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Entry version 110 (08 May 2019)
Sequence version 1 (15 Mar 2005)
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Protein

Protocadherin Fat 2

Gene

Fat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin Fat 2
Alternative name(s):
FAT tumor suppressor homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fat2
Synonyms:Fath2, Kiaa0811
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685369 Fat2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 4050ExtracellularSequence analysisAdd BLAST4032
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4051 – 4071HelicalSequence analysisAdd BLAST21
Topological domaini4072 – 4351CytoplasmicSequence analysisAdd BLAST280

Keywords - Cellular componenti

Cell junction, Cell membrane, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000040660119 – 4351Protocadherin Fat 2Add BLAST4333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi996N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1998N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2007N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3603N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3770N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3774N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3815N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3842N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3906N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3914 ↔ 3946By similarity
Disulfide bondi3953 ↔ 3964By similarity
Disulfide bondi3958 ↔ 3974By similarity
Disulfide bondi3976 ↔ 3985By similarity
Glycosylationi3991N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3992 ↔ 4003By similarity
Disulfide bondi3997 ↔ 4012By similarity
Disulfide bondi4014 ↔ 4023By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5F226

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5F226

PeptideAtlas

More...
PeptideAtlasi
Q5F226

PRoteomics IDEntifications database

More...
PRIDEi
Q5F226

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5F226

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5F226

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000055333 Expressed in 84 organ(s), highest expression level in cerebellum

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5F226 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5F226, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000067556

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5F226

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 148Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 256Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini363 – 458Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini459 – 564Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini565 – 669Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini716 – 820Cadherin 6PROSITE-ProRule annotationAdd BLAST105
Domaini821 – 925Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini926 – 1032Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1033 – 1142Cadherin 9PROSITE-ProRule annotationAdd BLAST110
Domaini1138 – 1242Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1243 – 1346Cadherin 11PROSITE-ProRule annotationAdd BLAST104
Domaini1350 – 1448Cadherin 12PROSITE-ProRule annotationAdd BLAST99
Domaini1449 – 1555Cadherin 13PROSITE-ProRule annotationAdd BLAST107
Domaini1556 – 1660Cadherin 14PROSITE-ProRule annotationAdd BLAST105
Domaini1661 – 1758Cadherin 15PROSITE-ProRule annotationAdd BLAST98
Domaini1759 – 1872Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1873 – 1968Cadherin 17PROSITE-ProRule annotationAdd BLAST96
Domaini1969 – 2070Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2071 – 2171Cadherin 19PROSITE-ProRule annotationAdd BLAST101
Domaini2172 – 2272Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2273 – 2379Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2380 – 2481Cadherin 22PROSITE-ProRule annotationAdd BLAST102
Domaini2482 – 2585Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2586 – 2692Cadherin 24PROSITE-ProRule annotationAdd BLAST107
Domaini2693 – 2799Cadherin 25PROSITE-ProRule annotationAdd BLAST107
Domaini2800 – 2908Cadherin 26PROSITE-ProRule annotationAdd BLAST109
Domaini2909 – 3013Cadherin 27PROSITE-ProRule annotationAdd BLAST105
Domaini3014 – 3115Cadherin 28PROSITE-ProRule annotationAdd BLAST102
Domaini3116 – 3220Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3221 – 3323Cadherin 30PROSITE-ProRule annotationAdd BLAST103
Domaini3324 – 3428Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3429 – 3533Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3534 – 3631Cadherin 33PROSITE-ProRule annotationAdd BLAST98
Domaini3775 – 3946Laminin G-likePROSITE-ProRule annotationAdd BLAST172
Domaini3949 – 3986EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini3988 – 4024EGF-like 2PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4147 – 4261Pro-richAdd BLAST115
Compositional biasi4286 – 4289Poly-Gly4

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046499

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5F226

KEGG Orthology (KO)

More...
KOi
K16506

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVRDQEM

Database of Orthologous Groups

More...
OrthoDBi
12779at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5F226

