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Entry version 136 (02 Dec 2020)
Sequence version 2 (17 Apr 2007)
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Protein

Mesoderm-specific transcript homolog protein

Gene

MEST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5EB52

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5EB52

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-MEST, MEST-like

MEROPS protease database

More...
MEROPSi
S33.972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mesoderm-specific transcript homolog protein (EC:3.-.-.-)
Alternative name(s):
Paternally-expressed gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEST
Synonyms:PEG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000106484.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7028, MEST

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601029, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5EB52

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4232

Open Targets

More...
OpenTargetsi
ENSG00000106484

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30762

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5EB52, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MEST

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145566794

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002844181 – 335Mesoderm-specific transcript homolog proteinAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5EB52

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5EB52

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5EB52

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5EB52

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5EB52

PeptideAtlas

More...
PeptideAtlasi
Q5EB52

PRoteomics IDEntifications database

More...
PRIDEi
Q5EB52

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62757 [Q5EB52-1]
62758 [Q5EB52-2]
62759 [Q5EB52-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5EB52, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5EB52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5EB52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Monoallelic expression of paternally derived allele was observed in all fetal tissues examined, including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin and placenta. In 75-day fetus, expressed in the amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle and liver.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106484, Expressed in placenta and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5EB52, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5EB52, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000106484, Tissue enhanced (breast, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
110390, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q5EB52, 22 interactors

Molecular INTeraction database

More...
MINTi
Q5EB52

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000223215

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5EB52, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 310AB hydrolase-1Sequence analysisAdd BLAST240

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi98 – 103RVIALD6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4178, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020336_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5EB52

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDMLGFG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5EB52

TreeFam database of animal gene trees

More...
TreeFami
TF329307

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR000073, AB_hydrolase_1
IPR000639, Epox_hydrolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00561, Abhydrolase_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00412, EPOXHYDRLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5EB52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRRDRLRRM REWWVQVGLL AVPLLAAYLH IPPPQLSPAL HSWKSSGKFF
60 70 80 90 100
TYKGLRIFYQ DSVGVVGSPE IVVLLHGFPT SSYDWYKIWE GLTLRFHRVI
110 120 130 140 150
ALDFLGFGFS DKPRPHHYSI FEQASIVEAL LRHLGLQNRR INLLSHDYGD
160 170 180 190 200
IVAQELLYRY KQNRSGRLTI KSLCLSNGGI FPETHRPLLL QKLLKDGGVL
210 220 230 240 250
SPILTRLMNF FVFSRGLTPV FGPYTRPSES ELWDMWAGIR NNDGNLVIDS
260 270 280 290 300
LLQYINQRKK FRRRWVGALA SVTIPIHFIY GPLDPVNPYP EFLELYRKTL
310 320 330
PRSTVSILDD HISHYPQLED PMGFLNAYMG FINSF
Length:335
Mass (Da):38,830
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2EC0CD6BEC9079A
GO
Isoform 2 (identifier: Q5EB52-2) [UniParc]FASTAAdd to basket
Also known as: Isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:326
Mass (Da):37,591
Checksum:i3B524B416A48A292
GO
Isoform 3 (identifier: Q5EB52-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     218-251: Missing.

Show »
Length:292
Mass (Da):33,757
Checksum:iE0F310C8D967DB49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWU9C9JWU9_HUMAN
Mesoderm-specific transcript homolo...
MEST
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRA9C9JRA9_HUMAN
Mesoderm-specific transcript homolo...
MEST
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCM6C9JCM6_HUMAN
Mesoderm-specific transcript homolo...
MEST
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUD2C9JUD2_HUMAN
Mesoderm-specific transcript homolo...
MEST
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW74C9JW74_HUMAN
Mesoderm-specific transcript homolo...
MEST
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG66C9JG66_HUMAN
Mesoderm-specific transcript homolo...
MEST
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN52R4GN52_HUMAN
Mesoderm-specific transcript homolo...
MEST
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90E → K in BAA11432 (PubMed:8884280).Curated1
Sequence conflicti168L → H in BAA11432 (PubMed:8884280).Curated1
Sequence conflicti222G → W in BAA21757 (PubMed:9158153).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0245321 – 9Missing in isoform 2 and isoform 3. 2 Publications9
Alternative sequenceiVSP_024533218 – 251Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78611 mRNA Translation: BAA11432.1
Y11534 mRNA Translation: CAA72297.1
D87367 mRNA Translation: BAA21757.1
AB045582 Genomic DNA Translation: BAC02716.1
BT007056 mRNA Translation: AAP35705.1
CR457040 mRNA Translation: CAG33321.1
AK312688 mRNA Translation: BAG35568.1
CR627364 mRNA Translation: CAH10465.1
CH471070 Genomic DNA Translation: EAW83766.1
BC002413 mRNA Translation: AAH02413.1
BC090049 mRNA Translation: AAH90049.1
BC011908 mRNA Translation: AAH11908.1
BC014564 mRNA Translation: AAH14564.1
BC018695 mRNA Translation: AAH18695.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5822.1 [Q5EB52-1]
CCDS5823.1 [Q5EB52-2]
CCDS59081.1 [Q5EB52-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001240829.1, NM_001253900.1
NP_001240830.1, NM_001253901.1 [Q5EB52-3]
NP_001240831.1, NM_001253902.1 [Q5EB52-3]
NP_002393.2, NM_002402.3 [Q5EB52-1]
NP_803490.1, NM_177524.2 [Q5EB52-2]
NP_803491.1, NM_177525.2 [Q5EB52-2]
XP_016867707.1, XM_017012218.1 [Q5EB52-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000223215; ENSP00000223215; ENSG00000106484 [Q5EB52-1]
ENST00000341441; ENSP00000342749; ENSG00000106484 [Q5EB52-2]
ENST00000378576; ENSP00000367839; ENSG00000106484 [Q5EB52-3]
ENST00000393187; ENSP00000376884; ENSG00000106484 [Q5EB52-2]
ENST00000416162; ENSP00000408933; ENSG00000106484 [Q5EB52-3]
ENST00000427521; ENSP00000409505; ENSG00000106484 [Q5EB52-3]
ENST00000462132; ENSP00000495770; ENSG00000106484 [Q5EB52-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4232

