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Protein
Submitted name:

NMDA receptor subunit 3B

Gene

GRIN3B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
NMDA receptor subunit 3BImported
Gene namesi
Name:GRIN3BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei571 – 593HelicalSequence analysisAdd BLAST23
Transmembranei613 – 632HelicalSequence analysisAdd BLAST20
Transmembranei644 – 669HelicalSequence analysisAdd BLAST26
Transmembranei828 – 847HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500425610223 – 1043Sequence analysisAdd BLAST1021

Proteomic databases

PRIDEiQ5F0I5

Structurei

3D structure databases

ProteinModelPortaliQ5F0I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini458 – 810PBPeInterPro annotationAdd BLAST353
Domaini459 – 522Lig_chan-Glu_bdInterPro annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili983 – 1003Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
HOVERGENiHBG052634
KOiK05214

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Q5F0I5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFVRALXLG LALTLGPGSA GGRPQPCGVL ARLGGSVRLG ALMPRAPLAR
60 70 80 90 100
ARARAALARA ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV
110 120 130 140 150
AALLAFPEAR PELLQLHFLA AATETPVLSL LRREARAPLG APNPFHLQLH
160 170 180 190 200
WASPLETLLD VLAAVLQAHA WEDVGLALCR TQDPGGLVTL WTSRAGRPPQ
210 220 230 240 250
LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC DIARARRVLE
260 270 280 290 300
AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV
310 320 330 340 350
ARALGSATQV QPKRALLPAP VNCGXLQPAG PESPGRFLAR FLANTSFQGR
360 370 380 390 400
TGPVWVTGSS QVHMSRHLKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG
410 420 430 440 450
ASAWPPPPQG AQVRPKLHVV TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSATLDALF AALANGSAPR ALRKCCYGYC IDLLERLAED TPXEFELYPV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINTARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP
610 620 630 640 650
YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES
710 720 730 740 750
SAEAYIKKSF PDMHAHMRRH SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSDLSEF ISRYKSSGFI
810 820 830 840 850
DLFHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL GLGSALLSSL
860 870 880 890 900
GEHAFFRLAL PHIRKGSRLL YWLHTSQKIH RALNTEPPEG SKEETAEAEP
910 920 930 940 950
SGPEVEQQQQ QXDQPTAPEG WKRARRAVDK ERRVCFLLEP AVVVAPEADA
960 970 980 990 1000
EAEAAPREGP VWLCSNGRPP AARPTGAPQP GKLQELERRI KVARERLRQA
1010 1020 1030 1040
LVRRGEPLVQ LGDSARHRPR RLLQARAAPA EAPPHSGRRG SQE
Length:1,043
Mass (Da):112,888
Last modified:March 15, 2005 - v1
Checksum:i1DE2CDD27BE5EBC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY507106 mRNA Translation: AAS87020.1
RefSeqiNP_619635.1, NM_138690.2
UniGeneiHs.660378

Genome annotation databases

GeneIDi116444
KEGGihsa:116444

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY507106 mRNA Translation: AAS87020.1
RefSeqiNP_619635.1, NM_138690.2
UniGeneiHs.660378

3D structure databases

ProteinModelPortaliQ5F0I5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5F0I5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116444
KEGGihsa:116444

Organism-specific databases

CTDi116444
H-InvDBiHIX0202918

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
HOVERGENiHBG052634
KOiK05214

Miscellaneous databases

ChiTaRSiGRIN3B human

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5F0I5_HUMAN
AccessioniPrimary (citable) accession number: Q5F0I5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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