UniProtKB - Q5EBL4 (RIPL1_HUMAN)
RILP-like protein 1
RILPL1
Functioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
GO - Biological processi
- cilium assembly Source: GO_Central
- epithelial cell morphogenesis Source: UniProtKB
- protein transport from ciliary membrane to plasma membrane Source: UniProtKB
- regulation of neuron death Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5EBL4 |
Names & Taxonomyi
Protein namesi | Recommended name: RILP-like protein 1Alternative name(s): Rab-interacting lysosomal-like protein 1 |
Gene namesi | Name:RILPL1 Synonyms:RLP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26814, RILPL1 |
MIMi | 614092, gene |
neXtProti | NX_Q5EBL4 |
VEuPathDBi | HostDB:ENSG00000188026.11 |
Subcellular locationi
Cytoskeleton
- centriole 1 Publication
- cilium basal body 1 Publication
Cytosol
- cytosol 2 Publications
Cytoskeleton
- centriole Source: UniProtKB-SubCell
- centrosome Source: UniProtKB
- ciliary basal body Source: GO_Central
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 291 | R → L or E: Loss of interaction with RAB8A and RAB10. 1 Publication | 1 | |
Mutagenesisi | 293 | R → L or E: Loss of interaction with RAB8A. 1 Publication | 1 | |
Mutagenesisi | 300 | R → L or E: No loss of interaction with RAB8A. 1 Publication | 1 | |
Mutagenesisi | 310 | K → L or E: Loss of interaction with RAB8A. 1 Publication | 1 | |
Mutagenesisi | 324 | K → L or E: No loss of interaction with RAB8A. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 353116 |
OpenTargetsi | ENSG00000188026 |
PharmGKBi | PA162401302 |
Miscellaneous databases
Pharosi | Q5EBL4, Tbio |
Genetic variation databases
BioMutai | RILPL1 |
DMDMi | 74736071 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299310 | 1 – 403 | RILP-like protein 1Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 47 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 259 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, S-nitrosylationProteomic databases
EPDi | Q5EBL4 |
jPOSTi | Q5EBL4 |
MassIVEi | Q5EBL4 |
MaxQBi | Q5EBL4 |
PaxDbi | Q5EBL4 |
PeptideAtlasi | Q5EBL4 |
PRIDEi | Q5EBL4 |
ProteomicsDBi | 62761 [Q5EBL4-1] 62762 [Q5EBL4-2] 62763 [Q5EBL4-3] |
PTM databases
iPTMneti | Q5EBL4 |
PhosphoSitePlusi | Q5EBL4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000188026, Expressed in apex of heart and 116 other tissues |
ExpressionAtlasi | Q5EBL4, baseline and differential |
Genevisiblei | Q5EBL4, HS |
Organism-specific databases
HPAi | ENSG00000188026, Group enriched (brain, heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Interacts (when S-nitrosylated) with GAPDH (By similarity).
Interacts with RAB8A; interaction is dependent on the phosphorylation of 'Thr-72' of RAB8A (PubMed:29125462, PubMed:30398148).
Interacts with RAB10 and RAB12; the interaction is dependent on the phosphorylation of 'Thr-73' of RAB10, and 'Ser-105' of RAB12 (PubMed:29125462, PubMed:30398148).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ5EBL4
With | #Exp. | IntAct |
---|---|---|
RAB8A [P61006] | 2 | EBI-2797110,EBI-722293 |
Isoform 3 [Q5EBL4-3]
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 131631, 10 interactors |
IntActi | Q5EBL4, 12 interactors |
STRINGi | 9606.ENSP00000366070 |
Miscellaneous databases
RNActi | Q5EBL4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 97 | RH1PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 291 – 356 | RH2PROSITE-ProRule annotationAdd BLAST | 66 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 76 – 258 | Sequence analysisAdd BLAST | 183 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QR9G, Eukaryota |
GeneTreei | ENSGT00940000157897 |
HOGENOMi | CLU_044133_3_0_1 |
InParanoidi | Q5EBL4 |
OMAi | SEKMAMD |
OrthoDBi | 890179at2759 |
PhylomeDBi | Q5EBL4 |
TreeFami | TF313489 |
Family and domain databases
InterProi | View protein in InterPro IPR019143, JNK/Rab-associated_protein-1_N IPR034743, RH1 IPR034744, RH2 IPR021563, RILP_dimer |
Pfami | View protein in Pfam PF09744, Jnk-SapK_ap_N, 1 hit PF11461, RILP, 1 hit |
PROSITEi | View protein in PROSITE PS51776, RH1, 1 hit PS51777, RH2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEERGSALA AESALEKNVA ELTVMDVYDI ASLVGHEFER VIDQHGCEAI
60 70 80 90 100
ARLMPKVVRV LEILEVLVSR HHVAPELDEL RLELDRLRLE RMDRIEKERK
110 120 130 140 150
HQKELELVED VWRGEAQDLL SQIAQLQEEN KQLMTNLSHK DVNFSEEEFQ
160 170 180 190 200
KHEGMSERER QVMKKLKEVV DKQRDEIRAK DRELGLKNED VEALQQQQTR
