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UniProtKB - Q5F226 (FAT2_MOUSE)

Entry version 121 (07 Oct 2020)
Sequence version 1 (15 Mar 2005)
Previous versions | rss
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Protein

Protocadherin Fat 2

Gene

Fat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin Fat 2
Alternative name(s):
FAT tumor suppressor homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fat2
Synonyms:Fath2, Kiaa0811
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2685369, Fat2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 4050ExtracellularSequence analysisAdd BLAST4032
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4051 – 4071HelicalSequence analysisAdd BLAST21
Topological domaini4072 – 4351CytoplasmicSequence analysisAdd BLAST280

Keywords - Cellular componenti

Cell junction, Cell membrane, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000040660119 – 4351Protocadherin Fat 2Add BLAST4333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi996N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1998N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2007N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3603N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3770N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3774N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3815N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3842N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3906N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3914 ↔ 3946By similarity
Disulfide bondi3953 ↔ 3964By similarity
Disulfide bondi3958 ↔ 3974By similarity
Disulfide bondi3976 ↔ 3985By similarity
Glycosylationi3991N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3992 ↔ 4003By similarity
Disulfide bondi3997 ↔ 4012By similarity
Disulfide bondi4014 ↔ 4023By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5F226

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5F226

PeptideAtlas

More...PeptideAtlasi		Q5F226

PRoteomics IDEntifications database

More...PRIDEi		Q5F226

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2654, 3 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q5F226, 37 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5F226

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5F226

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000055333, Expressed in cerebellum and 99 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5F226, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		232833, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q5F226, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000067556

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5F226, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5F226

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 148Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 256Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini363 – 458Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini459 – 564Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini565 – 669Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini716 – 820Cadherin 6PROSITE-ProRule annotationAdd BLAST105
Domaini821 – 925Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini926 – 1032Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1033 – 1142Cadherin 9PROSITE-ProRule annotationAdd BLAST110
Domaini1138 – 1242Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1243 – 1346Cadherin 11PROSITE-ProRule annotationAdd BLAST104
Domaini1350 – 1448Cadherin 12PROSITE-ProRule annotationAdd BLAST99
Domaini1449 – 1555Cadherin 13PROSITE-ProRule annotationAdd BLAST107
Domaini1556 – 1660Cadherin 14PROSITE-ProRule annotationAdd BLAST105
Domaini1661 – 1758Cadherin 15PROSITE-ProRule annotationAdd BLAST98
Domaini1759 – 1872Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1873 – 1968Cadherin 17PROSITE-ProRule annotationAdd BLAST96
Domaini1969 – 2070Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2071 – 2171Cadherin 19PROSITE-ProRule annotationAdd BLAST101
Domaini2172 – 2272Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2273 – 2379Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2380 – 2481Cadherin 22PROSITE-ProRule annotationAdd BLAST102
Domaini2482 – 2585Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2586 – 2692Cadherin 24PROSITE-ProRule annotationAdd BLAST107
Domaini2693 – 2799Cadherin 25PROSITE-ProRule annotationAdd BLAST107
Domaini2800 – 2908Cadherin 26PROSITE-ProRule annotationAdd BLAST109
Domaini2909 – 3013Cadherin 27PROSITE-ProRule annotationAdd BLAST105
Domaini3014 – 3115Cadherin 28PROSITE-ProRule annotationAdd BLAST102
Domaini3116 – 3220Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3221 – 3323Cadherin 30PROSITE-ProRule annotationAdd BLAST103
Domaini3324 – 3428Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3429 – 3533Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3534 – 3631Cadherin 33PROSITE-ProRule annotationAdd BLAST98
Domaini3775 – 3946Laminin G-likePROSITE-ProRule annotationAdd BLAST172
Domaini3949 – 3986EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini3988 – 4024EGF-like 2PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4147 – 4261Pro-richAdd BLAST115
Compositional biasi4286 – 4289Poly-Gly4

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1219, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000042_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5F226

KEGG Orthology (KO)

More...KOi		K16506

Identification of Orthologs from Complete Genome Data

More...OMAi		IYVHDQG

Database of Orthologous Groups

More...OrthoDBi		12779at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5F226

