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Protein

Ras-related protein Rab-18

Gene

Rab18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation
R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-RNO-8873719 RAB geranylgeranylation
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:Rab18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1308905 Rab18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211961 – 203Ras-related protein Rab-18Add BLAST203
PropeptideiPRO_0000370764204 – 206Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei144PhosphoserineBy similarity1
Lipidationi199S-palmitoyl cysteineSequence analysis1
Modified residuei203Cysteine methyl esterSequence analysis1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ5EB77
PRIDEiQ5EB77

PTM databases

iPTMnetiQ5EB77
PhosphoSitePlusiQ5EB77

Expressioni

Gene expression databases

BgeeiENSRNOG00000018972 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiQ5EB77 RN

Interactioni

Protein-protein interaction databases

IntActiQ5EB77, 4 interactors
MINTiQ5EB77
STRINGi10116.ENSRNOP00000025828

Structurei

3D structure databases

ProteinModelPortaliQ5EB77
SMRiQ5EB77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ5EB77
KOiK07910
OMAiMQSTVGM
OrthoDBiEOG091G0MOO
PhylomeDBiQ5EB77
TreeFamiTF313448

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EB77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSPR EESHGGGACG

GYCSVL
Length:206
Mass (Da):22,976
Last modified:March 15, 2005 - v1
Checksum:iD1A398067A6B9B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089957 mRNA Translation: AAH89957.1
RefSeqiNP_001012486.1, NM_001012468.1
UniGeneiRn.221766

Genome annotation databases

EnsembliENSRNOT00000025828; ENSRNOP00000025828; ENSRNOG00000018972
GeneIDi307039
KEGGirno:307039
UCSCiRGD:1308905 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089957 mRNA Translation: AAH89957.1
RefSeqiNP_001012486.1, NM_001012468.1
UniGeneiRn.221766

3D structure databases

ProteinModelPortaliQ5EB77
SMRiQ5EB77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5EB77, 4 interactors
MINTiQ5EB77
STRINGi10116.ENSRNOP00000025828

PTM databases

iPTMnetiQ5EB77
PhosphoSitePlusiQ5EB77

Proteomic databases

PaxDbiQ5EB77
PRIDEiQ5EB77

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025828; ENSRNOP00000025828; ENSRNOG00000018972
GeneIDi307039
KEGGirno:307039
UCSCiRGD:1308905 rat

Organism-specific databases

CTDi22931
RGDi1308905 Rab18

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ5EB77
KOiK07910
OMAiMQSTVGM
OrthoDBiEOG091G0MOO
PhylomeDBiQ5EB77
TreeFamiTF313448

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation
R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-RNO-8873719 RAB geranylgeranylation
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q5EB77

Gene expression databases

BgeeiENSRNOG00000018972 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiQ5EB77 RN

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB18_RAT
AccessioniPrimary (citable) accession number: Q5EB77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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