ESCO1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609674, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5FWF5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000141446

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi622C → G: No effect on association with chromosomes. 1 Publication1
Mutagenesisi640F → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi643Q → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi644F → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi690D → N: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi725E → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi732R → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi735E → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi736E → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi756W → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi768G → D: Loss of autoacetylation. 2 Publications1
Mutagenesisi770S → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi771R → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi773W → G: Decreased thermal stability.Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi779 – 780RR → GG: Significant reduction in autoacetylation. 1 Publication2
Mutagenesisi780R → A: Nearly abolishes autoacetylation. 1 Publication1
Mutagenesisi782 – 783KI → EV: Significant reduction in autoacetylation. 1 Publication2
Mutagenesisi786R → C: Decreased thermal stability. Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi789E → A: Reduced autoacetylation. 2 Publications1
Mutagenesisi803K → A: Strongly reduced autoacetylation. 1 Publication1
Mutagenesisi809S → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi815G → R: Strongly decreased enzyme activity. No effect on thermal stability. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
114799

Open Targets

More...
OpenTargetsi
ENSG00000141446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134924215

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5FWF5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ESCO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241355

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000745391 – 840N-acetyltransferase ESCO1Add BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei200PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei412PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis, when associated with chromosomes.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5FWF5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5FWF5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5FWF5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5FWF5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5FWF5

PeptideAtlas

More...
PeptideAtlasi
Q5FWF5

PRoteomics IDEntifications database

More...
PRIDEi
Q5FWF5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62814 [Q5FWF5-1]
62815 [Q5FWF5-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q5FWF5

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5FWF5, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5FWF5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5FWF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141446, Expressed in tendon of biceps brachii and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5FWF5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5FWF5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141446, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The subunit structure is controversial. Monomer (PubMed:27803161). Homodimer (PubMed:27112597).

Curated2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125360, 29 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5FWF5

Database of interacting proteins

More...
DIPi
DIP-56674N

Protein interaction database and analysis system

More...
IntActi
Q5FWF5, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000269214

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5FWF5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1840
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5FWF5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 188DisorderedSequence analysisAdd BLAST188
Regioni221 – 300DisorderedSequence analysisAdd BLAST80
Regioni318 – 338DisorderedSequence analysisAdd BLAST21
Regioni486 – 505DisorderedSequence analysisAdd BLAST20
Regioni542 – 582DisorderedSequence analysisAdd BLAST41
Regioni772 – 774Acetyl-CoA bindingCombined sources2 Publications3
Regioni780 – 785Acetyl-CoA bindingCombined sources2 Publications6
Regioni812 – 814Acetyl-CoA bindingCombined sources2 Publications3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 44Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi45 – 97Polar residuesSequence analysisAdd BLAST53
Compositional biasi98 – 117Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi118 – 169Polar residuesSequence analysisAdd BLAST52
Compositional biasi174 – 188Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi228 – 243Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi266 – 291Polar residuesSequence analysisAdd BLAST26
Compositional biasi547 – 567Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acetyltransferase family. ECO subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri617 – 641CCHH-type1 PublicationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3014, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157762

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012128_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5FWF5

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMKSVHT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5FWF5

TreeFam database of animal gene trees

More...
TreeFami
TF314027

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026656, AcTrfase_ESCO1
IPR028005, AcTrfase_ESCO_Znf_dom
IPR028009, ESCO_Acetyltransf_dom

