UniProtKB - Q5FBX5 (Q5FBX5_HUMAN)
Protein
Interleukin-7
Gene
IL7
Organism
Homo sapiens (Human)
Status
Functioni
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.ARBA annotation
GO - Molecular functioni
- growth factor activity Source: InterPro
- interleukin-7 receptor binding Source: InterPro
GO - Biological processi
- immune response Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-7ARBA annotation |
Gene namesi | Name:IL7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104432.12 |
HGNCi | HGNC:6023, IL7 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5014586754 | 26 – 115 | Interleukin-7Sequence analysisAdd BLAST | 90 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | Q5FBX5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104432, Expressed in sperm and 175 other tissues |
Interactioni
GO - Molecular functioni
- growth factor activity Source: InterPro
- interleukin-7 receptor binding Source: InterPro
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-7/IL-9 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000004451 |
HOGENOMi | CLU_129929_2_0_1 |
OrthoDBi | 1433958at2759 |
Family and domain databases
Gene3Di | 1.20.1250.50, 2 hits |
InterProi | View protein in InterPro IPR001181, IL-7 IPR018049, IL-7/IL-9_CS IPR038325, IL7_sf |
Pfami | View protein in Pfam PF01415, IL7, 1 hit |
PRINTSi | PR00435, INTERLEUKIN7 |
SMARTi | View protein in SMART SM00127, IL7, 1 hit |
PROSITEi | View protein in PROSITE PS00255, INTERLEUKIN_7_9, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q5FBX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD
60 70 80 90 100
SMKEIGSNCL NNEFNFFKRH ICDANKEENK SLKEQKKLND LCFLKRLLQE
110
IKTCWNKILM GTKEH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP13232 | IL7_HUMAN | Interleukin-7 | IL7 | 177 | Annotation score: | ||
A0A0A0MTG5 | A0A0A0MTG5_HUMAN | Interleukin-7 | IL7 | 159 | Annotation score: | ||
Q5FBY3 | Q5FBY3_HUMAN | Interleukin-7 | IL7 | 71 | Annotation score: | ||
Q5FBY6 | Q5FBY6_HUMAN | IL7 nirs variant 3 | IL7 | 37 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083837 Genomic DNA No translation available. AC100854 Genomic DNA No translation available. AB102893 mRNA Translation: BAD89422.1 |
RefSeqi | NP_001186817.1, NM_001199888.1 |
Genome annotation databases
Ensembli | ENST00000379113; ENSP00000368408; ENSG00000104432 |
GeneIDi | 3574 |
UCSCi | uc022awj.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083837 Genomic DNA No translation available. AC100854 Genomic DNA No translation available. AB102893 mRNA Translation: BAD89422.1 |
RefSeqi | NP_001186817.1, NM_001199888.1 |
3D structure databases
SMRi | Q5FBX5 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q5FBX5 |
Protocols and materials databases
Antibodypediai | 12401, 732 antibodies |
DNASUi | 3574 |
Genome annotation databases
Ensembli | ENST00000379113; ENSP00000368408; ENSG00000104432 |
GeneIDi | 3574 |
UCSCi | uc022awj.2, human |
Organism-specific databases
CTDi | 3574 |
EuPathDBi | HostDB:ENSG00000104432.12 |
HGNCi | HGNC:6023, IL7 |
OpenTargetsi | ENSG00000104432 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000004451 |
HOGENOMi | CLU_129929_2_0_1 |
OrthoDBi | 1433958at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3574, 8 hits in 838 CRISPR screens |
ChiTaRSi | IL7, human |
GenomeRNAii | 3574 |
Gene expression databases
Bgeei | ENSG00000104432, Expressed in sperm and 175 other tissues |
Family and domain databases
Gene3Di | 1.20.1250.50, 2 hits |
InterProi | View protein in InterPro IPR001181, IL-7 IPR018049, IL-7/IL-9_CS IPR038325, IL7_sf |
Pfami | View protein in Pfam PF01415, IL7, 1 hit |
PRINTSi | PR00435, INTERLEUKIN7 |
SMARTi | View protein in SMART SM00127, IL7, 1 hit |
PROSITEi | View protein in PROSITE PS00255, INTERLEUKIN_7_9, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5FBX5_HUMAN | |
Accessioni | Q5FBX5Primary (citable) accession number: Q5FBX5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |