Klf15 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4."
    Gray S.J., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., DePina A., Haspel R., Jain M.K.
    J. Biol. Chem. 277:34322-34328(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Kruppel-like factor 15 regulates BMPER in endothelial cells."
    Helbing T., Volkmar F., Goebel U., Heinke J., Diehl P., Pahl H.L., Bode C., Patterson C., Moser M.
    Cardiovasc. Res. 85:551-559(2010) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4."
    Gray S.J., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., DePina A., Haspel R., Jain M.K.
    J. Biol. Chem. 277:34322-34328(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Kruppel-like factor 15 regulates BMPER in endothelial cells."
    Helbing T., Volkmar F., Goebel U., Heinke J., Diehl P., Pahl H.L., Bode C., Patterson C., Moser M.
    Cardiovasc. Res. 85:551-559(2010) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Kruppel-like factor 15 regulates BMPER in endothelial cells."
    Helbing T., Volkmar F., Goebel U., Heinke J., Diehl P., Pahl H.L., Bode C., Patterson C., Moser M.
    Cardiovasc. Res. 85:551-559(2010) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Circadian rhythms govern cardiac repolarization and arrhythmogenesis."
    Jeyaraj D., Haldar S.M., Wan X., McCauley M.D., Ripperger J.A., Hu K., Lu Y., Eapen B.L., Sharma N., Ficker E., Cutler M.J., Gulick J., Sanbe A., Robbins J., Demolombe S., Kondratov R.V., Shea S.A., Albrecht U.

    , Wehrens X.H., Rosenbaum D.S., Jain M.K.
    Nature 483:96-99(2012) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cardiac muscle hypertrophy in response to stress Source: RGDInferred from sequence orthologyⁱ
  • "Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy."
    Fisch S., Gray S., Heymans S., Haldar S.M., Wang B., Pfister O., Cui L., Kumar A., Lin Z., Sen-Banerjee S., Das H., Petersen C.A., Mende U., Burleigh B.A., Zhu Y., Pinto Y.M., Pinto Y., Liao R., Jain M.K.
    Proc. Natl. Acad. Sci. U.S.A. 104:7074-7079(2007) [PubMed] [Europe PMC] [Abstract]
• cellular glucose homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4."
    Gray S.J., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., DePina A., Haspel R., Jain M.K.
    J. Biol. Chem. 277:34322-34328(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to peptide Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines."
    Cullingford T.E., Butler M.J., Marshall A.K., Tham e.l. L., Sugden P.H., Clerk A.
    Biochim. Biophys. Acta 1783:1229-1236(2008) [PubMed] [Europe PMC] [Abstract]
• glial cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development."
    Fu H., Cai J., Clevers H., Fast E., Gray S., Greenberg R., Jain M.K., Ma Q., Qiu M., Rowitch D.H., Taylor C.M., Stiles C.D.
    J. Neurosci. 29:11399-11408(2009) [PubMed] [Europe PMC] [Abstract]
• glomerular visceral epithelial cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation."
    Mallipattu S.K., Liu R., Zheng F., Narla G., Ma'ayan A., Dikman S., Jain M.K., Saleem M., D'Agati V., Klotman P., Chuang P.Y., He J.C.
    J. Biol. Chem. 287:19122-19135(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of peptidyl-lysine acetylation Source: RGDInferred from sequence orthologyⁱ
  • "Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation."
    Haldar S.M., Lu Y., Jeyaraj D., Kawanami D., Cui Y., Eapen S.J., Hao C., Li Y., Doughman Y.Q., Watanabe M., Shimizu K., Kuivaniemi H., Sadoshima J., Margulies K.B., Cappola T.P., Jain M.K.
    Sci. Transl. Med. 2:26RA26-26RA26(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glucose import Source: RGDInferred from sequence orthologyⁱ
  • "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4."
    Gray S.J., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., DePina A., Haspel R., Jain M.K.
    J. Biol. Chem. 277:34322-34328(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4."
    Gray S.J., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., DePina A., Haspel R., Jain M.K.
    J. Biol. Chem. 277:34322-34328(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Kruppel-like factor 15 regulates BMPER in endothelial cells."
    Helbing T., Volkmar F., Goebel U., Heinke J., Diehl P., Pahl H.L., Bode C., Patterson C., Moser M.
    Cardiovasc. Res. 85:551-559(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy."
    Fisch S., Gray S., Heymans S., Haldar S.M., Wang B., Pfister O., Cui L., Kumar A., Lin Z., Sen-Banerjee S., Das H., Petersen C.A., Mende U., Burleigh B.A., Zhu Y., Pinto Y.M., Pinto Y., Liao R., Jain M.K.
    Proc. Natl. Acad. Sci. U.S.A. 104:7074-7079(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to insulin Source: RGDInferred from sequence orthologyⁱ
  • "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4."
    Gray S.J., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., DePina A., Haspel R., Jain M.K.
    J. Biol. Chem. 277:34322-34328(2002) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVDHLLPVDE TFSSPKCPVG YLGDRLASRQ PYHMLPSPIS EDDSDVSSPC 
        60         70         80         90        100
SCASPDSQAF CSCYSAGPGP EAQGSILDFL LSRATLGSGG ASGGVGDGSG 
       110        120        130        140        150
PVTWGSWRRA SVPVKEEHLC FPEFLSGDPD DVSRPFQPTL EEIEEFLEEN 
       160        170        180        190        200
MEAEVKEAPE SSSRDLEACS QLSAGSHRSH LHPESGGREC RTPPPGGTSG 
       210        220        230        240        250
GGTQGAGEGS AHDGPMPVLL QIQPVAVKQE AGAGPASPGQ APESVKVAQL 
       260        270        280        290        300
LVNIQGQTFA LLPQVVPSSN LNLSSKFVRI APVPIAAKPI GSGSLGPGPA 
       310        320        330        340        350
GLLVGQKFPK NPAAELLKMH KCTFPGCSKM YTKSSHLKAH LRRHTGEKPF 
       360        370        380        390        400
ACTWPGCGWR FSRSDELSRH RRSHSGVKPY QCPVCEKKFA RSDHLSKHIK 
       410 
VHRFPRSSRA VRAIN                                       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