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UniProtKB - Q5F3P8 (SET1B_CHICK)

Entry version 101 (02 Dec 2020)
Sequence version 1 (15 Mar 2005)
Previous versions | rss
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Protein

Histone-lysine N-methyltransferase SETD1B

Gene

SETD1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.354By similarity)
Alternative name(s):
SET domain-containing protein 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SETD1B
ORF Names:RCJMB04_10j6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003169951 – 2008Histone-lysine N-methyltransferase SETD1BAdd BLAST2008

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5F3P8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9031.ENSGALP00000038427

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 199RRMPROSITE-ProRule annotationAdd BLAST89
Domaini1869 – 1986SETPROSITE-ProRule annotationAdd BLAST118
Domaini1992 – 2008Post-SETPROSITE-ProRule annotationAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi674 – 748Pro-richAdd BLAST75
Compositional biasi1010 – 1271Glu-richAdd BLAST262
Compositional biasi1504 – 1609Pro-richAdd BLAST106

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1080, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5F3P8

Database of Orthologous Groups

More...OrthoDBi		1234689at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5F3P8

Family and domain databases

Conserved Domains Database

More...CDDi		cd12549, RRM_Set1B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B

The PANTHER Classification System

More...PANTHERi		PTHR45814:SF1, PTHR45814:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5F3P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFREIKAGE KAKHPEDHGK KQSSSWINGM ENSTQASTSV EKRNHHWRSY 
        60         70         80         90        100
KLIIDPALKK GQHKLYRYDG QHFSMPNSGI APVDCVRDPR IGRIWTKTKE 
       110        120        130        140        150
LELSVPKFKI DEFYVGPVPP KQVTFAKLND NIRENFLTDM CKKYGEVEEV 
       160        170        180        190        200
EILYNPKNKK HLGIAKVIFA TVKGAREAVQ HLHNTSVMGN IIHVELDTKG 
       210        220        230        240        250
ETRMRFYELL VNGLYTPQTL PVGTEQDASP TVNETLQLTD SLKRLKDSNL 
       260        270        280        290        300
SSVGSSVTPN SSTPFSHDTA YSSCRQDTPN SFSQFTPQSQ GTPHTPRLGT 
       310        320        330        340        350
PFSQDSTYSS RQTTPVYHFG QDSGYKHRRH ETKFTDAYNR RPGGHHYVHN 
       360        370        380        390        400
SPGVFRGTEH QFSTFKSHQQ EPVQFSHTPP LSHSSSSSYK SAFSPYQAPA 
       410        420        430        440        450
VFPQSEEQPF AQTSREAEYR RPAPPPAEMV VESSAATSAD FAPVKEKPEE 
       460        470        480        490        500
PPPLPDSNSA PEPSAPSFSQ TPERSETPGT PTMESEMQHN SLDSRIEMLL 
       510        520        530        540        550
KEQRTKLPFL NEHDSDNEVR MEGSPISSSS SQLSPIPMYG SNSQPGYRAQ 
       560        570        580        590        600
TPSSRPSSTG LEDISPTPLP DSDDDEPIPG TASLNQNSRG TSEASMTPID 
       610        620        630        640        650
QLNRASKVET LEVKEMVPGD QTPTSEKMDE SQHSSGEDME ISDDEMNSAP 
       660        670        680        690        700
ITSAECAKTI VVNSSVSNAA VMAPSIPPLP PPPGFPPLPP PPPPPPQPAF 
       710        720        730        740        750
PMPPPLPPPP PPTHPAVTVP PPPLPAPPGV PPPHILPPLP PFHPGMFPVM 
       760        770        780        790        800
QVDMISVLGN HWGGMPMSFQ MQTQMLSRMM QAQNTYQYPP FMGGRMQFVN 
       810        820        830        840        850
LPPYRPFSMG AARGRGQQWP PLPKFDPSVP PPGYEPKKED PHKATVDGVL 
       860        870        880        890        900
LVIVKELKAI MKRDLNRKMV EVVAFRAFDD WWDKKERLAK ASLTPVKSGG 
       910        920        930        940        950
ELEEKPKPKD RITSCLLENW NKGEGLGYEG IGLGIGLRGA IRLPSFKVKR 
