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UniProtKB - Q5EBM0 (CMPK2_HUMAN)

Entry version 130 (25 May 2022)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

UMP-CMP kinase 2, mitochondrial

Gene

CMPK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.09 mM for CMP
  2. KM=6.3 mM for UMP
  3. KM=1.31 mM for dCMP
  4. KM=0.1 mM for dUMP
  1. Vmax=1.64 µmol/min/mg enzyme towards CMP
  2. Vmax=0.19 µmol/min/mg enzyme towards UMP
  3. Vmax=1.77 µmol/min/mg enzyme towards dCMP
  4. Vmax=0.48 µmol/min/mg enzyme towards dUMP

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi259 – 266ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.4.14, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5EBM0

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q5EBM0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UMP-CMP kinase 2, mitochondrial (EC:2.7.4.14)
Alternative name(s):
Nucleoside-diphosphate kinase (EC:2.7.4.6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CMPK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27015, CMPK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611787, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5EBM0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134326

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		129607

Open Targets

More...OpenTargetsi		ENSG00000134326

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162382556

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5EBM0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CMPK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439392

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 98MitochondrionSequence analysisAdd BLAST98
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033152499 – 449UMP-CMP kinase 2, mitochondrialAdd BLAST351

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5EBM0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5EBM0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5EBM0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5EBM0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5EBM0

PeptideAtlas

More...PeptideAtlasi		Q5EBM0

PRoteomics IDEntifications database

More...PRIDEi		Q5EBM0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62766 [Q5EBM0-1]
62767 [Q5EBM0-2]
62768 [Q5EBM0-3]
62769 [Q5EBM0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5EBM0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5EBM0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Among all investigated tumors, leukemia cells show the most abundant expression.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134326, Expressed in epithelial cell of pancreas and 211 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5EBM0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134326, Tissue enhanced (brain, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256722

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5EBM0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q5EBM0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5EBM0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili380 – 412Sequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3327, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049896_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5EBM0

Identification of Orthologs from Complete Genome Data

More...OMAi		MAPPRCF

Database of Orthologous Groups

More...OrthoDBi		1450196at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5EBM0

TreeFam database of animal gene trees

More...TreeFami		TF328875

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR039430, Thymidylate_kin-like_dom
IPR014505, UMP-CMP_kinase_2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02223, Thymidylate_kin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF019736, dTMP_TKRP1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5EBM0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFARRLLRG PLSGPLLGRR GVCAGAMAPP RRFVLELPDC TLAHFALGAD 
        60         70         80         90        100
APGDADAPDP RLAALLGPPE RSYSLCVPVT PDAGCGARVR AARLHQRLLH 
       110        120        130        140        150
QLRRGPFQRC QLLRLLCYCP GGQAGGAQQG FLLRDPLDDP DTRQALLELL 
       160        170        180        190        200
GACQEAPRPH LGEFEADPRG QLWQRLWEVQ DGRRLQVGCA QVVPVPEPPL 
       210        220        230        240        250
HPVVPDLPSS VVFPDREAAR AVLEECTSFI PEARAVLDLV DQCPKQIQKG 
       260        270        280        290        300
KFQVVAIEGL DATGKTTVTQ SVADSLKAVL LKSPPSCIGQ WRKIFDDEPT 
       310        320        330        340        350
IIRRAFYSLG NYIVASEIAK ESAKSPVIVD RYWHSTATYA IATEVSGGLQ 
       360        370        380        390        400
HLPPAHHPVY QWPEDLLKPD LILLLTVSPE ERLQRLQGRG MEKTREEAEL 
       410        420        430        440 
EANSVFRQKV EMSYQRMENP GCHVVDASPS REKVLQTVLS LIQNSFSEP
Length:449
Mass (Da):49,448
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99F382E34332B6DE
GO
Isoform 2 (identifier: Q5EBM0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-303: LLKSPPSCIGQWRKIFDDEPTIIR → PQPITLCTSGQRTCSNLTLSCCSL
     304-449: Missing.

Show »
Length:303
Mass (Da):32,646
Checksum:i4C7D0715B7B970C6
GO
Isoform 3 (identifier: Q5EBM0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-449: YWHSTATYAI...SLIQNSFSEP → SQLGGTLYHPSLHLLGSEVCGTGILDSSHSSQGLE

Show »
Length:366
Mass (Da):39,562
Checksum:iCE09AA2A0A6E6DB3
GO
Isoform 4 (identifier: Q5EBM0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-449: Missing.

