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Protein

Insulin

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
InsulinUniRule annotation
Gene namesi
Name:Ins2Imported
ORF Names:mCG_11077Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96573 Ins2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501430976725 – 110InsulinSequence analysisAdd BLAST86

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000215 Expressed in 67 organ(s), highest expression level in dorsal pancreas

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.UniRule annotationSAAS annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 109IlGFInterPro annotationAdd BLAST82

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
HOVERGENiHBG006137
KOiK04526
OrthoDBiEOG091G0H56

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q5EEX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):12,364
Last modified:May 10, 2005 - v1
Checksum:i3554C8803D24FDAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099934 mRNA Translation: AAH99934.1
BC132650 mRNA Translation: AAI32651.1
BC132652 mRNA Translation: AAI32653.1
BC145554 mRNA Translation: AAI45555.1
AY899305 mRNA Translation: AAW83742.1
AK007612 mRNA Translation: BAB25135.1
CH466531 Genomic DNA Translation: EDL18179.1
CH466531 Genomic DNA Translation: EDL18180.1
RefSeqiNP_001172012.1, NM_001185083.2
NP_001172013.1, NM_001185084.2
NP_032413.1, NM_008387.5
UniGeneiMm.4946

Genome annotation databases

GeneIDi16334
KEGGimmu:16334

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099934 mRNA Translation: AAH99934.1
BC132650 mRNA Translation: AAI32651.1
BC132652 mRNA Translation: AAI32653.1
BC145554 mRNA Translation: AAI45555.1
AY899305 mRNA Translation: AAW83742.1
AK007612 mRNA Translation: BAB25135.1
CH466531 Genomic DNA Translation: EDL18179.1
CH466531 Genomic DNA Translation: EDL18180.1
RefSeqiNP_001172012.1, NM_001185083.2
NP_001172013.1, NM_001185084.2
NP_032413.1, NM_008387.5
UniGeneiMm.4946

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16334
KEGGimmu:16334

Organism-specific databases

CTDi16334
MGIiMGI:96573 Ins2

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
HOVERGENiHBG006137
KOiK04526
OrthoDBiEOG091G0H56

Miscellaneous databases

ChiTaRSiIns2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000215 Expressed in 67 organ(s), highest expression level in dorsal pancreas

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5EEX1_MOUSE
AccessioniPrimary (citable) accession number: Q5EEX1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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