210 220 230 240 250
LMKINHDLRH RVTVVEAQGK ALIEQKVELE ADLQTKEQEM GSLRAELGKL
260 270 280 290 300
RERLQGEHSQ NGEEEPETEP VGEESISDAE KVAMDLKDPN RPRFTLQELR
310 320 330 340 350
DVLHERNELK SKVFLLQEEL AYYKSEEMEE ENRIPQPPPI AHPRTSPQPE
360 370 380 390 400
SGIKRLFSFF SRDKKRLANT QRNVHIQESF GQWANTHRDD GYTEQGQEAL
QHL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GVV3 | A0A1B0GVV3_HUMAN | RILP-like protein 1 | RILPL1 | 386 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027605 | 1 – 151 | Missing in isoform 3. 1 PublicationAdd BLAST | 151 | |
Alternative sequenceiVSP_027606 | 1 – 24 | Missing in isoform 2. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_027607 | 152 – 153 | HE → MT in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_027608 | 357 – 403 | FSFFS…ALQHL → IFTAIMPMVAAGLIIDDPTL QPVRRLVSLV in isoform 2. 1 PublicationAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096697 mRNA Translation: BAC04845.1 AC055713 Genomic DNA No translation available. AC145423 Genomic DNA No translation available. BC080626 mRNA Translation: AAH80626.1 BC089444 mRNA Translation: AAH89444.1 |
CCDSi | CCDS45006.1 [Q5EBL4-1] |
RefSeqi | NP_001306172.1, NM_001319243.1 NP_001306173.1, NM_001319244.1 [Q5EBL4-3] NP_001306231.1, NM_001319302.1 [Q5EBL4-3] NP_847884.2, NM_178314.4 [Q5EBL4-1] |
Genome annotation databases
Ensembli | ENST00000376874; ENSP00000366070; ENSG00000188026 [Q5EBL4-1] |
GeneIDi | 353116 |
KEGGi | hsa:353116 |
UCSCi | uc001ufe.3, human [Q5EBL4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096697 mRNA Translation: BAC04845.1 AC055713 Genomic DNA No translation available. AC145423 Genomic DNA No translation available. BC080626 mRNA Translation: AAH80626.1 BC089444 mRNA Translation: AAH89444.1 |
CCDSi | CCDS45006.1 [Q5EBL4-1] |
RefSeqi | NP_001306172.1, NM_001319243.1 NP_001306173.1, NM_001319244.1 [Q5EBL4-3] NP_001306231.1, NM_001319302.1 [Q5EBL4-3] NP_847884.2, NM_178314.4 [Q5EBL4-1] |
3D structure databases
SMRi | Q5EBL4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131631, 10 interactors |
IntActi | Q5EBL4, 12 interactors |
STRINGi | 9606.ENSP00000366070 |
PTM databases
iPTMneti | Q5EBL4 |
PhosphoSitePlusi | Q5EBL4 |
Genetic variation databases
BioMutai | RILPL1 |
DMDMi | 74736071 |
Proteomic databases
EPDi | Q5EBL4 |
jPOSTi | Q5EBL4 |
MassIVEi | Q5EBL4 |
MaxQBi | Q5EBL4 |
PaxDbi | Q5EBL4 |
PeptideAtlasi | Q5EBL4 |
PRIDEi | Q5EBL4 |
ProteomicsDBi | 62761 [Q5EBL4-1] 62762 [Q5EBL4-2] 62763 [Q5EBL4-3] |
Protocols and materials databases
Antibodypediai | 31816, 98 antibodies |
DNASUi | 353116 |
Genome annotation databases
Ensembli | ENST00000376874; ENSP00000366070; ENSG00000188026 [Q5EBL4-1] |
GeneIDi | 353116 |
KEGGi | hsa:353116 |
UCSCi | uc001ufe.3, human [Q5EBL4-1] |
Organism-specific databases
CTDi | 353116 |
DisGeNETi | 353116 |
GeneCardsi | RILPL1 |
HGNCi | HGNC:26814, RILPL1 |
HPAi | ENSG00000188026, Group enriched (brain, heart muscle, skeletal muscle) |
MIMi | 614092, gene |
neXtProti | NX_Q5EBL4 |
OpenTargetsi | ENSG00000188026 |
PharmGKBi | PA162401302 |
VEuPathDBi | HostDB:ENSG00000188026.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR9G, Eukaryota |
GeneTreei | ENSGT00940000157897 |
HOGENOMi | CLU_044133_3_0_1 |
InParanoidi | Q5EBL4 |
OMAi | SEKMAMD |
OrthoDBi | 890179at2759 |
PhylomeDBi | Q5EBL4 |
TreeFami | TF313489 |
Enzyme and pathway databases
PathwayCommonsi | Q5EBL4 |
Miscellaneous databases
BioGRID-ORCSi | 353116, 18 hits in 880 CRISPR screens |
ChiTaRSi | RILPL1, human |
GenomeRNAii | 353116 |
Pharosi | Q5EBL4, Tbio |
PROi | PR:Q5EBL4 |
RNActi | Q5EBL4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188026, Expressed in apex of heart and 116 other tissues |
ExpressionAtlasi | Q5EBL4, baseline and differential |
Genevisiblei | Q5EBL4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019143, JNK/Rab-associated_protein-1_N IPR034743, RH1 IPR034744, RH2 IPR021563, RILP_dimer |
Pfami | View protein in Pfam PF09744, Jnk-SapK_ap_N, 1 hit PF11461, RILP, 1 hit |
PROSITEi | View protein in PROSITE PS51776, RH1, 1 hit PS51777, RH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIPL1_HUMAN | |
Accessioni | Q5EBL4Primary (citable) accession number: Q5EBL4 Secondary accession number(s): Q66K36, Q8N1M0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | March 15, 2005 | |
Last modified: | February 10, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries