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Protein

V-type proton ATPase subunit d 2

Gene

Atp6v0d2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1222556 ROS, RNS production in phagocytes
R-RNO-77387 Insulin receptor recycling
R-RNO-917977 Transferrin endocytosis and recycling
R-RNO-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit d 2
Short name:
V-ATPase subunit d 2
Alternative name(s):
Vacuolar proton pump subunit d 2
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1306900 Atp6v0d2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856601 – 350V-type proton ATPase subunit d 2Add BLAST350

Proteomic databases

PaxDbiQ5FVL0
PRIDEiQ5FVL0

Expressioni

Tissue specificityi

Epididymis and vas deferens.1 Publication

Gene expression databases

BgeeiENSRNOG00000006926 Expressed in 5 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009334

Structurei

3D structure databases

ProteinModelPortaliQ5FVL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase V0D/AC39 subunit family.Curated

Phylogenomic databases

eggNOGiKOG2957 Eukaryota
COG1527 LUCA
GeneTreeiENSGT00390000002200
HOGENOMiHOG000199065
HOVERGENiHBG018065
InParanoidiQ5FVL0
KOiK02146
OMAiDCMSENT
OrthoDBiEOG091G09L5
PhylomeDBiQ5FVL0
TreeFamiTF300857

Family and domain databases

Gene3Di1.20.1690.10, 2 hits
InterProiView protein in InterPro
IPR036079 ATPase_su_C-like
IPR002843 ATPase_V0-cplx_csu/dsu
IPR016727 ATPase_V0-cplx_dsu
IPR035067 V-type_ATPase_suC
PANTHERiPTHR11028 PTHR11028, 1 hit
PfamiView protein in Pfam
PF01992 vATP-synt_AC39, 1 hit
PIRSFiPIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMiSSF103486 SSF103486, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FVL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLETAELYFN VDHGYLEGLV RGCKASLLTQ QDYVNLVQCE TLEDLKIHLQ
60 70 80 90 100
TTDYGNFLAH ETNPLTVSKI DTEMRKKLCR EFDYFRNHSL EPLSTFFTYM
110 120 130 140 150
TCSYMIDNII LLMNGALQKK SVKEVLAKCH PLGRFTEMEA VNIAESASEL
160 170 180 190 200
FKAVLVETPL APFFQDCMSE NTLDELNIEL LRNKLYKSYL EAFYKFCKDH
210 220 230 240 250
GDVTAEVMCP ILEFEADRRA LIITLNSFGT ELSKEDRETL FPTCGKLYPE
260 270 280 290 300
GLRLLAQAED FEHMKRVADN YGVYKPLFDA VGGSGGKTLE DVFYEREVQM
310 320 330 340 350
NVLAFNRQFH YGVFYAYVKL KEQEMRNIVW IAECISQRHR TKINSYIPIL
Length:350
Mass (Da):40,520
Last modified:March 1, 2005 - v1
Checksum:i3B1E7969788BC6FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089917 mRNA Translation: AAH89917.1
RefSeqiNP_001011972.1, NM_001011972.1
UniGeneiRn.83540

Genome annotation databases

EnsembliENSRNOT00000009334; ENSRNOP00000009334; ENSRNOG00000006926
GeneIDi297932
KEGGirno:297932
UCSCiRGD:1306900 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089917 mRNA Translation: AAH89917.1
RefSeqiNP_001011972.1, NM_001011972.1
UniGeneiRn.83540

3D structure databases

ProteinModelPortaliQ5FVL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009334

Proteomic databases

PaxDbiQ5FVL0
PRIDEiQ5FVL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009334; ENSRNOP00000009334; ENSRNOG00000006926
GeneIDi297932
KEGGirno:297932
UCSCiRGD:1306900 rat

Organism-specific databases

CTDi245972
RGDi1306900 Atp6v0d2

Phylogenomic databases

eggNOGiKOG2957 Eukaryota
COG1527 LUCA
GeneTreeiENSGT00390000002200
HOGENOMiHOG000199065
HOVERGENiHBG018065
InParanoidiQ5FVL0
KOiK02146
OMAiDCMSENT
OrthoDBiEOG091G09L5
PhylomeDBiQ5FVL0
TreeFamiTF300857

Enzyme and pathway databases

ReactomeiR-RNO-1222556 ROS, RNS production in phagocytes
R-RNO-77387 Insulin receptor recycling
R-RNO-917977 Transferrin endocytosis and recycling
R-RNO-983712 Ion channel transport

Miscellaneous databases

PROiPR:Q5FVL0

Gene expression databases

BgeeiENSRNOG00000006926 Expressed in 5 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di1.20.1690.10, 2 hits
InterProiView protein in InterPro
IPR036079 ATPase_su_C-like
IPR002843 ATPase_V0-cplx_csu/dsu
IPR016727 ATPase_V0-cplx_dsu
IPR035067 V-type_ATPase_suC
PANTHERiPTHR11028 PTHR11028, 1 hit
PfamiView protein in Pfam
PF01992 vATP-synt_AC39, 1 hit
PIRSFiPIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMiSSF103486 SSF103486, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVA0D2_RAT
AccessioniPrimary (citable) accession number: Q5FVL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2005
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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