       960        970        980        990       1000
KEPPEAASAG DQKRIRPSTS VDDEDEESER DRDASDTTSD LSKKDAEAVG 
      1010       1020       1030       1040       1050
LRRRPARPLE LDSEGEEGDE TSGKEEESSS EKEEEQEEEG GLVKAAPGKE 
      1060       1070       1080       1090       1100
EEEDEDDEED EDDDEDEEDE EDYEETGVET SDKEEEQDSE EEDAASPSSS 
      1110       1120       1130       1140       1150
KAEVESSDES EDSSEFESSS DSDEDDDEEE EEEEDEEEEE EEEVAEDQDR 
      1160       1170       1180       1190       1200
EAMVAETEHE PASHELPDDK RETILELYPV DYMDATGLGL SEPALVEKDE 
      1210       1220       1230       1240       1250
GMEEVKAEES ECDQVPEESI AAETLKQLVM ERDQETKLAL SPICRPVEEP 
      1260       1270       1280       1290       1300
EPIVMLEPEV QECPKPESQD EAGTVCLSTP VAVFGEARPS KSSFFSKSDD 
      1310       1320       1330       1340       1350
SCLETHVKTK LPSAVEEEDR LPRTPGREVV VHSETDILLL PAHKVPSSTV 
      1360       1370       1380       1390       1400
PLPSTPGKEE SVVPPEKFPE QLMVTKTSIE EEIPRTPGRD ILAKSSHPLG 
      1410       1420       1430       1440       1450
KSQSTDTVPA TPGSDAPLTG SSLTLSSPQV PGSPFSYPSQ SPGINSGIPR 
      1460       1470       1480       1490       1500
TPGRDFNFTP TFPEAGATIP CLLSGKKQSE DDLDEKPFKE PLGASLTISM 
      1510       1520       1530       1540       1550
NSVPSPIPFA SPTQADFRTD MGLPPNEPIP IAALPCIPGD GRMPIEECKA 
      1560       1570       1580       1590       1600
EVKSVLLSPE APVGASILPP PPPHSVLPKR RPGRPRRSPP SVLSLDMYSG 
      1610       1620       1630       1640       1650
KTIEPPPVPV ALVESAMSKE LLSAHPDAFY GLKDPEAVTL DFRNDSFHEK 
      1660       1670       1680       1690       1700
IAAETVAEKL PFKELENQWN EDFKEEEAHA KPKRQWRRQK KSPEHLPVIP 
      1710       1720       1730       1740       1750
SPEYSPPQPQ FRPRSEFEEM TILYDIWNGG IDEEDIKFMC ITYDRLLQQD 
      1760       1770       1780       1790       1800
NGMDWLNDTL WVFHPSTSFS TPKKKKRDDG MREHVTGCAR SEGYYKIDKK 
      1810       1820       1830       1840       1850
DKLKYLNNSR AFAEEPPADT QGMSIPAQPH ASTRAGSERR SEQRRLLSSF 
      1860       1870       1880       1890       1900
TGSCDSDLLK FNQLKFRKKK LKFCKSHIHD WGLFAMEPIA ADEMVIEYVG 
      1910       1920       1930       1940       1950
QNIRQVIADM REKRYEDEGI GSSYMFRVDH DTIIDATKCG NFARFINHSC 
      1960       1970       1980       1990       2000
NPNCYAKVIT VESQKKIVIY SKQHINVNEE ITYDYKFPIE DVKIPCLCGS 

ENCRGTLN
Length:2,008
Mass (Da):223,085
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A1CD3C9279D614C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ851602 mRNA Translation: CAH65236.1

NCBI Reference Sequences

More...RefSeqi		NP_001025832.1, NM_001030661.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		416851

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		gga:416851

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851602 mRNA Translation: CAH65236.1
RefSeqiNP_001025832.1, NM_001030661.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038427

Proteomic databases

PaxDbiQ5F3P8

Genome annotation databases

GeneIDi416851
KEGGigga:416851

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9739

Phylogenomic databases

eggNOGiKOG1080, Eukaryota
InParanoidiQ5F3P8
OrthoDBi1234689at2759
PhylomeDBiQ5F3P8

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q5F3P8

Family and domain databases

CDDicd12549, RRM_Set1B, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B
PANTHERiPTHR45814:SF1, PTHR45814:SF1, 1 hit
PfamiView protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET1B_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5F3P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 15, 2005
Last modified: December 2, 2020
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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