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Protein

Caspase recruitment domain-containing protein 16

Gene

CARD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 16
Alternative name(s):
Caspase recruitment domain-only protein 1
Short name:
CARD-only protein 1
Caspase-1 inhibitor COP
Pseudo interleukin-1 beta converting enzyme
Short name:
Pseudo-ICE
Short name:
Pseudo-IL1B-converting enzyme
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARD16
Synonyms:COP, COP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204397.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33701 CARD16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5EG05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114769

Open Targets

More...
OpenTargetsi
ENSG00000204397

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164717628

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CARD16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74722547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003491801 – 197Caspase recruitment domain-containing protein 16Add BLAST197

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5EG05

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5EG05

PeptideAtlas

More...
PeptideAtlasi
Q5EG05

PRoteomics IDEntifications database

More...
PRIDEi
Q5EG05

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62773
62774 [Q5EG05-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5EG05

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5EG05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in patients suffering of Huntington disease.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204397 Expressed in 171 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_CARD16

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5EG05 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5EG05 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053981
HPA062805

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2.4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125339, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5EG05, 1 interactor

Molecular INTeraction database

More...
MINTi
Q5EG05

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364858

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5EG05

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5EG05

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 91CARDPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3573 Eukaryota
ENOG410ZQIE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111300

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006113

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5EG05

KEGG Orthology (KO)

More...
KOi
K12806

Identification of Orthologs from Complete Genome Data

More...
OMAi
CITDICE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0L5Y

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5EG05

TreeFam database of animal gene trees

More...
TreeFami
TF330675

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14

The PANTHER Classification System

More...
PANTHERi
PTHR10454 PTHR10454, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619 CARD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00114 CARD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5EG05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADKVLKEKR KLFIHSMGEG TINGLLDELL QTRVLNQEEM EKVKRENATV
60 70 80 90 100
MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAETLGLS AALQAVQDNP
110 120 130 140 150
AMPTCSSPEG RIKLCFLEDA QRIWKQKLQR CHVQNTIIKW SERYTSGSFE
160 170 180 190
MQWLFLRTNF IERFWRNILL LPLHKGSLYP RIPGLGKELQ TGTHKLS
Length:197
Mass (Da):22,625
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DCAC6A9B2FAE82F
GO
Isoform 2 (identifier: Q5EG05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-197: ALQAVQDNPA...ELQTGTHKLS → GPIPGN

Show »
Length:97
Mass (Da):10,737
Checksum:i8697C3B5706B9B91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQW1E9PQW1_HUMAN
Caspase recruitment domain-containi...
CARD16
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04627933R → S. Corresponds to variant dbSNP:rs35966314Ensembl.1
Natural variantiVAR_04628037Q → K. Corresponds to variant dbSNP:rs1042744Ensembl.1
Natural variantiVAR_04628156A → D. Corresponds to variant dbSNP:rs34534919Ensembl.1
Natural variantiVAR_046282167N → I. Corresponds to variant dbSNP:rs542571Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03521692 – 197ALQAV…THKLS → GPIPGN in isoform 2. 3 PublicationsAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF367017 mRNA Translation: AAK71682.1
AY885669 mRNA Translation: AAW78563.1
AK311902 mRNA Translation: BAG34843.1
CH471065 Genomic DNA Translation: EAW67062.1
BC117478 mRNA Translation: AAI17479.1
BC117480 mRNA Translation: AAI17481.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31661.1 [Q5EG05-1]
CCDS41705.1 [Q5EG05-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001017534.1, NM_001017534.1 [Q5EG05-1]
NP_443121.1, NM_052889.2 [Q5EG05-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.348365

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375704; ENSP00000364856; ENSG00000204397 [Q5EG05-2]
ENST00000375706; ENSP00000364858; ENSG00000204397 [Q5EG05-1]
ENST00000525374; ENSP00000433700; ENSG00000204397 [Q5EG05-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114769

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114769

UCSC genome browser

More...
UCSCi
uc001pio.2 human [Q5EG05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367017 mRNA Translation: AAK71682.1
AY885669 mRNA Translation: AAW78563.1
AK311902 mRNA Translation: BAG34843.1
CH471065 Genomic DNA Translation: EAW67062.1
BC117478 mRNA Translation: AAI17479.1
BC117480 mRNA Translation: AAI17481.1
CCDSiCCDS31661.1 [Q5EG05-1]
CCDS41705.1 [Q5EG05-2]
RefSeqiNP_001017534.1, NM_001017534.1 [Q5EG05-1]
NP_443121.1, NM_052889.2 [Q5EG05-2]
UniGeneiHs.348365

3D structure databases

ProteinModelPortaliQ5EG05
SMRiQ5EG05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125339, 3 interactors
IntActiQ5EG05, 1 interactor
MINTiQ5EG05
STRINGi9606.ENSP00000364858

PTM databases

iPTMnetiQ5EG05
PhosphoSitePlusiQ5EG05

Polymorphism and mutation databases

BioMutaiCARD16
DMDMi74722547

Proteomic databases

MaxQBiQ5EG05
PaxDbiQ5EG05
PeptideAtlasiQ5EG05
PRIDEiQ5EG05
ProteomicsDBi62773
62774 [Q5EG05-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375704; ENSP00000364856; ENSG00000204397 [Q5EG05-2]
ENST00000375706; ENSP00000364858; ENSG00000204397 [Q5EG05-1]
ENST00000525374; ENSP00000433700; ENSG00000204397 [Q5EG05-2]
GeneIDi114769
KEGGihsa:114769
UCSCiuc001pio.2 human [Q5EG05-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114769
DisGeNETi114769
EuPathDBiHostDB:ENSG00000204397.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CARD16
HGNCiHGNC:33701 CARD16
HPAiHPA053981
HPA062805
MIMi615680 gene
neXtProtiNX_Q5EG05
OpenTargetsiENSG00000204397
PharmGKBiPA164717628

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00940000159114
HOGENOMiHOG000111300
HOVERGENiHBG006113
InParanoidiQ5EG05
KOiK12806
OMAiCITDICE
OrthoDBiEOG091G0L5Y
PhylomeDBiQ5EG05
TreeFamiTF330675

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CARD16 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
COP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114769

Protein Ontology

More...
PROi
PR:Q5EG05

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204397 Expressed in 171 organ(s), highest expression level in leukocyte
CleanExiHS_CARD16
ExpressionAtlasiQ5EG05 baseline and differential
GenevisibleiQ5EG05 HS

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
PANTHERiPTHR10454 PTHR10454, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAR16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5EG05
Secondary accession number(s): Q96RJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 15, 2005
Last modified: December 5, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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