TreeFam database of animal gene trees

More...
TreeFami
TF316403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 28 hits
PF00008 EGF, 2 hits
PF02210 Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 33 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00282 LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 33 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 13 hits
PS50268 CADHERIN_2, 32 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5F226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLVLLGVAM VLLHRAACEK PLEETITPLT WRFTHSLYNA TIYENSAPKT
60 70 80 90 100
YVESPVKMGM YLAEPHWVVK YRIISGDAAG VFKTEEHVVG NFCFLRIRTK
110 120 130 140 150
SSNTALLNRE VRDSYTLVVQ ASDKSLEFEA LTQVVVHILD QNDLKPLFSP
160 170 180 190 200
PSYRFTISED RPLKSPICKV TATDADLGQN AEFYYAFNAR SEVFAIHPTS
210 220 230 240 250
GVVTVAGKLN VTWRGKYELQ VLAVDRMRKI SEGNGFGNLA PLVIYVEPVH
260 270 280 290 300
RKPPVITLVV LNPPEGDEGD IYATVTVDTN GSGAEVDSLE VVGGDPGKYF
310 320 330 340 350
KVLKSYAQGN EFNLVAVRDI NWAEHLHGFN ISLQTHSRSR FPSRSIIRAF
360 370 380 390 400
HLPPYTLANL RFEKAVYRVK LSEFSPPGSR VALVRVTTAL PTLRYALKPS
410 420 430 440 450
SGSTVFKLNA RTGLITTTKP VDFHEQNQYQ LHVKTSLGQA TTTVIIDIVD
460 470 480 490 500
CNNHAPVFNR SSYEGTLDEN IPPGTSVLTV TATDQDHGDN GHITYSIAGP
510 520 530 540 550
KAVPFSIDPY LGVISTTKSM DYELMKRIYT FRVRASDWGS PFRQEKEVSV
560 570 580 590 600
SLRLKNLNDN QPMFEEVNCT VSLRQDAPVG KSIMAVSAID MDELQNLKYE
610 620 630 640 650
IVSGNEQDYF HLNHFSGVIS LKRSFMNLTA VRPTVYSLKI TASDGKNYAS
660 670 680 690 700
PTTLKVTVVK DPRSEVPVQC DKTGVLTHIT KTILQSAGLQ GQEMGEEDFT
710 720 730 740 750
SLGNYQINHH APQFEDHFPQ SIDILEQVPV NTPLAHLAAT DPDPGFHGRL
760 770 780 790 800
VYVIADGNEE GCFDIELETG LLTVAAALDY ETTSFYVLNV TVYDLGTPPK
810 820 830 840 850
SSWKLLTVTV KDWNDKPPRF PPGGYQLTIS EDTEVGTTVA ELKTRDTDSE
860 870 880 890 900
DNGRVRYTLL TPTEKFSLHP LTGELVVTGQ LDRESEPQYI LKAEARDQPT
910 920 930 940 950
KGHQLFSVTD VIVTLEDIND NPPQCITEHS SLKVPEDMPL GTVLTFLDAS
960 970 980 990 1000
DPDLGPAGEV KYILVDDVHG TFRVDPMTGA LSLEKELDFE RRAGYNLSFW
1010 1020 1030 1040 1050
ASDSGRPLAR RTLCHVEVLV MDVNENLHSP HFSSFVYQGQ VQENSPAGTQ
1060 1070 1080 1090 1100
VMVVTAQDDD SGLDGELQYF LRAGTGLEAF SINQDTGMLE TLAPLDREFT
1110 1120 1130 1140 1150
PYYWLTVLAV DRGSVPLSAV TEVYIEVTDI NDNIPSMSRP VFYPSVKEDA
1160 1170 1180 1190 1200
PLGTSVLQLE AWDPDFSSQG KLTFNLTSGN HMGHFIVHPF TGLLSTAKQL
1210 1220 1230 1240 1250
DRENKDEYVL EVTVQDNGDP PLRSTSRVVV CVLDVNDNSP MFSHKLFNVR
1260 1270 1280 1290 1300
LSERLSPLSP EPVYRLVASD PDEGLNGSIT YSIEESDEES FRIDPVTGVV
1310 1320 1330 1340 1350
SSSSTFAAGE YNILTIKATD SGQPALSTSV RLHIEWIPQP RPSSIPLSFD
1360 1370 1380 1390 1400
ESHYSFAVME TDPVNHMLGV ISVEGRPGLF WFHISDGDKD MDFDIEKTTG
1410 1420 1430 1440 1450
SIVIARPLDT RRKSSYNLTV EVTDGFHTIA TQVHILMIAN INHHRPQFLQ
1460 1470 1480 1490 1500
DHYDIRVPQD TLPGVELLRV QATDQDHGKG LIYTIHSSRD PGSANLFQLD
1510 1520 1530 1540 1550
PSSGVLVTVG TLDLHSGPSQ HILTVMVRDQ EMPIKRNFVW VTIHVEDGNL
1560 1570 1580 1590 1600
HSPHFTQPRY EANVPDTTTP GTELLQVRAV DADRGANAEV HYSFLKGNSE
1610 1620 1630 1640 1650
GFFNIDSLLG IITVAQRLDH VHLNRHALTV KAEDQGSPQR HDLAMVVVHV
1660 1670 1680 1690 1700
HPSDSSAPIF SKDEYFIEIP ESVPIGSPIL LISAASSSDV TYELREGNKN
1710 1720 1730 1740 1750
SVFSMNSYSG LISTQKRLDH EKVSSYQLKI RGSNMAGVFT EVVALVYIID
1760 1770 1780 1790 1800
ENDNAPAFLK STFVGHISEA APLHSLILGE DNSPLVIRAS DSDQEANSLL
1810 1820 1830 1840 1850
VYKILEPEAL KFFKIDPSMG TLTITSELDY ETTPLFQFSI YVHDQGTPIL
1860 1870 1880 1890 1900
FAPRSARVII HVRDVNDSPP RFSEQIYEVA VVEPIHPGME LLTVQAEDND
1910 1920 1930 1940 1950
SKVTYSIKTS NTDEAVTIHP ITGQISVVNP AALRLFPKLN IRAFDGLYQD
1960 1970 1980 1990 2000
TAVVKISLTQ ALDKSLQFDQ DIYRARVTEN TPHSNVLVIL GVHGNHLNDT
2010 2020 2030 2040 2050
LSYFLLNGTD LFHMVKSAGV LQTRGVTFDR EQQDTHEVAV EVRDNRVPRR
2060 2070 2080 2090 2100
VAQALVRVSV EDVNDNIPEF QHLPYYTVIQ DGTEPGDVLF QVSATDKDLG
2110 2120 2130 2140 2150
ANGTVTYGFA EDYAYFRIDP YVGDISLKKP FDYQALNKYH LRVTARDAGT
2160 2170 2180 2190 2200
PPLQTEVEVH VTVRNKSNPL FQSPYYKVKV PENITLYTPI LHTQARSPEG
2210 2220 2230 2240 2250
LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKNKHV FTVRATDTAL
2260 2270 2280 2290 2300
GSFSEATVEV LVEDINDNPP TFSQLVYSTS VSEGSPAQTP VIQLLASDQD
2310 2320 2330 2340 2350
SGQNQDVSYQ IVEDGSDVSK FFRINGSTGE MFTIQELDYE AHQHFRVKVR
2360 2370 2380 2390 2400
ATDRGDPPLT GETLVVVNVS DINDNPPEFR EPQYEANVSE LATCGHLVLK
2410 2420 2430 2440 2450
VQALDPDIGD TSRLEYLILS GNQDRHFSIN STSGIISMFN LCKKQLDSSY
2460 2470 2480 2490 2500
NLRVGASDGV FQATVPVYIN TTNANKYSPE FQQNVYEAEL AENAKVGTKV
2510 2520 2530 2540 2550
IELLAIDKDS GPYGTVDYTI INKLAGERFF INPSGQITTL QKLDRENSTE
2560 2570 2580 2590 2600
RVIAIKIMAR DGGGKVAFCT VKIILTDEND NAPQFKASGY TVSIPSNVSR
2610 2620 2630 2640 2650
DSPIIQVLAY DADEGRNADV TYSVDSTEDL AEEIIEVNPT TGVVKVKESL
2660 2670 2680 2690 2700
VGLENKAVDF NIKAQDGGPP HWDSLVPVRL QVVPNEIPLP KFSEPLYTFS
2710 2720 2730 2740 2750
ASEDLPEGSE IGSVKAVAAQ DPIIYSLVQG TTPESNSDDV FSLDQDTGVL
2760 2770 2780 2790 2800
KVKKAMDHES TKWYQIDLMA HCPHEDTDLV SLVSVNIQVE DVNDNRPVFE
2810 2820 2830 2840 2850