The PANTHER Classification System

More...
PANTHERi
PTHR45884:SF1, PTHR45884:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13880, Acetyltransf_13, 1 hit
PF13878, zf-C2H2_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5FWF5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSIQEKSKE NSSKVTKKSD DKNSETEIQD SQKNLAKKSG PKETIKSQAK
60 70 80 90 100
SSSESKINQP ELETRMSTRS SKAASNDKAT KSINKNTVTV RGYSQESTKK
110 120 130 140 150
KLSQKKLVHE NPKANEQLNR RSQRLQQLTE VSRRSLRSRE IQGQVQAVKQ
160 170 180 190 200
SLPPTKKEQC SSTQSKSNKT SQKHVKRKVL EVKSDSKEDE NLVINEVINS
210 220 230 240 250
PKGKKRKVEH QTACACSSQC TQGSEKCPQK TTRRDETKPV PVTSEVKRSK
260 270 280 290 300
MATSVVPKKN EMKKSVHTQV NTNTTLPKSP QPSVPEQSDN ELEQAGKSKR
310 320 330 340 350
GSILQLCEEI AGEIESDNVE VKKESSQMES VKEEKPTEIK LEETSVERQI
360 370 380 390 400
LHQKETNQDV QCNRFFPSRK TKPVKCILNG INSSAKKNSN WTKIKLSKFN
410 420 430 440 450
SVQHNKLDSQ VSPKLGLLRT SFSPPALEMH HPVTQSTFLG TKLHDRNITC
460 470 480 490 500
QQEKMKEINS EEVKINDITV EINKTTERAP ENCHLANEIK PSDPPLDNQM
510 520 530 540 550
KHSFDSASNK NFSQCLESKL ENSPVENVTA ASTLLSQAKI DTGENKFPGS
560 570 580 590 600
APQQHSILSN QTSKSSDNRE TPRNHSLPKC NSHLEITIPK DLKLKEAEKT
610 620 630 640 650
DEKQLIIDAG QKRFGAVSCN VCGMLYTASN PEDETQHLLF HNQFISAVKY
660 670 680 690 700
VGWKKERILA EYPDGRIIMV LPEDPKYALK KVDEIREMVD NDLGFQQAPL
710 720 730 740 750
MCYSRTKTLL FISNDKKVVG CLIAEHIQWG YRVIEEKLPV IRSEEEKVRF
760 770 780 790 800
ERQKAWCCST LPEPAICGIS RIWVFSMMRR KKIASRMIEC LRSNFIYGSY
810 820 830 840
LSKEEIAFSD PTPDGKLFAT QYCGTGQFLV YNFINGQNST
Length:840
Mass (Da):94,983
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA36BE0EC1BE3EDF2
GO
Isoform 2 (identifier: Q5FWF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-701: GWKKERILAE...DLGFQQAPLM → VLLINHHECG...EGLEERKNSG
     702-840: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:701
Mass (Da):78,987
Checksum:iEA85A22EAD7134C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DH04A0A0C4DH04_HUMAN
N-acetyltransferase ESCO1
ESCO1
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36943 differs from that shown. Wrong choice of frame.Curated
The sequence BAB67804 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC03483 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti384S → L in BAB67804 (PubMed:11572484).Curated1
Sequence conflicti432P → S in CAH10682 (PubMed:17974005).Curated1
Sequence conflicti805E → A in BAC03483 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048167191N → S. Corresponds to variant dbSNP:rs35087820Ensembl.1
Natural variantiVAR_022648221T → M1 PublicationCorresponds to variant dbSNP:rs13381941Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014029652 – 701GWKKE…QAPLM → VLLINHHECGSEEEFITSLF LSMFNFRYTQRSFSFPIRFL EGLEERKNSG in isoform 2. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_014030702 – 840Missing in isoform 2. 2 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB067498 mRNA Translation: BAB67804.1 Different initiation.
AL832041 mRNA Translation: CAH10584.1
AL834200 mRNA Translation: CAH10682.1
EF444976 Genomic DNA Translation: ACA05989.1
EF444976 Genomic DNA Translation: ACA05990.1
CH471088 Genomic DNA Translation: EAX01128.1
CH471088 Genomic DNA Translation: EAX01127.1
BC036943 mRNA Translation: AAH36943.1 Sequence problems.
BC089426 mRNA Translation: AAH89426.1
AK090579 mRNA Translation: BAC03483.1 Different initiation.
BK001617 mRNA Translation: DAA02068.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32800.1 [Q5FWF5-1]

NCBI Reference Sequences

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RefSeqi
NP_443143.2, NM_052911.2 [Q5FWF5-1]
XP_011524100.1, XM_011525798.1 [Q5FWF5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000269214; ENSP00000269214; ENSG00000141446 [Q5FWF5-1]
ENST00000383276; ENSP00000372763; ENSG00000141446 [Q5FWF5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114799

