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Protein

Acyl-coenzyme A amino acid N-acyltransferase 2

Gene

Acnat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei234Charge relay systemBy similarity1
Active sitei327Charge relay systemBy similarity1
Active sitei361Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Protein family/group databases

ESTHERiratno-q5fvr5 Acyl-CoA_Thioesterase
MEROPSiS09.A50

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A amino acid N-acyltransferase 2By similarity (EC:2.3.1.-)
Gene namesi
Name:Acnat2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1359532 Acnat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003527761 – 418Acyl-coenzyme A amino acid N-acyltransferase 2Add BLAST418

Proteomic databases

PaxDbiQ5FVR5
PRIDEiQ5FVR5

PTM databases

iPTMnetiQ5FVR5
PhosphoSitePlusiQ5FVR5

Expressioni

Gene expression databases

BgeeiENSRNOG00000051912 Expressed in 3 organ(s), highest expression level in liver
ExpressionAtlasiQ5FVR5 baseline

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056642

Structurei

3D structure databases

ProteinModelPortaliQ5FVR5
SMRiQ5FVR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi416 – 418Microbody targeting signal3

Sequence similaritiesi

Belongs to the C/M/P thioester hydrolase family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410II3X Eukaryota
COG1073 LUCA
GeneTreeiENSGT00390000001046
HOGENOMiHOG000116219
HOVERGENiHBG000331
InParanoidiQ5FVR5
OMAiKIKAVCS
OrthoDBiEOG091G08KU
PhylomeDBiQ5FVR5
TreeFamiTF314911

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR016662 Acyl-CoA_thioEstase_long-chain
IPR014940 BAAT_C
IPR006862 Thio_Ohase/aa_AcTrfase
PfamiView protein in Pfam
PF08840 BAAT_C, 1 hit
PF04775 Bile_Hydr_Trans, 1 hit
PIRSFiPIRSF016521 Acyl-CoA_hydro, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5FVR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQLIATPSN ALADEPVSIR AIGLPPSQIV TITATVKDEK ENLFQSKAFY
60 70 80 90 100
KANEAGEVDL EQASALGGDY VGVHPMGLFC CLKPKRAFQR LIKKDVMNSP
110 120 130 140 150
LCICLDLYDS VCWLETVRIP PKASQIVHRW FAGPGVKREQ IREGRVRGAL
160 170 180 190 200
FLPPGKGPFP GIIDLFGSIG GLVEFRASLL ASRGFAVLAL AYFAYEDLPK
210 220 230 240 250
VLLEEDLDYF EEAANFLLAH PKIQQPGIGV ISVSKGAEIG LAMACYLKQV
260 270 280 290 300
VATVCINGPS AIFDFPLKYR DLVVTPMRLA FEKIQFHGSG AACFRHCWDP
310 320 330 340 350
QNMLNPPKIL PVEKAQGKIL FIVGENDQCL ASKLHAQRAM DRLRSHGRSS
360 370 380 390 400
GRMLAYPGAG HLIEPPYSPF CFACWDSVLG KPMLWGGDPI AHAAAQVHSW
410
REIQKFFRQH LLQSGGKL
Length:418
Mass (Da):46,011
Last modified:March 1, 2005 - v1
Checksum:i72297A19BE58CF00
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JV92A0A0G2JV92_RAT
Acyl-coenzyme A amino acid N-acyltr...
Acnat2
347Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089827 mRNA Translation: AAH89827.1
RefSeqiNP_001014085.1, NM_001014063.1
UniGeneiRn.162815

Genome annotation databases

EnsembliENSRNOT00000089232; ENSRNOP00000069269; ENSRNOG00000051912
GeneIDi313220
KEGGirno:313220
UCSCiRGD:1359532 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089827 mRNA Translation: AAH89827.1
RefSeqiNP_001014085.1, NM_001014063.1
UniGeneiRn.162815

3D structure databases

ProteinModelPortaliQ5FVR5
SMRiQ5FVR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056642

Protein family/group databases

ESTHERiratno-q5fvr5 Acyl-CoA_Thioesterase
MEROPSiS09.A50

PTM databases

iPTMnetiQ5FVR5
PhosphoSitePlusiQ5FVR5

Proteomic databases

PaxDbiQ5FVR5
PRIDEiQ5FVR5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089232; ENSRNOP00000069269; ENSRNOG00000051912
GeneIDi313220
KEGGirno:313220
UCSCiRGD:1359532 rat

Organism-specific databases

CTDi209186
RGDi1359532 Acnat2

Phylogenomic databases

eggNOGiENOG410II3X Eukaryota
COG1073 LUCA
GeneTreeiENSGT00390000001046
HOGENOMiHOG000116219
HOVERGENiHBG000331
InParanoidiQ5FVR5
OMAiKIKAVCS
OrthoDBiEOG091G08KU
PhylomeDBiQ5FVR5
TreeFamiTF314911

Miscellaneous databases

PROiPR:Q5FVR5

Gene expression databases

BgeeiENSRNOG00000051912 Expressed in 3 organ(s), highest expression level in liver
ExpressionAtlasiQ5FVR5 baseline

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR016662 Acyl-CoA_thioEstase_long-chain
IPR014940 BAAT_C
IPR006862 Thio_Ohase/aa_AcTrfase
PfamiView protein in Pfam
PF08840 BAAT_C, 1 hit
PF04775 Bile_Hydr_Trans, 1 hit
PIRSFiPIRSF016521 Acyl-CoA_hydro, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiACNT2_RAT
AccessioniPrimary (citable) accession number: Q5FVR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: March 1, 2005
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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