ADPYKAFLTE NMPGGTTVIQ VTANDQDTGS DGQVSYRLSV EPGSNIHQLF
2860 2870 2880 2890 2900
AVDSESGWIT TLQELDCETQ QTYRFYVVAF DHGQTIQLSS QALVEVSITD
2910 2920 2930 2940 2950
ENDNPPRFAS EDYRGSVVEN NEPGELVATL KTLDADISEQ NRQVTCYITE
2960 2970 2980 2990 3000
GDPLGQFSIS QVGDEWRITS RKTLDREHIA KYLLRITASD GKFQASVPVE
3010 3020 3030 3040 3050
VFVLDINDNS PQCSQLLYTG KVREDVTPGH FILKVSAIDV DMDTNAQITY
3060 3070 3080 3090 3100
SLHGPGAQEF KLDPHTGELT TLSVLDRERK DVYNLVAKAT DGGGQSCQAE
3110 3120 3130 3140 3150
VTLHIEDVND NAPRFFPSHC AVAVFDNTTV KTPVAVVFAR DPDQGVNAQV
3160 3170 3180 3190 3200
VYSLTDSADG QFSIDATSGV IRLEKPLQVR SSSAVELTVR ASDLGTPIPL
3210 3220 3230 3240 3250
STLGTVTVSI VGLEDYLPIF LNSEHSTQVP EDALIDMEVL YLATLTRPGS
3260 3270 3280 3290 3300
EKTGYHITGG NEQGKFRLDA HTGILYVNGS LDFETNPKYF LSIECSRKSS
3310 3320 3330 3340 3350
SSLSDVTTIV INVTDVNEHH PRFTHDLYTV RVLENAIVGD VILTVSASDD
3360 3370 3380 3390 3400
DGPVNSVITY SLVGGNQLGH FTIDPKKGKL QVAKALDWEQ TPSYSLRIRA
3410 3420 3430 3440 3450
TDSGQPPLHE DTEVAVEVVD VNDNPPRFFQ LNYSTAVQEN SPIGIKVLQL
3460 3470 3480 3490 3500
ILDDPDSPQN GPPYFFRITE GNTGSVFRVT PDGWLVTAGS LSRRAQEWYQ
3510 3520 3530 3540 3550
LHIEVSDSGL PPLSSSTLVR VHITEQSRYP PSTLPLEIFI TKGEEEFQGG
3560 3570 3580 3590 3600
MVGKIHATDR DPQDTLTYSL DREGSLGKYF TVGASDGKII ASQGLPRGRY
3610 3620 3630 3640 3650
LFNVTVSDGT FTTTTGVHVH VWHMGQEAPQ QAVWLGFHQL TPEELVSDHW
3660 3670 3680 3690 3700
RNLQRFLSNI LDIKRANIHL ASLQPAEVTA GVDVLLAFEG HSGTSYDLQE
3710 3720 3730 3740 3750
LASAIAHSAK EMEHSVGIQM RSALPVVPCQ GPSCQDQTCQ ETVSLEPRVG
3760 3770 3780 3790 3800
PSYSTARLSI LTPRHHLGKN CSCNGTTWRF SGQSYMRYRP LEAQNWQIHF
3810 3820 3830 3840 3850
YLKTLQPWAL LMFTNETASI SLKLANGFLH LEYRCPGGFY GNLSSHRPVN
3860 3870 3880 3890 3900
DGQWHSMLLE ERDTSVHLLV DITDNTSLVI PEECQGLRTE RHLLLGGLVP
3910 3920 3930 3940 3950
SNPSSNVSLG FEGCLDAVVV NSERLELLGH RKKMAGYLET WALSQCCWPG
3960 3970 3980 3990 4000
TTCSQNPCLN GGSCSPALGS GYLCRCPPLF SGRNCELGRE NCTSAPCQEG
4010 4020 4030 4040 4050
GTCVSSPEGT SCSCPHPYTG DRCEMEARGC SGGHCLITPE IKRGDWGQQE
4060 4070 4080 4090 4100
FLVIIVALPL LIIATVGLLL YCRRCKSHKP VAMEDPDLLA RSIGVDTQAS
4110 4120 4130 4140 4150
PAIELDPLNA GSCNDLNQLE PSKTSVPNEL VTFGPSSKQR PMVCSVPPRL
4160 4170 4180 4190 4200
PPAVVSSHPG HEPIIKRTWS GEELVYPSGA AVWPPTYSRK EHWEYPHPEA
4210 4220 4230 4240 4250
MQGPLPPSPR RHVSPAVMPD PAGLYGGFPF PLELENKRAP LPPRYSNQNL
4260 4270 4280 4290 4300
EDLIPPRPPS PREHLLAPCL NEYTAISYYH SQFRQGGGGP CLAEGGYKGV
4310 4320 4330 4340 4350
SMRLSRAGPS YADCEVNGGP APGRSQPRAP PNYEGSDMVE SDYGSCEEVM

