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Protein

Alpha-(1,3)-fucosyltransferase 10

Gene

fut10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable fucosyltransferase.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 10 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase X
Short name:
Fuc-TX
Short name:
FucT-X
Galactoside 3-L-fucosyltransferase 10
Short name:
Fucosyltransferase 10
Gene namesi
Name:fut10
ORF Names:zgc:195147
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-081022-183 fut10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 458LumenalSequence analysisAdd BLAST426

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990061 – 458Alpha-(1,3)-fucosyltransferase 10Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5F2N3

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000042310

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000006538
HOVERGENiHBG055521
InParanoidiQ5F2N3
KOiK09669
PhylomeDBiQ5F2N3

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR017176 Alpha-1_3-FUT_met
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit
PIRSFiPIRSF037332 Alpha1_3FUT_met, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5F2N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRISVKKLC SFCLCACAFA FLVMTFQVIE LLGQFEQTEH RQQIKRFEDI
60 70 80 90 100
KVQANAHVSD VQYPVIVWWS PLTGELGRLG ECGHNRCFFT VNKSYYSHPQ
110 120 130 140 150
TKAFLFYGTD FSIESLPLPR HKQHQWALFH EESPKNNYKL FHKPLITQFN
160 170 180 190 200
HTATFSRHSH LPLTTQHLED INTLTAQTHL LPLSYKNHLR QTLAPVVYVQ
210 220 230 240 250
SDCDPPSDRD TYIRELMQHI QVDSYGQCLH NKDLPPHLRD STAMDDQDFY
260 270 280 290 300
KILAQYKFIL AFENAVCDDY ITEKLWRPLK LGVVPVYYGA PNIHMWLPDN
310 320 330 340 350
QSAIVVNPNE PPKKLAQYLK RLDKNDWEYL KYLEWKHKRE ITNINLLKEL
360 370 380 390 400
KERPWGVQDI TQDNFIDVFE CMVCSRVWEN IHRQEEKLPP KVWRAEESHL
410 420 430 440 450
TCPPPKLFDF ALSSSSSLRQ MWGASYEQSK REARALAQML HTNTNFTITQ

FWREVFTD
Note: No experimental confirmation available.
Length:458
Mass (Da):54,036
Last modified:March 24, 2009 - v3
Checksum:i1C5510E6DA32C926
GO
Isoform 2 (identifier: Q5F2N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-30: Missing.
     387-387: Missing.

Show »
Length:454
Mass (Da):53,566
Checksum:iD138A3CFEDD718D2
GO

Sequence cautioni

The sequence AAI63176 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI52076 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11S → T in AAI63176 (Ref. 2) Curated1
Sequence conflicti54A → V in AAI63176 (Ref. 2) Curated1
Sequence conflicti99P → A in AAI63176 (Ref. 2) Curated1
Sequence conflicti102K → E in AAI63176 (Ref. 2) Curated1
Sequence conflicti389P → S in AAI63176 (Ref. 2) Curated1
Sequence conflicti453R → K in AAI63176 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03660328 – 30Missing in isoform 2. 1 Publication3
Alternative sequenceiVSP_036604387Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ879586 mRNA Translation: CAI52076.1 Different initiation.
BC163176 mRNA Translation: AAI63176.1 Different initiation.
RefSeqiNP_001012374.1, NM_001012374.1
UniGeneiDr.87751

Genome annotation databases

EnsembliENSDART00000161506; ENSDARP00000135630; ENSDARG00000100322 [Q5F2N3-1]
GeneIDi497615
KEGGidre:497615

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFUT10_DANRE
AccessioniPrimary (citable) accession number: Q5F2N3
Secondary accession number(s): B3DIM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 24, 2009
Last modified: July 18, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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