Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetyltransferase ESCO1

Gene

ESCO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053).6 Publications

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=77 µM for acetyl-CoA1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri617 – 641CCHH-type1 PublicationAdd BLAST25

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • acetyltransferase activity Source: UniProtKB
    • identical protein binding Source: IntAct
    • N-acetyltransferase activity Source: UniProtKB
    • peptide-lysine-N-acetyltransferase activity Source: UniProtKB
    • zinc ion binding Source: UniProtKB

    GO - Biological processi

    • peptidyl-lysine acetylation Source: UniProtKB
    • post-translational protein acetylation Source: UniProtKB
    • regulation of DNA replication Source: UniProtKB
    • sister chromatid cohesion Source: GO_Central

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase
    Biological processCell cycle
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2468052 Establishment of Sister Chromatid Cohesion

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q5FWF5

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    N-acetyltransferase ESCO1 (EC:2.3.1.-2 Publications)
    Alternative name(s):
    CTF7 homolog 1
    Establishment factor-like protein 1
    Short name:
    EFO1p
    Short name:
    hEFO1
    Establishment of cohesion 1 homolog 1
    Short name:
    ECO1 homolog 1
    Short name:
    ESO1 homolog 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ESCO1
    Synonyms:EFO1, KIAA1911
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000141446.10

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:24645 ESCO1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609674 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q5FWF5

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Chromosome, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi622C → G: No effect on association with chromosomes. 1 Publication1
    Mutagenesisi640F → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi643Q → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi644F → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi690D → N: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi725E → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi732R → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi735E → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi736E → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi756W → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi768G → D: Loss of autoacetylation. 2 Publications1
    Mutagenesisi770S → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi771R → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi773W → G: Decreased thermal stability.Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi779 – 780RR → GG: Significant reduction in autoacetylation. 1 Publication2
    Mutagenesisi780R → A: Nearly abolishes autoacetylation. 1 Publication1
    Mutagenesisi782 – 783KI → EV: Significant reduction in autoacetylation. 1 Publication2
    Mutagenesisi786R → C: Decreased thermal stability. Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi789E → A: Reduced autoacetylation. 2 Publications1
    Mutagenesisi803K → A: Strongly reduced autoacetylation. 1 Publication1
    Mutagenesisi809S → A: Strongly decreased enzyme activity. 1 Publication1
    Mutagenesisi815G → R: Strongly decreased enzyme activity. No effect on thermal stability. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    114799

    Open Targets

    More...
    OpenTargetsi
    ENSG00000141446

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134924215

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ESCO1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116241355

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000745391 – 840N-acetyltransferase ESCO1Add BLAST840

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei200PhosphoserineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Modified residuei412PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated during mitosis.1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q5FWF5

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q5FWF5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q5FWF5

    PeptideAtlas

    More...
    PeptideAtlasi
    Q5FWF5

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q5FWF5

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    62814
    62815 [Q5FWF5-2]

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    Q5FWF5

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q5FWF5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q5FWF5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000141446 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_ESCO1

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q5FWF5 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q5FWF5 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA042497

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    The subunit structure is controversial. Monomer (PubMed:27803161). Homodimer (PubMed:27112597).Curated2 Publications

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    125360, 24 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q5FWF5

    Database of interacting proteins

    More...
    DIPi
    DIP-56674N

    Protein interaction database and analysis system

    More...
    IntActi
    Q5FWF5, 14 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000269214

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1840
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q5FWF5

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q5FWF5

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni772 – 774Acetyl-CoA bindingCombined sources2 Publications3
    Regioni780 – 785Acetyl-CoA bindingCombined sources2 Publications6
    Regioni812 – 814Acetyl-CoA bindingCombined sources2 Publications3

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the acetyltransferase family. ECO subfamily.Curated

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri617 – 641CCHH-type1 PublicationAdd BLAST25

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3014 Eukaryota
    ENOG410XTJX LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157762

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG081483

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q5FWF5

    KEGG Orthology (KO)

