UniProtKB - Q5F416 (TIPIN_CHICK)
Protein
TIMELESS-interacting protein
Gene
TIPIN
Organism
Gallus gallus (Chicken)
Status
Functioni
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be required fin the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).By similarity
GO - Molecular functioni
- DNA binding Source: GO_Central
GO - Biological processi
- cell cycle phase transition Source: BHF-UCL
- cell division Source: UniProtKB-KW
- DNA replication checkpoint Source: UniProtKB
- intra-S DNA damage checkpoint Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- replication fork arrest Source: GO_Central
- replication fork protection Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, DNA damage, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: TIMELESS-interacting protein |
Gene namesi | Name:TIPIN ORF Names:RCJMB04_3n6 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- nuclear chromatin Source: UniProtKB
- nucleus Source: UniProtKB
- replication fork protection complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305256 | 1 – 283 | TIMELESS-interacting proteinAdd BLAST | 283 |
Proteomic databases
PaxDbi | Q5F416 |
Interactioni
Subunit structurei
Interacts with TIMELESS, which impairs TIMELESS self-association.
By similarityProtein-protein interaction databases
STRINGi | 9031.ENSGALP00000012365 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 74 – 150 | Interaction with TIMELESSBy similarityAdd BLAST | 77 |
Sequence similaritiesi
Belongs to the CSM3 family.Curated
Phylogenomic databases
eggNOGi | KOG3004, Eukaryota |
InParanoidi | Q5F416 |
OrthoDBi | 1505397at2759 |
PhylomeDBi | Q5F416 |
Family and domain databases
InterProi | View protein in InterPro IPR012923, Csm3 IPR040038, TIPIN/Csm3/Swi3 |
PANTHERi | PTHR13220, PTHR13220, 1 hit |
Pfami | View protein in Pfam PF07962, Swi3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5F416-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMIDPLENN LFDLPDYENT EDETFPPLPP PTSPGRGDAE WAQANGDPDG
60 70 80 90 100
NQQSETKDSS SAARKAVKRS IPKLDANRLV SERGLPALRH MFDNVKFKGK
110 120 130 140 150
GHEAEDLKTL LRHMEHWAHR LFPKLQFDDF IDRVESLGNK KEVQTCLKRI
160 170 180 190 200
RLDLPILHED FTANEGGGGE SNGLDMATEE VHSFSGNVGE LDSLPGTTLT
210 220 230 240 250
EEQQQRIKRN RQLALERRQA KMQCNSQSQH DELSPSYPEE ELNIPVARDL
260 270 280
TGALEDTQVT ATNVAVTETE DRERELQCAS EKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ851484 mRNA Translation: CAH65118.1 |
RefSeqi | NP_001012708.1, NM_001012690.1 |
Genome annotation databases
GeneIDi | 415548 |
KEGGi | gga:415548 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ851484 mRNA Translation: CAH65118.1 |
RefSeqi | NP_001012708.1, NM_001012690.1 |
3D structure databases
SMRi | Q5F416 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000012365 |
Proteomic databases
PaxDbi | Q5F416 |
Genome annotation databases
GeneIDi | 415548 |
KEGGi | gga:415548 |
Organism-specific databases
CTDi | 54962 |
Phylogenomic databases
eggNOGi | KOG3004, Eukaryota |
InParanoidi | Q5F416 |
OrthoDBi | 1505397at2759 |
PhylomeDBi | Q5F416 |
Miscellaneous databases
PROi | PR:Q5F416 |
Family and domain databases
InterProi | View protein in InterPro IPR012923, Csm3 IPR040038, TIPIN/Csm3/Swi3 |
PANTHERi | PTHR13220, PTHR13220, 1 hit |
Pfami | View protein in Pfam PF07962, Swi3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIPIN_CHICK | |
Accessioni | Q5F416Primary (citable) accession number: Q5F416 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | March 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families