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Entry version 88 (08 May 2019)
Sequence version 1 (15 Mar 2005)
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Protein
Submitted name:

Cardiac myosin heavy chain-alpha

Gene

myh6

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi178 – 185ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cardiac myosin heavy chain-alphaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myh6Imported
Synonyms:MHC-alphaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-968721 myh6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 81Myosin N-terminal SH3-likeInterPro annotationAdd BLAST50
Domaini85 – 775Myosin motorInterPro annotationAdd BLAST691

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni652 – 674Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili839 – 1090Sequence analysisAdd BLAST252
Coiled coili1098 – 1153Sequence analysisAdd BLAST56
Coiled coili1190 – 1371Sequence analysisAdd BLAST182
Coiled coili1373 – 1442Sequence analysisAdd BLAST70
Coiled coili1450 – 1470Sequence analysisAdd BLAST21
Coiled coili1485 – 1512Sequence analysisAdd BLAST28
Coiled coili1520 – 1600Sequence analysisAdd BLAST81
Coiled coili1605 – 1639Sequence analysisAdd BLAST35
Coiled coili1647 – 1709Sequence analysisAdd BLAST63
Coiled coili1717 – 1920Sequence analysisAdd BLAST204

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K17751

Database of Orthologous Groups

More...
OrthoDBi
47111at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5EC16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDAMMADFG AAAPFLRKSD KERLEAQTRI FDIKTEVFVP DTIQEFVKAK
60 70 80 90 100
ITSRDGGKVT AETADGKTVT VKDVDVHQQN PPKFDKIEDM AMLTFLHEPA
110 120 130 140 150
VLYNLKERYA AWMIYTYSGL FCVTVNPYKW LPVYNSEVVN AYRGKKRSEA
160 170 180 190 200
PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFASIAS
210 220 230 240 250
VGGKRDSSKG TLEDQIIQAN PALEAFGNAK TVRNDNSSRF GKFIRIHFGA
260 270 280 290 300
SGKLASADIE TYLLEKSRVI FQLKSERNYH IFYQILSNKK PELLDMMLVT
310 320 330 340 350
NNPYDYSYIS QGEVTVASID DADELMATDS AFDVLGFTAE EKVGVYKLTG
360 370 380 390 400
AIMHSGNMRF KQKQREEQAE PDGTEEADKA AYLMGLNSAD LLKGLCHPRV
410 420 430 440 450
KVGNEYVTKG QNVQQVYYSI GALGKSVYEK MFLWMVVRIN STLETKQPRQ
460 470 480 490 500
YFIGVLDIAG FEIFDFNSFE QLCINFTNEK LQQFFNHHMF VLEQEEYKKE
510 520 530 540 550
GIEWEFIDFG MDLQACIDLI EKPMGIMSIL EEECMFPKAS DMTFKAKLYD
560 570 580 590 600
NHLGKSNNFQ KPRNLKGKPE AHFALVHYAG TVDYNISGWL EKNKDPLNET
610 620 630 640 650
VVGLYQKSSL KLLANLFSNY AAADSDTGGK GKGGKKKGSS FQTVSALHRE
660 670 680 690 700
NLNKLMTNLR TTHPHFVRCI IPNERKAPGE MDNPLVMHQL RCNGVLEGIR
710 720 730 740 750
ICRKGFPNRI LYGDFRQRYR ILNPAAIPEG QFIDSRKGSE KLLGSIDIDH
760 770 780 790 800
TQYKFGHTKV FFKAGLLGLL EEMRDERLSR IITRIQAQSR VLLMRREFKK
810 820 830 840 850
ILERRDALLV IQWNIRAFMG VKNWPWMKLY FKIKPLLKTA ETEKEMANMK
860 870 880 890 900
EEFHRLKEAL EKSETRRKEL EEKMVSLLQE KNDLQLQVQA EQDNLNDAEE
910 920 930 940 950
RCEQLIKNKI QLEAKLKEQT ERLDDEEEMN AELTAKKRKL EDECSELKKD
960 970 980 990 1000
IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDDIIAKLT KEKKALQEAH
1010 1020 1030 1040 1050
QQTLDDLQAE EDKVNSLTKA KAKLEQQVDD LEGSLEQEKK LRMDMERAKR
1060 1070 1080 1090 1100
KLEGDLKLTQ ENVMDLENDK QQLEEKTKKK EFEISLLNSK IEDEQIMGMQ
1110 1120 1130 1140 1150
QQKKLKEHQA RIEELEEELE AERTARAKVE KLRSDLSREL EEISERLEEA
1160 1170 1180 1190 1200
GGATSVQMEL NKKREAEFLK LKRDLEESTL QSEATAATLR KKHADSVAEL
1210 1220 1230 1240 1250
SEQIDNLQRV KQKLEKEKSE FKLELDDVAS NMEQVVKSKV NLEKLCRTLE
1260 1270 1280 1290 1300
DQMNEHRTKF EEVQRTLNDL SSQKAKLQTE NGELTRRLDE KEALVSQMTR
1310 1320 1330 1340 1350
GKQTYSQQLE DLKRQLEEES KAKNALAHGL QSARHDCDLL REQYEEEQEA
1360 1370 1380 1390 1400
KAELQRVLSK ANAEVAQWRT KYETDAIQRT EELEEAKKKL AQRLQEAEEA
1410 1420 1430 1440 1450
VEAVNAKCSS LEKTKHRLQN EIEDLMVDLE RSNAAAAALD KKQRNFDKIL
1460 1470 1480 1490 1500
SEWKQKFEES QTELESSLKE SRSLSTELFK LKNAYEESLE HLETFKRENK
1510 1520 1530 1540 1550
NLQEEISDLT EQLGEGGKSI HELEKIRKQL EQEKMELQTA LEEAEASLEH
1560 1570 1580 1590 1600
EEGKILRAQL EFNQLKSEID RKIAEKDEEM EQVKRNNQRL VDALQTQLEA
1610 1620 1630 1640 1650
EIRSRNEALR VKKKMEGDLN EMEIQLSQAN RSAAEAHKHL KAAHGSLKDI
1660 1670 1680 1690 1700
QIQLDDTMRA NDDLKENSAI VERRNMLLQA ELEELRSILE QTERSRKLAE
1710 1720 1730 1740 1750
QELIETSERV QLLHSQNTSL INQKKKTETD LAQLQTEVEE AVQECRNAEE
1760 1770 1780 1790 1800
KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNMEQTIKDL QQRLDEAEQI
1810 1820 1830 1840 1850
AMKGGKKQLQ KLEGRVRELD NELEAEQKRN AESIKNMRKY ERRIKELTYQ
1860 1870 1880 1890 1900
TDEDKKNMAR LQDLVDKLQL KVKAYKRQAE EAEEQANSNL SKFRKVQHEL
1910 1920 1930
DEAEERADIA ESQVNKIRAK TRDVGGKKTL HEEE
Length:1,934
Mass (Da):223,357
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FA9400394D03382
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY913767 mRNA Translation: AAW88310.1

NCBI Reference Sequences

More...
RefSeqi
NP_001085070.1, NM_001091601.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
432141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:432141

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY913767 mRNA Translation: AAW88310.1
RefSeqiNP_001085070.1, NM_001091601.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi432141
KEGGixla:432141

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
432141
XenbaseiXB-GENE-968721 myh6

Phylogenomic databases

KOiK17751
OrthoDBi47111at2759

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5EC16_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5EC16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 8, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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