    More...
    KOi
    K11268

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    CQQEEMK

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0QVI

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q5FWF5

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314027

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR026656 AcTrfase_ESCO1
    IPR028005 AcTrfase_ESCO_Znf_dom
    IPR028009 ESCO_Acetyltransf_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11076:SF26 PTHR11076:SF26, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13880 Acetyltransf_13, 1 hit
    PF13878 zf-C2H2_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q5FWF5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MMSIQEKSKE NSSKVTKKSD DKNSETEIQD SQKNLAKKSG PKETIKSQAK
    60 70 80 90 100
    SSSESKINQP ELETRMSTRS SKAASNDKAT KSINKNTVTV RGYSQESTKK
    110 120 130 140 150
    KLSQKKLVHE NPKANEQLNR RSQRLQQLTE VSRRSLRSRE IQGQVQAVKQ
    160 170 180 190 200
    SLPPTKKEQC SSTQSKSNKT SQKHVKRKVL EVKSDSKEDE NLVINEVINS
    210 220 230 240 250
    PKGKKRKVEH QTACACSSQC TQGSEKCPQK TTRRDETKPV PVTSEVKRSK
    260 270 280 290 300
    MATSVVPKKN EMKKSVHTQV NTNTTLPKSP QPSVPEQSDN ELEQAGKSKR
    310 320 330 340 350
    GSILQLCEEI AGEIESDNVE VKKESSQMES VKEEKPTEIK LEETSVERQI
    360 370 380 390 400
    LHQKETNQDV QCNRFFPSRK TKPVKCILNG INSSAKKNSN WTKIKLSKFN
    410 420 430 440 450
    SVQHNKLDSQ VSPKLGLLRT SFSPPALEMH HPVTQSTFLG TKLHDRNITC
    460 470 480 490 500
    QQEKMKEINS EEVKINDITV EINKTTERAP ENCHLANEIK PSDPPLDNQM
    510 520 530 540 550
    KHSFDSASNK NFSQCLESKL ENSPVENVTA ASTLLSQAKI DTGENKFPGS
    560 570 580 590 600
    APQQHSILSN QTSKSSDNRE TPRNHSLPKC NSHLEITIPK DLKLKEAEKT
    610 620 630 640 650
    DEKQLIIDAG QKRFGAVSCN VCGMLYTASN PEDETQHLLF HNQFISAVKY
    660 670 680 690 700
    VGWKKERILA EYPDGRIIMV LPEDPKYALK KVDEIREMVD NDLGFQQAPL
    710 720 730 740 750
    MCYSRTKTLL FISNDKKVVG CLIAEHIQWG YRVIEEKLPV IRSEEEKVRF
    760 770 780 790 800
    ERQKAWCCST LPEPAICGIS RIWVFSMMRR KKIASRMIEC LRSNFIYGSY
    810 820 830 840
    LSKEEIAFSD PTPDGKLFAT QYCGTGQFLV YNFINGQNST
    Length:840
    Mass (Da):94,983
    Last modified:October 17, 2006 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA36BE0EC1BE3EDF2
    GO
    Isoform 2 (identifier: Q5FWF5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         652-701: GWKKERILAE...DLGFQQAPLM → VLLINHHECG...EGLEERKNSG
         702-840: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:701
    Mass (Da):78,987
    Checksum:iEA85A22EAD7134C0
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0C4DH04A0A0C4DH04_HUMAN
    N-acetyltransferase ESCO1
    ESCO1
    172Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH36943 differs from that shown. Wrong choice of frame.Curated
    The sequence BAB67804 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
    The sequence BAC03483 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti384S → L in BAB67804 (PubMed:11572484).Curated1
    Sequence conflicti432P → S in CAH10682 (PubMed:17974005).Curated1
    Sequence conflicti805E → A in BAC03483 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048167191N → S. Corresponds to variant dbSNP:rs35087820Ensembl.1
    Natural variantiVAR_022648221T → M1 PublicationCorresponds to variant dbSNP:rs13381941Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014029652 – 701GWKKE…QAPLM → VLLINHHECGSEEEFITSLF LSMFNFRYTQRSFSFPIRFL EGLEERKNSG in isoform 2. 2 PublicationsAdd BLAST50
    Alternative sequenceiVSP_014030702 – 840Missing in isoform 2. 2 PublicationsAdd BLAST139

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB067498 mRNA Translation: BAB67804.1 Different initiation.
    AL832041 mRNA Translation: CAH10584.1
    AL834200 mRNA Translation: CAH10682.1
    EF444976 Genomic DNA Translation: ACA05989.1
    EF444976 Genomic DNA Translation: ACA05990.1
    CH471088 Genomic DNA Translation: EAX01128.1
    CH471088 Genomic DNA Translation: EAX01127.1
    BC036943 mRNA Translation: AAH36943.1 Sequence problems.
    BC089426 mRNA Translation: AAH89426.1
    AK090579 mRNA Translation: BAC03483.1 Different initiation.
    BK001617 mRNA Translation: DAA02068.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS32800.1 [Q5FWF5-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_443143.2, NM_052911.2 [Q5FWF5-1]
    XP_011524100.1, XM_011525798.1 [Q5FWF5-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.464733

