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Entry version 76 (11 Dec 2019)
Sequence version 2 (24 Jul 2007)
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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

PDS5A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDS5ABy similarity
ORF Names:RCJMB04_6f4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002963441 – 1330Sister chromatid cohesion protein PDS5 homolog AAdd BLAST1330

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5F3V3

PRoteomics IDEntifications database

More...
PRIDEi
Q5F3V3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cohesin complex. Binds chromatin in a cohesin-dependent manner (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000023059

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5F3V3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati387 – 423HEATSequence analysisAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1525 Eukaryota
ENOG410XQW7 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230672

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5F3V3

KEGG Orthology (KO)

More...
KOi
K11267

Database of Orthologous Groups

More...
OrthoDBi
69768at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5F3V3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039776 Pds5

The PANTHER Classification System

More...
PANTHERi
PTHR12663 PTHR12663, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5F3V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFPAAQPKP AADGKIIYYP PGVKETTDKI TNDEVVKRLK MVVKTFMDMD
60 70 80 90 100
QDSEDEKQQY LPLALHLASE FFLRNPNKDV RLLVACCLAD IFRIYAPEAP
110 120 130 140 150
YTSHDKLKDI FLFITRQLKG LEDTKSPQFN RYFYLLENLA WVKSYNICFE
160 170 180 190 200
LEDCNEIFIQ LFRTLFSVIN NSHNQKVQMH MLDLMSSIIM EGDGVTQELL
210 220 230 240 250
DSILINLIPA HKNLNKQAFD LAKVLLKRTV QTIEPCIANF FNQVLVLGKS
260 270 280 290 300
SVSDLSEHVF DLILELFAID PHLLLSVMPQ LEFKLKSNDG EERLAVVRLL
310 320 330 340 350
AKLFGSKDSD LATQNRPLWQ CFLGRFNDIH VPVRLESVKF ASHCLMNHPD
360 370 380 390 400
LAKDLTEYLK VRSHDPEEAI RHDVIVTIIT AGKRDLSLVN DQLLGFVRER
410 420 430 440 450
TLDKRWRVRK EAMMGLAQLY KKYCLHAEAG KDAAEKVSWI KDKLLHIYYQ
460 470 480 490 500
NSIDDKLLVE KIFAQYLVPH NLETEERMKC LYYLYASLDP NAVKALNEMW
510 520 530 540 550
KCQNMLRSHV RELLDLHKQP TSEANSAAMF GKLMTIAKNL PDPGKAQDFV
560 570 580 590 600
KKFNQVLGDD EKLRSQLELL ISPTCSCKQA DVCVREIARK LANPKQPTNP
610 620 630 640 650
FLEMVKFLLE RIAPVHIDSE AISALVKLMN KSIEGTADDE EEGVSPDTAI
660 670 680 690 700
RAGLELLKVL SFTHPTSFHS AETYESLLQC LRMEDDKVAE AAIQIFRNTG
710 720 730 740 750
HKIETDLPQI RSTLIPILHQ KAKRGTPHQA KQAVHCIHAI FSNKEVQLAQ
760 770 780 790 800
IFEPLSRSLN ADVPEQLITP LVSLGHISML APDQFASPMK SVVANFVVKD
810 820 830 840 850
LLMNDRSTGE KNGKLWSPDE EVSPEVLAKV QAIKLLVRWL LGMKNNQSKS
860 870 880 890 900
ANSTLRLLSA MLVSEGDLTE QKRISKSDMS RLRLAAGSAI MKLAQEPCYH
910 920 930 940 950
EIITPEQFQL CALVINDECY QVRQIFAQKL HKALVKLLLP LEYMAIFALC
960 970 980 990 1000
AKDPVKERRA HARQCLLKNI SIRREYIKQN PMANEKLLSL LPEYVVPYMI
1010 1020 1030 1040 1050
HLLAHDPDFT KPQDVDQLRD VKECLWFMLE VLMTKNENNS HAFMKKMAEN
1060 1070 1080 1090 1100
IKLTRDAQSP DEPKANEKLY TVCDVALCVI NSKSALCNAD SPKDPVLPTK
1110 1120 1130 1140 1150
FFTQPEKDFS NDRNYISEET RVLLLTGKPK PTGVLDTVNK PLSATGRRPY
1160 1170 1180 1190 1200
IRTTGSETGS NISVNSELSS SAGNRSREQS SDISETGVSE NDENPVRIIS
1210 1220 1230 1240 1250
VTPAKTEPVK NKEINSDQAT QGNSTERGKK RTATASGTEN IHQKAEENNA
1260 1270 1280 1290 1300
DETGPSLAAK TRRGRPPKPE PQGTTAKNEE TNKPPVRGRK RAAASQESPG
1310 1320 1330
SLEAGNAKAP KQQDTAKKPA AAQRQIDLQR
Length:1,330
Mass (Da):150,132
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0241C02AEF8C1AF4
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH65181 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ851547 mRNA Translation: CAH65181.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001012598.1, NM_001012580.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
422787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:422787

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851547 mRNA Translation: CAH65181.1 Different initiation.
RefSeqiNP_001012598.1, NM_001012580.1

3D structure databases

SMRiQ5F3V3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023059

Proteomic databases

PaxDbiQ5F3V3
PRIDEiQ5F3V3

Genome annotation databases

GeneIDi422787
KEGGigga:422787

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23244

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
HOGENOMiHOG000230672
InParanoidiQ5F3V3
KOiK11267
OrthoDBi69768at2759
PhylomeDBiQ5F3V3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5F3V3

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDS5A_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5F3V3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 11, 2019
This is version 76 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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