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:114799

UCSC genome browser

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UCSCi
uc002kth.2, human [Q5FWF5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067498 mRNA Translation: BAB67804.1 Different initiation.
AL832041 mRNA Translation: CAH10584.1
AL834200 mRNA Translation: CAH10682.1
EF444976 Genomic DNA Translation: ACA05989.1
EF444976 Genomic DNA Translation: ACA05990.1
CH471088 Genomic DNA Translation: EAX01128.1
CH471088 Genomic DNA Translation: EAX01127.1
BC036943 mRNA Translation: AAH36943.1 Sequence problems.
BC089426 mRNA Translation: AAH89426.1
AK090579 mRNA Translation: BAC03483.1 Different initiation.
BK001617 mRNA Translation: DAA02068.1
CCDSiCCDS32800.1 [Q5FWF5-1]
RefSeqiNP_443143.2, NM_052911.2 [Q5FWF5-1]
XP_011524100.1, XM_011525798.1 [Q5FWF5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MXEX-ray2.60A/B654-836[»]
5T53X-ray2.70A599-825[»]
SMRiQ5FWF5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125360, 29 interactors
CORUMiQ5FWF5
DIPiDIP-56674N
IntActiQ5FWF5, 15 interactors
STRINGi9606.ENSP00000269214

PTM databases

CarbonylDBiQ5FWF5
GlyGeniQ5FWF5, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ5FWF5
PhosphoSitePlusiQ5FWF5

Genetic variation databases

BioMutaiESCO1
DMDMi116241355

Proteomic databases

EPDiQ5FWF5
jPOSTiQ5FWF5
MassIVEiQ5FWF5
MaxQBiQ5FWF5
PaxDbiQ5FWF5
PeptideAtlasiQ5FWF5
PRIDEiQ5FWF5
ProteomicsDBi62814 [Q5FWF5-1]
62815 [Q5FWF5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
21999, 69 antibodies

The DNASU plasmid repository

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DNASUi
114799

Genome annotation databases

EnsembliENST00000269214; ENSP00000269214; ENSG00000141446 [Q5FWF5-1]
ENST00000383276; ENSP00000372763; ENSG00000141446 [Q5FWF5-2]
GeneIDi114799
KEGGihsa:114799
UCSCiuc002kth.2, human [Q5FWF5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
114799
DisGeNETi114799

GeneCards: human genes, protein and diseases

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GeneCardsi
ESCO1
HGNCiHGNC:24645, ESCO1
HPAiENSG00000141446, Low tissue specificity
MIMi609674, gene
neXtProtiNX_Q5FWF5
OpenTargetsiENSG00000141446
PharmGKBiPA134924215
VEuPathDBiHostDB:ENSG00000141446

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3014, Eukaryota
GeneTreeiENSGT00940000157762
HOGENOMiCLU_012128_0_0_1
InParanoidiQ5FWF5
OMAiEMKSVHT
PhylomeDBiQ5FWF5
TreeFamiTF314027

Enzyme and pathway databases

PathwayCommonsiQ5FWF5
ReactomeiR-HSA-2468052, Establishment of Sister Chromatid Cohesion
SIGNORiQ5FWF5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
114799, 15 hits in 1023 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ESCO1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
114799
PharosiQ5FWF5, Tbio

Protein Ontology

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PROi
PR:Q5FWF5
RNActiQ5FWF5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141446, Expressed in tendon of biceps brachii and 217 other tissues
ExpressionAtlasiQ5FWF5, baseline and differential
GenevisibleiQ5FWF5, HS

Family and domain databases

InterProiView protein in InterPro
IPR026656, AcTrfase_ESCO1
IPR028005, AcTrfase_ESCO_Znf_dom
IPR028009, ESCO_Acetyltransf_dom
PANTHERiPTHR45884:SF1, PTHR45884:SF1, 1 hit
PfamiView protein in Pfam
PF13880, Acetyltransf_13, 1 hit
PF13878, zf-C2H2_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESCO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5FWF5
Secondary accession number(s): B0YJ11
, B0YJ12, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 17, 2006
Last modified: September 29, 2021
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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