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Protein

Telomeric repeat-binding factor

Gene

Terf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processCell cycleUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-171306 Packaging Of Telomere Ends
R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
Telomeric repeat-binding factorUniRule annotation
Gene namesi
Name:Terf1Imported
ORF Names:rCG_30535Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311574 Terf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, NucleusUniRule annotation, TelomereUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000007291 Expressed in 9 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043160

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini362 – 419HTH myb-typeInterPro annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG410IIKA Eukaryota
ENOG4111QH9 LUCA
GeneTreeiENSGT00530000063796
HOGENOMiHOG000132847
HOVERGENiHBG054097
KOiK11110
OMAiQKAWLWE
OrthoDBiEOG091G04CC
TreeFamiTF333209

Family and domain databases

Gene3Di1.25.40.210, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR013867 Telomere_rpt-bd_fac_dimer_dom
IPR036507 Telomere_rpt-bd_fac_dimer_sf
IPR017357 TERF1/2
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF08558 TRF, 1 hit
PIRSFiPIRSF038016 Telomere_bd-1_Pin2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014243 Telomere_repeat-bd_fac_dimer, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF63600 SSF63600, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit

Sequencei

Sequence statusi: Complete.

Q5EB98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTVTSAAP GARSNAGGTS ADSPEKEAAR DDAELFDCRV QLGPPREEEN
60 70 80 90 100
AELVAEAEAV AAGWMLDFLC LSLCRAFRDG RCEDFRQTRD SAEAIIHGLP
110 120 130 140 150
SLTAYQLKTV YICQFLTRVA AGKSLDAQFE VDERITPLES ALMIWDSIEK
160 170 180 190 200
EHDKLHEEIQ NLIKIQAVAV CMEMGSFKEA EEVFERIFGD PEFYTPLERK
210 220 230 240 250
LLKIISQKDV FHVLFQRFSY NLMMEKIQSY VECVLNEKSS TFLMKAATKV
260 270 280 290 300
VENEKARTVA SEDKAKATNT GTETEVNSNK GESVNGQQSV ETESLVDTGS
310 320 330 340 350
SVRSHKNALS PLKSRRLQPD FNRNEARTGT LQCEIATKRN RRTSGGNRLR
360 370 380 390 400
ISKNQPDTNE KHGRRKKQTW LWEEDRSLKC GVRKYGEGNW AKILSHYKFN
410 420
NRTSVMLKDR WRTMRRLRLI S
Length:421
Mass (Da):47,762
Last modified:March 15, 2005 - v1
Checksum:i8FA18DDB2A90BB10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125757 Genomic DNA No translation available.
BC089888 mRNA Translation: AAH89888.1
CH473984 Genomic DNA Translation: EDM11517.1
RefSeqiNP_001012482.1, NM_001012464.1
UniGeneiRn.33853

Genome annotation databases

EnsembliENSRNOT00000049741; ENSRNOP00000043160; ENSRNOG00000007291
GeneIDi297758
KEGGirno:297758
UCSCiRGD:1311574 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125757 Genomic DNA No translation available.
BC089888 mRNA Translation: AAH89888.1
CH473984 Genomic DNA Translation: EDM11517.1
RefSeqiNP_001012482.1, NM_001012464.1
UniGeneiRn.33853

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043160

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049741; ENSRNOP00000043160; ENSRNOG00000007291
GeneIDi297758
KEGGirno:297758
UCSCiRGD:1311574 rat

Organism-specific databases

CTDi7013
RGDi1311574 Terf1

Phylogenomic databases

eggNOGiENOG410IIKA Eukaryota
ENOG4111QH9 LUCA
GeneTreeiENSGT00530000063796
HOGENOMiHOG000132847
HOVERGENiHBG054097
KOiK11110
OMAiQKAWLWE
OrthoDBiEOG091G04CC
TreeFamiTF333209

Enzyme and pathway databases

ReactomeiR-RNO-171306 Packaging Of Telomere Ends
R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence

Gene expression databases

BgeeiENSRNOG00000007291 Expressed in 9 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di1.25.40.210, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR013867 Telomere_rpt-bd_fac_dimer_dom
IPR036507 Telomere_rpt-bd_fac_dimer_sf
IPR017357 TERF1/2
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF08558 TRF, 1 hit
PIRSFiPIRSF038016 Telomere_bd-1_Pin2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014243 Telomere_repeat-bd_fac_dimer, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF63600 SSF63600, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5EB98_RAT
AccessioniPrimary (citable) accession number: Q5EB98
Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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