Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 107 (12 Aug 2020)
Sequence version 1 (15 Mar 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Panton-Valentine Leucocidin F

Gene

lukF-PV

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Panton-Valentine Leucocidin FImported
Submitted name:
Panton-Valentine leukocidin chain FImported
Submitted name:
Panton-Valentine leukocidin chain F proteinImported
Submitted name:
Panton-valentine Leukocidin FImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lukF-PVImported
Synonyms:hlgB_1Imported, lukF- PVImported, LukPV-FImported, lukPV-FImported, lukPVFImported
ORF Names:NCTC6133_01921Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000255091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:5086

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501458675225 – 325Sequence analysisAdd BLAST301

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 308LeukocidinInterPro annotationAdd BLAST251

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aerolysin family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003963, Bi-component_toxin_staph
IPR016183, Leukocidin/Hemolysin_toxin
IPR036435, Leukocidin/porin_MspA_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07968, Leukocidin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01468, BICOMPNTOXIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56959, SSF56959, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01002, hlyII, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5FBD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIVKSSVV TSIALLLLSN TVDAAQHITP VSEKKVDDKI TLYKTTATSD
60 70 80 90 100
SDKLKISQIL TFNFIKDKSY DKDTLILKAA GNIYSGYTKP NPKDTISSQF
110 120 130 140 150
YWGSKYNISI NSDSNDSVNV VDYAPKNQNE EFQVQQTVGY SYGGDINISN
160 170 180 190 200
GLSGGGNGSK SFSETINYKQ ESYRTSLDKR TNFKKIGWDV EAHKIMNNGW
210 220 230 240 250
GPYGRDSYHS TYGNEMFLGS RQSNLNAGQN FLEYHKMPVL SRGNFNPEFI
260 270 280 290 300
GVLSRKQNAA KKSKITVTYQ REMDRYTNFW NQLHWIGNNY KDENRATHTS
310 320
IYEVDWENHT VKLIDTQSKE KNPMS
Length:325
Mass (Da):36,962
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1955C10D28DFCC4F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ993352 Genomic DNA Translation: ABK20316.1
EU368820 Genomic DNA Translation: ABY82077.1
EU368821 Genomic DNA Translation: ABY82079.1
FJ895584 Genomic DNA Translation: ACP43460.1
FJ895585 Genomic DNA Translation: ACP43462.1
FJ895586 Genomic DNA Translation: ACP43464.1
FJ821790 Genomic DNA Translation: ACV95995.1
FJ821791 Genomic DNA Translation: ACV95997.1
FJ821792 Genomic DNA Translation: ACV95999.1
FJ821793 Genomic DNA Translation: ACV96001.1
JN635504 Genomic DNA Translation: AEY80045.1
JN635505 Genomic DNA Translation: AEY80047.1
JN635506 Genomic DNA Translation: AEY80049.1
JN635507 Genomic DNA Translation: AEY80051.1
JN635508 Genomic DNA Translation: AEY80053.1
JN635509 Genomic DNA Translation: AEY80055.1
KF773712 Genomic DNA Translation: AHG99399.1
KF958030 Genomic DNA Translation: AHH31220.1
KF923964 Genomic DNA Translation: AHH31222.1
KM588922 Genomic DNA Translation: AIT97312.1
AB186917 Genomic DNA Translation: BAD89439.1
AB245448 Genomic DNA Translation: BAE94427.1
AB245449 Genomic DNA Translation: BAE94429.1
AB245450 Genomic DNA Translation: BAE94431.1
AB245451 Genomic DNA Translation: BAE94433.1
AB245452 Genomic DNA Translation: BAE94435.1
AB245453 Genomic DNA Translation: BAE94437.1
AB245454 Genomic DNA Translation: BAE94439.1
AB245455 Genomic DNA Translation: BAE94441.1
AB256036 Genomic DNA Translation: BAF34580.1
AB256037 Genomic DNA Translation: BAF34582.1
AB256038 Genomic DNA Translation: BAF34584.1
AB256039 Genomic DNA Translation: BAF34586.1
AB286959 Genomic DNA Translation: BAF63635.1
AB295470 Genomic DNA Translation: BAF76754.1
AB295471 Genomic DNA Translation: BAF76756.1
AB295472 Genomic DNA Translation: BAF76758.1
AB295473 Genomic DNA Translation: BAF76760.1
AB303645 Genomic DNA Translation: BAF93213.1
AB303646 Genomic DNA Translation: BAF93215.1
AB303647 Genomic DNA Translation: BAF93217.1
AB303648 Genomic DNA Translation: BAF93219.1
AB303649 Genomic DNA Translation: BAF93221.1
AB331244 Genomic DNA Translation: BAF97075.1
AB331245 Genomic DNA Translation: BAF97077.1
AB488779 Genomic DNA Translation: BAI22507.1
AB532024 Genomic DNA Translation: BAJ07317.1
AB532025 Genomic DNA Translation: BAJ07319.1
AB532026 Genomic DNA Translation: BAJ07321.1
AB532027 Genomic DNA Translation: BAJ07323.1
AB678712 Genomic DNA Translation: BAL14897.1
AB678713 Genomic DNA Translation: BAL14899.1
AB678714 Genomic DNA Translation: BAL14901.1
AB678715 Genomic DNA Translation: BAL14903.1
AB678716 Genomic DNA Translation: BAL14905.1
AB678717 Genomic DNA Translation: BAL14907.1
UHAP01000001 Genomic DNA Translation: SUK48343.1