Show »
Length:409
Mass (Da):44,959
Checksum:iA102FAA659D793D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti448E → G in AAH89425 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055997433K → R. Corresponds to variant dbSNP:rs6712141Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033238280 – 303LLKSP…PTIIR → PQPITLCTSGQRTCSNLTLS CCSL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_033239304 – 449Missing in isoform 2. 1 PublicationAdd BLAST146
Alternative sequenceiVSP_033240332 – 449YWHST…SFSEP → SQLGGTLYHPSLHLLGSEVC GTGILDSSHSSQGLE in isoform 3. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_033241410 – 449Missing in isoform 4. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK127983 mRNA Translation: BAC87217.1
BC016969 mRNA Translation: AAH16969.1
BC141802 mRNA Translation: AAI41803.1
BC132821 mRNA Translation: AAI32822.1
BC089425 mRNA Translation: AAH89425.1
BC144202 mRNA Translation: AAI44203.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42648.1 [Q5EBM0-1]
CCDS58695.1 [Q5EBM0-3]
CCDS58696.1 [Q5EBM0-4]

NCBI Reference Sequences

More...RefSeqi		NP_001243406.1, NM_001256477.1 [Q5EBM0-4]
NP_001243407.1, NM_001256478.1 [Q5EBM0-3]
NP_997198.2, NM_207315.3 [Q5EBM0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256722.10; ENSP00000256722.5; ENSG00000134326.12
ENST00000404168.1; ENSP00000384915.1; ENSG00000134326.12 [Q5EBM0-4]
ENST00000458098.5; ENSP00000396385.1; ENSG00000134326.12 [Q5EBM0-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		129607

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:129607

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000256722.10; ENSP00000256722.5; NM_207315.4; NP_997198.2

UCSC genome browser

More...UCSCi		uc002qyo.5, human [Q5EBM0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127983 mRNA Translation: BAC87217.1
BC016969 mRNA Translation: AAH16969.1
BC141802 mRNA Translation: AAI41803.1
BC132821 mRNA Translation: AAI32822.1
BC089425 mRNA Translation: AAH89425.1
BC144202 mRNA Translation: AAI44203.1
CCDSiCCDS42648.1 [Q5EBM0-1]
CCDS58695.1 [Q5EBM0-3]
CCDS58696.1 [Q5EBM0-4]
RefSeqiNP_001243406.1, NM_001256477.1 [Q5EBM0-4]
NP_001243407.1, NM_001256478.1 [Q5EBM0-3]
NP_997198.2, NM_207315.3 [Q5EBM0-1]

3D structure databases

AlphaFoldDBiQ5EBM0
SMRiQ5EBM0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256722

PTM databases

iPTMnetiQ5EBM0
PhosphoSitePlusiQ5EBM0

Genetic variation databases

BioMutaiCMPK2
DMDMi296439392

Proteomic databases

EPDiQ5EBM0
jPOSTiQ5EBM0
MassIVEiQ5EBM0
MaxQBiQ5EBM0
PaxDbiQ5EBM0
PeptideAtlasiQ5EBM0
PRIDEiQ5EBM0
ProteomicsDBi62766 [Q5EBM0-1]
62767 [Q5EBM0-2]
62768 [Q5EBM0-3]
62769 [Q5EBM0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26409, 86 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		129607

Genome annotation databases

EnsembliENST00000256722.10; ENSP00000256722.5; ENSG00000134326.12
ENST00000404168.1; ENSP00000384915.1; ENSG00000134326.12 [Q5EBM0-4]
ENST00000458098.5; ENSP00000396385.1; ENSG00000134326.12 [Q5EBM0-3]
GeneIDi129607
KEGGihsa:129607
MANE-SelectiENST00000256722.10; ENSP00000256722.5; NM_207315.4; NP_997198.2
UCSCiuc002qyo.5, human [Q5EBM0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		129607
DisGeNETi129607

GeneCards: human genes, protein and diseases

More...GeneCardsi		CMPK2
HGNCiHGNC:27015, CMPK2
HPAiENSG00000134326, Tissue enhanced (brain, salivary gland)
MIMi611787, gene
neXtProtiNX_Q5EBM0
OpenTargetsiENSG00000134326
PharmGKBiPA162382556
VEuPathDBiHostDB:ENSG00000134326

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3327, Eukaryota
GeneTreeiENSGT00940000154030
HOGENOMiCLU_049896_0_0_1
InParanoidiQ5EBM0
OMAiMAPPRCF
OrthoDBi1450196at2759
PhylomeDBiQ5EBM0
TreeFamiTF328875

Enzyme and pathway databases

BRENDAi2.7.4.14, 2681
PathwayCommonsiQ5EBM0
SABIO-RKiQ5EBM0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		129607, 16 hits in 1084 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		129607
PharosiQ5EBM0, Tbio

Protein Ontology

More...PROi		PR:Q5EBM0
RNActiQ5EBM0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134326, Expressed in epithelial cell of pancreas and 211 other tissues
GenevisibleiQ5EBM0, HS

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR039430, Thymidylate_kin-like_dom
IPR014505, UMP-CMP_kinase_2
PfamiView protein in Pfam
PF02223, Thymidylate_kin, 1 hit
PIRSFiPIRSF019736, dTMP_TKRP1, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMPK2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5EBM0
Secondary accession number(s): A2RUB0
, A5D8T2, B7ZM18, Q6ZRU2, Q96AL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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