UCSC genome browser

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UCSCi
uc003vqc.4, human [Q5EB52-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78611 mRNA Translation: BAA11432.1
Y11534 mRNA Translation: CAA72297.1
D87367 mRNA Translation: BAA21757.1
AB045582 Genomic DNA Translation: BAC02716.1
BT007056 mRNA Translation: AAP35705.1
CR457040 mRNA Translation: CAG33321.1
AK312688 mRNA Translation: BAG35568.1
CR627364 mRNA Translation: CAH10465.1
CH471070 Genomic DNA Translation: EAW83766.1
BC002413 mRNA Translation: AAH02413.1
BC090049 mRNA Translation: AAH90049.1
BC011908 mRNA Translation: AAH11908.1
BC014564 mRNA Translation: AAH14564.1
BC018695 mRNA Translation: AAH18695.1
CCDSiCCDS5822.1 [Q5EB52-1]
CCDS5823.1 [Q5EB52-2]
CCDS59081.1 [Q5EB52-3]
RefSeqiNP_001240829.1, NM_001253900.1
NP_001240830.1, NM_001253901.1 [Q5EB52-3]
NP_001240831.1, NM_001253902.1 [Q5EB52-3]
NP_002393.2, NM_002402.3 [Q5EB52-1]
NP_803490.1, NM_177524.2 [Q5EB52-2]
NP_803491.1, NM_177525.2 [Q5EB52-2]
XP_016867707.1, XM_017012218.1 [Q5EB52-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110390, 30 interactors
IntActiQ5EB52, 22 interactors
MINTiQ5EB52
STRINGi9606.ENSP00000223215

Protein family/group databases

ESTHERihuman-MEST, MEST-like
MEROPSiS33.972

PTM databases

GlyGeniQ5EB52, 1 site
iPTMnetiQ5EB52
PhosphoSitePlusiQ5EB52

Polymorphism and mutation databases

BioMutaiMEST
DMDMi145566794

Proteomic databases

EPDiQ5EB52
jPOSTiQ5EB52
MassIVEiQ5EB52
MaxQBiQ5EB52
PaxDbiQ5EB52
PeptideAtlasiQ5EB52
PRIDEiQ5EB52
ProteomicsDBi62757 [Q5EB52-1]
62758 [Q5EB52-2]
62759 [Q5EB52-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
946, 107 antibodies

The DNASU plasmid repository

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DNASUi
4232

Genome annotation databases

EnsembliENST00000223215; ENSP00000223215; ENSG00000106484 [Q5EB52-1]
ENST00000341441; ENSP00000342749; ENSG00000106484 [Q5EB52-2]
ENST00000378576; ENSP00000367839; ENSG00000106484 [Q5EB52-3]
ENST00000393187; ENSP00000376884; ENSG00000106484 [Q5EB52-2]
ENST00000416162; ENSP00000408933; ENSG00000106484 [Q5EB52-3]
ENST00000427521; ENSP00000409505; ENSG00000106484 [Q5EB52-3]
ENST00000462132; ENSP00000495770; ENSG00000106484 [Q5EB52-2]
GeneIDi4232
KEGGihsa:4232
UCSCiuc003vqc.4, human [Q5EB52-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4232
DisGeNETi4232
EuPathDBiHostDB:ENSG00000106484.14

GeneCards: human genes, protein and diseases

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GeneCardsi
MEST
HGNCiHGNC:7028, MEST
HPAiENSG00000106484, Tissue enhanced (breast, placenta)
MIMi601029, gene
neXtProtiNX_Q5EB52
OpenTargetsiENSG00000106484
PharmGKBiPA30762

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4178, Eukaryota
GeneTreeiENSGT00510000047602
HOGENOMiCLU_020336_3_0_1
InParanoidiQ5EB52
OMAiCDMLGFG
PhylomeDBiQ5EB52
TreeFamiTF329307

Enzyme and pathway databases

PathwayCommonsiQ5EB52
SIGNORiQ5EB52

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4232, 4 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MEST, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MEST_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4232
PharosiQ5EB52, Tbio

Protein Ontology

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PROi
PR:Q5EB52
RNActiQ5EB52, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000106484, Expressed in placenta and 244 other tissues
ExpressionAtlasiQ5EB52, baseline and differential
GenevisibleiQ5EB52, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR000073, AB_hydrolase_1
IPR000639, Epox_hydrolase-like
PfamiView protein in Pfam
PF00561, Abhydrolase_1, 1 hit
PRINTSiPR00412, EPOXHYDRLASE
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEST_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5EB52
Secondary accession number(s): B2R6S1
, O14973, O15007, Q6AI49, Q92571
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: December 2, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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