TreeFam database of animal gene trees

More...TreeFami		TF316403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR001791, Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 28 hits
PF00008, EGF, 2 hits
PF02210, Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 33 hits
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00282, LamG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 33 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232, CADHERIN_1, 13 hits
PS50268, CADHERIN_2, 32 hits
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS50025, LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5F226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLVLLGVAM VLLHRAACEK PLEETITPLT WRFTHSLYNA TIYENSAPKT 
        60         70         80         90        100
YVESPVKMGM YLAEPHWVVK YRIISGDAAG VFKTEEHVVG NFCFLRIRTK 
       110        120        130        140        150
SSNTALLNRE VRDSYTLVVQ ASDKSLEFEA LTQVVVHILD QNDLKPLFSP 
       160        170        180        190        200
PSYRFTISED RPLKSPICKV TATDADLGQN AEFYYAFNAR SEVFAIHPTS 
       210        220        230        240        250
GVVTVAGKLN VTWRGKYELQ VLAVDRMRKI SEGNGFGNLA PLVIYVEPVH 
       260        270        280        290        300
RKPPVITLVV LNPPEGDEGD IYATVTVDTN GSGAEVDSLE VVGGDPGKYF 
       310        320        330        340        350
KVLKSYAQGN EFNLVAVRDI NWAEHLHGFN ISLQTHSRSR FPSRSIIRAF 
       360        370        380        390        400
HLPPYTLANL RFEKAVYRVK LSEFSPPGSR VALVRVTTAL PTLRYALKPS 
       410        420        430        440        450
SGSTVFKLNA RTGLITTTKP VDFHEQNQYQ LHVKTSLGQA TTTVIIDIVD 
       460        470        480        490        500
CNNHAPVFNR SSYEGTLDEN IPPGTSVLTV TATDQDHGDN GHITYSIAGP 
       510        520        530        540        550
KAVPFSIDPY LGVISTTKSM DYELMKRIYT FRVRASDWGS PFRQEKEVSV 
       560        570        580        590        600
SLRLKNLNDN QPMFEEVNCT VSLRQDAPVG KSIMAVSAID MDELQNLKYE 
       610        620        630        640        650
IVSGNEQDYF HLNHFSGVIS LKRSFMNLTA VRPTVYSLKI TASDGKNYAS 
       660        670        680        690        700
PTTLKVTVVK DPRSEVPVQC DKTGVLTHIT KTILQSAGLQ GQEMGEEDFT 
       710        720        730        740        750
SLGNYQINHH APQFEDHFPQ SIDILEQVPV NTPLAHLAAT DPDPGFHGRL 
       760        770        780        790        800
VYVIADGNEE GCFDIELETG LLTVAAALDY ETTSFYVLNV TVYDLGTPPK 
       810        820        830        840        850
SSWKLLTVTV KDWNDKPPRF PPGGYQLTIS EDTEVGTTVA ELKTRDTDSE 
       860        870        880        890        900
DNGRVRYTLL TPTEKFSLHP LTGELVVTGQ LDRESEPQYI LKAEARDQPT 
       910        920        930        940        950
KGHQLFSVTD VIVTLEDIND NPPQCITEHS SLKVPEDMPL GTVLTFLDAS 
       960        970        980        990       1000
DPDLGPAGEV KYILVDDVHG TFRVDPMTGA LSLEKELDFE RRAGYNLSFW 
      1010       1020       1030       1040       1050
ASDSGRPLAR RTLCHVEVLV MDVNENLHSP HFSSFVYQGQ VQENSPAGTQ 
      1060       1070       1080       1090       1100
VMVVTAQDDD SGLDGELQYF LRAGTGLEAF SINQDTGMLE TLAPLDREFT 
      1110       1120       1130       1140       1150
PYYWLTVLAV DRGSVPLSAV TEVYIEVTDI NDNIPSMSRP VFYPSVKEDA 
      1160       1170       1180       1190       1200
PLGTSVLQLE AWDPDFSSQG KLTFNLTSGN HMGHFIVHPF TGLLSTAKQL 
      1210       1220       1230       1240       1250
DRENKDEYVL EVTVQDNGDP PLRSTSRVVV CVLDVNDNSP MFSHKLFNVR 
      1260       1270       1280       1290       1300
