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Entry version 101 (02 Dec 2020)
Sequence version 1 (15 Mar 2005)
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Protein

Histone-lysine N-methyltransferase SETD1B

Gene

SETD1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.354By similarity)
Alternative name(s):
SET domain-containing protein 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SETD1B
ORF Names:RCJMB04_10j6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003169951 – 2008Histone-lysine N-methyltransferase SETD1BAdd BLAST2008

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5F3P8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000038427

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 199RRMPROSITE-ProRule annotationAdd BLAST89
Domaini1869 – 1986SETPROSITE-ProRule annotationAdd BLAST118
Domaini1992 – 2008Post-SETPROSITE-ProRule annotationAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi674 – 748Pro-richAdd BLAST75
Compositional biasi1010 – 1271Glu-richAdd BLAST262
Compositional biasi1504 – 1609Pro-richAdd BLAST106

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1080, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5F3P8

Database of Orthologous Groups

More...
OrthoDBi
1234689at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5F3P8

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12549, RRM_Set1B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B

The PANTHER Classification System

More...
PANTHERi
PTHR45814:SF1, PTHR45814:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5F3P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFREIKAGE KAKHPEDHGK KQSSSWINGM ENSTQASTSV EKRNHHWRSY
60 70 80 90 100
KLIIDPALKK GQHKLYRYDG QHFSMPNSGI APVDCVRDPR IGRIWTKTKE
110 120 130 140 150
LELSVPKFKI DEFYVGPVPP KQVTFAKLND NIRENFLTDM CKKYGEVEEV
160 170 180 190 200
EILYNPKNKK HLGIAKVIFA TVKGAREAVQ HLHNTSVMGN IIHVELDTKG
210 220 230 240 250
ETRMRFYELL VNGLYTPQTL PVGTEQDASP TVNETLQLTD SLKRLKDSNL
260 270 280 290 300
SSVGSSVTPN SSTPFSHDTA YSSCRQDTPN SFSQFTPQSQ GTPHTPRLGT
310 320 330 340 350
PFSQDSTYSS RQTTPVYHFG QDSGYKHRRH ETKFTDAYNR RPGGHHYVHN
360 370 380 390 400
SPGVFRGTEH QFSTFKSHQQ EPVQFSHTPP LSHSSSSSYK SAFSPYQAPA
410 420 430 440 450
VFPQSEEQPF AQTSREAEYR RPAPPPAEMV VESSAATSAD FAPVKEKPEE
460 470 480 490 500
PPPLPDSNSA PEPSAPSFSQ TPERSETPGT PTMESEMQHN SLDSRIEMLL
510 520 530 540 550
KEQRTKLPFL NEHDSDNEVR MEGSPISSSS SQLSPIPMYG SNSQPGYRAQ
560 570 580 590 600
TPSSRPSSTG LEDISPTPLP DSDDDEPIPG TASLNQNSRG TSEASMTPID
610 620 630 640 650
QLNRASKVET LEVKEMVPGD QTPTSEKMDE SQHSSGEDME ISDDEMNSAP
660 670 680 690 700
ITSAECAKTI VVNSSVSNAA VMAPSIPPLP PPPGFPPLPP PPPPPPQPAF
710 720 730 740 750
PMPPPLPPPP PPTHPAVTVP PPPLPAPPGV PPPHILPPLP PFHPGMFPVM
760 770 780 790 800
QVDMISVLGN HWGGMPMSFQ MQTQMLSRMM QAQNTYQYPP FMGGRMQFVN
810 820 830 840 850
LPPYRPFSMG AARGRGQQWP PLPKFDPSVP PPGYEPKKED PHKATVDGVL
860 870 880 890 900
LVIVKELKAI MKRDLNRKMV EVVAFRAFDD WWDKKERLAK ASLTPVKSGG
910 920 930 940 950
ELEEKPKPKD RITSCLLENW NKGEGLGYEG IGLGIGLRGA IRLPSFKVKR
960 970 980 990 1000
