UniProtKB - Q5FVH2 (PLD3_RAT)
Protein
Phospholipase D3
Gene
Pld3
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in APP processing.By similarity
Catalytic activityi
- EC:3.1.4.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 199 | PROSITE-ProRule annotation | 1 | |
Active sitei | 201 | PROSITE-ProRule annotation | 1 | |
Active sitei | 206 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- N-acylphosphatidylethanolamine-specific phospholipase D activity Source: UniProtKB-EC
- phospholipase D activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-RNO-2029485 Role of phospholipids in phagocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipase D3 (EC:3.1.4.4)Short name: PLD 3 Alternative name(s): Choline phosphatase 3 Phosphatidylcholine-hydrolyzing phospholipase D3 |
Gene namesi | Name:Pld3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308248 Pld3 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 488 | LumenalSequence analysisAdd BLAST | 429 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280330 | 1 – 488 | Phospholipase D3Add BLAST | 488 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 132 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 385 | N-linked (GlcNAc...) asparagineCombined sources | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q5FVH2 |
PaxDbi | Q5FVH2 |
PRIDEi | Q5FVH2 |
PTM databases
iPTMneti | Q5FVH2 |
PhosphoSitePlusi | Q5FVH2 |
UniCarbKBi | Q5FVH2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000018390 Expressed in 10 organ(s), highest expression level in brain |
Genevisiblei | Q5FVH2 RN |
Interactioni
Subunit structurei
Interacts with APP.
By similarityProtein-protein interaction databases
BioGridi | 262748, 1 interactor |
IntActi | Q5FVH2, 2 interactors |
STRINGi | 10116.ENSRNOP00000054004 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 194 – 221 | PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Domaini | 409 – 435 | PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the phospholipase D family.Curated
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3603 Eukaryota ENOG410XQZ4 LUCA |
GeneTreei | ENSGT00950000183059 |
HOGENOMi | HOG000293407 |
InParanoidi | Q5FVH2 |
KOi | K16860 |
OMAi | DYYPLII |
OrthoDBi | 1057467at2759 |
PhylomeDBi | Q5FVH2 |
TreeFami | TF313378 |
Family and domain databases
InterProi | View protein in InterPro IPR032803 PLDc_3 IPR001736 PLipase_D/transphosphatidylase |
Pfami | View protein in Pfam PF00614 PLDc, 1 hit PF13918 PLDc_3, 1 hit |
SMARTi | View protein in SMART SM00155 PLDc, 2 hits |
PROSITEi | View protein in PROSITE PS50035 PLD, 2 hits |
i Sequence
Sequence statusi: Complete.
Q5FVH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPKLMYQEL KVPVEEPAGE LPMNEIEAWK AAEKKARWVL LVLILAVVGF
60 70 80 90 100
GALMTQLFLW EYGDLHLFGP NQHPAPCYDP CEAVLVESIP EGLEFPNATT
110 120 130 140 150
SNPSTSQAWL GLLAGAHSSL DIASFYWTLT NNDTHTQEPS AQQGEEVLQQ
160 170 180 190 200
LQALAPRGVK VRIAVSKPNG PLADLQSLLQ SGAQVRMVDM QKLTHGVLHT
210 220 230 240 250
KFWVVDQTHF YLGSANMDWR SLTQVKELGV VMYNCSCLAR DLTKIFEAYW
260 270 280 290 300
FLGQAGSSIP STWPRPFDTR YNQETPMEIC LNGTPALAYL ASAPPPLCPG
310 320 330 340 350
GRTPDLKALL SVVDNARSFI YIAVMNYLPT MEFSHPRRFW PAIDDGLRRA
360 370 380 390 400
AYERGVKVRL LISCWGHSEP SMRSFLLSLA ALRDNHTHSD IQVKLFVVPA
410 420 430 440 450
DEAQARIPYA RVNHNKYMVT ERTTYIGTSN WSGSYFTETA GTSLLVTQNG
460 470 480
HGGLRSQLEA VFLRDWESPY SHNLDTSADS VGNACRLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC089987 mRNA Translation: AAH89987.1 |
RefSeqi | NP_001012167.1, NM_001012167.1 XP_006228640.1, XM_006228578.3 XP_006228641.1, XM_006228579.3 XP_006228642.1, XM_006228580.2 XP_006228643.1, XM_006228581.3 |
Genome annotation databases
Ensembli | ENSRNOT00000057177; ENSRNOP00000054004; ENSRNOG00000018390 |
GeneIDi | 361527 |
KEGGi | rno:361527 |
UCSCi | RGD:1308248 rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC089987 mRNA Translation: AAH89987.1 |
RefSeqi | NP_001012167.1, NM_001012167.1 XP_006228640.1, XM_006228578.3 XP_006228641.1, XM_006228579.3 XP_006228642.1, XM_006228580.2 XP_006228643.1, XM_006228581.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 262748, 1 interactor |
IntActi | Q5FVH2, 2 interactors |
STRINGi | 10116.ENSRNOP00000054004 |
PTM databases
iPTMneti | Q5FVH2 |
PhosphoSitePlusi | Q5FVH2 |
UniCarbKBi | Q5FVH2 |
Proteomic databases
jPOSTi | Q5FVH2 |
PaxDbi | Q5FVH2 |
PRIDEi | Q5FVH2 |
Genome annotation databases
Ensembli | ENSRNOT00000057177; ENSRNOP00000054004; ENSRNOG00000018390 |
GeneIDi | 361527 |
KEGGi | rno:361527 |
UCSCi | RGD:1308248 rat |
Organism-specific databases
CTDi | 23646 |
RGDi | 1308248 Pld3 |
Phylogenomic databases
eggNOGi | KOG3603 Eukaryota ENOG410XQZ4 LUCA |
GeneTreei | ENSGT00950000183059 |
HOGENOMi | HOG000293407 |
InParanoidi | Q5FVH2 |
KOi | K16860 |
OMAi | DYYPLII |
OrthoDBi | 1057467at2759 |
PhylomeDBi | Q5FVH2 |
TreeFami | TF313378 |
Enzyme and pathway databases
Reactomei | R-RNO-2029485 Role of phospholipids in phagocytosis |
Miscellaneous databases
PROi | PR:Q5FVH2 |
Gene expression databases
Bgeei | ENSRNOG00000018390 Expressed in 10 organ(s), highest expression level in brain |
Genevisiblei | Q5FVH2 RN |
Family and domain databases
InterProi | View protein in InterPro IPR032803 PLDc_3 IPR001736 PLipase_D/transphosphatidylase |
Pfami | View protein in Pfam PF00614 PLDc, 1 hit PF13918 PLDc_3, 1 hit |
SMARTi | View protein in SMART SM00155 PLDc, 2 hits |
PROSITEi | View protein in PROSITE PS50035 PLD, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLD3_RAT | |
Accessioni | Q5FVH2Primary (citable) accession number: Q5FVH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 1, 2005 | |
Last modified: | November 13, 2019 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families