Genome annotation databases

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1280.4848.peg.1363

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ993352 Genomic DNA Translation: ABK20316.1
EU368820 Genomic DNA Translation: ABY82077.1
EU368821 Genomic DNA Translation: ABY82079.1
FJ895584 Genomic DNA Translation: ACP43460.1
FJ895585 Genomic DNA Translation: ACP43462.1
FJ895586 Genomic DNA Translation: ACP43464.1
FJ821790 Genomic DNA Translation: ACV95995.1
FJ821791 Genomic DNA Translation: ACV95997.1
FJ821792 Genomic DNA Translation: ACV95999.1
FJ821793 Genomic DNA Translation: ACV96001.1
JN635504 Genomic DNA Translation: AEY80045.1
JN635505 Genomic DNA Translation: AEY80047.1
JN635506 Genomic DNA Translation: AEY80049.1
JN635507 Genomic DNA Translation: AEY80051.1
JN635508 Genomic DNA Translation: AEY80053.1
JN635509 Genomic DNA Translation: AEY80055.1
KF773712 Genomic DNA Translation: AHG99399.1
KF958030 Genomic DNA Translation: AHH31220.1
KF923964 Genomic DNA Translation: AHH31222.1
KM588922 Genomic DNA Translation: AIT97312.1
AB186917 Genomic DNA Translation: BAD89439.1
AB245448 Genomic DNA Translation: BAE94427.1
AB245449 Genomic DNA Translation: BAE94429.1
AB245450 Genomic DNA Translation: BAE94431.1
AB245451 Genomic DNA Translation: BAE94433.1
AB245452 Genomic DNA Translation: BAE94435.1
AB245453 Genomic DNA Translation: BAE94437.1
AB245454 Genomic DNA Translation: BAE94439.1
AB245455 Genomic DNA Translation: BAE94441.1
AB256036 Genomic DNA Translation: BAF34580.1
AB256037 Genomic DNA Translation: BAF34582.1
AB256038 Genomic DNA Translation: BAF34584.1
AB256039 Genomic DNA Translation: BAF34586.1
AB286959 Genomic DNA Translation: BAF63635.1
AB295470 Genomic DNA Translation: BAF76754.1
AB295471 Genomic DNA Translation: BAF76756.1
AB295472 Genomic DNA Translation: BAF76758.1
AB295473 Genomic DNA Translation: BAF76760.1
AB303645 Genomic DNA Translation: BAF93213.1
AB303646 Genomic DNA Translation: BAF93215.1
AB303647 Genomic DNA Translation: BAF93217.1
AB303648 Genomic DNA Translation: BAF93219.1
AB303649 Genomic DNA Translation: BAF93221.1
AB331244 Genomic DNA Translation: BAF97075.1
AB331245 Genomic DNA Translation: BAF97077.1
AB488779 Genomic DNA Translation: BAI22507.1
AB532024 Genomic DNA Translation: BAJ07317.1
AB532025 Genomic DNA Translation: BAJ07319.1
AB532026 Genomic DNA Translation: BAJ07321.1
AB532027 Genomic DNA Translation: BAJ07323.1
AB678712 Genomic DNA Translation: BAL14897.1
AB678713 Genomic DNA Translation: BAL14899.1
AB678714 Genomic DNA Translation: BAL14901.1
AB678715 Genomic DNA Translation: BAL14903.1
AB678716 Genomic DNA Translation: BAL14905.1
AB678717 Genomic DNA Translation: BAL14907.1
UHAP01000001 Genomic DNA Translation: SUK48343.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PVLX-ray2.00A25-325[»]
6U3FX-ray1.78A25-325[»]
6U3YX-ray2.04A25-325[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Genome annotation databases

PATRICifig|1280.4848.peg.1363

Miscellaneous databases

PHI-baseiPHI:5086

Family and domain databases

InterProiView protein in InterPro
IPR003963, Bi-component_toxin_staph
IPR016183, Leukocidin/Hemolysin_toxin
IPR036435, Leukocidin/porin_MspA_sf
PfamiView protein in Pfam
PF07968, Leukocidin, 1 hit
PRINTSiPR01468, BICOMPNTOXIN
SUPFAMiSSF56959, SSF56959, 1 hit
TIGRFAMsiTIGR01002, hlyII, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5FBD2_STAAU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5FBD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: August 12, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again