LSERLSPLSP EPVYRLVASD PDEGLNGSIT YSIEESDEES FRIDPVTGVV 
      1310       1320       1330       1340       1350
SSSSTFAAGE YNILTIKATD SGQPALSTSV RLHIEWIPQP RPSSIPLSFD 
      1360       1370       1380       1390       1400
ESHYSFAVME TDPVNHMLGV ISVEGRPGLF WFHISDGDKD MDFDIEKTTG 
      1410       1420       1430       1440       1450
SIVIARPLDT RRKSSYNLTV EVTDGFHTIA TQVHILMIAN INHHRPQFLQ 
      1460       1470       1480       1490       1500
DHYDIRVPQD TLPGVELLRV QATDQDHGKG LIYTIHSSRD PGSANLFQLD 
      1510       1520       1530       1540       1550
PSSGVLVTVG TLDLHSGPSQ HILTVMVRDQ EMPIKRNFVW VTIHVEDGNL 
      1560       1570       1580       1590       1600
HSPHFTQPRY EANVPDTTTP GTELLQVRAV DADRGANAEV HYSFLKGNSE 
      1610       1620       1630       1640       1650
GFFNIDSLLG IITVAQRLDH VHLNRHALTV KAEDQGSPQR HDLAMVVVHV 
      1660       1670       1680       1690       1700
HPSDSSAPIF SKDEYFIEIP ESVPIGSPIL LISAASSSDV TYELREGNKN 
      1710       1720       1730       1740       1750
SVFSMNSYSG LISTQKRLDH EKVSSYQLKI RGSNMAGVFT EVVALVYIID 
      1760       1770       1780       1790       1800
ENDNAPAFLK STFVGHISEA APLHSLILGE DNSPLVIRAS DSDQEANSLL 
      1810       1820       1830       1840       1850
VYKILEPEAL KFFKIDPSMG TLTITSELDY ETTPLFQFSI YVHDQGTPIL 
      1860       1870       1880       1890       1900
FAPRSARVII HVRDVNDSPP RFSEQIYEVA VVEPIHPGME LLTVQAEDND 
      1910       1920       1930       1940       1950
SKVTYSIKTS NTDEAVTIHP ITGQISVVNP AALRLFPKLN IRAFDGLYQD 
      1960       1970       1980       1990       2000
TAVVKISLTQ ALDKSLQFDQ DIYRARVTEN TPHSNVLVIL GVHGNHLNDT 
      2010       2020       2030       2040       2050
LSYFLLNGTD LFHMVKSAGV LQTRGVTFDR EQQDTHEVAV EVRDNRVPRR 
      2060       2070       2080       2090       2100
VAQALVRVSV EDVNDNIPEF QHLPYYTVIQ DGTEPGDVLF QVSATDKDLG 
      2110       2120       2130       2140       2150
ANGTVTYGFA EDYAYFRIDP YVGDISLKKP FDYQALNKYH LRVTARDAGT 
      2160       2170       2180       2190       2200
PPLQTEVEVH VTVRNKSNPL FQSPYYKVKV PENITLYTPI LHTQARSPEG 
      2210       2220       2230       2240       2250
LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKNKHV FTVRATDTAL 
      2260       2270       2280       2290       2300
GSFSEATVEV LVEDINDNPP TFSQLVYSTS VSEGSPAQTP VIQLLASDQD 
      2310       2320       2330       2340       2350
SGQNQDVSYQ IVEDGSDVSK FFRINGSTGE MFTIQELDYE AHQHFRVKVR 
      2360       2370       2380       2390       2400
ATDRGDPPLT GETLVVVNVS DINDNPPEFR EPQYEANVSE LATCGHLVLK 
      2410       2420       2430       2440       2450
VQALDPDIGD TSRLEYLILS GNQDRHFSIN STSGIISMFN LCKKQLDSSY 
      2460       2470       2480       2490       2500
NLRVGASDGV FQATVPVYIN TTNANKYSPE FQQNVYEAEL AENAKVGTKV 
      2510       2520       2530       2540       2550
IELLAIDKDS GPYGTVDYTI INKLAGERFF INPSGQITTL QKLDRENSTE 
      2560       2570       2580       2590       2600
RVIAIKIMAR DGGGKVAFCT VKIILTDEND NAPQFKASGY TVSIPSNVSR 
      2610       2620       2630       2640       2650
DSPIIQVLAY DADEGRNADV TYSVDSTEDL AEEIIEVNPT TGVVKVKESL 
      2660       2670       2680       2690       2700
VGLENKAVDF NIKAQDGGPP HWDSLVPVRL QVVPNEIPLP KFSEPLYTFS 
      2710       2720       2730       2740       2750
ASEDLPEGSE IGSVKAVAAQ DPIIYSLVQG TTPESNSDDV FSLDQDTGVL 
      2760       2770       2780       2790       2800
KVKKAMDHES TKWYQIDLMA HCPHEDTDLV SLVSVNIQVE DVNDNRPVFE 
