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Protein

Solute carrier family 25 member 46

Gene

Slc25a46

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 46
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1305072 Slc25a46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei167 – 187Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei202 – 222Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei258 – 278Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei314 – 334Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei382 – 402Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918301 – 418Solute carrier family 25 member 46Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei45PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5EB62
PRIDEiQ5EB62

PTM databases

iPTMnetiQ5EB62
PhosphoSitePlusiQ5EB62

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in hindbrain, spinal cord and brain coronal sections containing corpus callosum, fornix, optic chiasm, thalamus, hypothalamus, midbrain, pons and cerebellum.1 Publication

Gene expression databases

BgeeiENSRNOG00000017091
ExpressionAtlasiQ5EB62 baseline and differential
GenevisibleiQ5EB62 RN

Interactioni

Subunit structurei

Interacts with IMMT.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023032

Structurei

3D structure databases

ProteinModelPortaliQ5EB62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 187Solcar 1Add BLAST92
Repeati311 – 416Solcar 2Add BLAST106

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2954 Eukaryota
ENOG410XRFB LUCA
GeneTreeiENSGT00390000015874
HOGENOMiHOG000007981
HOVERGENiHBG059752
InParanoidiQ5EB62
KOiK03454
OMAiEISHKWN
OrthoDBiEOG091G05RA
PhylomeDBiQ5EB62
TreeFamiTF313365

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
IPR039158 SLC25A46
PANTHERiPTHR21252 PTHR21252, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 1 hit
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 2 hits

Sequencei

Sequence statusi: Complete.

Q5EB62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRRPEGFD GLGYRGGVRD DPAFGGPFHA RSFGSGTELG HWVTTPPDIP
60 70 80 90 100
GSRNLHWGEK SPSYGVPSAP PTLEGPAEEP FPGGGDGPRP GRSSEQLNRF
110 120 130 140 150
AGFGIGLASL FTENVLAHPC IVLRRQCQVN YHARHYHLTP FSVINIMYSF
160 170 180 190 200
NKTQGPRALW KGMGSTFIVQ GVTLGAEGII SEFTPLPREV SQKWNPKQIG
210 220 230 240 250
EHLLLKCLTY MVAMPFYSAS LIETVQSEII RDNTGILECV KEGIGRVIGL
260 270 280 290 300
GVPHSKRLLP LFSLIFPTVL HGVLHYIISS IIQKIVLLIL KRKTCSSHLA
310 320 330 340 350
ESTSPMQNML DAYFPELIAN FAASLCSDVI LYPLETVLHR LHIQGTRTII
360 370 380 390 400
DNTDLGYEVL PINTQYEGMR DCVNTIKQEE GVFGFYKGFG AVIIQYTLHA
410
TILQITKIIY STLLQNSI
Length:418
Mass (Da):46,210
Last modified:June 26, 2007 - v2
Checksum:iDF0920EFF44F4B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109497 Genomic DNA No translation available.
BC090000 mRNA Translation: AAH90000.1
RefSeqiNP_001093985.1, NM_001100515.1
UniGeneiRn.12583

Genome annotation databases

EnsembliENSRNOT00000023032; ENSRNOP00000023032; ENSRNOG00000017091
GeneIDi291709
KEGGirno:291709
UCSCiRGD:1305072 rat

Similar proteinsi

Entry informationi

Entry nameiS2546_RAT
AccessioniPrimary (citable) accession number: Q5EB62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: July 18, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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