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1 to 25 of 25  Show
  1. 1
    "Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator."
    Keegan C.E., Hutz J.E., Else T., Adamska M., Shah S.P., Kent A.E., Howes J.M., Beamer W.G., Hammer G.D.
    Hum. Mol. Genet. 14:113-123(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION, INVOLVEMENT IN ACD.
    Category: Function, Pathology & Biotech, Expression, Sequences.
    Strain: DW/J.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 164 other entries.

  2. 2
    "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 10625 and mapped to 43846 other entries.

  3. 3
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Category: Sequences.
    Strain: Czech II.
    Tissue: Mammary gland.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  4. 4
    "OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation."
    Wan M., Qin J., Songyang Z., Liu D.
    J. Biol. Chem. 284:26725-26731(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STN1.
    Category: Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 and mapped to 23 other entries.

  5. 5
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-313 AND SER-317, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: PTM / Processing, Sequences.
    Tissue: Liver, Lung, Spleen and Testis.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 25326 other entries.

  6. 6
    "BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system."
    Magdaleno S., Jensen P., Brumwell C.L., Seal A., Lehman K., Asbury A., Cheung T., Cornelius T., Batten D.M., Eden C., Norland S.M., Rice D.S., Dosooye N., Shakya S., Mehta P., Curran T.
    PLoS Biol. 4:e86-e86(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:87873.

    This publication is mapped to 20511 other entries.

  7. 7
    "POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination."
    He H., Multani A.S., Cosme-Blanco W., Tahara H., Ma J., Pathak S., Deng Y., Chang S.
    EMBO J. 25:5180-5190(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:87873.

    This publication is mapped to 43 other entries.

  8. 8
    Category: Interaction.
    Annotation: Tpp1 is required for the protective function of Pot1 proteins. [GeneRIF:497652].
    Source: GeneRIF:497652, MGI:87873.

    This publication is mapped to 19 other entries.

  9. 9
    "Tpp1/Acd maintains genomic stability through a complex role in telomere protection."
    Else T., Theisen B.K., Wu Y., Hutz J.E., Keegan C.E., Hammer G.D., Ferguson D.O.
    Chromosome Res. 15:1001-1013(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:87873.

    This publication is mapped to 4 other entries.

  10. 10
    "Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis."
    Else T., Trovato A., Kim A.C., Wu Y., Ferguson D.O., Kuick R.D., Lucas P.C., Hammer G.D.
    Cancer Cell 15:465-476(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Tumors from Acd(acd/acd) p53(+/-) mice show a striking switch from the classic spectrum of p53(-/-) mice toward carcinomas. [GeneRIF:497652].
    Source: GeneRIF:497652, MGI:87873.

    This publication is mapped to 24 other entries.

  11. 11
    "Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis."
    Vlangos C.N., O'Connor B.C., Morley M.J., Krause A.S., Osawa G.A., Keegan C.E.
    Dev. Biol. 334:418-428(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Source: MGI:87873.

    This publication is mapped to 44 other entries.

  12. 12
    "Telomere protection by TPP1 is mediated by POT1a and POT1b."
    Kibe T., Osawa G.A., Keegan C.E., de Lange T.
    Mol. Cell. Biol. 30:1059-1066(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:87873.

    This publication is mapped to 16 other entries.

  13. 13
    "TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice."
    Tejera A.M., Stagno d'Alcontres M., Thanasoula M., Marion R.M., Martinez P., Liao C., Flores J.M., Tarsounas M., Blasco M.A.
    Dev. Cell 18:775-789(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:87873.

    This publication is mapped to 9 other entries.

  14. 14
    "How shelterin solves the telomere end-protection problem."
    de Lange T.
    Cold Spring Harb. Symp. Quant. Biol. 75:167-177(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Mouse gene deletion experiments revealed DNA-damage-response pathways that threaten chromosome ends and how the components of the telomeric shelterin complex prevent activation of these pathways.[Shelterin].
    Source: GeneRIF:497652.

    This publication is mapped to 39 other entries.

  15. 15
    "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:87873.

    This publication is mapped to 57460 other entries.

  16. 16
    "Additive effect of TAp63 deficiency on the adrenocortical dysplasia (acd) phenotype."
    O'Connor B.C., Macke E.L., Keegan C.E.
    Mamm. Genome 22:714-721(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Source: MGI:87873.

    This publication is mapped to 10 other entries.

  17. 17
    "Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST."
    Wu P., Takai H., de Lange T.
    Cell 150:39-52(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q5EE38.

    This publication is cited by 1 and mapped to 6 other entries.

  18. 18
    Category: Function.
    Source: MGI:87873.

    This publication is cited by 4 and mapped to 70 other entries.

  19. 19
    "Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation."
    Jones M., Osawa G., Regal J.A., Weinberg D.N., Taggart J., Kocak H., Friedman A., Ferguson D.O., Keegan C.E., Maillard I.
    J. Clin. Invest. 124:353-366(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd.
    Source: GeneRIF:497652.

    This publication is mapped to 1 other entry.

  20. 20
    "TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1."
    Frescas D., de Lange T.
    Mol. Cell. Biol. 34:1349-1362(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1. [GeneRIF:497652].
    Source: GeneRIF:497652, MGI:87873.

    This publication is mapped to 29 other entries.

  21. 21
    "TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling."
    Zimmermann M., Kibe T., Kabir S., de Lange T.
    Genes Dev. 28:2477-2491(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:87873.

    This publication is mapped to 35 other entries.

  22. 22
    "The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action."
    Grill S., Tesmer V.M., Nandakumar J.
    Cell Rep 22:1132-1140(2018) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: show that TPP1 NOB is critical for telomerase function and demonstrate that the telomerase interaction surface on TPP1 is more elaborate than previously appreciated.
    Source: GeneRIF:497652.

    This publication is mapped to 1 other entry.

  23. 23
    "High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype."
    Sucularli C., Thomas P., Kocak H., White J.S., O'Connor B.C., Keegan C.E.
    Gene 679:219-231(2018) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Analyses demonstrate that the majority of differentially expressed genes in acd mutant embryos are due to p53-dependent mechanisms and reflect the observed phenotypic differences between acd mutant and double mutant embryos.
    Source: GeneRIF:497652.

    This publication is mapped to 1 other entry.

  24. 24
    "Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency."
    Beamer W.G., Sweet H.O., Bronson R.T., Shire J.G., Orth D.N., Davisson M.T.
    J. Endocrinol. 141:33-43(1994) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Source: MGI:87873.

    This publication is mapped to 10 other entries.

  25. 25
    "Mammalian orthologues of a yeast regulator of nonsense transcript stability."
    Perlick H.A., Medghalchi S.M., Spencer F.A., Kendzior R.J. Jr., Dietz H.C.
    Proc. Natl. Acad. Sci. U.S.A. 93:10928-10932(1996) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:87873.

    This publication is cited by 1 and mapped to 7 other entries.

1 to 25 of 25  Show
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