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000269214; ENSP00000269214; ENSG00000141446 [Q5FWF5-1]
    ENST00000383276; ENSP00000372763; ENSG00000141446 [Q5FWF5-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    114799

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:114799

    UCSC genome browser

    More...
    UCSCi
    uc002kth.2 human [Q5FWF5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB067498 mRNA Translation: BAB67804.1 Different initiation.
    AL832041 mRNA Translation: CAH10584.1
    AL834200 mRNA Translation: CAH10682.1
    EF444976 Genomic DNA Translation: ACA05989.1
    EF444976 Genomic DNA Translation: ACA05990.1
    CH471088 Genomic DNA Translation: EAX01128.1
    CH471088 Genomic DNA Translation: EAX01127.1
    BC036943 mRNA Translation: AAH36943.1 Sequence problems.
    BC089426 mRNA Translation: AAH89426.1
    AK090579 mRNA Translation: BAC03483.1 Different initiation.
    BK001617 mRNA Translation: DAA02068.1
    CCDSiCCDS32800.1 [Q5FWF5-1]
    RefSeqiNP_443143.2, NM_052911.2 [Q5FWF5-1]
    XP_011524100.1, XM_011525798.1 [Q5FWF5-1]
    UniGeneiHs.464733

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4MXEX-ray2.60A/B654-836[»]
    5T53X-ray2.70A599-825[»]
    ProteinModelPortaliQ5FWF5
    SMRiQ5FWF5
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi125360, 24 interactors
    CORUMiQ5FWF5
    DIPiDIP-56674N
    IntActiQ5FWF5, 14 interactors
    STRINGi9606.ENSP00000269214

    PTM databases

    CarbonylDBiQ5FWF5
    iPTMnetiQ5FWF5
    PhosphoSitePlusiQ5FWF5

    Polymorphism and mutation databases

    BioMutaiESCO1
    DMDMi116241355

    Proteomic databases

    EPDiQ5FWF5
    MaxQBiQ5FWF5
    PaxDbiQ5FWF5
    PeptideAtlasiQ5FWF5
    PRIDEiQ5FWF5
    ProteomicsDBi62814
    62815 [Q5FWF5-2]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000269214; ENSP00000269214; ENSG00000141446 [Q5FWF5-1]
    ENST00000383276; ENSP00000372763; ENSG00000141446 [Q5FWF5-2]
    GeneIDi114799
    KEGGihsa:114799
    UCSCiuc002kth.2 human [Q5FWF5-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    114799
    DisGeNETi114799
    EuPathDBiHostDB:ENSG00000141446.10

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ESCO1

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0019345
    HGNCiHGNC:24645 ESCO1
    HPAiHPA042497
    MIMi609674 gene
    neXtProtiNX_Q5FWF5
    OpenTargetsiENSG00000141446
    PharmGKBiPA134924215

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3014 Eukaryota
    ENOG410XTJX LUCA
    GeneTreeiENSGT00940000157762
    HOVERGENiHBG081483
    InParanoidiQ5FWF5
    KOiK11268
    OMAiCQQEEMK
    OrthoDBiEOG091G0QVI
    PhylomeDBiQ5FWF5
    TreeFamiTF314027

    Enzyme and pathway databases

    ReactomeiR-HSA-2468052 Establishment of Sister Chromatid Cohesion
    SIGNORiQ5FWF5

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ESCO1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    114799

    Protein Ontology

    More...
    PROi
    PR:Q5FWF5

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000141446 Expressed in 203 organ(s), highest expression level in tendon of biceps brachii
    CleanExiHS_ESCO1
    ExpressionAtlasiQ5FWF5 baseline and differential
    GenevisibleiQ5FWF5 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR026656 AcTrfase_ESCO1
    IPR028005 AcTrfase_ESCO_Znf_dom
    IPR028009 ESCO_Acetyltransf_dom
    PANTHERiPTHR11076:SF26 PTHR11076:SF26, 1 hit
    PfamiView protein in Pfam
    PF13880 Acetyltransf_13, 1 hit
    PF13878 zf-C2H2_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESCO1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5FWF5
    Secondary accession number(s): B0YJ11
    , B0YJ12, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 17, 2006
    Last modified: December 5, 2018
    This is version 129 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again