F
Length:4,351
Mass (Da):480,109
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72F9DADAAA5467D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4010T → N in BAE21217 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL713870 Genomic DNA No translation available.
CH466575 Genomic DNA Translation: EDL33495.1
AK173031 mRNA Translation: BAD32309.1
AK132523 mRNA Translation: BAE21217.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36157.1

NCBI Reference Sequences

More...
RefSeqi
NP_001025159.1, NM_001029988.2
XP_006533385.1, XM_006533322.3
XP_006533386.1, XM_006533323.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000068853; ENSMUSP00000067556; ENSMUSG00000055333
ENSMUST00000108864; ENSMUSP00000104492; ENSMUSG00000055333

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
245827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:245827

UCSC genome browser

More...
UCSCi
uc007izf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713870 Genomic DNA No translation available.
CH466575 Genomic DNA Translation: EDL33495.1
AK173031 mRNA Translation: BAD32309.1
AK132523 mRNA Translation: BAE21217.1
CCDSiCCDS36157.1
RefSeqiNP_001025159.1, NM_001029988.2
XP_006533385.1, XM_006533322.3
XP_006533386.1, XM_006533323.3

3D structure databases

SMRiQ5F226
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5F226, 1 interactor
STRINGi10090.ENSMUSP00000067556

PTM databases

iPTMnetiQ5F226
PhosphoSitePlusiQ5F226

Proteomic databases

MaxQBiQ5F226
PaxDbiQ5F226
PeptideAtlasiQ5F226
PRIDEiQ5F226

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068853; ENSMUSP00000067556; ENSMUSG00000055333
ENSMUST00000108864; ENSMUSP00000104492; ENSMUSG00000055333
GeneIDi245827
KEGGimmu:245827
UCSCiuc007izf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2196
MGIiMGI:2685369 Fat2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000158507
HOGENOMiHOG000046499
InParanoidiQ5F226
KOiK16506
OMAiMVRDQEM
OrthoDBi12779at2759
PhylomeDBiQ5F226
TreeFamiTF316403

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5F226

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000055333 Expressed in 84 organ(s), highest expression level in cerebellum
GenevisibleiQ5F226 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 28 hits
PF00008 EGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 33 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00282 LamG, 1 hit
SUPFAMiSSF49313 SSF49313, 33 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 13 hits
PS50268 CADHERIN_2, 32 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5F226
Secondary accession number(s): Q3V1D4, Q69ZY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 15, 2005
Last modified: May 8, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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