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Protein

14-3-3 protein gamma

Gene

YWHAG

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein gamma
Gene namesi
Name:YWHAG
ORF Names:RCJMB04_5e12
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000586111 – 24714-3-3 protein gammaAdd BLAST247

Proteomic databases

PaxDbiQ5F3W6
PRIDEiQ5F3W6

Interactioni

Subunit structurei

Homodimer, and heterodimer with other family members.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interaction with phosphoserine on interacting proteinBy similarity1
Sitei132Interaction with phosphoserine on interacting proteinBy similarity1

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1635853,EBI-1635766

GO - Molecular functioni

Protein-protein interaction databases

BioGridi687033, 2 interactors
IntActiQ5F3W6, 1 interactor
STRINGi9031.ENSGALP00000027989

Structurei

3D structure databases

ProteinModelPortaliQ5F3W6
SMRiQ5F3W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
HOGENOMiHOG000240379
HOVERGENiHBG050423
InParanoidiQ5F3W6
KOiK16198
PhylomeDBiQ5F3W6

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5F3W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELGAVCQDV
110 120 130 140 150
LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS
160 170 180 190 200
EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
Length:247
Mass (Da):28,231
Last modified:March 15, 2005 - v1
Checksum:i86E57A78A1D6455F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851534 mRNA Translation: CAH65168.1
RefSeqiNP_001026648.1, NM_001031477.1
UniGeneiGga.9354

Genome annotation databases

GeneIDi427820
KEGGigga:427820

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851534 mRNA Translation: CAH65168.1
RefSeqiNP_001026648.1, NM_001031477.1
UniGeneiGga.9354

3D structure databases

ProteinModelPortaliQ5F3W6
SMRiQ5F3W6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi687033, 2 interactors
IntActiQ5F3W6, 1 interactor
STRINGi9031.ENSGALP00000027989

Proteomic databases

PaxDbiQ5F3W6
PRIDEiQ5F3W6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi427820
KEGGigga:427820

Organism-specific databases

CTDi7532

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
HOGENOMiHOG000240379
HOVERGENiHBG050423
InParanoidiQ5F3W6
KOiK16198
PhylomeDBiQ5F3W6

Miscellaneous databases

PROiPR:Q5F3W6

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1433G_CHICK
AccessioniPrimary (citable) accession number: Q5F3W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 15, 2005
Last modified: July 18, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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