UniProtKB - Q5FWC3 (M4A13_MOUSE)
Protein
Membrane-spanning 4-domains subfamily A member 13
Gene
Ms4a13
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in signal transduction as a component of a multimeric receptor complex.By similarity
Caution
It is uncertain whether Met-1 or Met-22 is the initiator.Curated
Keywordsi
Molecular function | Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane-spanning 4-domains subfamily A member 13Alternative name(s): Testis-expressed transmembrane protein 4.2 Short name: Tetm4.2 |
Gene namesi | Name:Ms4a13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920716, Ms4a13 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 15 – 35 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315056 | 1 – 203 | Membrane-spanning 4-domains subfamily A member 13Add BLAST | 203 |
Proteomic databases
PaxDbi | Q5FWC3 |
PRIDEi | Q5FWC3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000057240, Expressed in spermatid and 13 other tissues |
Genevisiblei | Q5FWC3, MM |
Family & Domainsi
Sequence similaritiesi
Belongs to the MS4A family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RTZG, Eukaryota |
GeneTreei | ENSGT00390000015662 |
HOGENOMi | CLU_1348559_0_0_1 |
InParanoidi | Q5FWC3 |
OMAi | GCSLWGI |
OrthoDBi | 1515352at2759 |
PhylomeDBi | Q5FWC3 |
TreeFami | TF353242 |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A |
PANTHERi | PTHR23320, PTHR23320, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5FWC3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MECRNPKVSS ANITVLGVIQ IMIGIYHVLM WYFLLLLYMG QIKGVFGTYE
60 70 80 90 100
PVTYKMGTSL WGFAFVISGA FTVKAAKYQS RHMILCTMSL NILCIIITIV
110 120 130 140 150
AASLTIVELS HFRSVSYRNY GQAKLGREVS RVLLCSYPLE FAIALLYSIS
160 170 180 190 200
SCAYLPLSSI VKSLVRKTWR LSSLAAWRQM IWLEAGNQEE TLESVTEVVE
GNS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030478 | 156 – 184 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF544402 mRNA Translation: AAQ11744.1 BC089483 mRNA Translation: AAH89483.1 |
CCDSi | CCDS29595.1 [Q5FWC3-1] CCDS84420.1 [Q5FWC3-2] |
RefSeqi | NP_001334364.1, NM_001347435.1 [Q5FWC3-2] NP_937867.2, NM_198224.3 [Q5FWC3-1] |
Genome annotation databases
Ensembli | ENSMUST00000073380; ENSMUSP00000073095; ENSMUSG00000057240 [Q5FWC3-1] ENSMUST00000188464; ENSMUSP00000140293; ENSMUSG00000057240 [Q5FWC3-2] |
GeneIDi | 73466 |
KEGGi | mmu:73466 |
UCSCi | uc008gru.1, mouse [Q5FWC3-1] uc008grv.1, mouse [Q5FWC3-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF544402 mRNA Translation: AAQ11744.1 BC089483 mRNA Translation: AAH89483.1 |
CCDSi | CCDS29595.1 [Q5FWC3-1] CCDS84420.1 [Q5FWC3-2] |
RefSeqi | NP_001334364.1, NM_001347435.1 [Q5FWC3-2] NP_937867.2, NM_198224.3 [Q5FWC3-1] |
3D structure databases
SMRi | Q5FWC3 |
ModBasei | Search... |
Proteomic databases
PaxDbi | Q5FWC3 |
PRIDEi | Q5FWC3 |
Protocols and materials databases
Antibodypediai | 50523, 57 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000073380; ENSMUSP00000073095; ENSMUSG00000057240 [Q5FWC3-1] ENSMUST00000188464; ENSMUSP00000140293; ENSMUSG00000057240 [Q5FWC3-2] |
GeneIDi | 73466 |
KEGGi | mmu:73466 |
UCSCi | uc008gru.1, mouse [Q5FWC3-1] uc008grv.1, mouse [Q5FWC3-2] |
Organism-specific databases
CTDi | 503497 |
MGIi | MGI:1920716, Ms4a13 |
Phylogenomic databases
eggNOGi | ENOG502RTZG, Eukaryota |
GeneTreei | ENSGT00390000015662 |
HOGENOMi | CLU_1348559_0_0_1 |
InParanoidi | Q5FWC3 |
OMAi | GCSLWGI |
OrthoDBi | 1515352at2759 |
PhylomeDBi | Q5FWC3 |
TreeFami | TF353242 |
Miscellaneous databases
BioGRID-ORCSi | 73466, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ms4a13, mouse |
PROi | PR:Q5FWC3 |
RNActi | Q5FWC3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000057240, Expressed in spermatid and 13 other tissues |
Genevisiblei | Q5FWC3, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A |
PANTHERi | PTHR23320, PTHR23320, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M4A13_MOUSE | |
Accessioni | Q5FWC3Primary (citable) accession number: Q5FWC3 Secondary accession number(s): Q717T1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | March 1, 2005 | |
Last modified: | February 10, 2021 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families