UniProtKB - Q5F364 (MRP1_CHICK)
Protein
Multidrug resistance-associated protein 1
Gene
ABCC1
Organism
Gallus gallus (Chicken)
Status
Functioni
Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 675 – 682 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1321 – 1328 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type xenobiotic transporter activity Source: GO_Central
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- glutathione transmembrane transporter activity Source: GO_Central
GO - Biological processi
- glutathione transmembrane transport Source: GO_Central
- transmembrane transport Source: GO_Central
- xenobiotic transport Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance-associated protein 1Alternative name(s): ATP-binding cassette sub-family C member 1 Leukotriene C(4) transporter Short name: LTC4 transporter |
Gene namesi | Name:ABCC1 Synonyms:MRP1 ORF Names:RCJMB04_32d20 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | ExtracellularBy similarityAdd BLAST | 33 | |
Transmembranei | 34 – 54 | Helical; Name=1PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 55 – 74 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 75 – 95 | Helical; Name=2PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 96 – 100 | ExtracellularBy similarity | 5 | |
Transmembranei | 101 – 121 | Helical; Name=3PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 122 – 133 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 134 – 154 | Helical; Name=4PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 155 – 172 | ExtracellularBy similarityAdd BLAST | 18 | |
Transmembranei | 173 – 193 | Helical; Name=5PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 194 – 315 | CytoplasmicBy similarityAdd BLAST | 122 | |
Transmembranei | 316 – 336 | Helical; Name=6PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 337 – 362 | ExtracellularBy similarityAdd BLAST | 26 | |
Transmembranei | 363 – 383 | Helical; Name=7PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 384 – 439 | CytoplasmicBy similarityAdd BLAST | 56 | |
Transmembranei | 440 – 460 | Helical; Name=8PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 461 – 463 | ExtracellularBy similarity | 3 | |
Transmembranei | 464 – 484 | Helical; Name=9PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 485 – 546 | CytoplasmicBy similarityAdd BLAST | 62 | |
Transmembranei | 547 – 567 | Helical; Name=10PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 568 – 589 | ExtracellularBy similarityAdd BLAST | 22 | |
Transmembranei | 590 – 610 | Helical; Name=11PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 611 – 961 | CytoplasmicBy similarityAdd BLAST | 351 | |
Transmembranei | 962 – 982 | Helical; Name=12PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 983 – 1019 | ExtracellularBy similarityAdd BLAST | 37 | |
Transmembranei | 1020 – 1040 | Helical; Name=13PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1041 – 1083 | CytoplasmicBy similarityAdd BLAST | 43 | |
Transmembranei | 1084 – 1104 | Helical; Name=14PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1105 | ExtracellularBy similarity | 1 | |
Transmembranei | 1106 – 1126 | Helical; Name=15PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1127 – 1197 | CytoplasmicBy similarityAdd BLAST | 71 | |
Transmembranei | 1198 – 1218 | Helical; Name=16PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1219 – 1220 | ExtracellularBy similarity | 2 | |
Transmembranei | 1221 – 1241 | Helical; Name=17PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1242 – 1525 | CytoplasmicBy similarityAdd BLAST | 284 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093355 | 1 – 1525 | Multidrug resistance-associated protein 1Add BLAST | 1525 |
Proteomic databases
PaxDbi | Q5F364 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 324 – 607 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 284 | |
Domaini | 641 – 865 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 225 | |