      2810       2820       2830       2840       2850
ADPYKAFLTE NMPGGTTVIQ VTANDQDTGS DGQVSYRLSV EPGSNIHQLF 
      2860       2870       2880       2890       2900
AVDSESGWIT TLQELDCETQ QTYRFYVVAF DHGQTIQLSS QALVEVSITD 
      2910       2920       2930       2940       2950
ENDNPPRFAS EDYRGSVVEN NEPGELVATL KTLDADISEQ NRQVTCYITE 
      2960       2970       2980       2990       3000
GDPLGQFSIS QVGDEWRITS RKTLDREHIA KYLLRITASD GKFQASVPVE 
      3010       3020       3030       3040       3050
VFVLDINDNS PQCSQLLYTG KVREDVTPGH FILKVSAIDV DMDTNAQITY 
      3060       3070       3080       3090       3100
SLHGPGAQEF KLDPHTGELT TLSVLDRERK DVYNLVAKAT DGGGQSCQAE 
      3110       3120       3130       3140       3150
VTLHIEDVND NAPRFFPSHC AVAVFDNTTV KTPVAVVFAR DPDQGVNAQV 
      3160       3170       3180       3190       3200
VYSLTDSADG QFSIDATSGV IRLEKPLQVR SSSAVELTVR ASDLGTPIPL 
      3210       3220       3230       3240       3250
STLGTVTVSI VGLEDYLPIF LNSEHSTQVP EDALIDMEVL YLATLTRPGS 
      3260       3270       3280       3290       3300
EKTGYHITGG NEQGKFRLDA HTGILYVNGS LDFETNPKYF LSIECSRKSS 
      3310       3320       3330       3340       3350
SSLSDVTTIV INVTDVNEHH PRFTHDLYTV RVLENAIVGD VILTVSASDD 
      3360       3370       3380       3390       3400
DGPVNSVITY SLVGGNQLGH FTIDPKKGKL QVAKALDWEQ TPSYSLRIRA 
      3410       3420       3430       3440       3450
TDSGQPPLHE DTEVAVEVVD VNDNPPRFFQ LNYSTAVQEN SPIGIKVLQL 
      3460       3470       3480       3490       3500
ILDDPDSPQN GPPYFFRITE GNTGSVFRVT PDGWLVTAGS LSRRAQEWYQ 
      3510       3520       3530       3540       3550
LHIEVSDSGL PPLSSSTLVR VHITEQSRYP PSTLPLEIFI TKGEEEFQGG 
      3560       3570       3580       3590       3600
MVGKIHATDR DPQDTLTYSL DREGSLGKYF TVGASDGKII ASQGLPRGRY 
      3610       3620       3630       3640       3650
LFNVTVSDGT FTTTTGVHVH VWHMGQEAPQ QAVWLGFHQL TPEELVSDHW 
      3660       3670       3680       3690       3700
RNLQRFLSNI LDIKRANIHL ASLQPAEVTA GVDVLLAFEG HSGTSYDLQE 
      3710       3720       3730       3740       3750
LASAIAHSAK EMEHSVGIQM RSALPVVPCQ GPSCQDQTCQ ETVSLEPRVG 
      3760       3770       3780       3790       3800
PSYSTARLSI LTPRHHLGKN CSCNGTTWRF SGQSYMRYRP LEAQNWQIHF 
      3810       3820       3830       3840       3850
YLKTLQPWAL LMFTNETASI SLKLANGFLH LEYRCPGGFY GNLSSHRPVN 
      3860       3870       3880       3890       3900
DGQWHSMLLE ERDTSVHLLV DITDNTSLVI PEECQGLRTE RHLLLGGLVP 
      3910       3920       3930       3940       3950
SNPSSNVSLG FEGCLDAVVV NSERLELLGH RKKMAGYLET WALSQCCWPG 
      3960       3970       3980       3990       4000
TTCSQNPCLN GGSCSPALGS GYLCRCPPLF SGRNCELGRE NCTSAPCQEG 
      4010       4020       4030       4040       4050
GTCVSSPEGT SCSCPHPYTG DRCEMEARGC SGGHCLITPE IKRGDWGQQE 
      4060       4070       4080       4090       4100
FLVIIVALPL LIIATVGLLL YCRRCKSHKP VAMEDPDLLA RSIGVDTQAS 
      4110       4120       4130       4140       4150
PAIELDPLNA GSCNDLNQLE PSKTSVPNEL VTFGPSSKQR PMVCSVPPRL 
      4160       4170       4180       4190       4200
PPAVVSSHPG HEPIIKRTWS GEELVYPSGA AVWPPTYSRK EHWEYPHPEA 
      4210       4220       4230       4240       4250
MQGPLPPSPR RHVSPAVMPD PAGLYGGFPF PLELENKRAP LPPRYSNQNL 
      4260       4270       4280       4290       4300
EDLIPPRPPS PREHLLAPCL NEYTAISYYH SQFRQGGGGP CLAEGGYKGV 
      4310       4320       4330       4340       4350
SMRLSRAGPS YADCEVNGGP APGRSQPRAP PNYEGSDMVE SDYGSCEEVM 

