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Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei232NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 206ADPUniRule annotation5
Nucleotide bindingi222 – 231ADPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciNGON242231:G1FZ9-745-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrDUniRule annotation
Ordered Locus Names:NGO0804
OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Taxonomic identifieri242231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000535 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161461 – 296ADP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST296

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5F8G9
SMRiQ5F8G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 292YjeF C-terminalUniRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 171NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000024581
KOiK17758
OMAiLGMLCCH

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5F8G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPVFHLSGE SRRRMLQTAL RFPHVFKARA EDSHKGTFGT LAVVGGSAGM
60 70 80 90 100
SGAPVLAASA AMYLGCGKVR AGFNQDTLPF AVIAGFPEIM LDTADGLTKR
110 120 130 140 150
QGINAWTAGC GLGTDAAAVE TVAAVLARNR DEAVVLDADA LNILSTDAET
160 170 180 190 200
RNLARGCKNL ILTPHPAEAA RLLGTTVAQV QADRTAAVRK IGAILGATVV
210 220 230 240 250
LKGHKTLVAA SDTEIYVNES GNAGLATAGS GDVLGGIIGS LLAQGVPVFE
260 270 280 290
AACAGAWLHG AAADVIKESA GIAAGLSAGE IAPAARWLRN WITESM
Length:296
Mass (Da):30,241
Last modified:March 15, 2005 - v1
Checksum:i05E38075637EC2FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA Translation: AAW89518.1
RefSeqiWP_003688608.1, NC_002946.2
YP_207930.1, NC_002946.2

Genome annotation databases

EnsemblBacteriaiAAW89518; AAW89518; NGO_0804
GeneIDi3281980
KEGGingo:NGO0804
PATRICifig|242231.10.peg.951

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA Translation: AAW89518.1
RefSeqiWP_003688608.1, NC_002946.2
YP_207930.1, NC_002946.2

3D structure databases

ProteinModelPortaliQ5F8G9
SMRiQ5F8G9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW89518; AAW89518; NGO_0804
GeneIDi3281980
KEGGingo:NGO0804
PATRICifig|242231.10.peg.951

Phylogenomic databases

HOGENOMiHOG000024581
KOiK17758
OMAiLGMLCCH

Enzyme and pathway databases

BioCyciNGON242231:G1FZ9-745-MONOMER

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNRD_NEIG1
AccessioniPrimary (citable) accession number: Q5F8G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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