Domaini | 969 – 1250 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 282 | |
Domaini | 1289 – 1521 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 233 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
InParanoidi | Q5F364 |
PhylomeDBi | Q5F364 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR005292, Multidrug-R_assoc IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
TIGRFAMsi | TIGR00957, MRP_assoc_pro, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q5F364-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGIESLCSAD ASEPFWDWNL TWHTENPDFT QCFQNTVLVW VPCIYLWVCF
60 70 80 90 100
PAYFLYLRSH DRGYIQMSIL NKAKTALGLI LWIVCWADLF YSFWERSQNI
110 120 130 140 150
FRAPFFLISP TVLGITMLLA TFLIQHERLK GVQSSGVMMI FWLISLLCAT
160 170 180 190 200
VIFRSKIMLA LNTDTEVDAF RYVTFCTYFI LLLVQLILSC FPEKPPLFSE
210 220 230 240 250
AVNDPKPCPE FSASFLSRIT FWWITGLMIQ GHRRPLEAKD LWSLNKEDTS
260 270 280 290 300
EEIVPGLAKN WAKEWAKTKR QPLNMLYSSK KQQKSSDSNG EVMEEAEALI
310 320 330 340 350
IKPSQRSSEA SLSKVLYKTF GPYFLMSFLF KAAHDLLMFT GPEILKLLIN
360 370 380 390 400
FVNNKSAPNW QGYFYTGLLF VCACLQTLIL HQYFHICFVT GMRLKTAIVG
410 420 430 440 450
VIYRKALVIT NSARKTSTVG EIVNLMSVDA QRFMDLATYI NMIWSAPLQV
460 470 480 490 500
ILALYLLWRN LGPSVLAGVA VMILLVPINA VMAMKTKTYQ VAQMKSKDNR
510 520 530 540 550
IKLMNEILNG IKVLKLYAWE LAFREKVLEI RQKELKVLKK SAYLAAMGTF
560 570 580 590 600
TWVCAPFLVA LSTFAVYVKV NKNNILDAQK AFVSLALFNI LRFPLNILPM
610 620 630 640 650
VISSIVEASV SLKRLRVFLS HEELDPDSII RGPITNAEGS IVVKNATFSW
660 670 680 690 700
SKTDPPSLNS INFTVPEGSL IAVVGQVGCG KSSLLSALLG EMDKKEGYVV
710 720 730 740 750
VKGSIAYVPQ QAWIQNATLE DNIIFGREMN ESRYKRVIEA CALLPDLEIL
760 770 780 790 800
PMGDRTEIGE KGVNLSGGQK QRVSLARAVY CNADTYLFDD PLSAVDAHVG
810 820 830 840 850
KHIFEKVIGP KGILKNKTRV LVTHAVNYLP QMDTILVMTD GEISEMGSYQ
860 870 880 890 900
ELLKQDGAFA EFLRTYANAE QSMESSDASS PSGKEGKPVE NGVLVNDATG
910 920 930 940 950
KLMHRQLSNS STYSRETGKS QHQSSTAELQ KPLAEKNSWK LTEADTAKTG
960 970 980 990 1000
RVKATVYWEY MKAIGLYISF LSVFLFMCNH IASLASNYWL SLWTDDPVVN
1010 1020 1030 1040 1050
GTQQYTNVRL GVYGALGISQ GIAVFGYSMA VSIGGIFASR HLHLDLLHNV
1060 1070 1080 1090 1100
LRSPMSFFER TPSGNLVSRF SKEIDTIDST IPPIIKMFMG STFNVIGACI
1110 1120 1130 1140 1150
IILLATPIAA VVIPPLGLVY LLVQRFYVAT SRQLKRLESV SRSPVYSHFN
1160 1170 1180 1190 1200
ETLLGVSVIR AFEEQKRFIK QNDMKVDENQ KAYYPSIVAN RWLAVRLEFV
1210 1220 1230 1240 1250
GNCIVLFAAL FAVIARNKLS PGLIGLSVSY SLQITAYLNW LVRMTSDLET
1260 1270 1280 1290 1300
NIVAVERVKE YAEMEKEAEW SIEETAPAST WPQEGKVEFR GFGLRYREDL
1310 1320 1330 1340 1350
DLVLKNINIT INGGEKVGIV GRTGAGKSSL TLGLFRINEA AEGEIIIDGI
1360 1370 1380 1390 1400
NIAKIGLHDL RFKITIIPQD PILFSGSLRM NLDPFDQHSD EDIWRSLELA
1410 1420 1430 1440 1450
HLKNFVSSLP DKLNHECSEG GENLSVGQRQ LVCLARALLR KSKILVLDEA
1460 1470 1480 1490 1500
TAAVDLETDN LIQSTIKSQF EECTVLTIAH RLNTIMDYTR VLVLDRGEVV
1510 1520
ECDSPDNLLQ AKGLFYSMAK DSGLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ851786 mRNA Translation: CAH65420.1 |
RefSeqi | NP_001012540.1, NM_001012522.1 |
Genome annotation databases
GeneIDi | 395416 |
KEGGi | gga:395416 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ851786 mRNA Translation: CAH65420.1 |
RefSeqi | NP_001012540.1, NM_001012522.1 |
3D structure databases
SMRi | Q5F364 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000010735 |
Proteomic databases
PaxDbi | Q5F364 |
Genome annotation databases
GeneIDi | 395416 |
KEGGi | gga:395416 |
Organism-specific databases
CTDi | 4363 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
InParanoidi | Q5F364 |
PhylomeDBi | Q5F364 |
Miscellaneous databases
PROi | PR:Q5F364 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR005292, Multidrug-R_assoc IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
TIGRFAMsi | TIGR00957, MRP_assoc_pro, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MRP1_CHICK | |
Accessioni | Q5F364Primary (citable) accession number: Q5F364 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | March 15, 2005 | |
Last modified: | April 7, 2021 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families