F
Length:4,351
Mass (Da):480,109
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72F9DADAAA5467D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4010T → N in BAE21217 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL713870 Genomic DNA No translation available.
CH466575 Genomic DNA Translation: EDL33495.1
AK173031 mRNA Translation: BAD32309.1
AK132523 mRNA Translation: BAE21217.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36157.1

NCBI Reference Sequences

More...RefSeqi		NP_001025159.1, NM_001029988.2
XP_006533385.1, XM_006533322.3
XP_006533386.1, XM_006533323.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000068853; ENSMUSP00000067556; ENSMUSG00000055333
ENSMUST00000108864; ENSMUSP00000104492; ENSMUSG00000055333

Database of genes from NCBI RefSeq genomes

More...GeneIDi		245827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:245827

UCSC genome browser

More...UCSCi		uc007izf.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713870 Genomic DNA No translation available.
CH466575 Genomic DNA Translation: EDL33495.1
AK173031 mRNA Translation: BAD32309.1
AK132523 mRNA Translation: BAE21217.1
CCDSiCCDS36157.1
RefSeqiNP_001025159.1, NM_001029988.2
XP_006533385.1, XM_006533322.3
XP_006533386.1, XM_006533323.3

3D structure databases

SMRiQ5F226
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi232833, 1 interactor
IntActiQ5F226, 1 interactor
STRINGi10090.ENSMUSP00000067556

PTM databases

GlyConnecti2654, 3 N-Linked glycans (3 sites)
GlyGeniQ5F226, 37 sites
iPTMnetiQ5F226
PhosphoSitePlusiQ5F226

Proteomic databases

MaxQBiQ5F226
PaxDbiQ5F226
PeptideAtlasiQ5F226
PRIDEiQ5F226

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		77918, 107 antibodies

Genome annotation databases

EnsembliENSMUST00000068853; ENSMUSP00000067556; ENSMUSG00000055333
ENSMUST00000108864; ENSMUSP00000104492; ENSMUSG00000055333
GeneIDi245827
KEGGimmu:245827
UCSCiuc007izf.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2196
MGIiMGI:2685369, Fat2

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1219, Eukaryota
GeneTreeiENSGT00940000158507
HOGENOMiCLU_000042_2_0_1
InParanoidiQ5F226
KOiK16506
OMAiIYVHDQG
OrthoDBi12779at2759
PhylomeDBiQ5F226
TreeFamiTF316403

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		245827, 0 hits in 18 CRISPR screens

Protein Ontology

More...PROi		PR:Q5F226
RNActiQ5F226, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000055333, Expressed in cerebellum and 99 other tissues
GenevisibleiQ5F226, MM

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00028, Cadherin, 28 hits
PF00008, EGF, 2 hits
PF02210, Laminin_G_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 33 hits
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00282, LamG, 1 hit
SUPFAMiSSF49313, SSF49313, 33 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 13 hits
PS50268, CADHERIN_2, 32 hits
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS50025, LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5F226
Secondary accession number(s): Q3V1D4, Q69ZY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 15, 2005
Last modified: October 7, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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