KEPPEAASAG DQKRIRPSTS VDDEDEESER DRDASDTTSD LSKKDAEAVG
1010 1020 1030 1040 1050
LRRRPARPLE LDSEGEEGDE TSGKEEESSS EKEEEQEEEG GLVKAAPGKE
1060 1070 1080 1090 1100
EEEDEDDEED EDDDEDEEDE EDYEETGVET SDKEEEQDSE EEDAASPSSS
1110 1120 1130 1140 1150
KAEVESSDES EDSSEFESSS DSDEDDDEEE EEEEDEEEEE EEEVAEDQDR
1160 1170 1180 1190 1200
EAMVAETEHE PASHELPDDK RETILELYPV DYMDATGLGL SEPALVEKDE
1210 1220 1230 1240 1250
GMEEVKAEES ECDQVPEESI AAETLKQLVM ERDQETKLAL SPICRPVEEP
1260 1270 1280 1290 1300
EPIVMLEPEV QECPKPESQD EAGTVCLSTP VAVFGEARPS KSSFFSKSDD
1310 1320 1330 1340 1350
SCLETHVKTK LPSAVEEEDR LPRTPGREVV VHSETDILLL PAHKVPSSTV
1360 1370 1380 1390 1400
PLPSTPGKEE SVVPPEKFPE QLMVTKTSIE EEIPRTPGRD ILAKSSHPLG
1410 1420 1430 1440 1450
KSQSTDTVPA TPGSDAPLTG SSLTLSSPQV PGSPFSYPSQ SPGINSGIPR
1460 1470 1480 1490 1500
TPGRDFNFTP TFPEAGATIP CLLSGKKQSE DDLDEKPFKE PLGASLTISM
1510 1520 1530 1540 1550
NSVPSPIPFA SPTQADFRTD MGLPPNEPIP IAALPCIPGD GRMPIEECKA
1560 1570 1580 1590 1600
EVKSVLLSPE APVGASILPP PPPHSVLPKR RPGRPRRSPP SVLSLDMYSG
1610 1620 1630 1640 1650
KTIEPPPVPV ALVESAMSKE LLSAHPDAFY GLKDPEAVTL DFRNDSFHEK
1660 1670 1680 1690 1700
IAAETVAEKL PFKELENQWN EDFKEEEAHA KPKRQWRRQK KSPEHLPVIP
1710 1720 1730 1740 1750
SPEYSPPQPQ FRPRSEFEEM TILYDIWNGG IDEEDIKFMC ITYDRLLQQD
1760 1770 1780 1790 1800
NGMDWLNDTL WVFHPSTSFS TPKKKKRDDG MREHVTGCAR SEGYYKIDKK
1810 1820 1830 1840 1850
DKLKYLNNSR AFAEEPPADT QGMSIPAQPH ASTRAGSERR SEQRRLLSSF
1860 1870 1880 1890 1900
TGSCDSDLLK FNQLKFRKKK LKFCKSHIHD WGLFAMEPIA ADEMVIEYVG
1910 1920 1930 1940 1950
QNIRQVIADM REKRYEDEGI GSSYMFRVDH DTIIDATKCG NFARFINHSC
1960 1970 1980 1990 2000
NPNCYAKVIT VESQKKIVIY SKQHINVNEE ITYDYKFPIE DVKIPCLCGS

ENCRGTLN
Length:2,008
Mass (Da):223,085
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A1CD3C9279D614C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ851602 mRNA Translation: CAH65236.1

NCBI Reference Sequences

More...
RefSeqi
NP_001025832.1, NM_001030661.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
416851

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:416851

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851602 mRNA Translation: CAH65236.1
RefSeqiNP_001025832.1, NM_001030661.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038427

Proteomic databases

PaxDbiQ5F3P8

Genome annotation databases

GeneIDi416851
KEGGigga:416851

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9739

Phylogenomic databases

eggNOGiKOG1080, Eukaryota
InParanoidiQ5F3P8
OrthoDBi1234689at2759
PhylomeDBiQ5F3P8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5F3P8

Family and domain databases

CDDicd12549, RRM_Set1B, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B
PANTHERiPTHR45814:SF1, PTHR45814:SF1, 1 hit
PfamiView protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET1B_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5F3P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 15, 2005
Last modified: December 2, 2020
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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